In the paper, the natural gas engine (NGE)model based on AVL BOOST software is built and simulated. The simulation value and experiment value coincide, showing that the NGE model is correct and reasonable. On this basis, the model has been used to analyze the effect of the key parameters, such as compression ratio, ignition advance angle, valve timing, supercharging ratio on the engine power, maximum combustion pressure, exhaust temperature, the maximum rise rate of pressure. Combined with the relevant theories of engine, the value ranges of the key parameters can be designed. The research achievement is valuable in the development and optimization matching of the NGE.