scholarly journals The correlation of blood pressure changes and cardiac morpho- functional restructuring in young athletes

2020 ◽  
Vol 65 (2) ◽  
pp. 62-70
Author(s):  
L. A. Balykova ◽  
A. S. Glotov ◽  
S. A. Ivyansky ◽  
A. A Shirokova ◽  
O. M. Soldatov ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Genetic Testing ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Myocardial Hypertrophy ◽  
Left Ventricular ◽  
Young Athletes ◽  
Genetic Determination ◽  
Complex Coordination

A steady increase in the number of young sportsmen predetermines the relevance of studying the nature and severity of cardiovascular system remodeling in young athletes, including the development of arterial hypertension (AH) and left ventricular myocardial hypertrophy (LVHM).Objective. To study the prevalence and nature of arterial hypertension (AH) and its associations with signs of cardiovascular remodeling in young athletes taking into account pathogenetic relationship and genetic determination.Characteristics of children and methods. The study included 80 young athletes (including 42 boys, average age 14,5±1,54 years), divided into 4 groups depending on the kind of sports (1 – cyclic, 2 – game, 3 – complex coordination, 4 – power). We used the following research methods: “office” (i.e. during visit to the doctor) measurement of blood pressure, electrocardiography, echocardiography, color Doppler scanning of the neck vessels, daily monitoring of blood pressure, bicycle ergometry, genetic testing using the original panel with 448 markers.Results. An increase in blood pressure at rest was detected in 2,5% of children engaged in power sports, an insufficient decrease at night – in 16,3% of children, and an excessive reaction of blood pressure to dosed physical activity – in 25% of children. These changes correlated with signs of sports remodeling, in particular with the formation of left ventricular myocardial hypertrophy, which was diagnosed in 7–12,5% of athletes. According to the results of genetic testing, pronounced polymorphism in the NO synthase gene at three loci (rs10918594, rs12143842, rs16847548) was associated with a reorganization of the cardiovascular system in 45% of athletes.Conclusion. Violation of the circadian profile of blood pressure and excessive reaction to physical activity demonstrate 7,5–25% of young athletes, especially those involved in complex coordination and power sports. These changes were associated with the severity of sports remodeling and determined by a genetic predisposition.

scholarly journals Predictive factors of cardiovascular changes depending on the type and intensity of physical activity in professional athletes

2021 ◽  
Vol 26 (10) ◽  
pp. 4647
Author(s):  
N. P Garganeeva ◽  
I. F. Taminova ◽  
V. V. Kalyuzhin ◽  
E. V Kalyuzhina ◽  
I. N. Smirnova
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Heart Rate ◽  
Logistic Regression ◽  
Prognostic Factors ◽  
Predictive Models ◽  
Left Ventricular ◽  
Professional Athletes ◽  
Young Athletes ◽  
Cardiovascular Changes

Aim. To determine the early predictive factors of cardiovascular changes in professional athletes, depending on the type and intensity of physical activity.Material and methods. A total of 136 male athletes were examined. Of these, 116 were professional athletes (age, 22,07±4,1 years) as follows: freestyle wrestling, judo (n=30), cross-country skiing, biathlon (n=27), powerlifting (n=33), volleyball (n=26). Control group included 20 athletes (age, 17,95±1,5 years) with a history of training less than 3 years. All participants underwent electrocardiography (ECG), echocardiography, cycle ergometry (CE) with assessment of physical performance at a heart rate of 170 bpm (PWC170) and maximum oxygen consumption (MOC). When creating predictive models of early cardiovascular changes, we used logistic regression, stepwise regression and Wald statistics. Differences were considered significant at p<0,05.Results. Predictive models of logistic regression using ROC analysis showed high sensitivity and specificity, a high percentage of correct predictions using data from echocardiography — 86,8%, CE — 80,9%, ECG and other indicators — 83,1%. A stepwise algorithm was used to select prognostic factors determining early cardiovascular changes in young athletes, depending on the stage of sports training, the intensity and type of dynamic and/or static exercise: left ventricular posterior wall thickness (p=0,008), left ventricular mass (p=0,001), stroke volume (p=0,002), end-systolic volume (p=0,001), PWC170 (p=0,025), MOC (p=0,003), recovery time of heart rate (HR) (p=0,029) and blood pressure (p=0,032) after submaximal exercise on a cycle ergometer, body mass index (p=0,029), heart rate (p=0,034), office systolic blood pressure (p=0,009), intraventricular (bundle) block (p=0,046), left ventricular repolarization abnormalities (p=0,010), mild cardiac connective tissue anomalies (p=0,035).Conclusion. The early prognostic factors established by the logistic regression affect the characteristics and risk of cardiovascular changes in each group of young athletes. This demonstrates the need to develop individual medical support programs, further monitoring, evaluation, correction and prevention of identified disorders, taking into account the type of sports, intensity and exercise.

scholarly journals Comparative characteristics of patients with arterial hypertension and stenosing atherosclerosis, depending on the localization of the pathologicalprocess in the vascular bed

2020 ◽  
Vol 22 (1) ◽  
pp. 36-38
Author(s):  
E V Kryukov ◽  
N P Potekhin ◽  
A N Fursov ◽  
E G Zakharova
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Myocardial Hypertrophy ◽  
Systemic Blood Pressure ◽  
Left Ventricular ◽  
Renal Arteries ◽  
Atherogenic Dyslipidemia ◽  
Comparison Groups ◽  
Vascular Stenosis ◽  
Brachiocephalic Arteries

A comparative analysis of the clinical and functional state of patients suffering from arterial hypertension is given, depending on the localization of vascular stenosis of atherosclerotic origin. It is shown that stenosing atherosclerosis often affects men with hypertension. Lesions of the brachiocephalic arteries and renal arteries in patients suffering from arterial hypertension are detected at a younger age than with other localizations. Patients suffering from lesions of the coronary and brachiocephalic arteries are characterized by the presence of concentric left ventricular myocardial hypertrophy and hyperlipidemia. In patients suffering from damage to the renal arteries, leg arteries, and multivascular pathology, myocardial hypertrophy is eccentric, in addition, they have atherogenic dyslipidemia and significant signs of renal dysfunction. An excessive decrease in blood pressure at night is most often recorded in people suffering from coronary atherosclerosis, and its excessive increase in patients suffering from damage to the arteries of the legs. Arterial hypertension in patients with stenosing atherosclerosis in most cases is well-mediated, however, with stenosis of the renal arteries and with multivascular lesions, it is less likely to achieve a level of «normal» or «high normal» systolic blood pressure than with damage to other vascular pools. Significant differences in the levels of both systolic and diastolic blood pressure in all comparison groups indicate a different effect of local hemodynamic disturbances on systemic blood pressure.

scholarly journals Norepinephrine-associated left ventricular outflow tract obstruction and systolic anterior movement

2019 ◽  
Vol 12 (12) ◽  
pp. e225879 ◽  
Author(s):  
Warner Mbuila Mampuya ◽  
Jonathan Dumont ◽  
Francois Lamontagne
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Outflow Tract ◽  
Myocardial Hypertrophy ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Outflow Tract ◽  
Increase Blood Pressure ◽  
Ventricular Outflow Tract Obstruction ◽  
Left Ventricular Outflow ◽  
Systolic Anterior Movement

In the perioperative setting, norepinephrine is used to increase blood pressure, an effect mediated mostly via arterial and venous vasoconstriction. Thus, norepinephrine is, allegedly, less likely to cause or worsen left ventricular outflow tract obstruction (LVOTO) than other inotropes. We report a case of norepinephrine-associated dynamic LVOTO and systolic anterior movement in a predisposed patient. This report highlights that unrecognised dynamic LVOTO may worsen shock parameters in patients treated with norepinephrine who have underlying myocardial hypertrophy.

scholarly journals The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)

2020 ◽  
Vol 16 (2) ◽  
pp. 221-230
Author(s):  
A. I. Kochetkov ◽  
M. V. Lopukhina ◽  
E. A. Kotaeva ◽  
A. A. Kirichenko ◽  
O. D. Ostroumova
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Left Ventricular ◽  
Favorable Effect ◽  
Newly Diagnosed ◽  
Functional Changes ◽  
Collagen Formation ◽  
Cardiovascular Morbidity And Mortality ◽  
Single Pill ◽  
Left Atrial Stiffness

Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart.

Initial left-ventricular mass predicts probability of uncontrolled blood pressure in arterial hypertension

2011 ◽  
Vol 29 (4) ◽  
pp. 803-808 ◽  
Author(s):  
Raffaele Izzo ◽  
Giovanni de Simone ◽  
Richard B Devereux ◽  
Renata Giudice ◽  
Marina De Marco ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Uncontrolled Blood Pressure ◽  
Ventricular Mass

scholarly journals Cushing’s Disease: Assessment of Early Cardiovascular Hemodynamic Dysfunction With Impedance Cardiography

2021 ◽  
Vol 12 ◽  
Author(s):  
Agnieszka Jurek ◽  
Paweł Krzesiński ◽  
Grzegorz Gielerak ◽  
Przemysław Witek ◽  
Grzegorz Zieliński ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Cushing’S Disease ◽  
Impedance Cardiography ◽  
Left Ventricular ◽  
Cushing's Disease ◽  
Control Group ◽  
Stroke Index ◽  
Disease Group ◽  
Hemodynamic Assessment

BackgroundCushing’s disease is a rare condition associated with a high cardiovascular risk and hypercortisolemia-related hemodynamic dysfunction, the extent of which can be assessed with a noninvasive method, called impedance cardiography. The standard methods for hemodynamic assessment, such as echocardiography or ambulatory blood pressure monitoring may be insufficient to fully evaluate patients with Cushing’s disease; therefore, impedance cardiography is being currently considered a new modality for assessing early hemodynamic dysfunction in this patient population. The use of impedance cardiography for diagnosis and treatment of Cushing’s disease may serve as personalized noninvasive hemodynamic status assessment and provide a better insight into the pathophysiology of Cushing’s disease. The purpose of this study was to assess the hemodynamic profile of Cushing’s disease patients and compare it with that in the control group.Material and MethodsThis observational prospective clinical study aimed to compare 54 patients with Cushing’s disease (mean age 41 years; with 64.8% of this population affected with arterial hypertension) and a matched 54-person control group (mean age 45 years; with 74.1% of this population affected with arterial hypertension). The hemodynamic parameters assessed with impedance cardiography included the stroke index (SI), cardiac index (CI), systemic vascular resistance index (SVRI), velocity index (VI), (ACI), Heather index (HI), and thoracic fluid content (TFC).ResultsThe Cushing’s disease group was characterized by a higher diastolic blood pressure and a younger age than the control group (82.9 vs. 79.1 mmHg, p=0.045; and 41.1 vs. 44.9 years, p=0.035, respectively). Impedance cardiography parameters in the Cushing’s disease group showed: lower values of SI (42.1 vs. 52.8 ml/m2; p ≤ 0.0001), CI (2.99 vs. 3.64 l/min/m2; p ≤ 0,0001), VI (42.9 vs. 52.1 1/1000/s; p=0.001), ACI (68.7 vs. 80.5 1/100/s2; p=0,037), HI (13.1 vs. 15.2 Ohm/s2; p=0.033), and TFC (25.5 vs. 27.7 1/kOhm; p=0.006) and a higher SVRI (2,515 vs. 1,893 dyn*s*cm-5*m2; p ≤ 0.0001) than those in the control group.ConclusionsCushing’s disease is associated with significantly greater vasoconstriction and left ventricular systolic dysfunction. An individual assessment with impedance cardiography may be useful in Cushing’s disease patients in order to identify subclinical cardiovascular complications of chronic hypercortisolemia as potential therapeutic targets.

scholarly journals No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy

2006 ◽  
Vol 111 (6) ◽  
pp. 365-372 ◽  
Author(s):  
Wolfgang Lieb ◽  
Juliane Bolbrinker ◽  
Angela Döring ◽  
Hans-Werner Hense ◽  
Jeanette Erdmann ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Left Ventricular Mass ◽  
Posterior Wall ◽  
Pressure Control ◽  
Population Based ◽  
Left Ventricular ◽  
Genotype Distribution ◽  
Cytochrome P450 3A ◽  
Ventricular Mass

A polymorphism in the cytochrome P450 3A CYP3A5 enzyme has been implicated in BP (blood pressure) control and arterial hypertension. Carriers of the CYP3A5*1 allele had high, whereas homozygous carriers of the CYP3A5*3 allele exhibit low, CYP3A5 expression in the kidney, where CYP3A5 represents the major CYP3A enzyme. The aim of the present study was to investigate the association of the CYP3A5*1 allele with BP, arterial hypertension, LVM [(left ventricular) mass] and LV geometry in a large Caucasian-population-based cohort. We compared BP, LVM and the prevalence of hypertension between carriers (CYP3A5*1/*1 and CYP3A5*1/*3 genotypes) and non-carriers (CYP3A5*3/*3 genotype) of the CYP3A5*1 allele in the echocardiographic substudy of the third MONICA (MONItoring trends and determinants in CArdiovascular disease) Augsburg survey. After exclusion of 269 individuals who were taking antihypertensive medication, 530 women and 554 men were available for analysis, revealing allele frequencies of 5.8 and 94.2% for the CYP3A5*1 and CYP3A5*3 alleles respectively. Overall, the presence of the CYP3A5*1 allele exhibited no effect on systolic or diastolic BP in either gender. One-third of the individuals in this cohort were hypertensive (BP ≥140/90 mmHg), and the genotype distribution between normotensive and hypertensive individuals revealed no association between CYP3A5*1 and hypertension after adjustment for age, BMI and gender (odds ratio, 1.02; P=0.92). Moreover, no effect of CYP3A5*1 on LVM, thickness of the septal and posterior wall and LV end-diastolic diameter was found. We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy.

CHRONIC KIDNEY DISEASE AND THE STATE OF THE CARDIOVASCULAR SYSTEM IN LOCOMOTIVE CREW WORKERS

2021 ◽  
Author(s):  
V.A. Zhmurov ◽  
◽  
D.V. Zhmurov ◽  
V.G. Yarkova
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiovascular System ◽  
Cardiovascular Events ◽  
Ventricular Remodeling ◽  
Myocardial Hypertrophy ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Professional Activities ◽  
Ckd Stage

Abstract: 967 employees of locomotive crews (drivers and their assistants of the Sverdlovsk railway of JSC «Russian Railways») were examined. It was revealed that CKD occurs in 12, 09% of employees of locomotive crews. As the CKD stage increases, the progression of changes in the cardiovascular system was found in locomotive crew workers. A high percentage of the prognostically unfavorable variant of left ventricular remodeling - eccentric myocardial hypertrophy (25% - 39.1%, depending on the stage of CKD) was found. These changes may be a factor of adverse cardiovascular events in employees of locomotive crews, which must be taken into account when admitting to professional activities.

Study of some parameters of electrocardiography of skiers-riders

2021 ◽  
pp. 68-75
Author(s):  
Sergey V. Saykin ◽  
Valery N. Yakovlev
Keyword(s):  
Physical Activity ◽  
Cardiovascular System ◽  
Motor Skills ◽  
The Body ◽  
Young Athletes ◽  
Functional Diagnosis ◽  
Electrocardiographic Examination ◽  
One Year ◽  
The One ◽  
Very High

Very high results, the achievement of which is possible only with long systematic train-ing with the use of large and sometimes excessive physical activity characterizes modern sports. The preparation process from beginner to master of sports takes an average of 5–10 years. During this time, the athlete must develop and improve special physical and mental qualities, as well as master certain motor skills specific to this sport. Therefore, children's and youth's organisms of athletes are subject to increased loads, especially in classes that develop endurance. But not always physical activity contributes to the strengthening of the body, sometimes excessive loads, especially with the wrong approach, lead to complications from the cardiovascular system, in particular, to changes in heart rate. Therefore, the issue of adapting the functions of the heart of young athletes to muscle loads becomes increasingly important. The purpose of the work was to study the activities of the cardiovascular system of skiers-riders in the preparatory period of the one-year cycle. Currently, various methods of functional diagnosis of the cardiovascular system are used. We considered the results obtained during electrocardiographic examination of skiers-riders. We investigated electrical activity of the heart and presented model characteristics according to the considered indicators.

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