An Insight into Algicidal Mechanism of Bacillus Altitudinis G3 from Dysfunctional Photosystem and Overproduction of Reactive Oxygen Species

2021 ◽  
Author(s):  
Xiping Hou ◽  
Yaoyao Yan ◽  
Yuqin Wang ◽  
Xiaohui Zhang ◽  
Xianzhu Dai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Bacillus Altitudinis ◽  
Insight Into

scholarly journals Comparative Reactive Oxygen Species (ROS) Content among Various Flavored Disposable Vape Bars, including Cool (Iced) Flavored Bars

Toxics ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 235
Author(s):  
Shaiesh Yogeswaran ◽  
Thivanka Muthumalage ◽  
Irfan Rahman
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Health Effects ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Aerosol Generator ◽  
Pulmonary Cells ◽  
Single Puff ◽  
Insight Into

Studies have shown that aerosols generated from flavored e-cigarettes contain Reactive Oxygen Species (ROS), promoting oxidative stress-induced damage within pulmonary cells. Our lab investigated the ROS content of e-cigarette vapor generated from disposable flavored e-cigarettes (vape bars) with and without nicotine. Specifically, we analyzed vape bars belonging to multiple flavor categories (Tobacco, Minty Fruit, Fruity, Minty/Cool (Iced), Desserts, and Drinks/Beverages) manufactured by various vendors and of different nicotine concentrations (0–6.8%). Aerosols from these vape bars were generated via a single puff aerosol generator; these aerosols were then individually bubbled through a fluorogenic solution to semi-quantify ROS generated by these bars in H2O2 equivalents. We compared the ROS levels generated by each vape bar as an indirect determinant of their potential to induce oxidative stress. Our results showed that ROS concentration (μM) within aerosols produced from these vape bars varied significantly among different flavored vape bars and identically flavored vape bars with varying nicotine concentrations. Furthermore, our results suggest that flavoring chemicals and nicotine play a differential role in generating ROS production in vape bar aerosols. Our study provides insight into the differential health effects of flavored vape bars, in particular cool (iced) flavors, and the need for their regulation.

A novel insight into the mode of action of glufosinate: how reactive oxygen species are formed

2020 ◽  
Vol 144 (3) ◽  
pp. 361-372 ◽  
Author(s):  
Hudson K. Takano ◽  
Roland Beffa ◽  
Christopher Preston ◽  
Philip Westra ◽  
Franck E. Dayan
Keyword(s):  
Reactive Oxygen Species ◽  
Mode Of Action ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Insight Into

scholarly journals Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1191 ◽  
Author(s):  
Frank Weinberg ◽  
Nithya Ramnath ◽  
Deepak Nagrath
Keyword(s):  
Reactive Oxygen Species ◽  
Tumor Microenvironment ◽  
Reactive Oxygen ◽  
Physiological Effects ◽  
Oxygen Species ◽  
Proliferative Effect ◽  
Low Levels ◽  
Cellular Components ◽  
Anti Tumor Activity ◽  
Insight Into

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity.

scholarly journals Protection of Mycobacterium tuberculosis from Reactive Oxygen Species Conferred by the mel2 Locus Impacts Persistence and Dissemination

2009 ◽  
Vol 77 (6) ◽  
pp. 2557-2567 ◽  
Author(s):  
Suat L. G. Cirillo ◽  
Selvakumar Subbian ◽  
Bing Chen ◽  
Torin R. Weisbrod ◽  
William R. Jacobs ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mycobacterium Tuberculosis ◽  
Bacterial Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Wild Type ◽  
Primary Mechanism ◽  
Insight Into ◽  
Increased Susceptibility

ABSTRACT Persistence of Mycobacterium tuberculosis in humans represents a major roadblock to elimination of tuberculosis. We describe identification of a locus in M. tuberculosis, mel2, that displays similarity to bacterial bioluminescent loci and plays an important role during persistence in mice. We constructed a deletion of the mel2 locus and found that the mutant displays increased susceptibility to reactive oxygen species (ROS). Upon infection of mice by aerosol the mutant grows normally until the persistent stage, where it does not persist as well as wild type. Histopathological analyses show that infection with the mel2 mutant results in reduced pathology and both CFU and histopathology indicate that dissemination of the mel2 mutant to the spleen is delayed. These data along with growth in activated macrophages and infection of Phox−/− and iNOS−/− mice and bone marrow-derived macrophages suggest that the primary mechanism by which mel2 affects pathogenesis is through its ability to confer resistance to ROS. These studies provide the first insight into the mechanism of action for this novel class of genes that are related to bioluminescence genes. The role of mel2 in resistance to ROS is important for persistence and dissemination of M. tuberculosis and suggests that homologues in other bacterial species are likely to play a role in pathogenesis.

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