scholarly journals Human La Protein: An RNA-Binding Protein Involved in Ovarian Cancer Development and Multidrug Resistance

2020 ◽  
Vol Volume 13 ◽  
pp. 10721-10727
Author(s):  
Xuan Huang ◽  
Jing Tang
Keyword(s):  
Ovarian Cancer ◽  
Multidrug Resistance ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cancer Development ◽  
La Protein

scholarly journals The RNA binding protein QKI5 suppresses ovarian cancer via down-regulating transcriptional coactivator TAZ

2021 ◽  
Author(s):  
Tao Liu ◽  
Yu Yang ◽  
Zhe Xie ◽  
Qingya Luo ◽  
Dan Yang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Transcriptional Coactivator

scholarly journals The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer

2015 ◽  
Vol 44 (3) ◽  
pp. 1227-1246 ◽  
Author(s):  
Thomas G. Hopkins ◽  
Manuela Mura ◽  
Hiba A. Al-Ashtal ◽  
Roni M. Lahr ◽  
Normala Abd-Latip ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Transcriptional Regulator

scholarly journals RNA binding protein RBM3 promotes a cancer stem cell phenotype with multidrug resistance

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Anand Venugopal ◽  
Deep Kwatra ◽  
Shane Stecklein ◽  
Satish Ramalingam ◽  
Dharmalingam Subramaniam ◽  
...  
Keyword(s):  
Stem Cell ◽  
Multidrug Resistance ◽  
Cancer Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Phenotype ◽  
Cancer Stem Cell Phenotype ◽  
Stem Cell Phenotype

scholarly journals The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

2012 ◽  
Vol 8 (4) ◽  
pp. 290-297 ◽  
Author(s):  
Michelina Plateroti ◽  
Patricia Rosa de Araujo ◽  
Acarizia Eduardo da Silva ◽  
Luiz O. F. Penalva
Keyword(s):  
Colon Cancer ◽  
Intestinal Epithelium ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cancer Development ◽  
Major Player

scholarly journals RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Shengtan Wang ◽  
Zaihong Li ◽  
Genhai Zhu ◽  
Lan Hong ◽  
Chunyan Hu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Rna Binding ◽  
Epithelial Mesenchymal Transition ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Circular Rnas ◽  
Ovarian Cancer Cells ◽  
Loss Of Function ◽  
Mesenchymal Transition ◽  
Repressive Effect

Abstract Background Circular RNAs (circRNAs) are increasingly recognized as important regulators in cancer including ovarian cancer (OC). This work focuses on the effects of circ_0000745 on the OC development of and molecules involved. Methods Expression of circ_0000745 in collected OC tissues and the acquired OC cell lines was examined by RT-qPCR. The stability of circ_0000745 in cells was examined by RNase R treatment. The target transcripts interacted with circ_0000745 were predicted using bioinformatic systems. Gain- and loss-of-function studies of circ_0000745, microRNA (miR)-3187-3p and erb-b2 receptor tyrosine kinase 4 (ERBB4) were conducted to determine their functions on proliferation, migration, invasion and stem cell property of OC cells. Results Circ_0000745 and ERBB4 were abundantly expressed while miR-3187-3p was poorly expressed in OC tissues and cells. Circ_0000745 sequestered miR-3187-3p and blocked its repressive effect on ERBB4. Downregulation of circ_0000745 reduced proliferation, aggressiveness, epithelial-mesenchymal transition, and stemness of SK-OV-3 cells, but this reduction was blocked upon miR-3187-3p inhibition or ERBB4 upregulation. By contrast, artificial induction of circ_0000745 upregulation, miR-3187-3p upregulation and ERBB4 downregulation led to inverse trends in ES-2 cells. ERBB4 promoted the phosphorylation of the PI3K/AKT signaling pathway. An RNA binding protein IGF2BP2 was found to circ_0000745 bind to and promote its expression and stability. Conclusion This study demonstrated that circ_0000745 upregulated by IGF2BP2 promotes aggressiveness and stemness of OC cells through a miR-3187-3p/ERBB4/PI3K/AKT axis. Circ_0000745 may serve as a promising target for OC treatment.

scholarly journals Silencing the Double-Stranded RNA Binding Protein DGCR8 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion

2013 ◽  
Vol 32 (3) ◽  
pp. 769-778 ◽  
Author(s):  
Yuqi Guo ◽  
Peng Tian ◽  
Chuanhe Yang ◽  
Zhibing Liang ◽  
Min Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Rna Binding ◽  
Ovarian Cancer Cell ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Double Stranded Rna

scholarly journals Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer

2010 ◽  
Vol 8 (1) ◽  
pp. 78 ◽  
Author(s):  
Åsa Ehlén ◽  
Donal J Brennan ◽  
Björn Nodin ◽  
Darran P O'Connor ◽  
Jakob Eberhard ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Favourable Prognosis ◽  
Cisplatin Sensitivity

scholarly journals Characterization of the Expression of the RNA Binding Protein eIF4G1 and Its Clinicopathological Correlation with Serous Ovarian Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163447 ◽  
Author(s):  
Lanfang Li ◽  
Qingya Luo ◽  
Zhe Xie ◽  
Guiqin Li ◽  
Chengyi Mao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Serous Ovarian Cancer ◽  
Clinicopathological Correlation

scholarly journals The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

2021 ◽  
Author(s):  
Shekoufeh Almasi ◽  
Bernard J. Jasmin
Keyword(s):  
Rna Binding ◽  
Current Knowledge ◽  
Binding Protein ◽  
Neuromuscular Disorders ◽  
Expression Patterns ◽  
Rna Binding Protein ◽  
Rna Metabolism ◽  
Cancer Development ◽  
Cell Functions

AbstractThe double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs have been described in different organisms, including humans. Two human orthologues of Staufen, named Staufen1 (STAU1) and Staufen2 (STAU2), share some structural and functional similarities. However, given their different spatio-temporal expression patterns, each of these orthologues plays distinct roles in cells. In the current review, we focus on the role of STAU1 in cell functions and cancer development. Since its discovery, STAU1 has mostly been studied for its involvement in various aspects of RNA metabolism. Given the pivotal role of RNA metabolism within cells, recent studies have explored the mechanistic impact of STAU1 in a wide variety of cell functions ranging from cell growth to cell death, as well as in various disease states. In particular, there has been increasing attention on the role of STAU1 in neuromuscular disorders, neurodegeneration, and cancer. Here, we provide an overview of the current knowledge on the role of STAU1 in RNA metabolism and cell functions. We also highlight the link between STAU1-mediated control of cellular functions and cancer development, progression, and treatment. Hence, our review emphasizes the potential of STAU1 as a novel biomarker and therapeutic target for cancer diagnosis and treatment, respectively.

scholarly journals RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Xiaojuan Lin ◽  
Jianfeng Shen ◽  
Dan Peng ◽  
Xinhong He ◽  
Congjian Xu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Ovarian Cancer Cells
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