scholarly journals Kimura Disease With Allergic Bronchopulmonary Aspergillosis: A Case Report

2021 ◽  
Author(s):  
Ruiyun Fan ◽  
Guopeng Xu ◽  
Ying Chen ◽  
Jinghuan Lv ◽  
Zhongwei Zhang
Keyword(s):  
Lymph Nodes ◽  
Age Of Onset ◽  
Systemic Disease ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Neck Region ◽  
Final Diagnosis ◽  
Unknown Etiology ◽  
Kimura Disease ◽  
Multiple Organs ◽  
Missed Diagnosis

Abstract Background: Kimura disease (KD) is a rare chronic idiopathic condition of unknown etiology that is prevalent in Asian males. It often causes subcutaneous lumps and enlarged lymph nodes, especially in head and neck region. But KD is also a systemic disease that can involve multiple organs, such as the kidneys and skin. Case presentation: Here, we report a 62-year-old Chinese man who was characterized by paroxysmal cough, enlarged inguinal lymph nodes, recurrent skin itching, and elevated IgE antibodies specific to A. fumigatus. After a comprehensive inspection, the final diagnosis for this patient was KD with Atopic Bronchopulmonary Aspergillosis (ABPA). Conclusions: The age of onset and the location of the lump involved were not the most common. This study described the patient’s diagnosis and treatment process. The coexistence of the two special diseases will provide clinicians with some enlightenment on the etiology of KD. Moreover, we hope to arouse the attention of multidisciplinary team to explore the potential relationship between KD and ABPA. It will contribute to preventing the misdiagnosis and missed diagnosis of KD.

A manifestation of sarcoidosis in the neck region

2018 ◽  
Vol 7 (2) ◽  
pp. 11-15
Author(s):  
Anna Rzepakowska ◽  
Karolina Stańska ◽  
Ewa Osuch_Wójcikiewicz ◽  
Daniel Majszyk ◽  
Kazimierz Niemczyk
Keyword(s):  
Lymph Nodes ◽  
Salivary Glands ◽  
Histopathological Examination ◽  
Systemic Disease ◽  
Neck Region ◽  
Diagnostic Procedures ◽  
Pulmonary Sarcoidosis ◽  
Initial Assessment ◽  
Unknown Etiology ◽  
Surgical Removal

Sarcoidosis is a systemic disease of unknown etiology. It is characterized by a formation of lumps known as noncaseating granulomas, which are not affected by necrosis. Typical collections of inflammatory cells may be found in any organ tissues but mainly in the lungs, skin or lymph nodes. Head and neck organs involvement is rare, although sarcoidosis can be found in lymph nodes, salivary glands, larynx, and sinuses. A search was performed based on medical records of patients admitted to the Department of Otolaryngology within four previous years. We analyzed two cases of sarcoidosis of salivary glands (parotid and submandibular), two cases of larynx involvement and one case of lymphadenopathy due to sarcoidosis. Patients (4 women and 1 man), age range 26-76 years old, were directed to the Otolaryngology Department with neck lymphadenopathy or a suspicion of a neoplastic tumor of salivary gland or larynx. Only one patient had the previous diagnosis of pulmonary sarcoidosis. Preoperative diagnostic procedures such as ultrasonography, biopsy, chest radiography did not suggest sarcoidosis on the initial assessment of other patients. Surgical removal of the pathological findings and histopathological examination confirmed extrapulmonary sarcoidosis. The computed tomography of lungs confirmed coexisting pulmonary sarcoidosis in only one patient.

Cardiac Sarcoidosis: Cytokine Patterns in the Course of the Disease

2003 ◽  
Vol 127 (9) ◽  
pp. 1207-1210 ◽  
Author(s):  
Michael Schoppet ◽  
Sabine Pankuweit ◽  
Bernhard Maisch
Keyword(s):  
Time Course ◽  
Mononuclear Cells ◽  
Cardiac Sarcoidosis ◽  
Systemic Disease ◽  
Healing Process ◽  
Unknown Etiology ◽  
Enzyme Linked Immunosorbent Assay ◽  
Rapid Decline ◽  
Peripheral Blood Mononuclear ◽  
Multiple Organs

Abstract Sarcoidosis is a chronic systemic disease of unknown etiology, which is characterized by noncaseating epitheloid granulomas usually in multiple organs. Here we describe changes in cytokine mRNA expression by peripheral blood mononuclear cells (PBMCs) and changes of cytokine protein levels in plasma over a time course of 12 months in a patient with sarcoidosis confined to the heart as diagnosed by endomyocardial biopsy. Mitogen-stimulated PBMCs exhibited a more TH1 cytokine profile at onset of symptoms before immunosuppressive therapy was initiated, with a change to a TH0 response in the course of the disease as evidenced by multiplex-polymerase chain reaction. In plasma, high levels of interleukin-6 could be detected by an enzyme-linked immunosorbent assay system, with rapid decline correlating with immunosuppression and improving clinical course. These changes may point to a role of TH1 and TH2 cytokines in the pathogenesis and the healing process of cardiac sarcoidosis.

Our Experience in Treating a Rare Clinical Case Angiomyomatous Hamartomas of Head and Neck Region; Case Report

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Hakobyan Gagik
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
External Carotid Artery ◽  
Unknown Etiology ◽  
External Carotid ◽  
Head And Neck Region ◽  
Neck Masses ◽  
Head And Neck Masses

Angiomyomatous hamartoma of head and neck region is very are disease, of unknown etiology and more often than not it can be misdiagnosed preoperatively. Materials and Methods: In a study we present a case of angiomyomatous hamartoma in the carotid triangle, a site where a tumor has an invasion to external carotid artery, treatment carried out by surgical excision, after histological examination, the final diagnosis was made. The patient was under observation for 3 years, there were no relapses. Conclusion: The diagnosis of angiomyomatous hamartoma is based on histologic examination. Although this entity is rare, we believe that head and neck surgeons should include it in the differential diagnosis of head and neck masses.

scholarly journals Kimura Disease: A case report and review of literature

2018 ◽  
Vol 17 (1) ◽  
pp. 152-154
Author(s):  
Partha Pratim Sinha Roy ◽  
Parthasarathi Ghosh ◽  
Dwaipayan Samaddar ◽  
Gautam Das
Keyword(s):  
Case Report ◽  
Inflammatory Disease ◽  
Medical Science ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Review Of Literature ◽  
Kimura Disease ◽  
Head And Neck Region ◽  
Blood Eosinophilia

Kimura disease is a rare chronic inflammatory disease with angiolymphatic proliferation of unknown etiology predominantly seen among young Asian males. It classically shows a triad of non-tender subcutaneous masses predominantly in head and neck region with tissue and blood eosinophilia and raised serum IgE level. Here we present a case report of a 24 years male with bilateral pre-auricular and post-auricular swelling for 6 years. The diagnosis of Kimura disease was made on the basis of clinical and histopathological examination.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.152-154

scholarly journals Assessment of Cardiac Sarcoidosis with Advanced Imaging Modalities

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Makoto Orii ◽  
Toshio Imanishi ◽  
Takashi Akasaka
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Systemic Disease ◽  
Imaging Modalities ◽  
Unknown Etiology ◽  
Advanced Imaging ◽  
Multiple Organs ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnostic Modalities

Sarcoidosis is a chronic systemic disease of unknown etiology that is characterized by the presence of noncaseating epithelioid granulomas, usually in multiple organs. Several studies have shown that sarcoidosis might be the result of an exaggerated granulomatous reaction after exposure to unidentified antigens in genetically susceptible individuals. Cardiac involvement may occur and lead to an adverse outcome: the heart mechanics will be affected and that causes ventricular failure, and the cardiac electrical system will be disrupted and lead to third degree atrioventricular block, malignant ventricular tachycardia, and sudden cardiac death. Thus, early diagnosis and treatment of this potentially devastating disease is critically important. However, sensitive and accurate imaging modalities have not been established. Recent studies have demonstrated the promising potential of cardiac magnetic resonance imaging (MRI) and18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) in the diagnosis and assessment of cardiac sarcoidosis (CS). In this review, we discuss the epidemiology, etiology, histological findings, and clinical features of sarcoidosis. We also introduce advanced imaging including18F-FDG PET and cardiac MRI as more reliable diagnostic modalities for CS.

scholarly journals Thirty Two Years Male Patient with Adult Still’s Disease

1970 ◽  
Vol 9 (1) ◽  
pp. 58-61
Author(s):  
Ahmedul Kabir ◽  
Tushar Kanti Barman ◽  
Jayanta Banik
Keyword(s):  
Significant Proportion ◽  
Febrile Illness ◽  
Final Diagnosis ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Adult Onset ◽  
Still’S Disease ◽  
Laboratory Findings ◽  
Still's Disease ◽  
Multiple Organs

A rare systemic inflammatory disorder is Adult onset Still's disease (AOSD), characterized by diverse clinical and laboratory findings, which is often difficult to diagnose. It is responsible for a significant proportion of cases of acute febrile illness in young adults. Adult Onset Stills Disease (AOSD) usually affects multiple organs, but it is a diagnosis of exclusion. Here we describe a case of a 32-year old patient with fever of unknown etiology, arthralgia, sore throat and skin rash. The final diagnosis of Still's disease was made by clinical and laboratory criteria and exclusion of other causes of similar presentation.   DOI = 10.3329/jom.v9i1.1428 J MEDICINE 2008; 9 : 58-61

scholarly journals Kimura Disease of the Nose

2021 ◽  
Vol 6 (2) ◽  
pp. 61-64
Author(s):  
Zalilah Musa ◽  
Abdul Razak Ismail ◽  
Irfan Mohamad
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Surgical Excision ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Nasal Bridge ◽  
Chronic Inflammatory Disorder

Introduction: Kimura disease is a rare chronic inflammatory disorder affecting the subcutaneous tissue. It is of unknown etiology mainly occurring in head and neck region. Case report: A 34-year-old Malay lady presented with a gradually enlarging, painless right nasal bridge mass for one year duration. Clinical examination revealed a firm, immobile swelling measuring 2 cm x 2 cm. Nasal endoscopy showed no extension of the mass into the right nasal cavity. Surgical excision was performed where histopathological examination reported as finding consistent with Kimura disease. Conclusion: Kimura disease is extremely a rare benign disease, which can affect the head and neck structures. Manifestation at the nasal region is an extremely rare occurrence. Histopathological examination is needed to diagnose the disease.

scholarly journals Sarcoidosis: Review of Diagnosis and Treatment

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Shoor S ◽  
Keyword(s):  
Lymph Nodes ◽  
Age Of Onset ◽  
Fungal Infections ◽  
Upper Airway ◽  
Organ Damage ◽  
Unknown Etiology ◽  
Common Disease ◽  
Caucasian Americans ◽  
Autoimmune Rheumatic Disease ◽  
Necrotizing Granuloma

Background: Sarcoidosis is a systemic heterogenous granulomatous disease of unknown etiology that results in inflammation of pulmonary and extrapulmonary sites. In a minority of patients it can result in fibrosis and permanent organ damage. Most commonly mentioned causes of sarcoidosis include atypical mycobacterium, proprionobacterium and inorganic dusts. Once exposed to an organic or inorganic, an Antigen Presenting Cell (APC) prepares and presents the antigen to a T cell and its respective HLA locus. In a susceptible person, this provides cytokine production, differentiation into T helper cells and provokes an immune response that in its early stages is allayed by corticosteroids or other immunomodulatory agents. In the majority of patients appropriate immunomodulatory therapy will control the disease and prevent progression. However, in 20-25 % the disease can progress and lead to organ damage or compromise and fibrosis. Sarcoidosis is a relatively common disease with an incidence of 2.3-17.8 per 100,000. It is 2-4 times more common in African Americans than Caucasian Americans with the mean age of onset of 45-50 years of age. Unlike autoimmune rheumatic disease the disease occurs almost as commonly in men than women. Sources: A Medline, Pub Med review from 1999-2021. Spectrum of Disease: Sarcoidosis occurs in 90-98 % of patients during the course of their disease. Eleven to twenty two percent of patients have involvement of either the liver, Skin, ocular (uveitis), Lymph nodes and spleen. The upper airway, liver, CNS and heart comprise <10% of cases each and the bone, joints/ muscle, and hypercalcemia < 5%. Diagnosis: With the exception of Lofgren’s and Heerfordt’syndromes the presence of non-caseating/necrotizing granuloma must be present on biopsy of at least one site and mycobacterial or fungal infections or malignancy must be ruled out. If clinically suspicious, Skin and peripheral lymph nodes are the least invasive areas for biopsy and if hilar or mediastinal nodes are suggestive, an EBUS approach is recommended. In organs such as the heart and CNS where biopsy is either insensitive or invasive, a Cardiologist and Neurologist in concert with a Rheumatologist can make a probable diagnosis based on clinical presentation, PET or MRI and exclusion of alternative diseases.

scholarly journals SARS-CoV-2 Causes a Systemically Multiple Organs Damages and Dissemination in Hamsters

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhiqi Song ◽  
Linlin Bao ◽  
Pin Yu ◽  
Feifei Qi ◽  
Shuran Gong ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Lymph Nodes ◽  
Diffuse Alveolar Damage ◽  
Systemic Disease ◽  
Treatment Strategies ◽  
Antigen Expression ◽  
Viral Rna ◽  
Post Inoculation ◽  
Focal Lesions ◽  
Multiple Organs

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread across the world and impacted global healthcare systems. For clinical patients, COVID-19 not only induces pulmonary lesions but also affects extrapulmonary organs. An ideal animal model that mimics COVID-19 in humans in terms of the induced systematic lesions is urgently needed. Here, we report that Syrian hamster is highly permissive to SARS-CoV-2 and exhibit diffuse alveolar damage and induced extrapulmonary multi-organs damage, including spleen, lymph nodes, different segments of alimentary tract, kidney, adrenal gland, ovary, vesicular gland and prostate damage, at 3–7 days post inoculation (dpi), based on qRT-PCR, in situ hybridization and immunohistochemistry detection. Notably, the adrenal gland is a novel target organ, with abundant viral RNA and antigen expression detected, accompanied by focal to diffuse inflammation. Additionally, viral RNA was also detected in the corpus luteum of the ovary, vesicular gland and prostate. Focal lesions in liver, gallbladder, myocardium, and lymph nodes were still present at 18 dpi, suggesting potential damage after disease. Our findings illustrate systemic histological observations and the viral RNA and antigen distribution in infected hamsters during disease and convalescence to recapitulate those observed in humans with COVID-19, providing helpful data to the pathophysiologic characterization of SARS-CoV-2-induced systemic disease and the development of effective treatment strategies.

scholarly journals Incidence, characteristics, determinants and prognostic impact of recurrent syncope

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Zimmermann ◽  
J Du Fay De Lavallaz ◽  
T Nestelberger ◽  
D Gualandro ◽  
P Badertscher ◽  
...  
Keyword(s):  
Patient Characteristics ◽  
Coronary Intervention ◽  
Final Diagnosis ◽  
Major Adverse Cardiovascular Events ◽  
Unknown Etiology ◽  
Funding Source ◽  
Prognostic Impact ◽  
Lasso Regression ◽  
Recurrence Rates ◽  
Increased Risk

Abstract Background The incidence, characteristics, determinants, and prognostic impact of recurrent syncope are largely unknown, causing uncertainty for both patients and physicians. Methods We characterized recurrent syncope including sex-specific aspects and its impact on death and major adverse cardiovascular events (MACE) in a large prospective international multicenter study enrolling patients ≥40 years presenting with syncope to the emergency department (ED). Syncope etiology was centrally adjudicated by two independent and blinded cardiologists using all information becoming available during syncope work-up and 12-month follow-up. MACE were defined as a composite of all-cause death, acute myocardial infarction, surgical or percutaneous coronary intervention, life-threatening arrhythmia including cardiac arrest, pacemaker or implantable cardioverter defibrillator implantation, valve intervention, heart-failure, gastrointestinal bleeding or other bleeding requiring transfusion, intracranial hemorrhage, ischemic stroke or transient ischemic attack, sepsis and pulmonary embolism. Results Incidence of recurrent syncope among 1790 patients was 20% (95%-confidence interval (CI) 18% to 22%) within 24 months. Patients with an adjudicated final diagnosis of cardiac syncope (hazard ratio (HR) 1.50, 95%-CI 1.11 to 2.01) or syncope of unknown etiology even after central adjudication (HR 2.11, 95%-CI 1.54 to 2.89) had an increased risk for syncope recurrence (Figure). LASSO regression fit on all patient information available early in the ED identified more than three previous episodes of syncope as the only independent predictor for recurrent syncope (HR 2.13, 95%-CI 1.64 to 2.75). Recurrent syncope within the first 12 months after the index event carried an increased risk for all-cause death (HR 1.59, 95%-CI 1.06 to 2.38) and MACE (HR 2.24, 95%-CI 1.67 to 3.01), whereas recurrences after 12 months did not have a significant impact on outcome measures. Conclusion Recurrence rates of syncope are substantial and vary depending on syncope etiology. There seem to be no reliable patient characteristics available early on the ED that allow for the prediction of recurrent syncope with only a history of more than three previous syncope being associated with a higher risk for future recurrences. Importantly, recurrent syncope within the first 12 months carries an increased risk for death and MACE. Figure 1 Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Swiss National Science Foundation, Swiss Heart Foundation

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