Hypochromic Red Cells as Predictors of Anemia in Patients Undergoing Hemodialysis: An Observation Retrospective Study

Abstract The percentage of hypochromic red blood cells (%HRC) estimates the availability of iron by evaluating the degree of hemoglobinization. We investigated whether %HRC was a predictor of anemia in patients undergoing hemodialysis. We recruited 142 patients undergoing routine hemodialysis between 2017 and 2019. Delta hemoglobin level (ΔHb)1mo-baseline was calculated as the difference between the hemoglobin level at 1 month after study enrollment and that at study enrollment. Development of anemia was defined as hemoglobin level ≤15% of baseline. The median %HRC was 3.1%. There was a significant negative correlation between (ΔHb)1mo- baseline and %HRC (r = -0.63, P < 0.001). The incidence of anemia was significantly higher in patients with %HRC >3.1% than in those with %HRC ≤3.1%. In the multivariate logistic regression analysis, %HRC was significantly related to the development of anemia (odds ratio 2.57, 95% confidence interval [CI] 1.72–3.85, P < 0.001). The best cutoff value for %HRC to predict the development of anemia was 4.3%, with a sensitivity and specificity of 67.74 (95% CI, 54.7–79.1) and 97.50 (95% CI, 91.3– 99.7), respectively. %HRC is an independent predictor of anemia in patients undergoing hemodialysis. %HRC ≤4.3% is an early marker to consider changing the anemia treatment.

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Hypochromic red cells as predictors of anemia in patients undergoing hemodialysis: an observational retrospective study

Scientific Reports ◽

10.1038/s41598-021-03746-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Youn Kyung Kee ◽

Hee Jung Jeon ◽

Jieun Oh ◽

Dong Ho Shin

Keyword(s):

Blood Cells ◽

Odds Ratio ◽

Independent Predictor ◽

Multivariate Logistic Regression Analysis ◽

Significant Negative Correlation ◽

Hemoglobin Level ◽

Multivariate Logistic Regression ◽

Study Enrollment ◽

The Difference ◽

Anemia Treatment

AbstractThe percentage of hypochromic red blood cells (%HRC) estimates the availability of iron by evaluating the degree of hemoglobinization. We investigated whether %HRC was a predictor of anemia in patients undergoing hemodialysis. We recruited 142 patients undergoing routine hemodialysis between 2017 and 2019. Delta hemoglobin level (ΔHb)1mo-baseline was calculated as the difference between the hemoglobin level at 1 month after study enrollment and that at the time of study enrollment. Development of anemia was defined as hemoglobin level ≤ 15% of baseline. The median %HRC was 3.1%. There was a significant negative correlation between (ΔHb)1mo- baseline and %HRC (r = − 0.63, P < 0.001). The incidence of anemia was significantly higher in patients with %HRC > 3.1% than in those with %HRC ≤ 3.1%. In the multivariate logistic regression analysis, %HRC was significantly related to the development of anemia (odds ratio 2.57, 95% confidence interval [CI] 1.72–3.85, P < 0.001). The best cutoff value for %HRC to predict the development of anemia was 4.3%, with a sensitivity and specificity of 67.74 (95% CI, 54.7–79.1) and 97.50 (95% CI, 91.3– 99.7), respectively. %HRC is an independent predictor of anemia in patients undergoing hemodialysis. %HRC ≤ 4.3% is an early marker to consider changing the anemia treatment.

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LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2018-022757 ◽

2018 ◽

Vol 8 (10) ◽

pp. e022757 ◽

Cited By ~ 4

Author(s):

Qiang Zhao ◽

Fen Liu ◽

Ying-Hong Wang ◽

Hong-Mei Lai ◽

Qian Zhao ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Independent Predictor ◽

Multivariate Logistic Regression Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Sectional Study ◽

Multivariate Logistic Regression ◽

Obese Adults ◽

Cross Sectional

ObjectiveThe aim of this study was to explore the relationship between low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C) ratio and common carotid atherosclerotic plaque (CCAP) among obese adults of Uygur community in Xinjiang, China.DesignA hospital-based cross-sectional study.SettingFirst Affiliated Hospital of Xinjiang Medical University.ParticipantsA total of 1449 obese adults of Uygur population who were free of coronary artery disease were included in our study from 1 January 2014 to 31 December 2016.MethodologyLipid profiles, other routine laboratory parameters and intima-media thickness of the common carotid artery were measured in all participants. Multivariate logistic regression analysis was used to examine the association between LDL-C:HDL-C ratio and CCAP.ResultsFour hundred and fifteen (28.64%) participants had CCAP. Participants with CCAP had significantly higher LDL-C:HDL-C ratio compared with those without CCAP (3.21 [2.50, 3.88] vs 2.33 [1.95, 2.97], p<0.001). Multivariate logistic regression analysis showed high LDL-C:HDL-C ratio as independent predictor of CCAP after adjusting for conventional cardiovascular risk factors. The top LDL-C:HDL-C ratio quartile (≥3.25) had an OR of 9.355 (95% CI 6.181 to 14.157) compared with the bottom quartile (<2.07) of LDL-C:HDL-C ratio (p<0.001) after adjustment for age, body mass index, smoking, diabetes mellitus and serum level of total cholesterol.ConclusionCCAP is highly prevalent in Uygur obese adults. A high LDL-C:HDL-C ratio is an independent predictor of CCAP. It may help identify obese individuals who are at high risk of CCAP and who may benefit from intensive LDL-lowering therapy.

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Serum uric acid is associated with cardiac diastolic dysfunction among women with preserved ejection fraction

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00402.2015 ◽

2015 ◽

Vol 309 (5) ◽

pp. H986-H994 ◽

Cited By ~ 14

Author(s):

Shinpei Nogi ◽

Shu-ichi Fujita ◽

Yusuke Okamoto ◽

Shun Kizawa ◽

Hideaki Morita ◽

...

Keyword(s):

Logistic Regression ◽

Uric Acid ◽

Regression Analysis ◽

Ejection Fraction ◽

Diastolic Dysfunction ◽

Odds Ratio ◽

Multivariate Logistic Regression Analysis ◽

Left Ventricular ◽

Preserved Ejection Fraction ◽

Multivariate Logistic Regression

Serum uric acid (SUA) is associated with the severity and prognosis of systolic heart failure. We investigated the potential association between SUA and cardiac diastolic dysfunction among total of 744 cardiac patients (202 women and 542 men) who had preserved left ventricular ejection fraction. Presence of diastolic dysfunction was assessed by echocardiographic data, plasma B-type natriuretic peptide concentration, and left ventricular hypertrophy. Univariate analysis showed that the prevalence of diastolic dysfunction increased with increasing SUA value in women, but not in men. When sex-nonspecific SUA quartiles were used, multivariate logistic regression analysis, among female patients who were not taking uric acid lowering medication, showed that the third (SUA, 5.7–6.4 mg) and the fourth (SUA, ≥6.5 mg/dl) SUA quartiles were associated with diastolic dysfunction with an odds ratio of 3.25 ( P < 0.05) and 8.06 ( P < 0.001), respectively, when compared with the first SUA quartile (≤4.7 mg/dl). When sex-specific SUA quartiles were used among these population, multivariate logistic regression analysis showed that the fourth SUA quartile (≥5.7 mg/dl) was associated with diastolic dysfunction with an odds ratio of 5.34 ( P < 0.05) when compared with the first SUA quartile (≤4.1 mg/dl). By contrast, the relationship between SUA and diastolic dysfunction was not significant in men, irrespective of which of the sex-nonspecific or sex-specific SUA quartiles were used. These data indicated that among cardiac patients with preserved ejection fraction, SUA was significantly associated with diastolic dysfunction in women but not in men.

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G6PD deficiency, absence of α-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia

Blood ◽

10.1182/blood-2008-03-143891 ◽

2008 ◽

Vol 112 (10) ◽

pp. 4314-4317 ◽

Cited By ~ 98

Author(s):

Françoise Bernaudin ◽

Suzanne Verlhac ◽

Sylvie Chevret ◽

Martine Torres ◽

Lena Coic ◽

...

Keyword(s):

Risk Factors ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

G6pd Deficiency ◽

Odds Ratio ◽

Multivariate Logistic Regression Analysis ◽

Multivariate Logistic Regression ◽

Alpha Thalassemia ◽

Independent Risk Factors ◽

First Time

AbstractStroke is predicted by abnormally high cerebral velocities by transcranial doppler (TCD). This study aimed at defining predictive factors for abnormally high velocities (≥ 2 m/sec) based on the Créteil pediatric sickle cell anemia (SCA) cohort composed of 373 stroke-free SCA children. α genes and β-globin haplotypes were determined. Biologic parameters were obtained at baseline. α-thalassemia was present in 155 of 325 and G6PD deficiency in 36 of 325 evaluated patients. TCD was abnormal in 62 of 373 patients. Multivariate logistic regression analysis showed that G6PD deficiency (odds ratio [OR] = 3.36, 95% confidence interval [CI] 1.10-10.33; P = .034), absence of alpha-thalassemia (OR = 6.45, 95% CI 2.21-18.87; P = .001), hemoglobin (OR per g/dL = 0.63, 95% CI 0.41-0.97; P = .038), and lactate dehydrogenase (LDH) levels (OR per IU/L = 1.001, 95% CI 1.000-1.002; P = .047) were independent risk factors for abnormally high velocities. This study confirms the protective effect of alpha-thalassemia and shows for the first time that G6PD deficiency and hemolysis independently increase the risk of cerebral vasculopathy.

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Torus Mandibularis in Patients Receiving Hemodialysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18189451 ◽

2021 ◽

Vol 18 (18) ◽

pp. 9451

Author(s):

Pei-Ching Chang ◽

Shao-Yu Tai ◽

Chia-Lin Hsu ◽

Aileen I. Tsai ◽

Jen-Fen Fu ◽

...

Keyword(s):

Odds Ratio ◽

Prospective Observational Study ◽

Multivariate Logistic Regression Analysis ◽

Phosphate Level ◽

Chang Gung Memorial Hospital ◽

Poor Oral Hygiene ◽

Multivariate Logistic Regression ◽

Younger Age ◽

Mandibular Tori ◽

Bone Structures

Reports on the prevalence of torus mandibularis among dialysis patients have been limited and inconclusive. A wide variety of oral manifestations has been found in patients with hyperparathyroidism. Furthermore, uremia-related changes in facial bone structures have been described in the literature. This prospective observational study examined 322 hemodialysis patients treated at the Chang Gung Memorial Hospital from 1 August to 31 December 2016. Two subgroups were identified: patients with torus mandibularis (n = 25) and those without (n = 297). Clinical oral examinations including inspection and palpation were employed. Our study found that most mandibular tori were symmetric (84.0%), nodular (96.0%), less than 2 cm in size (96.0%), and located in the premolar area (92.0%). Poor oral hygiene was observed among these patients, with 49.7% and 24.5% scoring 3 and 4, respectively, on the Quigley-Hein plaque index. More than half (55.0%) of patients lost their first molars. Multivariate logistic regression analysis revealed that blood phosphate level (odds ratio = 1.494, p = 0.029) and younger age (odds ratio = 0.954, p = 0.009) correlated significantly with torus mandibularis. The prevalence of torus mandibularis in patients receiving hemodialysis in this study was 7.8%. Younger age and a higher blood phosphate level were predictors for torus mandibularis in these patients.

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Clinical Predictors of Arterial Extravasation, Rebleedingand Mortality Following Angiographic Interventions in Gastrointestinal Bleeding

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.273.daz ◽

2018 ◽

Vol 27 (3) ◽

pp. 221-226 ◽

Cited By ~ 2

Author(s):

Prasoon Mohan ◽

John Manov ◽

Alexander Diaz-Bode ◽

Sree Venkat ◽

Michael Langston ◽

...

Keyword(s):

Logistic Regression ◽

Independent Predictor ◽

Hemodynamic Instability ◽

Hemoglobin Level ◽

Gi Bleeding ◽

Multivariate Logistic Regression ◽

Clinical Predictors ◽

Lower Gi Bleeding ◽

History Of ◽

Negative Predictor

Background & Aims: The aim of this study was to identify clinical and imaging predictors of arterial extravasation, post embolization rebleeding and 30-day mortality in gastrointestinal (GI) bleeding. Method: This retrospective study included 114 patients who underwent angiography for upper or lower GI bleeding. Multivariate logistic regression was used to identify clinical and imaging predictors. Results: Angiography demonstrated arterial extravasation in 22 patients (19%) and embolization was performed in 48 (42%) patients including prophylactic embolization in 26 (56%). Fall in hemoglobin level from baseline was an independent predictor of arterial extravasation with 65% increased odds for every unit drop (OR 1.65, 95%CI 1.13-2.40, p=0.01). Age <60 years was a negative predictor of rebleed within 30-days (OR 0.94, 95%CI 0.89-1.00, p=0.04). Patients with a history of malignancy were more likely to rebleed (OR 4.4, 95%CI 1.06-18.36, p=0.04). Hemodynamic instability prior to angiography (OR 13.22, 95%CI 1.65-106.07, p=0.02), history of malignancy (OR 1.36, 95%CI 1.49-10.49, p=0.01), number of units of platelets transfused (OR 1.42, 95%CI 1.02-1.97, p=0.04) and rebleed after angiography (OR 46.8, 95%CI 4.80-456.14, p<0.01) were predictors of 30-day mortality. Prophylactic embolization was not a predictor of rebleed or 30-day mortality. Conclusions: This paper identified important clinical predictors of arterial extravasation, rebleed and 30-day mortality in GI bleedings, which will assist in patient selection and help to improve the overall angiographic management of GI bleeding.

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Abstract WP2: Long-Term Functional Outcomes Following Mechanical Thrombectomy Stratified by Race- Insights From the STAR Collaboration

Stroke ◽

10.1161/str.51.suppl_1.wp2 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Sami Al Kasab ◽

Eyad Almallouhi ◽

Diego J Lozano ◽

David J McCarthy ◽

Vasu A Saini ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Mechanical Thrombectomy ◽

Independent Predictor ◽

Multivariate Logistic Regression Analysis ◽

Vascular Risk ◽

Multivariate Logistic Regression ◽

White Patients

Introduction: Previous research reported higher prevalence of vascular risk factors and worse outcomes after stroke in non-white patients compared to whites. Whether similar results still apply in the post mechanical thrombectomy era remains unknown. Methods: The STAR registry combined the prospectively maintained databases of 11 thrombectomy-capable stroke centers in the US, Europe, and Asia. Consecutive patients who underwent MT were included in these analyses. Baseline features, risk factors, location of occlusion, time from symptom onset, tPA receipt, procedural complication rates, symptomatic hemorrhage, and long-term functional outcome were compared between white and non-white patients. Multivariate logistic regression analysis was performed to evaluate the impact of race on long-term outcome. Results: Total of 2,284 patients were included in this analysis. Of those, 1,436 (62.9%) were white. Baseline features and outcomes are summarized in table 1. Non-white patients were older ( 71 Vs 66, p=<0.001), more likely to be female ( 53.1% Vs 48.5%, p=0.034), had lower NIHSS on admission ( 15 Vs 16, p=<0.001), higher prevalence of hypertension, hyperlipidemia, diabetes, lower incidence of atrial fibrillation, higher rate of tPA receipt, shorter onset to groin access times, and longer procedural times. White patients had higher rates of successful revascularization (77.4% Vs 72.3%, p=0.006) and longer hospital stay. On multivariate logistic regression analysis, white race was an independent predictor of good 90-day outcome (OR 1.35, 95% CI 1.03-1.76, P=0.031) after controlling for age, sex, location of occlusion, IV-tPA, ASPECT score, procedure duration and final TICI score. Conclusion: In this study, white race was independent predictor of good 90-day outcome. This finding could be due to higher prevalence of vascular risk factors in non-white patients.

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Androgen‐responsive tripartite motif 36 enhances tumor‐suppressive effect by regulating apoptosis‐related pathway in prostate cancer

10.31234/osf.io/hb792 ◽

2020 ◽

Author(s):

Lungwani Muungo

Keyword(s):

Cell Proliferation ◽

Independent Predictor ◽

Multivariate Logistic Regression Analysis ◽

Suppressive Effect ◽

Multivariate Logistic Regression ◽

Tripartite Motif ◽

Du145 Cells ◽

And Function ◽

Related Pathway ◽

Tumor Suppressive Effect

Tripartite motif 36 (TRIM36) belongs to the TRIM family, most members of which areinvolved in ubiquitination and degradation of target proteins by functioning as E3ubiquitin ligases. The function of TRIM36 has not been well documented, therefore,we investigated the clinical significance and function of TRIM36 in human prostatecancer (PC). Multivariate logistic regression analysis showed that TRIM36 immunoreactivitywas an independent predictor of cancer-specificsurvival of PC patients.Gain-of-functionstudy revealed that overexpression of TRIM36 suppressed cell proliferationand migration of LNCaP, 22Rv1, and DU145 cells. Moreover, TRIM36knockdown using siRNA suppressed apoptosis and promoted cell proliferation andmigration in LNCaP and 22Rv1 cells. Furthermore, our microarray analysis revealedthat the apoptosis-relatedpathway was significantly upregulated by TRIM36 overexpression.The TUNEL assay showed that apoptosis promoted by docetaxel treatmentwas alleviated in siTRIM36-treatedLNCaP and 22Rv1 cells. Taken together, theseresults suggest that high expression of TRIM36 is associated with favorable prognosisand that TRIM36 plays a tumor-suppressiverole by inhibiting cell proliferation andmigration as well as promoting apoptosis in PC.

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Periodontal Disease May be Associated With the Occurrence of Diabetic Retinopathy: A Subgroup Analysis of The Survey of the Diabetes Coordination Notebook in Gifu

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0879-1890 ◽

2019 ◽

Vol 128 (04) ◽

pp. 231-238 ◽

Cited By ~ 1

Author(s):

Yukio Horikawa ◽

Akio Suzuki ◽

Mayumi Enya ◽

Ken-ichi Hashimoto ◽

Shohei Nishida ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Periodontal Disease ◽

Subgroup Analysis ◽

Hba1c Level ◽

Glycated Hemoglobin ◽

Multivariate Logistic Regression Analysis ◽

Community Pharmacies ◽

Multivariate Logistic Regression ◽

Dental Visits ◽

The Difference

Abstract Aims A questionnaire survey of the prevalence of diabetic retinopathy was recently conducted in Japan. A subgroup analysis to examine the association of periodontal disease with diabetic retinopathy in subjects with diabetes and prediabetes was conducted. Methods The association of the presence of periodontal disease with the occurrence of diabetic retinopathy was examined using multivariate logistic regression analysis. Results Of 27 016 subjects who completed a survey at 217 community pharmacies, 5 572 had diabetes or prediabetes, among whom 522 and 1 421 had retinopathy or periodontal disease, respectively. Therapy duration≥10 years (OR: 2.73, 95% CI: 2.17–3.43, P<0.001), periodontal disease (OR: 2.10, 95% CI: 1.68–2.62, P<0.001) and glycated hemoglobin (HbA1c) ≥ 7.0% (OR: 1.64, 95% CI: 1.32–2.04, P<0.001) were significantly associated with the occurrence of retinopathy, while retinopathy (OR: 2.11, 95% CI: 1.69–2.63, P<0.001) and therapy duration ≥10 years (OR: 1.24, 95% CI: 1.06–1.46, P=0.007) were significantly associated with the occurrence of periodontal disease. The prevalence of retinopathy was much higher in diabetic subjects with periodontal disease than in those without it (15.1% vs. 7.8%, P<0.001). Notably, the difference of prevalence of retinopathy between subjects with and without periodontal disease was statistically significant even at HbA1c 6.0–6.9% (15.2% vs. 7.3%, P<0.01). Conclusions These findings indicate that the target HbA1c level for diabetes patients with periodontal disease may be set lower than for those without it, and that regular dental visits should be prescribed for the management of periodontal disease and the prevention of diabetic retinopathy.

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Frequency of Electrolyte Derangement after Transurethral Resection of Prostate: Need for Postoperative Electrolyte Monitoring

Advances in Urology ◽

10.1155/2015/415735 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Wajahat Aziz ◽

M. Hammad Ather

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Transurethral Resection ◽

Odds Ratio ◽

Older Patients ◽

Sodium Level ◽

Multivariate Logistic Regression Analysis ◽

Transurethral Resection Of Prostate ◽

Multivariate Logistic Regression ◽

Lower Serum

Objective. To determine the electrolyte derangement following transurethral resection of prostate (TURP).Methods. All patients undergoing TURP from June 2012 to April 2013 were included. Preoperative electrolytes were performed within a week of procedures. Monopolar TURP using 1.5% glycine was performed. Serum Na+and K+were assessed within 1 hour postoperatively and subsequently if clinically indicated.Results. The study included 280 patients. Sixty-six patients (23.6%) had electrolyte derangement after TURP. Patients with deranged electrolytes were older (mean age of 73.41 ± 4.08 yrs. versus 68.93 yrs. ± 10.34) and had a longer mean resection time (42.5 ± 20.04 min versus 28.34 ± 14.64 min). Mean weight of tissue resected (41.49 ± 34.46 g versus 15.33 ± 9.74 g) and volume of irrigant used (23.55 ± 15.20 L versus 12.81 ± 7.57 L) were also significantly higher in patients with deranged electrolytes (allp=0.00). On multivariate logistic regression analysis preoperative sodium level was found to be a significant predictor of postoperative electrolyte derangement (odds ratio 0.267, S.E. = 0.376, andpvalue = 0.00).Conclusion. Electrolyte derangement occurs in older patients, with larger amount of tissue and longer time of resection and higher volume of irrigant, and in those with lower serum preoperative sodium levels.

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