Hepatic Tumor Stiffness Measured by Shear Wave Elastography is Prognostic for HCC Progression Following Treatment With Anti-PD-1 Antibodies Plus Lenvatinib: A Retrospective Analysis of Two Independent Cohorts

2022 ◽  
Author(s):  
Guosheng Yuan ◽  
Fuli Xie ◽  
Yangda Song ◽  
Qi Li ◽  
Rong Li ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Hepatic Tumor ◽  
Tumor Stiffness

Assessment of Tumor Stiffness With Shear Wave Elastography in a Human Prostate Cancer Xenograft Implantation Model

2017 ◽  
Vol 36 (5) ◽  
pp. 955-963 ◽  
Author(s):  
Yiru Wang ◽  
Binwei Yao ◽  
Hongfei Li ◽  
Yan Zhang ◽  
Hanjing Gao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Tumor Stiffness ◽  
Implantation Model

Tumor stiffness measured by Shear-wave elastography: association with disease-free survival in women with Early-stage breast cancer

2021 ◽  
pp. 20210584
Author(s):  
Jin You Kim ◽  
Jin Joo Kim ◽  
Lee Hwangbo ◽  
Hie Bum Suh ◽  
Ji Won Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Shear Wave ◽  
Proportional Hazards ◽  
Early Stage ◽  
Disease Free Survival ◽  
Shear Wave Elastography ◽  
Cox Proportional Hazards ◽  
Free Survival ◽  
Tumor Stiffness ◽  
Disease Free

Objective: To determine whether shear-wave elastography (SWE)-measured tumor stiffness is associated with disease-free survival in females with early-stage invasive breast cancer. Methods: This retrospective study included 202 consecutive females (mean age, 52.9 years; range, 25–84 years) with newly diagnosed T1–two breast cancer who underwent preoperative SWE between April 2015 and January 2016. Tumor stiffness was assessed and quantitative SWE features of each breast lesion were obtained by a breast radiologist. Cox proportional hazards models were used to identify associations between SWE features and disease-free survival after adjusting for clinicopathologic factors. Results: Fifteen (7.4%) patients exhibited recurrence after a median follow-up of 56 months. Mean (Emean), minimum, and maximum elasticity values were higher in females with recurrence than in those without recurrence (184.4, 138.3, and 210.5 kPa vs 134.9, 101.7, and 163.6 kPa, respectively; p = 0.005, p = 0.005, and p = 0.012, respectively). Receiver operating characteristics curve analysis for prediction of recurrence showed that Emean yielded the largest area under the curve (0.717) among the quantitative SWE parameters, and the optimal cut-off value was 121.7 kPa. Multivariable Cox proportional hazards analysis revealed that higher Emean (>121.7 kPa) [adjusted hazard ratio (HR), 10.01; 95% CI: 1.31–76.33; p = 0.026] and lymphovascular invasion (adjusted HR, 7.72; 95% CI: 1.74–34.26; p = 0.007) were associated with worse disease-free survival outcomes. Conclusion: Higher SWE-measured Emean was associated with worse disease-free survival in females with early-stage invasive breast cancer. Advances in knowledge: Tumor stiffness assessed with shear-wave elastography might serve as a quantitative imaging biomarker of disease-free survival in females with T1–two breast cancer.

scholarly journals Tumor stiffness measured by shear wave elastography correlates with tumor hypoxia as well as histologic biomarkers in breast cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Joonghyun Yoo ◽  
Bo Kyoung Seo ◽  
Eun Kyung Park ◽  
Myoungae Kwon ◽  
Hoiseon Jeong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Shear Wave ◽  
Tumor Hypoxia ◽  
Prognostic Significance ◽  
Multivariable Analysis ◽  
Shear Wave Elastography ◽  
High Grade ◽  
Glucose Transporter 1 ◽  
Glut1 Expression ◽  
Tumor Stiffness

Abstract Background Shear wave elastography (SWE) is an ultrasound technique for the noninvasive quantification of tissue stiffness. The hypoxic tumor microenvironment promotes tumor stiffness and is associated with poor prognosis in cancer. We aimed to investigate the correlation between tumor hypoxia and histologic biomarkers and tumor stiffness measured by SWE in breast cancer. Methods From June 2016 to January 2018, 82 women with invasive breast cancer who underwent SWE before treatment were enrolled. Average tumor elasticity (Eaverage) and tumor-to-fat elasticity ratio (Eratio) were extracted from SWE. Immunohistochemical staining of glucose transporter 1 (GLUT1) was used to assess tumor hypoxia in breast cancer tissues and automated digital image analysis was performed to assess GLUT1 activities. Spearman correlation and logistic regression analyses were performed to identify associations between GLUT1 expression and SWE values, histologic biomarkers, and molecular subtypes. The Mann–Whitney U test, t test, or Kruskal–Wallis test was used to compare SWE values and histologic features according to the GLUT1 expression (≤the median vs > median). Results Eaverage (r = 0.676) and Eratio (r = 0.411) correlated significantly with GLUT1 expression (both p <  0.001). Eaverage was significantly higher in cancers with estrogen receptor (ER)–, progesterone receptor (PR)–, Ki67+, and high-grade (p <  0.05). Eratio was higher in cancers with Ki67+, lymph node metastasis, and high-grade (p <  0.05). Cancers with high GLUT1 expression (>median) had higher Eaverage (mean, 85.4 kPa vs 125.5 kPa) and Eratio (mean, 11.7 vs 17.9), and more frequent ER– (21.7% vs 78.3%), PR– (26.4% vs 73.1%), Ki67+ (31.7%% vs 68.3%), human epidermal growth factor receptor 2 (HER2) + (25.0% vs 75.0%), high-grade (28.6% vs 71.4%), and HER2-overexpressing (25.0% vs 75.0%) and triple-negative (23.1% vs 76.9%) subtypes (p <  0.05). Multivariable analysis showed that Eaverage was independently associated with GLUT1 expression (p <  0.001). Conclusions Tumor stiffness on SWE is significantly correlated with tumor hypoxia as well as histologic biomarkers. In particular, Eaverage on SWE has independent prognostic significance for tumor hypoxia in the multivariable analysis and can potentially be used as a noninvasive imaging biomarker to predict prognosis and pretreatment risk stratification in breast cancer patients.

scholarly journals Tumor stiffness measured by quantitative and qualitative shear wave elastography of breast cancer

2018 ◽  
pp. 20170830 ◽  
Author(s):  
Eun Jee Song ◽  
Yu-Mee Sohn ◽  
Mirinae Seo
Keyword(s):  
Breast Cancer ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Tumor Stiffness

Liver Elastography in Healthy Children Using Three Different Systems – How Many Measurements Are Necessary?

2020 ◽  
Author(s):  
Anders Batman Mjelle ◽  
Anesa Mulabecirovic ◽  
Roald Flesland Havre ◽  
Edda Jonina Olafsdottir ◽  
Odd Helge Gilja ◽  
...  
Keyword(s):  
Shear Wave ◽  
Transient Elastography ◽  
Intraclass Correlation ◽  
Age Groups ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Healthy Children ◽  
Significant Difference ◽  
Pediatric Liver Disease ◽  
Liver Elastography

Abstract Purpose Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the essence when examining children, we wanted to evaluate if a reliable result can be achieved with fewer acquisitions. Materials and Methods 243 healthy children aged 4–17 years were examined after three hours of fasting. Participants were divided into four age groups: 4–7 years; 8–11 years; 12–14 years and 15–17 years. Both two-dimensional shear wave elastography (2D-SWE; GE Logiq E9) and point shear wave elastography (pSWE; Samsung RS80A with Prestige) were performed in all participants, while transient elastography (TE, Fibroscan) was performed in a subset of 87 children aged 8–17 years. Median liver stiffness measurement (LSM) values of 3, 4, 5, 6, 7, and 8 acquisitions were compared with the median value of 10 acquisitions (reference standard). Comparison was performed for all participants together as well as within every specific age group. We investigated both the intraclass correlation coefficient (ICC) with absolute agreement and all outliers more than 10 %, 20 % or ≥ 0.5 or 1.0 kPa from the median of 10 acquisitions. Results For all three systems there was no significant difference between three and ten acquisitions, with ICCs ≥ 0.97. All systems needed 4 acquisitions to achieve no LSM deviating ≥ 1.0 kPa of a median of ten. To achieve no LSM deviating ≥ 20 % of a median of ten acquisitions, pSWE and TE needed 4 acquisitions, while 2D-SWE required 6 acquisitions. Conclusion Our results contradict recommendations of 10 acquisitions for pSWE and TE and only 3 for 2D-SWE.

The novel point shear-wave elastography method ElastPQ® is accurate for non-invasive evaluation of liver fibrosis and portal hypertension

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
TA Bucsics ◽  
B Grasl ◽  
P Schwabl ◽  
M Mandorfer ◽  
J Dmitrieva ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
The Novel ◽  
Non Invasive ◽  
Invasive Evaluation
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