Analysis of Incidence and Clinical Characteristics of RSV Infection in Hospitalized Children: A Retrospective Study

AbstractNow there is no clinical scale for early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study is to identify indicators and develop an early predictive scale for RMPP in hospitalized children. First we conducted a retrospective cohort study of children with M. pneumoniae pneumonia admitted to Children’s Hospital of Nanjing Medical University, China in 2016. Children were divided into two groups, according to whether their pneumonia were refractory and the results were used to develop an early predictive scale. Second we conducted a prospective study to validate the predictive scale for RMPP in children in 2018. 618 children were included in the retrospective study, of which 73 with RMPP. Six prognostic indicators were identified and included in the prognostic assessment scale. The sensitivity of the prognostic assessment scale was 74.0% (54/73), and the specificity was 88.3% (481/545) in the retrospective study. 944 children were included in the prospective cohort, including 92 with RMPP, the sensitivity of the prognostic assessment scale was 78.3% (72/92) and the specificity was 86.2% (734/852). The prognostic assessment scale for RMPP has high diagnostic accuracy and is suitable for use in standard clinical practice.

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Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study

BMC Pediatrics ◽

10.1186/s12887-021-02507-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Caiying Wang ◽

Huimin Zhang ◽

Yanlan Zhang ◽

Lin Xu ◽

Min Miao ◽

...

Keyword(s):

Retrospective Study ◽

Clinical Characteristics ◽

Severe Disease ◽

Severe Pneumonia ◽

Infants And Children ◽

Critically Ill Children ◽

Young Infants ◽

Incidence And Mortality ◽

Increasing Trend ◽

Medical University

Abstract Background The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants Methods A retrospective study was conducted, and 184 infants and children with pertussis who had been hospitalized in the Department of Pediatrics of Beijing Ditan Hospital affiliated with Capital Medical University from January 2016 to December 2017 were included. Clinical data of the patients were collected and the clinical characteristics were statistically analyzed Results Among the 184 patients, 41.85% were infants < 3 months of age, and 65.22% of the total patients were not vaccinated against pertussis. There were 22 critically ill children, among whom 4 died, and compared with mild cases, they had a higher proportion of children younger than 3 months of age and infants not vaccinated against pertussis (63.64% vs. 38.89% and 100% vs. 60.49%, respectively); a higher proportion of children with severe pneumonia (100% vs. 0%); higher leukocyte count(× 109/L , 35.80 ± 20.53 vs 19.41 ± 8.59); and a higher proportion of children with severe hyperleukocytosis (18.18% vs. 0%, respectively) (P<0.05) Conclusions 1. Infants aged <3 months not vaccinated for pertussis appear more likely to become infected and have more severe disease. 2. Severe pneumonia and hyperleukocytosis are the main mechanisms underlying severe pertussis.

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Clinical characteristics of uterine rupture without previous Cesarean section: A 25‐year retrospective study

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.14761 ◽

2021 ◽

Author(s):

Peng Zhao ◽

Chang Su ◽

Caifeng Wang ◽

Junbi Xu ◽

Xiaoxia Bai

Keyword(s):

Retrospective Study ◽

Cesarean Section ◽

Uterine Rupture ◽

Clinical Characteristics ◽

Previous Cesarean Section ◽

Previous Cesarean

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Characteristics of patients with osteonecrosis of the jaw with oral versus intravenous bisphosphonate treatment

Maxillofacial Plastic and Reconstructive Surgery ◽

10.1186/s40902-021-00310-w ◽

2021 ◽

Vol 43 (1) ◽

Author(s):

Seung-Hun Lee ◽

So-Young Choi ◽

Min-Su Bae ◽

Tae-Geon Kwon

Keyword(s):

Retrospective Study ◽

Clinical Characteristics ◽

Demographic Data ◽

Osteonecrosis Of The Jaw ◽

Group Differences ◽

Bisphosphonate Treatment ◽

Administration Route ◽

Lesion Number ◽

Different Characteristics ◽

Intravenous Bisphosphonate

Abstract Purpose This retrospective study was aimed to evaluate the clinical characteristics and treatment outcomes in patients with osteonecrosis of the jaw who were receiving oral versus intravenous (IV) bisphosphonate (BP). Materials and methods This retrospective study enrolled subjects who had been diagnosed with medication-related osteonecrosis of the jaw (MRONJ) during the period from July 2010 to June 2014. Information regarding the following demographic and clinical characteristics was collected: demographic data, administration route and type of BP, duration of BP medication, primary disease, number of involved sites, location of the lesion, number of surgeries, outcome of treatments, and laboratory test. All the patients were divided into oral and IV BP groups; and the between-group differences were compared. Results Total 278 patients were divided into two groups as per the route of BP administration. The proportion of oral BP-related MRONJ group were more dominant over IV BP group (oral BP, n = 251; IV BP, n = 27). In the IV BP group, the average dosing duration (31.4 months) was significantly shorter than that in the oral BP group (53.1 months) (P < 0.001). The average number of involved sites in the oral BP group (1.21 ± 0.48) was smaller than that in the IV BP group (1.63 ± 0.84) (P < 0.001). The average number of surgeries was higher in the IV BP group (1.65 ± 0.95) as compared to that in the oral BP group (0.98 ± 0.73) (P < 0.001). Outcome after the surgery for MRONJ after IV BP was poor than oral BP group. Conclusion IV administration of BP causes greater inhibition of bone remodeling and could lead more severe inflammation. Therefore, even if the duration of IV administration of BP is shorter than that of oral BP, the extent of the lesion could be more extensive. Therefore, the result suggests that the MRONJ after IV BP for cancer patients needs to be considered as different characteristics to oral BP group for osteoporosis patents.

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