scholarly journals Improving of psychological status and inflammatory biomarkers during omalizumab for chronic spontaneous urticaria

2020 ◽  
pp. FSO618
Author(s):  
Laura Diluvio ◽  
Arianna Piccolo ◽  
Francesco Marasco ◽  
Laura Vollono ◽  
Caterina Lanna ◽  
...  

Background: Depression and anxiety are the most common psychiatric comorbidities in chronic spontaneous urticaria (CSU). Omalizumab is a monoclonal antibody approved for CSU treatment. We evaluated the prevalence of anxiety and depression in CSU patients before and after treatment with omalizumab. Materials & methods: A total of 30 patients were enrolled in the study: 15 patients affected by CSU and treated with omalizumab and the other 15 healthy subjects did not receive any systemic therapy. All patients were evaluated using Hospital Anxiety and Depression Scale, CRP and erythrocyte sedimentation rate, at baseline and after 6 months. Results: The omalizumab group after 6 months of therapy had a decrease of all the scores and biomarkers. Conclusion: Omalizumab allowed an improvement of urticaria and mental comorbidities.

2021 ◽  
Vol 36 (6) ◽  
pp. 1171-1171
Author(s):  
Winter Olmos ◽  
Daniel W Lopez-Hernandez ◽  
Isabel Munoz ◽  
Laura Schierholz ◽  
Rachel A Rugh-Fraser ◽  
...  

Abstract Introduction We examined the relationship between depression and anxiety, language, and functional outcomes in persons with traumatic brain injury (TBI). Methods The sample consisted of 48 acute TBI (ATBI: 23 Spanish-English Bilinguals; 25 English monolinguals), 30 chronic TBI (CTBI: 17 Spanish English Bilinguals; 12 English monolinguals), and 47 healthy comparison (HC: 29 Spanish-English Bilinguals; 18 English monolinguals) participants. The Hospital Anxiety and Depression Scale was used to measure depression (HADS-D) and anxiety (HADS-A). The Mayo Portland Adaptability Inventory-4 (MPAI-4) was used to measure functional outcomes (ability, adjustment, participation). Results An ANCOVA, controlling for age, revealed the ATBI group reported lower anxiety levels compared to the CTBI group, p = 0.034 np2 = 0.06. HC participants demonstrated significantly higher functional ability compared to both TBI groups, p < 0.05, np2 = 0.08–0.19. The ATBI group demonstrated worse participation scores compared to the CTBI and HC groups, p = 0.001, np2 = 0.11. Pearson correlations revealed mood was related to functional status in ATBI monolinguals (HADS-A: r = 0.29–0.64; HADS-D, r = 0.49–0.62). Monolingual participants with ATBI demonstrated correlations between depressive symptoms and functional adjustment (r = 0.57, p = 0.005) and ability (r = 0.44, p = 0.034). For monolinguals with CTBI, HADS-A correlated with functional outcomes, r = 0.60–0.66, p < 0.05. For bilinguals with CTBI, functional outcomes correlated with HADS-A, r = 0.53–0.66, p < 0.05, and HADS-D, r = 0.54–0.66, p < 0.05. For HC monolinguals, functional outcomes correlated with HADS-A, r = 0.53–0.70, p < 0.05, and HADS-D, r = 0.50–0.72, p < 0.05. Finally, for HC bilinguals, functional outcomes correlated with HADS-A, r = 0.59–0.68, p < 0.05. Conclusion Our results suggest that a relationship between anxiety and depressive symptoms is related more to functional outcomes in monolingual TBI survivors compared to bilingual TBI survivors.


1993 ◽  
Vol 15 (2) ◽  
pp. 69-74 ◽  
Author(s):  
Brendan T. Carroll ◽  
Roger G. Kathol ◽  
Russell Noyes ◽  
Tina G. Wald ◽  
Gerald H. Clamon

2017 ◽  
Vol 20 ◽  
Author(s):  
Alejandro Magallares ◽  
Patricia Bolaños-Rios ◽  
Inmaculada Ruiz-Prieto ◽  
Pilar Benito de Valle ◽  
Jose Antonio Irles ◽  
...  

AbstractObesity may be considered a social stigma. In addition, people with obesity are frequently aware of stigma directed at others who have a similar weight and come to think stigmatized thoughts about themselves. Our study focused specifically on how blatant and subtle discrimination and weight self-stigma are related to depression and anxiety in people with obesity. The sample comprised 170 participants from the Clinical Nutrition Unit of the “Hospital de Valme” (Seville, Spain). The Weight Self-Stigma Questionnaire, the Multidimensional Perceived Discrimination Scale, and the Hospital Anxiety and Depression Scale were used. It was found that blatant and subtle discrimination and weight self-stigma were positively related to depression (.31, .38, and .45 respectively) and anxiety (.30, .36, and .49 respectively; all ps < .01). The path analysis conducted showed that there was a mediational effect of weight self-stigma between blatant (β = .36) and subtle discrimination (β = .40) and depression (β = .24) and anxiety (β = .49; all ps < .01). According to these results, it can be said that weight self-stigma was a full mediator in the model found because the relationships between the independent and the dependent variables were non-significant. Finally, results are discussed in the frame of the obesity stigma literature, and some clinical implications of the results of the study are suggested.


2021 ◽  
Author(s):  
Zheyi Shao ◽  
Chao Huang ◽  
Ying Zhang ◽  
Shanshan Li ◽  
Donglin Wang ◽  
...  

Abstract Purpose: To investigate whether the FCVB could help improve the mental health of patients with impending eye atrophy. Methods: Fifty-five patients who underwent FCVB implantation from 2017 to 2019 were screened to take part in this retrospective study. The researchers used independent third parties to distribute questionnaires, including the Hospital Anxiety and Depression Scale and the interpersonal sensitivity part of the Symptom Checklist 90 (SCL-90) scale to score the patients' depression, anxiety, and interpersonal sensitivity before and after surgery. Finally, 52 responses were collected.Results: After FCVB implantation, patients had significantly better mental health and less depression, anxiety, and interpersonal sensitivity levels. Before FCVB implantation, 44.23% of patients with ocular trauma and retinal detachment were depressed, 48.08% were anxious, and 19.23% were sensitive to interpersonal communication. After FCVB implantation, 17.31% were depressed, 15.38% were anxious, and 9.62% were sensitive to interpersonal communication. However, baseline demographic and clinical data, such as age, gender, occupation, finance, pre-FCVB-implantation vision, number of surgeries before FCVB implantation, postoperative period length, and surgical satisfaction, had no significant effects on psychological scores of mental health before and after surgery (P> 0.05). Conclusion: Mental health (depression, anxiety, and interpersonal sensitivity) significantly improved in patients after FCVB implantation.


2018 ◽  
Vol 10 (Especial 5) ◽  
pp. 89-94
Author(s):  
Silas de Oliveira Damasceno ◽  
José Henrique Piedade Cardoso ◽  
Raíssa Puzzi Ladvig ◽  
Luana Martins de Paula ◽  
Renilton José Pizzol ◽  
...  

Pain, anxiety, and depression are symptoms that need attention in physiotherapeutic practice, once they influence the functionality of patients, so understanding them becomes an important tool. The aim of the study was to verify the levels of pain, depression, and anxiety in patients attended at a physiotherapy center. A cross-sectional clinical study in which a sociodemographic questionnaire was applied, the Visual Analogue Scale (VAS), the Hospital Anxiety and Depression Scale (HADS) and the Roland Morris Disability Questionnaire (MRQ). Seven patients participated and presented a MRI score of 18.57 ± 2.63 points, HADS in the topic anxiety 12.71 ± 5.43 points, HADS depression 9.57 ± 5.22 points and the resting VAS presented an average of 4 , 42 ± 3.9 pain points and in motion showed 8.71 ± 0.95. It is concluded that the population with low back pain has high intensity of pain, probable anxiety and possible level of depression.


2021 ◽  
Vol 79 (8) ◽  
pp. 682-685
Author(s):  
Eduardo Almeida Guimarães Nogueira ◽  
Flavia Rodrigues de Oliveira ◽  
Vitor Martinez de Carvalho ◽  
Carina Telarolli ◽  
Yara Dadalti Fragoso

ABSTRACT Background: Catastrophization is a psychological aspect of pain that alters its perception and expression. Objective: To investigate the feature of catastrophization in migraine. Methods: An online survey of individuals suffering from migraine attacks at least twice a month, for at least one year was carried out. Confidentiality was assured and participants gave details of their headache (including a visual analogue pain scale) and answered the Hospital Anxiety and Depression Scale and the Catastrophization Scale questionnaires. Results: The survey included 242 individuals with migraine attacks at least twice a month. The median scores observed in this group of individuals were 7 for pain, 11 for anxiety, 7 for depression, and 2 for catastrophization. Catastrophization had no correlation with the duration (p=0.78) or intensity (p=0.79) of the migraine. There was no correlation between catastrophization and headache frequency (p=0.91) or the monthly amount of headache medication taken (p=0.85). High scores for catastrophization (≥3.0) were identified in one third of the participants. These high scores were not associated with age, headache duration, pain severity, frequency of attacks, or traits of depression or anxiety. There was a moderate association between both depression and anxiety traits with catastrophization. Conclusions: Catastrophization seems to be a trait of the individual and appears to be unrelated to the characteristics of the migraine.


2020 ◽  
Vol 5 (3) ◽  
pp. 273-285
Author(s):  
Pınar Ünal-Aydın ◽  
Yasin Arslan ◽  
Orkun Aydın

The goal of this study was to examine the effects of mindfulness (MF) and spiritual intelligence (SI) as predictors of depression and anxiety, the most frequent manifestations of mental disorders – among 184 Turkish participants of diverse ages, predominantly students, living in Istanbul and Sarajevo. Four instruments were administered either directly or via web-based services: Scale for Spiritual Intelligence (SSI), Hospital anxiety and depression scale (HADS), Five Facet Mindfulness Questionnaire – Short Form (FFMQ-S) and Sociodemographic Information Form. Through the use of linear regression analysis, Actaware (b=-.19, p≤.001), Nonjudge (b=-.22, p≤.001), Nonreact (b=-.19, p≤.001) subscales of FFMQ-S were found to be negative predictors for depression and anxiety, whereas, Self-understanding subscale of SSI was not significant. Although our findings suggest that spiritual intelligence is not significant in prediction of depression and anxiety, our research provides empirical evidence for the link between MF, SI, depression and anxiety, as well as revealing MF as predictor for anxiety and depression which may be useful for further improvements in the scope of current interventions.


1993 ◽  
Vol 21 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Egil Andersson

The H.A.D.-scale was originally used as a screening test for assessing the presence of clinically significant degrees of anxiety and depression. It has also been used as a measuring instrument outside hospital care. The main questions in this study are: l) Do the test items fit a sample of non-clinical persons? 2) Are the two subscales of Depression and Anxiety homogeneous? In total 163 persons answered the questionnaire. Two factor analyses are reviewed, a two factor solution and a four factor solution. The two factor solution did not split the items in the way originally intended. A four factor analysis with three interpreted factors gave a better solution. The analysis leads us to recommend great caution when interpreting the H.A.D.-scale, especially when used in a population outside of hospital care.


2017 ◽  
Vol 41 (S1) ◽  
pp. S236-S236 ◽  
Author(s):  
H. Hoang ◽  
E. Stenager ◽  
E. Stenager

ObjectiveTo examine the risk of depression and anxiety in MS patients in the post-diagnostic period by using clinical screening instruments and a diagnostic structured clinical interview.MethodA population of 134 MS patients was examined for the risk of depression and anxiety in the post-diagnostic period of MS using the clinical screening instruments Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS). Within six weeks of diagnosis, patients with cut-off > 12 for BDI and > 7 for HADS were offered a clinical structured interview using the Schedules for Clinical Assessment in Neuropsychiatry/SCAN Version 2.1.ResultsThe prevalence of depressive symptoms and depression in the post-diagnostic period of MS was 49.2% when using the screening instruments, but only 15.2% when using the SCAN interview. For anxiety, the prevalence was 3.4% for both the screening instruments and the SCAN interview in the post-diagnostic period of MS.ConclusionMS patients have a risk of depression and anxiety in the post-diagnostic period of MS, but it is crucial to consider which tools to use in a clinical setting to investigate depression and anxiety in MS patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.


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