scholarly journals Incidence, characteristics, maternal complications, and perinatal outcomes associated with preeclampsia with severe features and HELLP syndrome

2018 ◽  
Vol Volume 10 ◽  
pp. 371-377 ◽  
Author(s):  
Kiattisak Kongwattanakul ◽  
Piyamas Saksiriwuttho ◽  
Sukanya Chaiyarach ◽  
Kaewjai Thepsuthammarat
Keyword(s):  
Hellp Syndrome ◽  
Perinatal Outcomes ◽  
Maternal Complications

scholarly journals Maternal and perinatal outcome in patients of preeclampsia with and without HELLP syndrome

2019 ◽  
Vol 8 (5) ◽  
pp. 2065
Author(s):  
Hritul Madge ◽  
Sunita Seth
Keyword(s):  
Hellp Syndrome ◽  
Perinatal Outcomes ◽  
Perinatal Morbidity ◽  
Maternal Complications ◽  
Tertiary Referral Centre ◽  
Admission Rates ◽  
Maternal Morbidity And Mortality ◽  
Mother And Child ◽  
Laboratory Investigations ◽  
Nicu Admission

Background: Preeclampsia is seen in about 5-10% of all pregnancies and HELLP Syndrome occurs in 6-12% of these patients. Both are known to increase maternal and perinatal morbidity. The study aims to provide a comprehensive view of these myriad outcomes in the mother and neonate both, in each of the groups. It also compares the incidence of such outcomes in mother and child, in preeclampsia only and in those complicated by HELLP syndrome.Methods: This prospective, observational, comparative study was conducted at a tertiary referral centre. 55 patients with preeclampsia were compared with 55 patients with HELLP syndrome. The relevant clinical features, laboratory investigations and the maternal and perinatal outcomes along with the incidence were studied and results analyzed.Results: Significant differences were observed in laboratory parameters and duration of ICU stay in patients with preeclampsia and patients with HELLP syndrome. Incidence of maternal complications and need for blood transfusion was greater in HELLP syndrome. Only marginal differences were observed in birth weight, NICU admission rates and neonatal mortality rates.Conclusions: HELLP syndrome is associated with increased maternal morbidity and mortality as compared to preeclampsia. Neonatal outcomes appear to be influenced; only marginally, by HELLP syndrome, nevertheless, their incidence is more than in preeclampsia. Aggressive treatment for pregnant women appears to decrease the maternal mortality rate.

scholarly journals Partial HELLP Syndrome: maternal and perinatal outcome

2002 ◽  
Vol 120 (6) ◽  
pp. 180-184 ◽  
Author(s):  
Joelcio Francisco Abbade ◽  
José Carlos Peraçoli ◽  
Roberto Antonio Araújo Costa ◽  
Iracema de Mattos Paranhos Calderon ◽  
Vera Therezinha Medeiros Borges ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Hellp Syndrome ◽  
Laboratory Tests ◽  
Gestational Hypertension ◽  
Mode Of Delivery ◽  
Perinatal Outcomes ◽  
Chronic Hypertension ◽  
Maternal Complications ◽  
Blood Pressure Elevation ◽  
Elevated Liver Enzymes

CONTEXT: HELLP syndrome is a severe complication of pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count. Some pregnant women develop just one or two of the characteristics of this syndrome, which is termed Partial HELLP Syndrome (PHS). OBJECTIVE: The objective of this study was to evaluate the repercussions on maternal and perinatal outcomes among women that developed PHS and to compare these women with those whose gestational hypertension or preeclampsia did not show alterations for HELLP syndrome in laboratory tests. DESIGN: Observational, retrospective and analytical study. SETTING: Maternity Department of Hospital das Clínicas, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil. SAMPLE: Pregnant or post-delivery women who had a blood pressure elevation that was first detected after mid-pregnancy, with or without proteinuria, between January 1990 and December 1995. MAIN MEASUREMENTS: Analysis was made of maternal age, race, parity, hypertension classification, gestational age at the PHS diagnosis, alterations in laboratory tests for HELLP syndrome, time elapsed to discharge from hospital, maternal complications, mode of delivery, incidence of preterm birth, intrauterine growth restriction, stillborn and neonatal death. RESULTS: Three hundred and eighteen women were selected; forty-one women (12.9%) had PHS and 277 of them (87.1%) did not develop any of the alterations of the HELLP syndrome diagnosis. Preeclampsia was a more frequent type of hypertension in the PHS group than in the hypertension group. None of the women with isolated chronic hypertension developed PHS. The rate of cesarean delivery, eclampsia, and preterm delivery was significantly greater in the PHS group than in the hypertension group. CONCLUSION: We observed that aggressive procedures had been adopted for patients with PHS. These resulted in immediate interruption of pregnancy, with elevated cesarean rates and preterm delivery. Such decisions need to be reviewed, in order to reduce the cesarean rate and the incidence of preterm delivery.

scholarly journals Maternal Perinatal Outcomes Related to Advanced Maternal Age in Preeclampsia Pregnant Women

2020 ◽  
Author(s):  
Bestari Dianing Tyas ◽  
Pudji Lestari ◽  
Muhammad Ilham Aldika Akbar
Keyword(s):  
Hellp Syndrome ◽  
Maternal Age ◽  
Post Partum ◽  
Perinatal Outcomes ◽  
Advanced Maternal Age ◽  
The Other ◽  
Reproductive Age ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Significant Difference

Objective: This study aims to analyze the effect of advanced maternal age (>35 years old) in maternal and perinatal outcomes of preeclampsia women. Materials and methods: This is a retrospective cross-sectional study involved all women who were diagnosed with preeclampsia at Universitas Airlangga Hospital (Surabaya, Indonesia) between January 2016 until May 2017. The participant was divided into two groups based on maternal ages: the first group was women older than 35 years old (advanced maternal age - AMA), and the other group was 20-34 years old (reproductive age - RA). The primary outcomes of this study were the maternal and perinatal outcome. Results: There were a total of 43 AMA preeclampsia women and 105 RA preeclampsia women. The AMA preeclampsia group had a higher proportion of poor maternal outcome (the occurence of any complication: pulmonary edema, HELLP syndrome, visual impairment, post partum hemorrhage, and eclampsia) compared to RA preeclampsia group (60,5% vs 33,3%, p = 0,002; OR 3,059, CI 1,469-6,371). There was no significant difference in the other maternal complications such as HELLP syndrome, pulmonary oedema, and eclampsia. The only difference was the occurrence of postpartum haemorrhage which was higher in the AMA group (16,3% vs 4,8%, p = 0,02; OR 3,889, CI 1,161-13,031). The prevalence of cesarean delivery was more common in AMA group (53,3% vs 28,6%, p = 0,004; OR 2.825, CI 1.380-5.988). The AMA preeclampsia women also had poorer perinatal outcomes compared to the RA group (81,4% vs 59%, p = 0,009; OR 3.034 CI 1.283-7.177). AMA women had a higher risk of perinatal complication such as prematurity (OR 3.266 CI 1.269-8.406), IUGR (OR 4.474 CI 1.019-19.634), asphyxia (OR 4.263 CI 2.004-9.069), and infection (OR 2.138 CI 1.040-4.393). Conclusion: Advanced maternal age increases the risk of poorer maternal and neonatal outcomes in preeclampsia patients. The addition of advanced maternal ages in preeclampsia should raise the awareness of the health provider, tighter monitoring, complete screening and early intervention if needed to minimize the risk of complications.  

scholarly journals Periodontal intervention effects on pregnancy outcomes in women with preeclampsia.

1969 ◽  
Vol 40 (2) ◽  
pp. 177-184
Author(s):  
Julián A. Herrera ◽  
Santiago Vélez Medina ◽  
Rodolfo Molano ◽  
Virna Medina ◽  
Javier E. Botero ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Hellp Syndrome ◽  
Severe Preeclampsia ◽  
Maternal Complications ◽  
Frequent Finding ◽  
Mild Preeclampsia ◽  
Social Demographic ◽  
Study Inclusion ◽  
Clinical Stability

Objective: To determine the efficacy of periodontal intervention on pregnancy outcome in mild preeclamptic women. Methods: A sample of 60 pregnant women with mild preeclampsia (blood pressure levels < 160/110 mm and proteinuria >300 mg/l in 24 hours urine) from the Hospital Universitario del Valle (Cali, Colombia) was included to the study. Preeclamptic women were randomized in two groups, one with periodontal intervention (PIG, N=28) and another in which the periodontal intervention was practiced after childbirth (NPIG, N=32). Maternal socio-demographic, medical and periodontal data were obtained. PIG included patients in which supragingival and subgingival cleaning within ultrasonic and manual devices were performed after study inclusion. The progression from mild to severe preeclampsia, eclampsia or HELLP syndrome, the number of days of clinical stability and the percentile of birth-weight adjusted for gestational age were evaluated in both groups. Results: Most of the patients (60%) were multigravids. Gestational age at inclusion was 31.8±1.6 weeks. Chronic periodontitis was a frequent finding (61.7%). Social, demographic, medical and periodontal conditions were similar between both groups. Disease progression to severe preeclampsia, eclampsia or HELLP syndrome was also similar (89.2% PIG versus 84.4%, p=0.65) (OR=1.06 IC 95% 0.87-1.29, p=0.65). Days of clinical stability were similar between the groups (median 10 days , range 1-46, PIG versus 12 days, range 1-59, p=0.57) and the percentile of birth weight adjusted with gestational age had no differences between the groups (median percentil 50 range 5-90 PIG versus percentil 55 range 5-95, p=0.73). Conclusion: Periodontal intervention does not seem to harm the health, the severity or alter the frequency on maternal complications in mild preeclampsia subjects.

scholarly journals Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and ≥34 Weeks’ Gestation

2015 ◽  
Vol 32 (4) ◽  
pp. 359-363 ◽  
Author(s):  
Tugba Kinay ◽  
Canan Kucuk ◽  
Fulya Kayikcioglu ◽  
Jale Karakaya
Keyword(s):  
Hellp Syndrome ◽  
Perinatal Outcomes ◽  
Severe Preeclampsia

scholarly journals Maternal and perinatal outcome in patients with severe pre eclampsia/ eclampsia with and without HELLP syndrome

2014 ◽  
Vol 1 (4) ◽  
pp. 7-12
Author(s):  
T Gupta ◽  
N Gupta ◽  
J Jain ◽  
S Gupta ◽  
P Bhatia ◽  
...  
Keyword(s):  
Birth Weight ◽  
Hellp Syndrome ◽  
Perinatal Outcome ◽  
P Value ◽  
Maternal Complications ◽  
Singleton Pregnancy ◽  
Prospective Longitudinal Study ◽  
Entire Study ◽  
Group 3 ◽  
Prospective Longitudinal

OBJECTIVE: To evaluate the occurrence of HELLP syndrome inpatients with severe pre eclampsia & eclampsia and to compare the maternal & perinatal outcome in patients with and without HELLP syndrome (partial and true). METHOD: This was a prospective longitudinal study conducted in the Department of Obstetrics & Gynaecology, E.S.I. PGIMSR,NewDelhi from August 2011-April 2013. 50 pregnant women with singleton pregnancy with severe pre eclampsia detected at 28 or more weeks of gestation were enrolled. Patients were divided into three groups: group 1 with severe pre eclampsia, group 2 with severe pre eclampsia with partial HELLP syndrome and group 3 with severe pre eclampsia with true HELLP syndrome. Patients in three groups were compared in regard to maternal complications, gestational age atdelivery, mode ofdelivery, hospital stay andperinatal outcome. RESULTS: Prevalence of HELLP syndrome in severe pre eclampsia was 40% (partial HELLP= 28% and true= 12%). Antenatal and maternal complications were more in true HELLP syndrome patients as compared to other groups. PPH was observed in 40% of entire study group. DIC was found more in true HELLP syndrome patient with high statistically significant p value<0.001 Blood and its product transfusion was more in true HELLP syndrome. There was 100% ICU admission in group 3. In severe pre eclampsia, 11 neonates had birth weight >2.5kg. Where as in partial and true HELLP syndrome, no neonate had birth weight more than 2.5kg.This difference was statistically significant. There was 100% NICU admission in HELLP syndrome, 91.66% in partial HELLP syndrome and 42.3% in severe preeclampsia. The perinatal morbidity and mortality was higher in HELLP syndrome patients than in patient with severe pre eclampsia without HELLP syndrome. CONCLUSION: The study concludes that both maternal and perinatal outcome were adverse in HELLP syndrome than in severe pre eclampsia without HELLP syndrome. DOI: http://dx.doi.org/10.3126/jucms.v1i4.9564 Journal of Universal College of Medical Sciences (2013) Vol.1 No.04: 7-12

scholarly journals Fetomaternal outcome in pregnancy with HELLP syndrome

2020 ◽  
Vol 9 (7) ◽  
pp. 2860
Author(s):  
Prachi M. Shelat ◽  
Rupa C. Vyas ◽  
Sapana R. Shah ◽  
Naimish D. Nathwani
Keyword(s):  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Care Center ◽  
Tertiary Care ◽  
Peripheral Blood Smear ◽  
Intrauterine Death ◽  
Tertiary Care Center ◽  
Maternal Complications ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count

Background: HELLP Syndrome is a serious complication of pregnancy induced hypertensive disorders. It is defined as a triad of hemolysis, elevated liver enzymes, and low platelet count (HELLP). Objectives of this study was to find out incidence of HELLP syndrome in pre-eclampsia, eclampsia and its overall incidence. To analyse the clinical profile of HELLP syndrome. To study maternal and perinatal outcome including morbidity and mortality.Methods: A retrospective study was conducted from July 2017 to September 2019 at a tertiary care center with inclusion criteria of abnormal peripheral blood smear, elevated liver enzymes (LDH, aspartate aminotransferase), and low platelet count.Results: HELLP syndrome was more common in younger age group (45%) and in primigravida (52.5%). Most of the patients presented at >36 weeks of gestation (40%) and most of the patients delivered by caesarean section (67.5%). Maternal complications were acute renal failure (27.5%), DIC (22.5%), maternal mortality (7.5%). Neonatal complications associated were intrauterine death (27.5%), prematurity (25%) and intrauterine growth retardation (15%).Conclusions: Thus, HELLP syndrome requires an early diagnosis and early initiation of treatment at tertiary care center with all the medical facilities available.

HELLP syndrome in severe preeclampsia: The perinatal outcomes

2017 ◽  
Vol 7 ◽  
pp. 61 ◽  
Author(s):  
Siti Rahmayanti ◽  
Detty Siti Nurdiati
Keyword(s):  
Hellp Syndrome ◽  
Perinatal Outcomes ◽  
Severe Preeclampsia

Legionella infection in pregnancy: imitator of HELLP syndrome, presenting as acute respiratory failure and septic shock

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Moti Gulersen ◽  
Eran Bornstein
Keyword(s):  
Septic Shock ◽  
Hellp Syndrome ◽  
Laboratory Evaluation ◽  
Maternal Complications ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Antigen Testing ◽  
In Pregnancy

Abstract Background Legionnaires’ disease in pregnancy may cause severe maternal complications. Hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome is a disorder associated with significant maternal and fetal morbidity and mortality. Several medical conditions have been described as imitators of this syndrome, presenting with similar laboratory abnormalities. Case presentation A healthy, multiparous woman presented at 26 weeks’ gestation with fever, headache and general malaise, rapidly progressing to septic shock and respiratory collapse. Laboratory evaluation revealed similar abnormalities to those seen with HELLP syndrome. Emergent cesarean delivery was performed for worsening maternal and fetal conditions. Following delivery, infection with Legionella was diagnosed on urinary antigen testing. Supportive care was administered in the intensive care unit. Conclusion Legionnaires’ disease should be considered in gravidas presenting with rapidly deteriorating respiratory status, septic shock and laboratory abnormalities mimicking HELLP syndrome.

Sign in / Sign up

Export Citation Format

Share Document