Aspect Ratio of PEGylated Upconversion Nanocrystals Affects the Cellular Uptake

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Download Full-text

Perceptual and Emotional Responses as a Function of Film Aspect Ratio as Viewed on a Television Screen

PsycEXTRA Dataset ◽

10.1037/e413782005-390 ◽

1999 ◽

Author(s):

Norman G. Gordon ◽

Michael J. Johnson

Keyword(s):

Aspect Ratio ◽

Emotional Responses ◽

Television Screen

Download Full-text

In a rat model of transient ischemia, acute albumin leakage across the blood-brain barrier is often followed by rapid cellular uptake

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0277 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S277-S277

Author(s):

Tavarekere N Nagaraja ◽

Kelly A Keenan ◽

Joseph D Fenstermacher ◽

Robert A Knight

Keyword(s):

Blood Brain Barrier ◽

Cellular Uptake ◽

Rat Model ◽

Brain Barrier ◽

Transient Ischemia ◽

Blood Brain ◽

Albumin Leakage

Download Full-text

Modification of MnS inclusion by tellurium in 38MnVS6 micro-alloyed steel

Metallurgical Research & Technology ◽

10.1051/metal/2020066 ◽

2020 ◽

Vol 117 (6) ◽

pp. 615

Author(s):

Ping Shen ◽

Lei Zhou ◽

Qiankun Yang ◽

Zhiqi Zeng ◽

Kenan Ai ◽

...

Keyword(s):

Fatigue Life ◽

Aspect Ratio ◽

Strong Influence ◽

Experimental Results ◽

Alloyed Steel ◽

Equivalent Diameter ◽

Small Aspect Ratio ◽

Steel Quality ◽

Eds Analysis ◽

Micro Alloyed Steel

In 38MnVS6 steel, the morphology of sulfide inclusion has a strong influence on the fatigue life and machinability of the steel. In most cases, the MnS inclusions show strip morphology after rolling, which significantly affects the steel quality. Usually, the MnS inclusion with a spherical morphology is the best morphology for the steel quality. In the present work, tellurium was applied to 38MnVS6 micro-alloyed steel to control the MnS inclusion. Trace tellurium was added into 38MnVS6 steel and the effect of Te on the morphology, composition, size and distribution of MnS inclusions were investigated. Experimental results show that with the increase of Te content, the equivalent diameter and the aspect ratio of inclusion decrease strikingly, and the number of inclusions with small aspect ratio increases. The inclusions are dissociated and spherized. The SEM-EDS analysis indicates that the trace Te mainly dissolves in MnS inclusion. Once the MnS is saturated with Te, MnTe starts to generate and wraps MnS. The critical Te/S value for the formation of MnTe in the 38MnV6 steel is determined to be approximately 0.075. With the increase of Te/S ratio, the aspect ratio of MnS inclusion decreases and gradually reaches a constant level. The Te/S value in the 38MnVS6 steel corresponding to the change of aspect ratio from decreasing to constant ranges from 0.096 to 0.255. This is most likely to be caused by the saturation of Te in the MnS inclusion. After adding Te in the steel, rod-like MnS inclusion is modified to small inclusion and the smaller the MnS inclusion, the lower the aspect ratio.

Download Full-text

Die Anämie bei malignen Tumorerkrankungen

Nuklearmedizin ◽

10.1055/s-0038-1629491 ◽

1989 ◽

Vol 28 (05) ◽

pp. 193-200 ◽

Cited By ~ 1

Author(s):

E. Aulbert

Keyword(s):

Cellular Uptake ◽

Tumor Tissue ◽

Malignant Tumors ◽

The Other ◽

Novikoff Hepatoma ◽

Cellular Accumulation ◽

Tumor Mass ◽

Proliferation Activity ◽

Morris Hepatoma ◽

Cellular Incorporation

Cellular uptake of 67Ga-labelled transferrin by the tumor tissue was studied in rats with tumors of different malignancy and different tumor mass using the slowly growing Morris hepatoma 5123C, the moderately growing Novikoff hepatoma and the very fast and aggressive Yoshida hepatoma AH130. The cellular accumulation of 67Ga-transferrin was found to correlate with the proliferation activity of the tumor. The 67Ga-transferrin concentration in the very fast growing Yoshida hepatoma was 4.8 times higher than the concentration in the slowly growing Morris hepatoma. The uptake of 67Ga-transferrin by the tumors resulted in a faster disappearance of circulating 67Ga-transferrin from the blood. The rate of disappearance correlated with the proliferation activity and the spread of the tumors. Using tumors of identical size the elimination of 67Ga-transferrin from the blood was much faster in the rats with Yoshida hepatoma than in those with the slowly growing Morris hepatoma. On the other hand, using tumors of different tumor size it could be demonstrated that the rate of disappearance of 67Ga-transferrin from the blood correlated directly with tumor mass. It is concluded that cellular incorporation of transferrin within the tumor cells results in a loss of circulating transferrin, which correlates with tumor mass and proliferation of tumor. This mechanism is supposed to be the cause for the hypotransferrinemia seen in patients with malignant tumors.

Download Full-text

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

Journal of Drug Discovery and Therapeutics ◽

10.32553/jddt.v6i10.444 ◽

2018 ◽

Vol 6 (10) ◽

Author(s):

Hosam Zaghloul ◽

Doaa A. Shahin ◽

Ibrahim El- Dosoky ◽

Mahmoud E. El-awady ◽

Fardous F. El-Senduny ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Cellular Uptake ◽

Superparamagnetic Iron Oxide ◽

Cyclin B1 ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Mcf7 Cells ◽

M Phase ◽

The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Download Full-text

PENINGKATAN KEMAMPUAN GURU BAHASA INDONESIA DALAM MENYUSUN RENCANA PROGRAM PEMBELAJARAN (RPP) SDN 015 PAGARAN TAPAH DARUSSALAM MELALUI METODE PEMBERIAN TUGAS

Primary: Jurnal Pendidikan Guru Sekolah Dasar ◽

10.33578/jpfkip.v5i3.3956 ◽

2017 ◽

Vol 5 (3) ◽

pp. 713

Author(s):

Mukhlis '

Keyword(s):

Aspect Ratio ◽

Duty Cycle ◽

Lesson Plans ◽

Learning Program ◽

School Subjects ◽

Bahasa Indonesia

Based on the observation of some teachers found the symptoms as follows: the lack of abilityof Indonesian teachers in designing learning program (RPP), the learning device is only usedas a supplement and not to the needs of teaching, most teachers again if asked the lessonanswered not have or has not been made. The purpose of this research is to improve theability of Indonesian teachers in designing learning program (RPP) at SDN 015 PagaranTapah Darussalam through the method of administration tasks. This type of research is actionresearch school. Subjects in this study were teachers Indonesian as many as 12 people. Basedon the analysis and discussion can be concluded that the method of administration tasks canimprove the ability of Indonesian teachers in making learning device in SDN 015 PagaranTapah Darussalam through the method of administration tasks. Under these conditions, thelevel of acceptance of teachers increased. The aspect ratio capability Indonesian teachers inpreparing lesson plans through the provision of duty cycle I and II of the increase from 56%and the second cycle to 79%.

Download Full-text