scholarly journals Misconceptions of Fruit and Vegetable Nutritional Quality

HortScience ◽  
1996 ◽  
Vol 31 (4) ◽  
pp. 693e-693
Author(s):  
James B. Magee

Many concepts of the nutritional value of fruit and vegetables generally accepted in the past, in the light of more knowledge, today are considered “misconceptions.” For example, the tomato, once considered poisonous, then shown edible, later proved to be a “good” food and a valuable source of minerals and vitamin C, today shows the potential for significant anti-cancer activity. Results of a 6-year study of the dietary habits of 47,000 men reported up to a 45% reduction in the incidence of prostate cancer of those who ate 10 or more servings per week of tomato-based products. Other misconceptions to be discussed include nightshade vegetables and arthritis, apples after meals to clean the teeth and gums, and “if a little is good for you, a lot must be better.” Today's nutritional ideas about many fruits and vegetables may become tomorrow's misconceptions as our knowledge of the composition (e.g., phytochemicals) of fruits and vegetables increases. Examples of this are include the use of muscadine pomace and the nutritive value of strawberries.

2017 ◽  
Vol 524 (1-2) ◽  
pp. 101-110 ◽  
Author(s):  
Meong Cheol Shin ◽  
Kyoung Ah Min ◽  
Heesun Cheong ◽  
Cheol Moon ◽  
Yongzhuo Huang ◽  
...  

Biomaterials ◽  
2014 ◽  
Vol 35 (30) ◽  
pp. 8635-8648 ◽  
Author(s):  
Murali M. Yallapu ◽  
Sheema Khan ◽  
Diane M. Maher ◽  
Mara C. Ebeling ◽  
Vasudha Sundram ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Nurul Azwa Abd Wahab ◽  
Faridah Abas ◽  
Iekhsan Othman ◽  
Rakesh Naidu

Diarylpentanoids exhibit a high degree of anti-cancer activity and stability in vitro over curcumin in prostate cancer cells. Hence, this study aims to investigate the effects of a diarylpentanoid, 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (MS13) on cytotoxicity, anti-proliferative, apoptosis-inducing, anti-migration properties, and the underlying molecular mechanisms on treated androgen-independent prostate cancer cells, DU 145 and PC-3. A cell viability assay has shown greater cytotoxicity effects of MS13-treated DU 145 cells (EC50 7.57 ± 0.2 µM) and PC-3 cells (EC50 7.80 ± 0.7 µM) compared to curcumin (EC50: DU 145; 34.25 ± 2.7 µM and PC-3; 27.77 ± 6.4 µM). In addition, MS13 exhibited significant anti-proliferative activity against AIPC cells compared to curcumin in a dose- and time-dependent manner. Morphological observation, increased caspase-3 activity, and reduced Bcl-2 protein levels in these cells indicated that MS13 induces apoptosis in a time- and dose-dependent. Moreover, MS13 effectively inhibited the migration of DU 145 and PC-3 cells. Our results suggest that cell cycle-apoptosis and PI3K pathways were the topmost significant pathways impacted by MS13 activity. Our findings suggest that MS13 may demonstrate the anti-cancer activity by modulating DEGs associated with the cell cycle-apoptosis and PI3K pathways, thus inhibiting cell proliferation and cell migration as well as inducing apoptosis in AIPC cells.


MedChemComm ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 1414-1420 ◽  
Author(s):  
Marcella Bassetto ◽  
Salvatore Ferla ◽  
Gilda Giancotti ◽  
Fabrizio Pertusati ◽  
Andrew D. Westwell ◽  
...  

A novel antiproliferative molecular scaffold was designed by rational modification of known antiandrogens, achieving a significant improvement in anti-cancer activity.


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