Infections caused by Clostridium difficile in cancer patients

The purpose of the studywas to determine the role of antibiotics as a risk factor of Clostridium difficile-associated diarrhea in hospitalized cancer patients.Material and Methods. The study included 844 hospitalized cancer patients with diarrhea. The presence of Clostridium difficile toxins A and B in the fecal samples was determined by enzyme immunoassay.Results.Clostridium difficile toxins A and B were detected in 100 cancer patients (42 % men and 58 % women). The incidence of Clostridium difficile-associated diarrhea was higher in women than in men (р<0.02). Patients with hemoblastosis and gastrointestinal tumors were more susceptible to the development of Clostridium difficile associated diarrhea (p<0.02). The use of cephalosporin antibiotics was the main risk factor (р<0.001). In our study, 46 % of the patients took antibiotics.Conclusion.Clostridium difficile was shown to play a significant role in the development of diarrhea in cancer patients, and early detection of Clostridium difficile infection contributes to the early onset of therapy.

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Chronic Heart Failure as a Risk Factor for Clostridium difficile-Associated Diarrhea

The American Journal of Gastroenterology ◽

10.14309/00000434-201210001-00507 ◽

2012 ◽

Vol 107 ◽

pp. S210-S211

Author(s):

Vipin Mittal ◽

Anish Shah ◽

Arya Karki ◽

Sushant Nanavati ◽

Priyank Shah ◽

...

Keyword(s):

Heart Failure ◽

Risk Factor ◽

Chronic Heart Failure ◽

Clostridium Difficile ◽

Clostridium Difficile Associated Diarrhea

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Clinical impact of switching conventional enzyme immunoassay with nucleic acid amplification test for suspected Clostridium difficile-associated diarrhea

American Journal of Infection Control ◽

10.1016/j.ajic.2012.04.329 ◽

2013 ◽

Vol 41 (4) ◽

pp. 373-375 ◽

Cited By ~ 4

Author(s):

Steven W. Johnson ◽

Meganne Kanatani ◽

Romney M. Humphries ◽

Daniel Z. Uslan

Keyword(s):

Nucleic Acid ◽

Clostridium Difficile ◽

Enzyme Immunoassay ◽

Nucleic Acid Amplification Test ◽

Clinical Impact ◽

Nucleic Acid Amplification ◽

Clostridium Difficile Associated Diarrhea

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Epidemic Clostridium difficile-Associated Diarrhea: Role of Second- and Third-Generation Cephalosporins

Infection Control and Hospital Epidemiology ◽

10.2307/30145537 ◽

1994 ◽

Vol 15 (2) ◽

pp. 88-94 ◽

Cited By ~ 36

Author(s):

David E. Nelson ◽

Steven B. Auerbach ◽

Aldona L. Baltch ◽

Ethel Desjardin ◽

Consuelo Beck-Sague ◽

...

Keyword(s):

Clostridium Difficile ◽

Third Generation ◽

Clostridium Difficile Associated Diarrhea ◽

Third Generation Cephalosporins

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Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Journal of Oncology ◽

10.1155/2010/257058 ◽

2010 ◽

Vol 2010 ◽

pp. 1-11 ◽

Cited By ~ 40

Author(s):

Marie-Claude Beauchamp ◽

Amber Yasmeen ◽

Ariane Knafo ◽

Walter H. Gotlieb

Keyword(s):

Ovarian Cancer ◽

Growth Factor ◽

Early Detection ◽

Cancer Patients ◽

Signs And Symptoms ◽

Advanced Stage ◽

Insulin Growth Factor ◽

Therapeutic Modalities ◽

Growth Factor Pathways

Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to overcome chemoresistance observed in ovarian cancer patients. Evidence accumulates suggesting that the insulin/insulin growth factor (IGF) pathways could act as a good therapeutic target in several cancers, including ovarian cancer. In this paper, we will focus on the role of insulin/IGF in ovarian cancer tumorigenesis and treatment.

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The Role of C-reactive Protein and Interleukin 6 in the Cases of Preeclampsia Associated with Obesity

Revista de Chimie ◽

10.37358/rc.19.3.7011 ◽

2019 ◽

Vol 70 (3) ◽

pp. 805-808 ◽

Cited By ~ 1

Author(s):

Izabella Petre ◽

Marius Craina ◽

Nicolae Suciu ◽

Alina Sisu ◽

Radu Dumitru Moleriu ◽

...

Keyword(s):

Risk Factor ◽

Early Detection ◽

Pregnant Women ◽

Interleukin 6 ◽

Inflammatory Markers ◽

Inflammatory Condition ◽

European Level ◽

C Reactive Protein ◽

Reactive Protein

In the management of preeclampsia/eclampsia, it would be useful at least at European level, to have clear protocols for early detection and approach of cases with hypertension, as well as to create an algorithm to identify the predisposition to hypertensive pregnancy pathology. The aim has been to identify the favorable factors and the evolution of the pregnancy in the 100 patients admitted to the obstetrics clinic between January 2014 and December 2018, aged between 15-44 years, who have been diagnosed with preeclampsia. In recent years, the management of pregnant women with preeclampsia has improved a lot due to a better understanding of the pathogenesis and a refinement of adequate pregnancy monitoring. Obesity has been shown to be a risk factor in preeclampsia. Several studies have identified preeclampsia as an inflammatory condition. A large number of inflammatory markers, such as C-reactive protein (PCR) and Interleukin 6 (IL-6), have been shown to be elevated in pregnant women with preeclampsia.

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