ELEVATED SERUM URIC ACID LEVELS- A RISK FACTOR IN ACUTE NON-EMBOLIC ISCHEMIC STROKE.

Background: Stroke or cerebrovascular accident (CVA) is noted as the second cause of mortality, especially in the elderly population. Recent studies indicated that higher concentrations of uric acid are involved in various vascular diseases. The findings of previous investigations suggest that, elevated serum alkaline phosphatase (ALP) levels may have a pathophysiological character in the occurrence of atherosclerotic vascular disease (AVD) of the heart and brain. This study evaluated the association between serum uric acid (SUA) levels, serum lipid levels, serum alkaline phosphatase (ALP) levels, and changes in ischemic cerebrovascular accident patients.Methods: All patients with Ischemic cerebrovascular accident age >50 years were included based on their clinical, laboratory, and radiological findings (including computed tomography (CT)/magnetic resonance imaging (MRI)) those admitted in our hospital. As control group 200 healthy individuals matched for sex and age were recruited from the same demographic area.Result: Multiple logistic regression analysis findings proposed four components as significant predictors in ischemic cerebrovascular accident (serum uric acid, serum ALP, LDL and HDL. In this study, it was found, that patients with ischemic cerebrovascular accident had significant difference (p<0.001) in serum uric acid and serum ALP than normal patients (non-ischemic cerebrovascular accident patients).Conclusions: Patients with ischemic cerebrovascular accident had significant difference (p<0.001) in SUA and serum ALP than normal patients (non-ischemic cerebrovascular accident patients). High SUA levels were observed to be associated significantly with ischemic stroke. On the basis of our study design, we cannot clarify that the elevated levels are the risk of ischemic stroke and it requires further studies.

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Mechanistic Insights of Soluble Uric Acid-related Kidney Disease

Current Medicinal Chemistry ◽

10.2174/0929867326666181211094421 ◽

2020 ◽

Vol 27 (30) ◽

pp. 5056-5066 ◽

Cited By ~ 2

Author(s):

Pan Jing ◽

Min Shi ◽

Liang Ma ◽

Ping Fu

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Kidney Disease ◽

Serum Uric Acid ◽

Independent Risk Factor ◽

Elevated Serum ◽

Tubulointerstitial Fibrosis ◽

Renal Diseases ◽

Glomerular Hypertrophy ◽

Progression Of Kidney Disease

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Considerable studies have demonstrated that soluble uric acid was involved in the pathophysiology of renal arteriolopathy, tubule injury, tubulointerstitial fibrosis, as well as glomerular hypertrophy and glomerulosclerosis. In the review, we summarized the mechanistic insights of soluble uric acid related renal diseases.

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Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

Cureus ◽

10.7759/cureus.6007 ◽

2019 ◽

Author(s):

Muhammad Ali Tariq ◽

Sohaib A Shamim ◽

Kiran F Rana ◽

Aisha Saeed ◽

Bilal Haider Malik

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Poor Outcomes

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Study of Serum Uric Acid Level as an Independent Risk Factor in Acute Ischemic Stroke

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/95 ◽

2020 ◽

Vol 7 (9) ◽

pp. 442-445

Author(s):

Chandrashekhar K ◽

Mohammed Anwar Hussain ◽

Ishwar S. Hasabi ◽

Suryakanth Suryakanth ◽

Chethan K. Ganteppanavar

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level

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Serum uric acid as a prognostic indicator in acute ischemic stroke

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20201338 ◽

2020 ◽

Vol 8 (4) ◽

pp. 1435

Author(s):

Chandana Kaspa ◽

Shankar Govindu

Keyword(s):

Uric Acid ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Elevated Serum ◽

Prognostic Indicator ◽

Uric Acid Concentration ◽

Risk Of Death ◽

Increased Risk ◽

Serum Uric Acid Concentration

Background: Association between serum uric acid (SUA) and the outcome of acute ischemic stroke is debated and needs to be evaluated. The present study was conducted to study the serum uric acid concentration as an indicator of outcome among acute ischaemic stroke and to determine the role of serum uric acid as a risk factor for acute ischemic stroke.Methods: An observational study where 50 patients who presented within 48 hours of onset of stroke admitted to medical wards of government general Hospital Guntur were selected for the study.Results: Out of 50 patients included for the study, 6 belonged to the age group of 30-40 years. Majority were male (66%) and 44.5% of the males and 76.5% of females showed raised serum uric acid levels. 25 out of 50 patients were diabetic (i.e. 50%) Among them 16 had serum uric acid >6 mg% (ie.64%), 56% of the patients were hypertensive and among them 71% were found to have uric acid levels greater than 6mgs%, 38 out of 50 patients had bad outcome, with elevated uric acid levels found 30 among them. In the present study, BMI and outcome of Stroke were significantly associated with Serum Uric acid levels.Conclusions: Serum uric acid levels can be used as a prognostic indicator as a marker for increased risk of stroke. Elevated serum urate concentration may stratify risk of death after acute stroke.

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The Relationship Between Elevated Serum Uric Acid and Risk of Stroke in Adult: An Updated and Dose–Response Meta-Analysis

Frontiers in Neurology ◽

10.3389/fneur.2021.674398 ◽

2021 ◽

Vol 12 ◽

Author(s):

Tianci Qiao ◽

Hongyun Wu ◽

Wei Peng

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Ischemic Stroke ◽

Dose Response ◽

Hemorrhagic Stroke ◽

Elevated Serum ◽

Significant Risk ◽

Significant Difference ◽

Subgroup Analyses ◽

The Relationship

Background: Uric acid (UA) is proposed as a potential risk factor for stroke in adult, yet the results from published studies are not generally accordant.Method: We included prospective studies that explored the relationship between serum UA (SUA) and strokes. In this study, strokes include ischemic stroke and hemorrhagic stroke, which consists of intracerebral hemorrhage and subarachnoid hemorrhage. The effect-size estimates were expressed as hazard ratio (HR) and 95% confidence interval (CI). Sensitivity and subgroup analyses were performed to assess the robustness of the pooled estimation and potential sources of heterogeneity between studies.Results: We meta-analyzed 19 prospective cohort articles, which involve 37,386 males and 31,163 females. Overall analyses results showed a significant association between a 1 mg/dl increase in high levels of SUA and the risk of total stroke (HR = 1.13; 95% CI: 1.09–1.18; P < 0.001), ischemic stroke (HR = 1.15; 95% CI: 1.10–1.21; P < 0.001), and hemorrhagic stroke (HR = 1.07; 95% CI: 1.00 to 1.15; P = 0.046). No significant difference was found between ischemic stroke and hemorrhagic stroke. In the subgroup analyses, the association of high SUA levels and the risk of total stroke was statistically significant in females (HR = 1.19; 95% CI: 1.12–1.26; P < 0.001) and males (HR = 1.11; 95% CI: 1.05–1.17; P < 0.001). Coincidentally, the association was also statistically significant for ischemic stroke, both in females (HR = 1.26; 95% CI: 1.17–1.36; P < 0.001) and in males (HR = 1.12; 95% CI: 1.06–1.19; P < 0.001). However, for hemorrhagic stroke, it was only statistically significant in females (HR = 1.19; 95% CI: 1.04–1.35; P = 0.01). Our dose–response research indicated the J-shaped trend between the ascending SUA levels and the higher risk of suffering from a stroke.Conclusions: Our findings indicate that elevated SUA is a significant risk factor for adult stroke, both for ischemic stroke and hemorrhagic stroke, and especially in females.

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A STUDY OF SERUM URIC ACID LEVELAND RISK FOR ACUTE ISCHEMIC NONEMBOLIC STROKE IN ELDERLY SUBJECTS

10.36106/ijsr/0833253 ◽

2020 ◽

pp. 1-3

Author(s):

Somnath Ghosh ◽

Apurba Bikash Pramanik ◽

Shampa Maity ◽

Pulakesh Sinha ◽

Debarshi Jana

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Ischemic Stroke ◽

Statistical Analysis ◽

Serum Uric Acid ◽

Independent Risk Factor ◽

Case Control ◽

Elderly Subjects ◽

Cross Sectional ◽

Medical College

The study is conducted to determine the association between serum uric acid (SUA) and acute non embolic ischemic stroke and to assess its risk factor potential using statistical analysis. The observational, cross-sectional, case control, retrospective was conducted in the N.R.S. Medical College and Hospital, Kolkata. Study was done from 1st February 2017 to 30th September 2018 i.e., through one and half year period. About 200 patients(100cases & 100 controls). It was also found that serum uric acid was also independent risk factor for causing acute ischemic non embolic stroke. It is also suggested that further studies are required to assess whether lowering of SUA level with drugs can actually reduce the risk of ischemic stroke.

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