Prevalence and Associations of Asteroid Hyalosis: The Beijing Eye Study

Abstract Background: To determine the prevalence and associations of asteroid hyalosis (AH) in a Chinese population-based cohort.Methods: The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). AH is a condition in which small yellow-white, spherical particles known as asteroid bodies (ABs) are present within the vitreous body.Results: Fundus photographs were gradable in 3419 subjects. AH was detected in 65 (0.9%, 95% CI: 0.7%, 1.2%) eyes of 53 (1.5%, 95% CI: 1.1%, 1.9%) subjects. AH was bilateral in 18.9%. Mean age of all subjects with AH was 69.2± 9.5 years (median, 71.0 years; range, 51–91 years), mean refractive error was 0.63±1.53D (median, 0.75 D; range, -4.12 to 4.00D). In multivariate analysis, prevalence of AH was associated with elder age (P=0.014, OR 1.057), thicker lens (P=0.034, OR 3.843), higher refractive error (P=0.016, OR 1.401).Conclusions: In adult Chinese in Beijing, the prevalence of AH was 0.9% for eyes or 1.5% for subjects. AH was associated with elder age, thicker lens and higher refractive error. It does not support previous observations of an association of AH with diabetes or other systemic indicators.

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Choroidal shift in myopic eyes in the 10-year follow-up Beijing eye study

Scientific Reports ◽

10.1038/s41598-021-94226-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jost B. Jonas ◽

Yan Ni Yan ◽

Qi Zhang ◽

Rahul A. Jonas ◽

Ya Xing Wang

Keyword(s):

Spatial Relationship ◽

Population Based ◽

Retinal Vessels ◽

Beijing Eye Study ◽

Choroidal Vessel ◽

Choroidal Vasculature ◽

Fundus Photographs ◽

Relationship Of ◽

Choroidal Vessels ◽

Myopic Maculopathy

AbstractThe aim of the study was to assess longitudinal changes in the spatial relationship of the choroidal vasculature to retinal vasculature in myopic eyes. In the population-based longitudinal Beijing Eye Study in 2001/2011, we examined all highly myopic eyes with assessable fundus photographs and a randomized group of non-highly myopic. Using fundus photographs, we qualitatively assessed changes in the location of major choroidal vessels in relationship to retinal vessels. The study consisted of 85 highly myopic eyes (58 participants;age:64.8 ± 9.4 years) and 85 randomly selected non-highly myopic eyes. A choroidal shift in relationship to the retinal vessels was detected more often in the highly myopic group than the non-highly myopic group (47/85 (55%) vs 6/85 (7%); P < 0.001). In the highly myopic group, the choroidal vessel shift occurring on the disc-fovea line in 39 (44%) eyes, was similar to, or smaller than, the enlargement in gamma zone width in 26 (67%) eyes and in 11 (28%) eyes respectively. The choroidal vessel shift was larger (P = 0.002) in eyes without choroidal vessels in gamma zone than in eyes with large choroidal vessels in gamma zone. In 14 (17%) eyes, a localized centrifugal choroidal shift was observed in association with an increase in the stage of myopic maculopathy. The results suggest that highly myopic eyes show a change in the position of large choroidal vessels in relationship to retinal vessels, in association with development or enlargement of gamma zone and an increase in the stage of myopic maculopathy.

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Prevalence of myopic maculopathy in the German population: results from the Gutenberg health study

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-315255 ◽

2019 ◽

pp. bjophthalmol-2019-315255 ◽

Cited By ~ 1

Author(s):

Susanne Hopf ◽

Christina Korb ◽

Stefan Nickels ◽

Andreas Schulz ◽

Thomas Münzel ◽

...

Keyword(s):

Refractive Error ◽

Population Based ◽

Health Study ◽

Multivariable Logistic Regression Analysis ◽

German Population ◽

Gutenberg Health Study ◽

Diffuse Atrophy ◽

Systemic Factors ◽

Fundus Photographs ◽

Myopic Maculopathy

AimsTo determine the prevalence of myopic maculopathy in the general population in Germany and to analyse potential associations with ocular and systemic factors.DesignThe Gutenberg Health Study is a population-based study, including 15 010 participants aged 35–74 years.MethodsMyopic maculopathy was graded in phakic eyes with spherical equivalent ≤−6 D by assessing fundus photographs according to a recent international photographic classification system (META-PM). 801 eyes of 519 participants (mean age 51.0±0.77 years) met the conditions and had gradable fundus photographs. Age-specific prevalence estimates were computed. Multivariable logistic regression analysis was used to assess associated factors with myopic maculopathy.ResultsMyopic maculopathy was present in 10.3% (95% CI 7.9 to 13.3) study participants. The prevalence was 8.6% (95% CI 6.1% to 11.9%) in the 397 right eyes and 8.7% (95% CI 6.2% to 12.0%) in the 404 left eyes. The most common type of pathology was diffuse atrophy (8.1%), followed by patchy atrophy (1.3%) and macular atrophy (0.5%); plus lesions were present in 3% (right eyes). Age (OR 1.07 per year, 95% CI 1.03 to 1.11, p<0.001), higher myopic refractive error (p<0.001), and male gender (p=0.02) were associated with myopic maculopathy, while cardiovascular risk factors and socioeconomic factors were not.ConclusionsThe prevalence of myopic maculopathy in the German population was 0.5%, and 10% in high myopic participants, aged 35–74 years. These population-based data are the first in Europe. Myopic maculopathy was related to severity of myopic refractive error and age.

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Sleep quality as a mediator of the association between coping styles and mental health: a population-based ten-year comparative study in a Chinese population

Journal of Affective Disorders ◽

10.1016/j.jad.2021.01.045 ◽

2021 ◽

Vol 283 ◽

pp. 147-155

Author(s):

Qing Wang ◽

Jingxuan Zhang ◽

Ruzhan Wang ◽

Can Wang ◽

Yanhu Wang ◽

...

Keyword(s):

Mental Health ◽

Sleep Quality ◽

Comparative Study ◽

Chinese Population ◽

Coping Styles ◽

Population Based

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Plasma Sphingolipid Profile in Association with Incident Metabolic Syndrome in a Chinese Population-Based Cohort Study

Nutrients ◽

10.3390/nu13072263 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2263

Author(s):

Huan Yun ◽

Qi-Bin Qi ◽

Geng Zong ◽

Qing-Qing Wu ◽

Zhen-Hua Niu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Inflammatory Markers ◽

Chinese Population ◽

Population Based ◽

Chinese People ◽

Inflammatory Signaling ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Bioactive Sphingolipids ◽

Multivariable Adjustment

Although bioactive sphingolipids have been shown to regulate cardiometabolic homeostasis and inflammatory signaling pathways in rodents, population-based longitudinal studies of relationships between sphingolipids and onset of metabolic syndrome (MetS) are sparse. We aimed to determine associations of circulating sphingolipids with inflammatory markers, adipokines, and incidence of MetS. Among 1242 Chinese people aged 50–70 years who completed the 6-year resurvey, 76 baseline plasma sphingolipids were quantified by high-throughput liquid chromatography-tandem mass spectrometry. There were 431 incident MetS cases at 6-year revisit. After multivariable adjustment including lifestyle characteristics and BMI, 21 sphingolipids mainly from ceramide and hydroxysphingomyelin subclasses were significantly associated with incident MetS. Meanwhile, the baseline ceramide score was positively associated (RRQ4 versus Q1 = 1.31; 95% CI 1.05, 1.63; ptrend = 0.010) and the hydroxysphingomyelin score was inversely associated (RRQ4 versus Q1 = 0.60; 95% CI 0.45, 0.79; ptrend < 0.001) with incident MetS. When further controlling for clinical lipids, both associations were attenuated but remained significant. Comparing extreme quartiles, RRs (95% CIs) of MetS risk were 1.34 (95% CI 1.06, 1.70; ptrend = 0.010) for ceramide score and 0.71 (95% CI 0.51, 0.97; ptrend = 0.018) for hydroxysphingomyelin score, respectively. Furthermore, a stronger association between ceramide score and incidence of MetS was evidenced in those having higher inflammation levels (RRQ4 versus Q1 1.57; 95% CI 1.16, 2.12; pinteraction = 0.004). Our data suggested that elevated ceramide concentrations were associated with a higher MetS risk, whereas raised hydroxysphingomyelin levels were associated with a lower MetS risk beyond traditional clinical lipids.

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Natural course of long-term postherniorrhaphy pain in a population-based cohort

Scandinavian Journal of Pain ◽

10.1016/j.sjpain.2009.09.012 ◽

2010 ◽

Vol 1 (1) ◽

pp. 55-59 ◽

Cited By ~ 6

Author(s):

Gabriel Sandblom ◽

Maija-Liisa Kalliomäki ◽

Ulf Gunnarsson ◽

Torsten Gordh

Keyword(s):

Multivariate Analysis ◽

Postoperative Pain ◽

Hernia Repair ◽

Groin Hernia ◽

Population Based ◽

Persistent Pain ◽

Natural Course ◽

Hernia Surgery ◽

Persistent Postoperative Pain ◽

Postherniorrhaphy Pain

AbstractBackgroundPersistent pain after hernia repair is widely recognised as a considerable problem, although the natural course of postoperative pain is not fully understood. The aim of the present study was to explore the natural course of persistent pain after hernia repair in a population-based cohort and identify risk factors for prolonged pain duration.MethodsThe study cohort was assembled from the Swedish Hernia Register (SHR), which has compiled detailed information on more than 140 000 groin hernia repairs since 1992. All patients operated on for groin hernia in the County of Uppsala, Sweden, 1998–2004 were identified in the SHR. Those who were still alive in 2005 received the Inguinal Pain Questionnaire, a validated questionnaire with 18 items developed with the aim of assessing postherniorrhaphy pain, by mail. Reminders were sent to non-responders 5 months after the first mail. The halving time was estimated from a linear regression of the logarithmic transformation of the prevalence of pain each year after surgery. A multivariate analysis with pain persisting more than 1 month with a retrospective question regarding time to pain cessation as dependent variable was performed.ResultsAltogether 2834 repairs in 2583 patients were recorded, 162 of who had died until 2005. Of the remaining patients, 1763 (68%) responded to the questionnaire. In 6.7 years the prevalence of persistent pain had decreased by half for the item “pain right now” and in 6.8 years for the item “worst pain last week”. The corresponding figures if laparoscopic repair was excluded were 6.4 years for “pain right now” and 6.4 years for “worst pain past week”. In a multivariate analysis, low age, postoperative complication and open method of repair were found to predict an increased risk for pain persistence exceeding 1 month.ConclusionPersistent postoperative pain is a common problem following hernia surgery, although it often recedes with time. It is more protracted in young patients, following open repair and after repairs with postoperative complications. Whereas efforts to treat persistent postoperative pain, in particular neuropathic pain, are often fruitless, this group can at least rely on the hope that the pain, for some of the patients, gradually decreases with time. On the other hand, 14% still reported a pain problem 7 years after hernia surgery. We do not know the course after that.Although no mathematical model can provide a full understanding of such a complex process as the natural course of postoperative pain, assuming an exponential course may help to analyse the course the first years after surgery, enable comparisons with other studies and give a base for exploring factors that influence the duration of the postoperative pain. Halving times close to those found in our study could also be extrapolated from other studies, assuming an exponential course.

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The prevalence and causes of visual impairment in Dariyah, a rural community in Saudi Arabia

African Vision and Eye Health ◽

10.4102/aveh.v80i1.579 ◽

2021 ◽

Vol 80 (1) ◽

Author(s):

Waleed Alghamdi ◽

Godwin O. Ovenseri-Ogbomo

Keyword(s):

Saudi Arabia ◽

Visual Impairment ◽

Rural Community ◽

Refractive Error ◽

Population Based ◽

Vision Impairment ◽

Health Examination ◽

Refractive Errors ◽

Cross Sectional ◽

Eye Examination

Background: Visual impairment is disproportionately distributed between rural and urban dwellers. Rural dwellers have limited access to the eye care services that are available in urban cities.Aim: The aim of this study was to determine the prevalence and causes of visual impairment in Dariyah, a rural community in the Qassim region, Saudi Arabia.Setting: This research comprised a population-based assessment of the vision and visual status of the inhabitants of Dariyah community.Methods: A cross-sectional descriptive study was conducted amongst the inhabitants of the community of Dariyah. A comprehensive eye examination consisting of visual acuity, ocular health examination, objective and subjective refraction was performed. The examinations were conducted by registered ophthalmologists and optometrists from the Qassim University. Vision impairments were categorised according to the International Classification of Diseases (ICD), Section 9D90, ‘Vision impairment including blindness’ (2018).Results: In all, 68 (24.5%) participants had vision impairment (using the better-seeing eye), with refractive errors being the main cause of vision impairment. Other causes of vision impairment included cataract (20, 7.2%), trichiasis (5, 1.8%) and glaucoma (2, 0.7%). Refractive errors were present in 193 (69.7%), with astigmatism being the commonest refractive error. About 60% of those with refractive errors presented without spectacles for correction, and 20% reported that they had never had an eye examination. Refractive errors could not be determined in 19 (6.9%) of the subjects because of conditions such as matured cataract and other ocular abnormalities.Conclusion: Uncorrected refractive error was found to be the leading cause of vision impairment in this rural community in Saudi Arabia.

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Abstract 17: Prehospital Deterioration During Transport by Emergency Medical Services for Stroke Patients: A Population-Based Study

Stroke ◽

10.1161/str.48.suppl_1.17 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Sabreena J Gillow ◽

Heidi Sucharew ◽

Kathleen Alwell ◽

Charles J Moonmaw ◽

Daniel Woo ◽

...

Keyword(s):

Atrial Fibrillation ◽

Multivariate Analysis ◽

Univariate Analysis ◽

Onset Time ◽

Population Based ◽

Neurological Deterioration ◽

Stroke Patients ◽

Stroke Subtype ◽

Hospital Arrival ◽

Neurologic Deterioration

Introduction: Stroke patients can experience neurological change in the prehospital setting. We sought to identify factors associated with prehospital neurologic deterioration. Methods: Among the Greater Cincinnati/Northern Kentucky region (pop. ~1.3 million), we screened all 15 local hospitals’ admissions from 2010 for acute stroke, and included patients with age ≥20 and complete EMS records. Glasgow Coma Scale (GCS) at hospital arrival was compared with GCS evaluated by EMS, with decrease ≥2 points considered neurologic deterioration. Data obtained included age, sex, race, medical history, antiplatelet or anticoagulant use, stroke subtype [ischemic (IS), ICH, or SAH] and IS subtype (e.g., small vessel, large vessel, cardioembolic), seizure at onset, time from symptom onset to EMS arrival, time from EMS to hospital arrival, blood pressure and serum glucose on EMS arrival, and EMS level of training. Univariate analysis was completed using Wilcoxon rank sum test for continuous measures and chi-square or Fisher’s exact test for categorical measures. Multivariate analysis was completed on variables with p ≤ 0.20 in the univariate analysis. Results: Of 2708 total stroke patients, 1097 (870 IS, 176 ICH, 51 SAH) had EMS records (median [IQR] age 74 [61, 83] years; 56% female; 21% black). Onset to EMS arrival was ≤4.5 hours for 508 cases (46%), and median time from EMS to hospital arrival was 26 minutes. Neurological deterioration occurred in 129 cases (12%), including 9.1% of IS and 22% of ICH/SAH. In multivariate analysis, black race, atrial fibrillation, ICH or SAH subtype, and ALS transport were associated with neurological deterioration. Conclusion: Atrial fibrillation may predict prehospital deterioration in stroke, and preferential transport of patients with acute worsening to centers capable of managing hemorrhagic stroke may be justifiable. Further studies are needed to identify why race is associated with deterioration and potential areas of intervention.

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