Extracorporeal blood purification in the complex treatment of the novel coronavirus infection: the review of opportunities

The aim of the study was to research the hyperbaric oxygenation effect on the condition of patients in the course of complex treatment aimed at rehabilitation after suffering from COVID-19 pneumonia. Results: the impact of hyperbaric oxygenation on the body of patients who have suffered from the novel coronavirus infection provides a positive dynamics and improves their quality of life. Conclusion: in the process of rehabilitating patients who have undergone the new coronavirus infection, it is necessary to use various physiotherapeutic measures, including hyperbaric oxygenation.

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Effectiveness of immobilized probiotics for complex therapy of novel coronavirus infection COVID-19 in hospital settings

10.47183/mes.2020.021 ◽

2020 ◽

Author(s):

NG Bomshteyn ◽

YuV Bolotov ◽

IA Kim ◽

DV Trukhin

Keyword(s):

Prospective Observational Study ◽

Clinical Laboratory ◽

The Novel ◽

Complex Treatment ◽

Open Label ◽

Probiotic Treatment ◽

Complex Therapy ◽

Coronavirus Infection ◽

The Russian Federation ◽

Novel Coronavirus

Taking into account the gut–lung microbiota axis, the new probiotic treatment methods for COVID-19 are currently being discussed. There are effective medicinal preparations of domestic manufacture in the Russian Federation, the immobilized probiotics. The study was aimed to determine the effectiveness of the mixed immobilized probiotic containing the immobilized B. bifidum and lactobacilli L. plantarum (100 million CFU per dose) or the simple immobilized probiotic containing the immobilized B. bifidum (500 million CFU per dose) in the complex therapy of patients with COVID-19. During the open-label, prospective, observational study 70 patients with confirmed diagnosis of COVID-19 received complex treatment which included the immobilized probiotics. All patients were discharged from the hospital with imporoved health status, as well as with improved instrumental and laboratory indicators: body temperature returned to normal in all patients; shortness of breath, cough, feeling of chest tightening, myalgia and headache disappeared; the patients regained sense of smell and taste; the weakness decreased or disappeared (pathognomic symptom for COVID-19). The dynamics of clinical, laboratory and instrumental indicators reflecting the course of the novel coronavirus infection demonstrates the effectiveness of the used complex therapy. The immobilized probiotics may be recommended for the complex treatment of patients with COVID-19.

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Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19)

10.21203/rs.3.rs-29229/v3 ◽

2020 ◽

Author(s):

Masoumeh Asgharpour ◽

Hamed Mehdinezhad ◽

Masoumeh Bayani ◽

Mahmoud Sadeghi Haddad Zavareh ◽

Seyed Hossein Hamidi ◽

...

Keyword(s):

Controlled Trial ◽

Blood Purification ◽

Medical Sciences ◽

Therapeutic Approaches ◽

C Reactive Protein ◽

Reactive Protein ◽

Extracorporeal Blood ◽

Extracorporeal Blood Purification ◽

Beneficial Impact ◽

Coronavirus Infection

Abstract Background Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines. Methods This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH). Results Five men and five women with a mean age of 57.30±18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60%±3.94% and increased to 92.13%±3.28% after them (p<0.001). Serum IL-6 showed a reduction from 139.70±105.62 to 72.06±65.87 pg/mL (p=0.073); and c-reactive protein increased from 136.25±84.39 to 78.25±38.67 mg/L (P=0.016). Conclusions Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients.

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Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19)

10.21203/rs.3.rs-29229/v1 ◽

2020 ◽

Author(s):

Masoumeh Asgharpour ◽

Hamed Mehdinezhad ◽

Masoumeh Bayani ◽

Mahmoud Sadeghi Haddad Zavareh ◽

Seyed Hossein Hamidi ◽

...

Keyword(s):

Controlled Trial ◽

Blood Purification ◽

Medical Sciences ◽

Therapeutic Approaches ◽

C Reactive Protein ◽

Reactive Protein ◽

Extracorporeal Blood ◽

Extracorporeal Blood Purification ◽

Beneficial Impact ◽

Coronavirus Infection

Abstract Background Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines. Methods This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH). Results Five men and five women with a mean age of 57.30 ± 18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60%±3.94% and increased to 92.13%±3.28% after them (p < 0.001). Serum IL-6 showed a reduction from 139.70 ± 105.62 to 72.06 ± 65.87 pg/mL (p = 0.073); and c-reactive protein increased from 136.25 ± 84.39 to 78.25 ± 38.67 mg/L (P = 0.016). Conclusions Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients.

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Association and treatment of diabetes in patients affected by Covid-19

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3591 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1198-1201

Author(s):

Syed Yasir Afaque

Keyword(s):

Diabetes Mellitus ◽

Prognostic Value ◽

Heart Diseases ◽

The Novel ◽

The World ◽

Treatment Of Diabetes ◽

Coronavirus Infection ◽

Composite Outcomes ◽

Novel Coronavirus ◽

The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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Faculty Opinions recommendation of Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13826957.15269065 ◽

2012 ◽

Author(s):

Claudio Ronco ◽

Zaccaria Ricci

Keyword(s):

Blood Purification ◽

Experimental Sepsis ◽

Extracorporeal Blood ◽

Extracorporeal Blood Purification

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Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres

Nature Biomedical Engineering ◽

10.1038/s41551-020-00673-x ◽

2021 ◽

Author(s):

Xin Song ◽

Haifeng Ji ◽

Yupei Li ◽

Yuqin Xiong ◽

Li Qiu ◽

...

Keyword(s):

Coagulation Factors ◽

Blood Purification ◽

Extracorporeal Blood ◽

Extracorporeal Blood Purification ◽

Hydrogel Microspheres

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High cytokine levels and cytokine storm in the novel coronavirus infection

Vrač skoroj pomoŝi (Emergency Doctor) ◽

10.33920/med-02-2102-04 ◽

2021 ◽

pp. 38-47

Author(s):

Maksim Leonidovich Maksimov ◽

Albina Ayratovna Zvegintseva ◽

Lyudmila Yurievna Kulagina ◽

Albina Zainutdinovna Nigmedzyanova ◽

Elvina Ramisovna Kadyseva

Keyword(s):

Peripheral Blood ◽

High Frequency ◽

The Novel ◽

Cytokine Storm ◽

The Public ◽

Systemic Inflammatory Reaction ◽

Scientific World ◽

Cytokine Levels ◽

Coronavirus Infection ◽

Novel Coronavirus

A review article is based on current foreign sources. The level of cytokines in the peripheral blood can be increased in many diseases, but in some cases there may be an excess of their normal concentration in tens, hundreds or more times with the development of a peculiar clinical picture, which is based on a systemic inflammatory reaction. In the literature this condition has received the figurative name «cytokine storm», which highlights an extremely violent reaction of the immune system with an unknown (often unfavorable) outcome. Close attention of the scientific world and the public to the problem of extremely high levels of cytokines in the peripheral blood (hypercytokinemia) was drawn due to the high frequency of the cytokine storm in the novel coronavirus infection.

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FEATURES OF THE COURSE AND TACTICS OF MANAGING CHILDREN WITH KIDNEYS AND URINARY TRACT DISEASES DURING THE PANDEMIC OF NEW CORONAVIRUS INFECTION COVID-19

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-4-74-79 ◽

2021 ◽

Vol 100 (4) ◽

pp. 74-79

Author(s):

I.M. Kagantsov ◽

◽

V.V. Sizonov ◽

V.G. Svarich ◽

K.P. Piskunov ◽

...

Keyword(s):

Age Groups ◽

Clinical Manifestations ◽

Routine Care ◽

The Novel ◽

Urinary System ◽

Death Rates ◽

Global Pandemic ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

Significant Health

The novel coronavirus infection (SARS-CoV-2), which first appeared in Wuhan, China in December 2019, has been declared a global pandemic by WHO. COVID-19 affects people of all age groups. The disease in children is usually asymptomatic or mild compared to adults, and with a significantly lower death rates. Data on kidney damage in children with COVID-19, as well as the effect of coronavirus infection on the course of diseases of the genitourinary system, are limited, the risks of contracting a new coronavirus infection in children with significant health problems, including those with chronic kidney disease, remain uncertain. The pandemic has affected the activities of surgeons treating diseases of the urinary system in children. Since the prospects for the end of the pandemic are vague, it is necessary to formulate criteria for selecting patients who can and should be provided with routine care in the pandemic. The purpose of this review is to highlight the features of the clinical manifestations and treatment of children with COVID-19, occurring against the background of previous renal pathology or complicating its course.

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