scholarly journals A Rare Case Report of Invasive Ocular Surface Squamous Neoplasm of Conjunctiva

2020 ◽  
Vol 7 (8) ◽  
pp. C107-110
Author(s):  
Noopur Subhash Patil ◽  
Shivraj N Kanthikar ◽  
Prashant B Chege ◽  
Sheela N Kulkarni
Keyword(s):  
Ocular Surface ◽  
Histopathological Examination ◽  
Tumor Control ◽  
Invasive Squamous Cell Carcinoma ◽  
Solar Ultraviolet Radiation ◽  
Ocular Irritation ◽  
Presenting Symptoms ◽  
Rare Case Report ◽  
Operative Control ◽  
Good Tumor Control

Ocular surface neoplasm(OSSN) represent a rare but broad spectrum of disease, including mild dysplasia on one end of the spectrum and invasive Squamous cell carcinoma(SCC) on the other. Thus, the diagnosis completely depends on histopathological examination of the lesion. The incidence of ocular surface neoplasia is strongly associated with factors like solar ultraviolet radiation, HIV and human papilloma virus(HPV) infections. Most lesions occur at the limbus within the interpalpebral fissure particularly the nasal side. Their importance lies in the fact that they mimic benign lesions like pterygium or even chronic conjunctivitis and thus can be misinterpreted and inadequately treated. Red eye and ocular irritation are the most common presenting symptoms. No tumor related deaths or metastasis are generally seen. Surgery with intra-operative control of surgical margins and adjunctive chemotherapy, immunotherapy and cryotherapy result in good tumor control rates, with promising results in aggressive, recurrent and large tumors.

scholarly journals Clinico-Pathological Study of Ocular Surface Squamous Neoplasia in a Tertiary Care Centre of Western Region of Nepal

2019 ◽  
Vol 7 (1) ◽  
pp. 9-13
Author(s):  
Sushila Patel ◽  
Binita Bhattarai Pokharel ◽  
Anita Shah ◽  
Manita Sunam Goda ◽  
Saraswati Khadka Thapa
Keyword(s):  
Ocular Surface ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Western Region ◽  
Invasive Squamous Cell Carcinoma ◽  
Care Centre ◽  
Ocular Surface Squamous Neoplasia ◽  
Tertiary Care Centre ◽  
Male Predominance ◽  
Wide Range

INTRODUCTION: Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjunctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. In recent times, the incidence of OSSN seems to be on the rise, especially in developing countries. The present study was aimed to analyse demographic pattern, clinical characteristics, and histopathology findings of OSSN in a tertiary care centre of western region of Nepal.  MATERIAL AND METHODS: It was a retrospective study. We analyzed 94 cases of OSSN who presented to cornea department of Lumbini Eye Institute, Bhairahawa, Nepal over a period 1.5 years from 1st July 2017 to 31st December 2018. All the patients with OSSN, detailed clinical history and examination were recorded. Lesions were excised with a 3 mm margin clearance and sent for histopathological examination.  RESULTS: Mean age of our patients with OSSN was 48.89±17.955 years ranging from 17 to 85 years. There were 52 (55.32%) male and 42 (44.68%) female. Mean duration of presentation was 6.34±6.17 months. A solitary nodule at the limbus was the commonest presentation. Right eyes were involved more than left eyes. Lesions were found most commonly on temporal site 52 (55.32%) followed by nasal 36 (38.30%). On histopathological examination benign lesions were found in 31 (32.98%) eyes, preinvasive lesion in 50 (53.19%) eyes and invasive lesions in 13 (13.83%) eyes.  CONCLUSION: OSSN were seen more commonly in young adults with male predominance. Benign and pre invasive lesions are found more commonly than invasive lesions.

Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

2021 ◽  
pp. 112067212110071
Author(s):  
Vijitha S Vempuluru ◽  
Monalisha Pattnaik ◽  
Neha Ghose ◽  
Swathi Kaliki
Keyword(s):  
Risk Factors ◽  
Ocular Surface ◽  
Histopathological Examination ◽  
Topical Steroid ◽  
Case Series ◽  
Intraepithelial Neoplasia ◽  
Excisional Biopsy ◽  
Ocular Surface Squamous Neoplasia ◽  
Retrospective Case

Purpose: To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN). Methods: Retrospective case series. Results: Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31 years (median, 24 years; range, 2–60 years). Risk factors for bilateral OSSN included xeroderma pigmentosum ( n = 15, 60%), human immunodeficiency virus infection ( n = 3, 12%), conjunctival xerosis ( n = 1, 4%), and topical steroid use ( n = 1, 4%). There were no identifiable ocular or systemic risk factors in 7 (28%) patients. Presentation was synchronous in 14 (56%) and metachronous in 11 (44%) patients. Tumor morphology was bilaterally similar in 12 (48%) patients. Histopathological examination ( n = 36) revealed conjunctival intraepithelial neoplasia (CIN) grade 1 in 4 (8%); grade 2 in 7 (14%); carcinoma in situ in 5 (10%), and invasive carcinoma in 20 (40%). Primary management of OSSN ( n = 49) included excisional biopsy ( n = 31, 62%), topical immunotherapy (IFN α2B) ( n = 11; 22%), topical Mitomycin C (MMC) ( n = 3, 6%), enucleation ( n = 1, 2%), orbital exenteration ( n = 2, 4%), and plaque brachytherapy (PBT) ( n = 1, 2%). One patient was lost to follow-up after detection of tumor in the second eye. Recurrent tumors were noted in 16 (32%) eyes and binocular globe salvage was achieved in 16 (64%) patients at a mean follow up of 41 months (median 30 months; range, 1–164 months). Conclusion: OSSN occurrence can be synchronous or metachronous. Meticulous examination of the fellow eye is important for an early diagnosis of OSSN.

scholarly journals Solitary Trichoepithelioma of Nose: A Rare Case Report and Review of Literature

2015 ◽  
Vol 6 (3) ◽  
pp. 115-117
Author(s):  
Sachin Lal Shilpakar ◽  
Bivek Aryal ◽  
Shyam Thapa Chettri ◽  
Apar Pokharel ◽  
Deepak Paudel
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Histopathological Examination ◽  
Hair Follicles ◽  
Review Of Literature ◽  
Solitary Lesion ◽  
Biological Potential ◽  
Rare Case Report ◽  
The Face ◽  
Head Neck

ABSTRACT The trichoepithelioma is a benign cutaneous neoplasm which is derived from hair follicles. It is common in the face, but there are only three reports of the solitary occurrence on the nose. It is often not recognized because of its rarity, controversial classification, origin and biological potential. The objective of this paper is to present a case of solitary trichoepithelioma on the nose, histopathological examination and treatment. It should be considered as a differential diagnosis of a solitary lesion of nose which is confused with basal cell carcinoma. The confirmation by histopathological examination is essential. How to cite this article Sah BP, Shilpakar SL, Aryal B, Chettri ST, Pokharel A, Mishra S, Paudel D. Solitary Trichoepithelioma of Nose: A Rare Case Report and Review of Literature. Int J Head Neck Surg 2015;6(3):115-117.

scholarly journals Melanosis of the Uterine Cervix: A Rare Case Report

2021 ◽  
Author(s):  
Nikhil Sanjay Deshpande ◽  
Aditi Mittal ◽  
Anil B Munemane ◽  
Ravindra Raosaheb Karle
Keyword(s):  
Uterine Cervix ◽  
Histopathological Examination ◽  
Basal Layer ◽  
Pathological Finding ◽  
Final Diagnosis ◽  
Pathological Examination ◽  
Macular Lesion ◽  
Melanocytic Lesions ◽  
Rare Case Report ◽  
S 100

Cervical melanosis is a rare entity in the spectrum of melanocytic lesions of uterine cervix. Melanosis is defined as presence of melanocytes in the basal layer of squamous epithelium causing hyperpigmentation. Authors here by report a case of 57-year-old female who underwent vaginal hysterectomy for third degree utero-vaginal prolapse, showed an incidental gross pathological finding of brownish macular lesion. Histopathological examination showed hyperpigmentation of basal layer without increase in melanocytes. On immunohistochemical examination, basal melanocytes were highlighted by S-100 and HMB 45 immunostains. Thus final diagnosis of cervical melanosis was made. Clinical differentials of cervical pigmented melanocytic lesions include cervical melanomas, blue nevi, congenital or traumatic lesions and melanosis, hence vigilant clinical, gross pathological examination and biopsy is warranted.

scholarly journals Giant Ocular Surface Squamous Neoplasia Wrapping Almost the Whole Cornea: A Case Report

2020 ◽  
Vol 42 (2) ◽  
pp. 94-96
Author(s):  
Poonam Shrestha ◽  
Mukesh Pandey
Keyword(s):  
Ocular Surface ◽  
Histopathological Examination ◽  
Promising Result ◽  
Intraepithelial Neoplasia ◽  
Surgical Excision ◽  
Treatment Modalities ◽  
Ocular Surface Squamous Neoplasia ◽  
History Of ◽  
Grade 3 ◽  
Clinical Pictures

Ocular surface squamous neoplasia (OSSN) includes the dysplastic lesions involving the epithelium of conjunctiva and cornea with various clinical pictures. Histopathological examination of the excised tissue is the benchmark for diagnosis. Surgery, chemotherapy, immunotherapy are the various treatment modalities which in combination shows promising result. We present here a case of 83 years old female patient with history of fleshy mass covering the cornea and the patient was diagnosed clinically as ocular surface squamous neoplasia. Patient underwent surgical excision of the mass followed by cryotherapy. Histopathological examination revealed conjunctival intraepithelial neoplasia of grade 3. Six months after treatment the patient is completely tumor free with no recurrence.

Management of Entropion and Trichiasis

2011 ◽  
Author(s):  
David H. Verity ◽  
Geoffrey E. Rose
Keyword(s):  
Ocular Surface ◽  
Lower Eyelid ◽  
Complete Loss ◽  
Secondary Effects ◽  
Orbicularis Muscle ◽  
Eyelid Margin ◽  
Ocular Irritation ◽  
Age Related ◽  
Causative Factors ◽  
Gentle Traction

Entropion is a posterior rotation of the upper or lower lid margin against the globe; the causes include involutional changes within the eyelid tissues or cicatricial shortening of the posterior lamella of the eyelid. Congenital lower lid entropion is rare and results from an excess of skin and orbicularis oculi muscle being only loosely attached to the eyelid retractors. The symptoms of entropion—which include ocular irritation, lid spasm, pain, redness, and watering—are worse in the presence of a keratinized lid margin (occurring in cicatricial disease) and where the ocular surface is compromised. Discomfort may lead to secondary blepharospasm, which exacerbates the entropion by causing the preseptal part of the orbicularis muscle to override the pretarsal component. The eyelids and globe should be examined to identify underlying causative factors—in particular the degree and position of tissue laxity, the position of the eyelid margin and lashes, and the thickness of the tarsus. Any secondary effects of entropion, both within the lid and on the ocular surface, should also be noted. 7-1-1 Tissue Laxity. Aging of collagen and the force of gravity leads to eyelid laxity and an excess of tissues, particularly the anterior lamella of the lid. Stretching of the orbicularis muscle and canthal tendons results in horizontal laxity, and eyelid stability is further compromised by enophthalmos due to age-related fat atrophy. Where there is a relative dissociation between the anterior and posterior lamellae, the preseptal orbicularis muscle overrides the pretarsal muscle, leading to eyelid inversion, and this effect is exacerbated both by laxity of the lower lid retractors and age-related tarsal atrophy. Tissue laxity in the absence of orbicularis overriding tends to cause ectropion; with complete loss of retractor action, this can result in complete eversion of the tarsus (“shelf ectropion”). Horizontal laxity of the eyelid tissues is assessed by grasping the lid skin and applying gentle traction in the appropriate direction. The overall horizontal laxity is judged by the extent to which the eyelid can be parted from the globe—greater than about 6 mm is abnormal for a lower eyelid—and by the speed with which the retracted lid returns to the surface of the globe (the “spring-back” test).

scholarly journals Cerebral Coenurosis Masquerading as Malignancy: A Rare Case Report from India

2019 ◽  
Vol 10 (02) ◽  
pp. 367-370
Author(s):  
Shamila Mohamed Ali ◽  
P. Somashekara Reddy ◽  
S. Venugopal ◽  
Manmeet Chhabra ◽  
Anita Mahadevan
Keyword(s):  
Case Report ◽  
Characteristic Feature ◽  
Rare Case ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Hydatid Cysts ◽  
The Third ◽  
Rare Case Report ◽  
Cerebral Coenurosis ◽  
Cuticular Layer

ABSTRACTHuman coenurosis is a rare zoonotic disease caused by the larvae of Tinea multiceps seen in sheep-rearing countries. We report the case of a 63-year-old male who was referred to our hospital with a working diagnosis of skull base chondrosarcoma. Histopathological examination after surgical excision revealed characteristic feature of coenurus with multiple scolices invaginating from the outer cuticular layer. Coenuri are often mistaken for giant cysticercal cysts and hydatid cysts. Despite its wide prevalence in cattle, only two cases of human coenurosis are reported from India till date. We report the third case from India.

Initial Observation among Patients with Vestibular Schwannoma

2020 ◽  
Author(s):  
Henry Ruiz-Garcia ◽  
Jennifer Peterson ◽  
Janet Leon ◽  
Timothy Malouff ◽  
Laura Vallow ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Local Control ◽  
Cox Regression ◽  
Multivariable Analysis ◽  
Internal Auditory Canal ◽  
Local Therapy ◽  
Definitive Treatment ◽  
Tumor Control ◽  
Presenting Symptoms ◽  
Initial Observation

Abstract Introduction Vestibular schwannomas (VS) are slow growing tumors. Although there are a wide variety of available treatment options, these tumors are often initially observed. We aimed to establish the presenting symptoms and outcomes of patients treated with initial observation at our institution. Methods The medical records of patients with radiographically diagnosed VS were reviewed from 1989 to 2018. Actuarial estimates of radiographic tumor control and freedom of local therapy were calculated and compared using Cox regression analyses. Results A total of 360 patients were diagnosed with VS at our institution from 1989 through 2018 with a median age of 59.9 years. After radiographic diagnosis, 243 patients (67.5%) opted for initial observation. Local control at 1, 5, and 10 years was 91, 67, and 58%, respectively. On multivariable analysis, factors associated with shorter time to radiographic tumor progression included younger patient age (p = 0.016) and tumors with an extracanalicular component (p = 0.032). Regarding time until definitive treatment only larger baseline American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) tumor size predicted for earlier initiation of therapy (p < 0.001), although this was restricted to tumors with an extracanalicular component (p = 0.004), as opposed to purely internal auditory canal tumors (p = 0.839). Conclusions Many patients who were initially observed continued to have satisfactory local control rates at 10 years. In patients with extracanalicular tumors, larger AAO-HNS tumor measurements were associated with earlier radiographic tumor progression and shorter time to local therapy, with 7 mm serving as a potential threshold value for extracanalicular tumors. Younger patients and tumors with primarily an extracanalicular portion may warrant closer observation.

scholarly journals Human Dirofilariasis Due to D.Repens Presenting as a Chest Wall Swelling : A Rare Case Report

2012 ◽  
Vol 02 (01) ◽  
pp. 51-53
Author(s):  
Harish S. Permi ◽  
Pretty D'Souza ◽  
K.R. Bhagavan ◽  
Mary Raju ◽  
Pooja Sarda
Keyword(s):  
Chest Wall ◽  
Rare Case ◽  
Histopathological Examination ◽  
Chest Wall Tumor ◽  
Anopheles Mosquitoes ◽  
Chest Wall Tumors ◽  
Rare Case Report ◽  
Human Dirofilariasis ◽  
Wall Tumor

AbstractPrimary Dirofilariasis is caused by a Zoonotic filarial nematode. It is transmitted to humans by Culex, Aedes, or Anopheles mosquitoes, which ingest blood-containing microfilaria from affected dogs, cats, or raccoons. Chest wall tumors are uncommon lesions that originate from blood vessels, nerves, bone, cartilage, or fat. We report a case of Human Dirofilariasis due to D. Repens occurring in the chest wall in a 32 year old male. Clinical diagnosis of benign chest wall tumor was considered and it was excised. Histopathological examination confirmed it as Dirofilaria repens. On regular follow up he is doing fine.

Rare Case Report Of Mesenteric Fibromatosis

2015 ◽  
Vol 87 (9) ◽  
Author(s):  
Radhika Vidyasagar ◽  
Sudarshan ◽  
Sreedhar ◽  
Subramanya ◽  
Vidya Bhat
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Histopathological Examination ◽  
Mesenteric Tumor ◽  
Mesenteric Fibromatosis ◽  
Rare Case Report

AbstractMesenteric fibromatosis is a part of the clinical-pathologic spectrum of deep fibromatoses. We report this rare case of primary mesenteric tumor that was diagnosed to be a mesenteric fibromatosis on histopathological examination.In majority of patients it may remain asymptomatic and the management of these tumors depends on histopathological examination. Postoperatively, patient was well and subsequent follow up showed normal recovery.

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