scholarly journals TYPOLOGY OF PATHOPERSONOLOGICAL TRANSFORMATIONS IN PATIENTS WITH SCHIZOAFFECTIVE DISORDER

2020 ◽  
Vol 8 (1) ◽  
pp. 34-42
Author(s):  
M. Ye. Khomitskyi
Keyword(s):  
Statistical Analysis ◽  
Psychiatric Hospital ◽  
Schizoaffective Disorder ◽  
Social Rehabilitation ◽  
Endogenous Psychoses ◽  
Quantitative Characteristics ◽  
Definitive Solution ◽  
Episodic Course ◽  
Social Labor

The issue of diagnostics, treatment and social rehabilitation of patients with endogenous psychoses with episodic course remains one of the most urgent problems of psychiatry, which, despite the considerable advances of science and practice, has not found a definitive solution. Significant difficulties of nosological separation in the group of endogenous psychoses with episodic course and evaluation of the pathopersonological aspect of the clinic are related to schizoaffective disorder. The aim of the study was to establish a typology of pathopersonological transformations in patients with schizoaffective disorder based on the analysis of clinical-psychopathological, medical-psychological, clinical-ethological characteristics of remission. On the basis of “Regional Clinical Psychiatric Hospital” (Zaporizhzhіa) 102 persons with the established diagnosis of schizoaffective disorder were examined. The main methods of the study were clinical psycho-pathological, psychodiagnostic, patho-psychological, clinical-anamnestic, clinical-medical, social-medical and statistical analysis. As a result of the conducted research, on the basis of the analysis of clinical-psychopathological, medical-psychological, clinical-ethological characteristics of remission, the typology of pathopersonological transformations was established. The presence and prevalence of 4 main types of pathopersonological transformations in schizoaffective disorder (“affective-labile” (20.1 % of the contingent), “paranoid-dysthymic” (17.3 %), “hysteroid-agonistic” (25.9 %), “Neurocognitive-deficient” (16.9 %) and “mixed” (19.8 % of the contingent)), which differ in clinical-anamnestic, clinical-psychopathological, medical-psychological, neuropsychological and clinical-ethological characteristics and cause social (labor and family) maladjustment of varying degrees. The clinical-anamnestic, clinical-psychopathological, medical-psychological, neuropsychological and clinical-ethological features identified in the study can be used to determine the type of pathopersonological transformations and its severity in patients with schizoaffective disorder and, accordingly, quantitative characteristics of individually needed psychopharmacological, psychotherapeutic and social rehabilitation activities and evaluation of their effectiveness in dynamics.

scholarly journals Characteristics of personality in patients with endogenous psychoses with an episodicаl course in the context of post-manifest pathopersonаlogical transformations (comparative analysis)

2020 ◽  
Keyword(s):  
Differential Diagnosis ◽  
Comparative Analysis ◽  
Schizoaffective Disorder ◽  
Affective Disorders ◽  
Economic Consequences ◽  
Personality Characteristics ◽  
Simultaneous Increase ◽  
Personal Profile ◽  
Endogenous Psychoses ◽  
Episodic Course

Solution of the problems of differential diagnosis, treatment and social rehabilitation of patients with endogenous psychoses with episodic course is one of the most complex and urgent problems of clinical psychiatry, which is caused by polymorphism and variability of symptoms, decrease or loss of critical attitude toward the disease, with grave social and economic consequences. The aim of the study is to establish, on the basis of the results of the comparative analysis of the characteristics of the personal profile, the features and nosospecific differences of post-manifest pathopersonаlogical transformations in patients with schizophrenia, schizoaffective disorder and affective disorders in remission / intermissions. The study examined the personality characteristics of endogenous psychoses with an episodic course in remission / intermission conditions and established signs and nosospecific differences in post-manifest pathological transformations in patients with schizophrenia, schizoaffective disorder, and affective disorders. Existing pathopersonalogical transformations are characterized by signs of multidirectional tendencies of compensatory tension of personal resources, which is confirmed by the presence of several moderately elevated (65-75 T-points) indicators of individual scales and a simultaneous increase in indicators of both hyposthenic (2nd and 7th scales) and hypersthenic ( 4th and 9th scales) registers. In schizoaffective disorder, such scales are the 2nd (65.36±12.28 T-points), 4th (73.23±11.83 T-points), 8th (68.40±12.33 T-points) and 9th (66.05±12.02 T-points); in affective disorders, these are the 2nd, 4th and 8th scales (67.72±13.96, 67.08±9.53 and 65.90±10.08 T-points, respectively); for schizophrenia, such scales are the 2nd (72.37 ± 16.80 T-points), 4th (69.47±12.48 T-points), 7th (66.59±15.69 T-points) ) and 8th (71.73±19.95 T-points). The obtained data can be used as a component of the differential diagnosis system and personified psychotherapeutic support.

scholarly journals Clinical-psychopathological and medical-social characteristics of patients with endogenous psychoses with an episodic course in the context of post-manifestation pathopersonological transformations

2019 ◽  
Author(s):  
Mykola Khomitskyi
Keyword(s):  
Schizoaffective Disorder ◽  
Complex Structure ◽  
Diagnostic System ◽  
Personal Characteristics ◽  
Social Characteristics ◽  
Clinical Aspects ◽  
Rehabilitation Care ◽  
Main Research ◽  
Endogenous Psychoses ◽  
Episodic Course

The determination of the nosological affi liation of a separate clinical case in the group of endogenous psychoses is a decisive factor in adequate psychopharmacotherapy. The clinical aspects of post-manifestation pathopersonological transformations of endo genous psychosis with an episodic course remain the least studied and require study to improve the quality of diff erential diagnosis, treatment and rehabilitation. The aim of this study was to conduct a comparative analysis of personal characteristics, types of attitude toward the disease and adaptability of patients with schizophrenia and schizoaff ective disorder. On the basis of the Regional Clinical Psychiatric Hospital (Zaporizhzhia, Ukraine), 312 patients were examined, among them 102 patients with aff ective disorders; 102 patients suffering from schizoaffective disorder and 108 patients diagnosed with schizo phrenia, paranoid form, episodic course. The main research methods were clinical-psychopathological, clinical-follow-up, clinical-anamnestic and medical-social, as well as medicalstatistical analysis. The study revealed signs and nosospecific diff erences in indicators of social (labor and family) maladjustment, as well as positive, negative and general psychopathological disorders (according to PANSS) in endogenous psychoses with an episodic course, confi rming the presence of post-manifestation pathopersonological transformations. In the group of endogenous psychosis with an episodic course, pathopersonological transformations in schizoaff ective disorder are characterized by the most complex structure and are a nosospecific marker. Further studies of remission/intermission in endo genous psychosis open up the possibility of developing a differential diagnostic system and algorithms for providing personalized medical and rehabilitation care. Keywords: schizoaffective disorder, affective disorders, schizophrenia, clinic, social maladjustment, differential diagnosis, pathopersonological transformations

scholarly journals MODERN SCIENTIFIC VIEWS ON THE CLINIC, SYSTEMATICS, DIAGNOSIS AND PATHOPERSONALOGY OF ENDOGENOUS PSYCHOSIS WITH EPISODIC COURSE (LITERATURE RIVIEW)

2020 ◽  
pp. 57-65
Author(s):  
В.Л. Підлубний ◽  
Микола Хоміцький
Keyword(s):  
Maintenance Therapy ◽  
Clinical Case ◽  
Diagnostic Techniques ◽  
Diagnostic Assessment ◽  
Psychopathological Symptoms ◽  
Persistent Symptoms ◽  
Social Rehabilitation ◽  
Endogenous Psychoses ◽  
Episodic Course ◽  
Endogenous Psychosis

The aim of the study. To study the literature in order to identify modern scientific views on the clinic, systematics, diagnosis and pathopersonalogy of endogenous psychoses with episodic course. Results. The analysis of the literature shows that the diagnostic and classification approaches of endogenous psychoses with episodic course, are focused on polymorphic and variable symptoms of exacerbation of the disease. This leads to diagnostic mistakes, errors in the appointment of maintenance therapy, deterioration of compliance and further deepening of social maladaptation of patients. Refusal to develop the mechanisms of pathogenesis on the basis of the nosological approach will inevitably lead to a regression of the level of treatment and rehabilitation approaches - from ethiopathogenetic to symptomatic. Conclusions. Thus, at present, the importance of diagnostic techniques aimed at assessing and differentiating persistent symptoms of the disease in the period of remission of endogenous psychoses and relate to pathopersonalogical transformations. Research and correct diagnostic assessment of this multicomponent cluster of psychopathological symptoms allows to assess the nosological affiliation of a particular clinical case and to determine the necessary pharmacological and social rehabilitation effects in order to correct existing pathopersonalogical transformations and prevent exacerbation of endogenous psychosis.

scholarly journals STRUCTURE AND TYPES OF RESPONSE TO THE DISEASE DUE TO ADAPTABILITY / MALADAPTATION IN PATIENTS WITH SCHIZOAFFECTIVE DISORDER IN THE STATE OF REMISSION IN CONTEXT OF PATHOPERSONOLOGICAL TRANSFORMATIONS IN POST-MANIFESTATION PERIOD

2019 ◽  
pp. 7-14
Author(s):  
Mykola Khomitskiy
Keyword(s):  
Psychiatric Hospital ◽  
Schizoaffective Disorder ◽  
Diagnostic Algorithm ◽  
The State ◽  
Social Adaptation ◽  
Disease Response ◽  
Remission Period ◽  
Clinical Variants ◽  
Mixed Types

The aim of the study of the structure and types of disease response and adaptability / maladaptationin patients with schizoaffective disorder in remission.Contingents and methods. On the basis of the Regional Clinical Psychiatric Hospital (Zaporizhzhia), 102 patients with the diagnosis of «schizoaffectivedisorder» were examined using the TOBOL test method.Results. The analysis of the structure and types of the response to the disease and the adaptation / maladaptation indices in patients with schizoaffectivedisorder in remission period was performed. Schizoaffective disorder is characterized by maladaptive effect on the patient, which is confirmed by low indicators of the demonstration of harmonious response to the disease (7.8%) and prevalence of maladaptive types of response to the disease in patients (71.6%).The typology of the response to the disease for patients with schizoaffective disorder is characterized by the prevalence of «mixed» types over «pure» and«diffuse». The types of response to the disease that occur most often in the schizoaffective disorder are egocentric (42.2%) and ergophatic (35.3%). The mostcharacteristic clinical variants are ergophatic-anosognosic (16.7%) and anxious-egocentric (15.7%).Conclusioms. Schizoaffective disorder is characterized by maladaptive effect on the patient, which is confirmed by low indicators of the demonstration ofharmonious response to the disease (7.8%) and prevalence of maladaptive types of response to the disease in patients (71.6%). The obtained data can beapplied as assessment of the nosospecific pathopersonalogical component when creating a differential diagnostic algorithm and with the aim of developingprograms for reducing the maladaptive effects of the schizoaffective disorder and improving the level of social adaptation.

scholarly journals Систематизація сортів та селекційних ліній пшениці озимої за кількісними ознаками в умовах контрольованого середовища з використанням кластерного аналізу

2018 ◽  
pp. 56-65
Author(s):  
В. М. Тищенко ◽  
О. В. Гусенкова ◽  
М. В. Дубенець ◽  
А. В. Колісник
Keyword(s):  
Cluster Analysis ◽  
Statistical Analysis ◽  
Winter Wheat ◽  
Yield Potential ◽  
Wheat Varieties ◽  
Breeding Lines ◽  
Quantitative Characteristics ◽  
High Level ◽  
Late Sowing

Викладено результати чотирьохрічних досліджень (2013–2016 рр.) із визначення збалансованості кількісних ознак сортів та селекційних ліній пшениці озимої за строками сівби при використанні кластерного аналізу. В досліді використовували 2 строки сівби: ранній (1 вересня, СП-1) і пізній (1 жовтня, СП-3). Головною метою при аналізі кращих груп і кластерів був пошук сортів і селекційних ліній (СЛ) пшениці озимої, які в статистичному аналізі мали високі показники двох складових врожаю – кількість зерен в колосі (КЗ) та маса зерна з колосу (М1). Також було досліджено як в кращих групах і на дендрограмах виділялись сорти і генотипи, які були кращими як в першому, так і в третьому строкові сівби не лише за КЗ і М1, а й за іншими господарськи цінним ознакам і  за врожайністю. У результаті кластерного аналізу були сформовані групи сортів та селекційних ліній пшениці озимої, в яких міститься інформація про рівень формування ознак за ранніх та пізніх строків сівби. Нами були виділені генотипи пшениці озимої, як носії високого рівня кількісних ознак, особливо ознак потенціалу врожайності за ранніх та пізніх строків сівби, які можна використовувати як перспективний селекційний матеріал. Перевага кластерного аналізу по відношенню до статистичного аналізу полягає в тому, що кластерний аналіз дає змогу ідентифікувати сорти і селекційні лінії по збалансованості за господарськи корисними ознаками, а в статистичному аналізі ми можемо відібрати і виділити  тільки  окремі кількісні ознаки по їх рівню формування і мінливості і за врожайністю. The article presents the results of four-year studies (2013–2016) on the determination of the balance of quantitative characteristics of varieties and selection lines of winter wheat by the use of cluster analysis. The experiment used 2 sowing lines: early (1 September, SP-1) and late (October 1, SP-3). The main goal, when analyzing the best groups and clusters, was the search for winter wheat varieties and breeding lines (SL), which in the statistical analysis had high indicators of two components of the harvest – the number of grains in the ear (KZ) and the mass of grain from the ear (M1). Also we investigate how in the best groups and on dendrograms varieties and genotypes were distinguished, which were better both in the first and in the third term sowing, not only in terms of the number of grains in the ear and the mass of grain from the ear, but also on other economic and valuable features and by yield. It should be noted that the study of varieties, or SL by the terms of sowing, gives unique opportunities to evaluate the material under study in terms of the formation of quantitative characteristics. We can form groups of varieties or SLs, where we will have information about the level of formation of signs at early, optimal, or late sowing. We can also distinguish genotypes as carriers of a high level of quantitative attributes, especially signs of yield potential in the early or late sowing, as the usual statistical analysis does not provide information on the balance of signs in one or another variety of winter wheat. We believe that cluster analysis makes it possible to identify varieties using the Euclidean metric in terms of the balance of quantitative attributes. Based on the research carried out on the use of cluster analysis in the technology of breeding process for 2013–2016, selected varieties and constant selection lines are balanced by economically useful features that can be used as a promising breeding material and as parent components for hybridization. The advantage of cluster analysis with respect to statistical analysis is that cluster analysis enables identification of varieties and breeding lines on a balance basis for economically useful features, and in the statistical analysis we can select and allocate only certain quantitative attributes according to their level of formation and variability and by yield.

scholarly journals INFORMATIONAL-EDUCATIONAL WORK AMONG MENTAL PATIENTS’ RELATIVES AS A PART OF SOCIAL REHABILITATION

2009 ◽  
Vol 17 (1) ◽  
pp. 68
Author(s):  
D. S. Petrov ◽  
O. E. Konovalov
Keyword(s):  
Psychiatric Hospital ◽  
Inpatient Treatment ◽  
Treatment Process ◽  
Educational Programs ◽  
Educational Work ◽  
Mental Patients ◽  
Social Rehabilitation ◽  
Psychoeducational Programs ◽  
Working Out

In the article the questions of development of educational programs for mental patients’ families have been studied. We present the results of questioning of people, whose relatives have been admitted to Ryazan district clinical psychiatric hospital for inpatient treatment. The results obtained show the level of relatives’ awareness of treatment modes, techniques of prevention of exacerbations, and their role in the treatment process of the patient. The importance of estimation of awareness of mental patients’ relatives and working out of special psychoeducational programs for optimization and improvement of rehabilitation actions have been emphasized.

scholarly journals Structure and types of response to disease and indexes of adaptability/maladaptation in endogenous psychoses with episodic course in the context of pathopersonalogical transformations in post-manifestation period

2019 ◽  
Vol 27 (3) ◽  
pp. 57
Author(s):  
Mykola Khomitskyi
Keyword(s):  
Key Words ◽  
Adaptive Capacity ◽  
Key Words Schizophrenia ◽  
Endogenous Psychoses ◽  
Episodic Course ◽  
Endogenous Psychosis

The study examined the structure and types of attitude toward the disease (ATD) and adaptability/maladaptation indices in 312 patients with endogenous episodic episodes (schizophrenia, schizoaff ective disorder (SAD) and aff ective disorders (AD)) in remission/ intermittent states and compared them. Characteristics of ATD and indicators of adaptability/disadaptation in endogenous psychosis with episodic course in the remission/intermission period are a sign of stable post-manifestation of pathopersonalogical transformations and have nosospecifi c diff erences. Patients suffering from endogenous episodic psychosis have a reserve of personal adaptive capacity. This is confirmed by the fact that among patients with maladaptive types of ATD, a signifi cant percentage is of the types with an interpsychic orientation (74.0 % of the contingent in AD, 55.9 % of those surveyed with SAD and 57.6 % with schizophrenia), which is a sign of the use of personal reserves in confronting the negative eff ects of the disease. The above-mentioned reserve of personal adaptation possibilities in AD is the largest, as shown by the larger (χ2 = 6.065, p < 0.05) percentages of types with an interpsychic orientation in the structure of maladaptive types of ATD. The obtained data can be implemented into the system of diff erential diagnosis and counteraction to social maladaptation, which is formed as a result of the disease. Key words: schizophrenia, schizoaff ective disorder, aff ective disorders, clinic, adaptation, pathopersonalogical features

Therapy of Schizoaffective Disorder and Paranoid Schizophrenia with Episodic Course

2019 ◽  
Vol 4 (2) ◽  
pp. 101-105
Author(s):  
L. A. Ivanova ◽  
O. P. Vorsina ◽  
T. A. Eliseeva ◽  
K. A. Frolovа ◽  
E. V. Sapozhnikova
Keyword(s):  
Adverse Events ◽  
Schizoaffective Disorder ◽  
Paranoid Schizophrenia ◽  
Cognitive Disorders ◽  
Tolerability Profile ◽  
Clinical Impression ◽  
Treatment Level ◽  
Icd 10 ◽  
Episodic Course ◽  
Pre Treatment

Background. The use of atypical antipsychotics in schizophrenia contributes to the reduction of psychotic, affective, negative and cognitive disorders.Aims. To evaluate the effectiveness of ziprasidone therapy in patients with schizoaffective disorder and paranoid schizophrenia with episodic course.Materials and methods. In accordance with ICD-10 there were 14 (63.6 %) people with schizoaffective disorder (F25), 8 (36.4 %) people with paranoid schizophrenia, episodic course (F20.x1). Treatment with ziprasidone lasted 42 days. The dose of ziprasidone in 6 patients (27.3 %) was 80 mg, in 10 patients (45.5 %) – 120 mg, in 6 patients (27.3 %) – 160 mg. Evaluation of the effectiveness of ziprasidone therapy was carried out using psychometric scales (PANSS, General clinical impression scale to assess the effectiveness of therapy – CGI-S, CGI-I), adverse events were registered with the UKU scale.Results. The number of respondents was 19 (86.3 %) (reduction of the total score on the PANSS scale > 20 % of the pre-treatment level). Ziprasidone was effective in patients with schizoaffective disorder with a significant decrease in total score on PANSS subscales to the 14 th day of therapy (p < 0.05), with paranoid schizophrenia with episodic course – by the 21st day (p < 0.01). According to the CGI-S scale at the end of therapy, “borderline condition” was observed in 10 patients (52.6 %), mild severity – in 3 (15.8 %), normal condition – in 6 (31.6 %). CGI-I scale showed a significant improvement in 10 patients (52.6 %), marked improvement – in 9 patients (47.4 %). Among the mild adverse events that do not require discontinuation of the drug, we noted: weakness – in 3 patients (15.8 %), drowsiness – in 3 (15.8 %), impaired concentration – in 2 (10.5 %), orthostatic dizziness – in 2 (10.5 %), galactorrhea – in 1 (5.3 %).Conclusions. Ziprasidone is an effective antipsychotic drug that has a safe tolerability profile. It can be used in patients with schizoaffective disorders and paranoid schizophrenia with episodic course.

scholarly journals The comparison of Lithuanian texts’ styles by using the statistical analysis of the universal quantitative characteristics

2010 ◽  
Vol 51 ◽  
Author(s):  
Karolina Piaseckienė ◽  
Marijus Radavičius ◽  
Raimundas Stiklius
Keyword(s):  
Statistical Analysis ◽  
Linear Models ◽  
Automatic Processing ◽  
Efficient Algorithms ◽  
Mathematical Statistics ◽  
Quantitative Characteristics ◽  
Language Styles ◽  
Text Content ◽  
Log Linear

Lithuanian language is quite complex and flexible, and its significantly complicates the development of efficient algorithms for the automatic processing of Lithuanian texts. For studying text-styles features were selected the universal quantitative characteristics that are unrelated to the text content and can be calculated for any text. This article shows how mathematical Statistics can help to distinguish and interpret the Lithuanian language styles. Studies of the log-linear models show theconnection between the letters and sounds structure and the scientific and fiction.

Sign in / Sign up

Export Citation Format

Share Document