scholarly journals Determinants of Associated Events Following AZD1222 (Covishield) Vaccination in a High-Risk Population in Nepal

2021 ◽  
Author(s):  
Kapil Madi Poudel ◽  
Neha Shah ◽  
Manab Prakash ◽  
Santosh Kumar Deo ◽  
Sunita Bhandari ◽  
...  
Keyword(s):  
High Risk ◽  
Adverse Events ◽  
Female Gender ◽  
Vaccine Safety ◽  
Cross Sectional Study ◽  
High Risk Population ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Frontline Workers ◽  
Reduce Mortality Rate

Abstract Background: Vaccination is the most effective method to prevent the spread of infectious diseases and helps reduce mortality rate and economic costs associated with the pandemic. Despite these advantages, misinformation and rumors on vaccine safety and efficacy can lead to increased hesitation or fear towards vaccination. This study reports the incidence of adverse events following Covishield vaccination, their associated factors, medication used for their management, and attitudes about vaccine safety. Methods: A randomised cross-sectional study was conducted from the sample of Covishield-vaccinated individuals from a secondary hospital, two primary health centres, and 36 health posts in eastern Nepal. Individuals (n = 602) were randomly sampled from a population (N = 1013) who had received the first dose of Covishield, namely frontline workers and other high-risk populations. The second-round follow-up had 516 participants. Association of incidence and severity of post-vaccination events with socio-demographic variables, comorbidity status, and medication use were estimated. Results: Among the 79.9% of participants who reported adverse events after receiving the first dose, two-thirds of complaints were mild (67.4%, 95% CI 63.2–71.6) with the most common complaint being pain at the injection site (86.5%). Paracetamol or its combination were used in majority cases (95.2%). After the second dose, only 31.2% (95% CI 27.2–35.2) reported adverse events, the overwhelming majority of which were mild (95.7%) and required a lower frequency of medication (7.4% vs. 25.9%). Adverse Event following immunization were significantly associated with being 18–30 years old (χ2 = 16.9, df = 3, p < 0.001) and female gender (χ2 = 5.2, df = 1, p < 0.05). Prior to the first dose, 86.0% of participants (95% CI 83.3–88.8%) perceived the vaccine to be safe, and 96.0% recommended the vaccine post-vaccination, while 96.8% were interested in receiving the second dose.Conclusions: Overall, vaccination associated events were mild and majority were managed with paracetamol or its combination. Effective counselling about adverse events before vaccination should be prioritised to reduce hesitation and fear.

scholarly journals Prevalence of SARS-CoV-2 Antibodies in Multiple Sclerosis: The Hidden Part of the Iceberg

2020 ◽  
Vol 9 (12) ◽  
pp. 4066
Author(s):  
Nicola Capasso ◽  
Raffaele Palladino ◽  
Emma Montella ◽  
Francesca Pennino ◽  
Roberta Lanzillo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
High Risk ◽  
Cross Sectional Study ◽  
Low Risk ◽  
High Risk Population ◽  
Chi Square ◽  
Cross Sectional ◽  
Risk Population ◽  
Exact Test ◽  
Chi Square Test

Background. We compared the prevalence of SARS-CoV-2 IgG/IgM in multiple sclerosis (MS), low-risk, and high-risk populations and explored possible clinical correlates. Methods. In this cross-sectional study, we recruited MS patients, low-risk (university staff from non-clinical departments), and high-risk individuals (healthcare staff from COVID-19 wards) from 11 May to 15 June 2020. We used lateral flow immunoassay to detect SARS-CoV-2 IgG and IgM. We used t-test, Fisher’s exact test, chi square test, or McNemar’s test, as appropriate, to evaluate between-group differences. Results. We recruited 310 MS patients (42.3 ± 12.4 years; females 67.1%), 862 low-risk individuals (42.9 ± 13.3 years; females 47.8%), and 235 high-risk individuals (39.4 ± 10.9 years; females 54.5%). The prevalence of SARS-CoV-2 IgG/IgM in MS patients (n = 9, 2.9%) was significantly lower than in the high-risk population (n = 25, 10.6%) (p < 0.001), and similar to the low-risk population (n = 11, 1.3%) (p = 0.057); these results were also confirmed after random matching by age and sex (1:1:1). No significant differences were found in demographic, clinical, treatment, and laboratory features. Among MS patients positive to SARS-CoV-2 IgG/IgM (n = 9), only two patients retrospectively reported mild and short-lasting COVID-19 symptoms. Conclusions. MS patients have similar risk of SARS-CoV-2 infection to the general population, and can be asymptomatic from COVID-19, also if using treatments with systemic immunosuppression.

scholarly journals Psychological Impact of COVID-19 Pandemic and Related Variables: A Cross-Sectional Study in a Sample of Workers in a Spanish Tertiary Hospital

2021 ◽  
Vol 18 (7) ◽  
pp. 3608
Author(s):  
Mónica Leira-Sanmartín ◽  
Agustín Madoz-Gúrpide ◽  
Enriqueta Ochoa-Mangado ◽  
Ángela Ibáñez
Keyword(s):  
Healthcare Workers ◽  
Online Survey ◽  
General Health Questionnaire ◽  
Psychological Impact ◽  
Female Gender ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Frontline Workers ◽  
Assessment And Treatment

Introduction: We intend to objectify the psychological impact of the COVID-19 pandemic on the workers of a tertiary hospital. Methods: All the workers were invited to an online survey. In total, 657 workers were recruited, including 536 healthcare workers (HCWs) and 121 non-healthcare workers (nHCWs). General Health Questionnaire-12 items (GHQ-12) was used as a screening tool. Sociodemographic data, working environmental conditions, and health behaviors were also analyzed. Results: inadequate sleep, poor nutritional and social interaction habits, misuse of psychotropics, female gender, COVID-19 clinical diagnosis, and losing a relative by COVID-19 were variables associated with higher probability of GHQ-12 positive screening. Significant differences between “frontline workers” and the rest were not found, nor was higher the probability of psychological distress in healthcare workers compared to non-healthcare workers. After 3 months from the peak of the pandemic, 63.6% of participants screening positive in GHQ-12 reported remaining “the same or worse.” Limitations: Causal inferences cannot be established. Retrieval and selection biases must be considered as the survey was not conducted during the peak of the outbreak. Conclusions: psychological impact of COVID-19 has been broad, heavy, and persistent in our institution. Proper assessment and treatment must be offered to all hospital workers.

Antimicrobial resistance of Neisseria gonorrhoeae in Jakarta, Indonesia: a cross-sectional study

Sexual Health ◽  
2020 ◽  
Vol 17 (1) ◽  
pp. 9
Author(s):  
Wresti Indriatmi ◽  
Rizky Lendl Prayogo ◽  
Hanny Nilasari ◽  
Lis Surachmiati Suseno
Keyword(s):  
High Risk ◽  
Neisseria Gonorrhoeae ◽  
Local Treatment ◽  
Cross Sectional Study ◽  
Diffusion Method ◽  
High Risk Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
Risk Population ◽  
Factors Associated

Background Neisseria gonorrhoeae has developed resistance to various antimicrobials. At least 10 countries have reported treatment failures with extended-spectrum cephalosporins. Periodic surveillance is essential to determine local treatment guidelines. This study was conducted to determine the resistance of N. gonorrhoeae to penicillin, tetracycline, levofloxacin, cefixime and ceftriaxone among the high-risk population for acquiring STIs in Jakarta and to identify factors associated with resistance. Methods: A cross-sectional study was conducted in Jakarta, Indonesia, from September to November 2018. In all, 98 high-risk males and females who fulfilled the study criteria were included. Specimens were collected from urethral or endocervical swabs, put into Amies transport medium and then transported to the Laboratory of Clinical Microbiology, Universitas Indonesia for culture and identification. Proven gonococcal isolates were examined for susceptibility to various antimicrobials using the disk diffusion method according to Clinical and Laboratory Standard Institute guidelines. Results: Of the 98 specimens, 35 were confirmed to be N. gonorrhoeae. The proportion of N. gonorrhoeae specimens resistant to penicillin, tetracycline, levofloxacin, cefixime and ceftriaxone among the high-risk population was 97.1%, 97.1%, 34.3%, 0% and 0% respectively. The possible factors associated with resistance could only be analysed for levofloxacin. Age, sexual orientation and a history of orogenital sexual activity during the past month were not associated with N. gonorrhoeae resistance to levofloxacin. Conclusion: This study detected no resistance of N. gonorrhoeae to cefixime and ceftriaxone. Further studies with larger samples are needed to obtain more representative results of N. gonorrhoeae resistance and the possible factors associated with resistance.

scholarly journals Clinical value of self-assessment risk of osteoporosis in Chinese

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 190-195 ◽  
Author(s):  
Hong-Mei Zhang ◽  
Hui-Ling Liu ◽  
Xuan Wang ◽  
Wei Chen ◽  
Dan Chen ◽  
...  
Keyword(s):  
High Risk ◽  
Age Groups ◽  
Risk Groups ◽  
Cross Sectional Study ◽  
Height Loss ◽  
High Risk Population ◽  
Clinical Value ◽  
Self Assessment ◽  
Cross Sectional ◽  
Medium Risk

AbstractBackgroundEarly detection of high-risk population for osteoporosis is the key to preventing this disease. Methodology: In this cross-sectional study a continuous sample of 270 women and 89 men (age: 20–90 years) was divided into four groups by age (≤ 55 or > 55 years) and sex. Participants completed the IOF test. Low-, medium-, and high-risk grades were defined by an OSTA index of greater than -1, -1 to -4, and less than -4, respectively. Results: Most participants were categorized in the low-risk group (240 people, 66.9%), followed by the medium-risk (102 people, 28.4%) and high-risk groups (17 people, 4.7%). Compared to women, men in both age groups had significantly higher OSTA index and greater numbers of positive answers on the IOF test. 64.3% individuals were susceptible to osteoporosis risk (≥1 positive answers on the IOF test). Multiple regression analysis demonstrated that family history of fragility fracture (OR: 0.503, 95% CI: 0.26–0.97), height loss exceeding 3 cm (OR: 2.51, 95% CI: 1.55–4.05), and earlier menopause (OR: 0.434, 95% CI: 0.19–0.97) were associated with higher risk grades. Conclusions: Combined use of the OSTA and IOF test is a simple and effective method for assessing the risk of osteoporosis.

scholarly journals Prevalence of Chronic Kidney Disease among the High Risk Population in South-Western Ghana; A Cross Sectional Study

2015 ◽  
Vol 2 ◽  
pp. 76 ◽  
Author(s):  
Richard KD Ephraim ◽  
Sylvester Biekpe ◽  
Samuel A. Sakyi ◽  
Prince Adoba ◽  
Hope Agbodjakey ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
High Risk ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
High Risk Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
Risk Population

scholarly journals Healthcare Workers Exposure Risk Assessment: A Survey among Frontline Workers in Designated COVID-19 Treatment Centers in Ghana

2020 ◽  
Vol 11 ◽  
pp. 215013272096948
Author(s):  
Mary Eyram Ashinyo ◽  
Stephen Dajaan Dubik ◽  
Vida Duti ◽  
Kingsley Ebenezer Amegah ◽  
Anthony Ashinyo ◽  
...  
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Virus Infection ◽  
Healthcare Workers ◽  
Assessment Tool ◽  
Cross Sectional Study ◽  
Infection Prevention And Control ◽  
Cross Sectional ◽  
Frontline Workers ◽  
High Level

Background: Healthcare workers (HCWs) are faced with an elevated risk of exposure to SARS-COV-2 due to the clinical procedures they perform on COVID-19 patients. However, data for frontline HCWs level of exposure and risk of COVID-19 virus infection are limited. Objective: We investigated the level of exposure and risk of COVID-19 virus infection among HCWs in COVID-19 treatment centers in Ghana. Methods: A cross-sectional study was utilized in this study and HCWs were invited by convenience to participate in the study, 408 HCWs in 4 COVID-19 treatment centers participated in the study. Adherence to infection prevention and control (IPC) measures were used to categorized HCWs as low or high risk of COVID-19 virus infection. The WHO COVID-19 risk assessment tool was used to collect quantitative data from the study participants. Results: There was a high (N = 328, 80.4%) level of occupational exposure to the COVID-19 virus. However, only 14.0% of the exposed HCWs were at high risk of COVID-19 virus infection. Healthcare workers who performed or were present during any aerosol-generating procedures (AGP) were 23.8 times more likely to be exposed compared to HCWs who did not perform or were absent during any AGP (AOR 23.83; 95% CI: 18.45, 39.20). High risk of COVID-19 virus infection was less likely among registered nurses (AOR = 0.09; 95% CI: 0.02, 0.60), HCWs who performed or were present during any AGP (AOR = 0.05; 95% CI: 0.01, 0.50) and HCWs with a master’s degree qualification (AOR 0.06; 95% CI: 0.01, 0.63). Conclusion: Despite the high level of exposure to the COVID-19 virus among HCWs in the treatment centers, only 14.0% were at high risk of COVID-19 virus infection. To protect this group of HCWs, treatment centers and HCWs should continue to adhere to WHO and national IPC protocols in managing of COVID-19 cases.

scholarly journals Perceptions of healthcare workers in high-risk areas of a Singapore hospital during COVID-19: a cross-sectional study

2021 ◽  
Author(s):  
PSA Au-Yong ◽  
WM Peh ◽  
FHX Koh ◽  
LM Teo ◽  
SP Ng ◽  
...  
Keyword(s):  
High Risk ◽  
Healthcare Workers ◽  
Female Gender ◽  
Cross Sectional Study ◽  
Emotional Impact ◽  
Sectional Study ◽  
Cross Sectional ◽  
Protective Measures ◽  
Electronic Survey ◽  
Precautionary Measures

Introduction: There is worldwide concern over the psycho-emotional impact of COVID-19 on healthcare workers (HCWs). This study aimed to elicit HCWs’ perceptions of the adequacy of protective measures in high-risk clinical areas and the factors associated with these perceptions. Methods: This was a cross-sectional study conducted in April 2020. An anonymous electronic survey was sent via email to operating theatre (OT) and intensive care unit (ICU) staff of Sengkang General Hospital, Singapore. Results: Of the 358 eligible participants, 292 (81.6%) responded to the survey. 93.2% of the participants felt that precautionary measures at work were sufficient and 94.9% acknowledged that adequate training was provided. More than 60% of the participants opined that their chances of contracting COVID-19 were moderate to high. Female gender, nursing occupation and duration of service < 10 years were significantly associated with increased fear of contracting COVID-19, less control over occupational exposure and lower perceived need to care for COVID-19 patients. Having young children at home did not significantly affect these perceptions. The most important ICU precautions were availability of personal protective equipment outside the rooms of COVID-19 positive patients (95.3%) and having visitor restrictions (95.3%). The most important OT measures were having a dedicated OT for COVID-19 positive patients (91.2%) and having simulation as part of protocol familiarisation (91.7%). Conclusion: Overall, there was high confidence in the adequacy of COVID-19 protective measures to prevent healthcare transmission in Singapore. The pandemic had a lower degree of psycho-emotional impact on HCWs here as compared to other countries.

Sign in / Sign up

Export Citation Format

Share Document