scholarly journals Comprehensive assessment of patients with chronic obstructive pulmonary disease by means of multicomponent ADO index and Charlson comorbidity index

2018 ◽  
pp. 182-184 ◽  
Author(s):  
E. Kochetova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Correlation Coefficient ◽  
Charlson Comorbidity Index ◽  
Comprehensive Assessment ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Comorbidity Index

The purpose of this study was to investigate the ADO index, and index of comorbidity of Charlson in patients with chronic obstructive pulmonary disease (COPD). Materials and methods: 207 patients with chronic obstructive pulmonary disease (COPD) were observed. The investigated group was made by the patients having the long experience of smoking. Research of function of external breath was studied with multimodular installation of type «Master-Lab/Jaeger». Patients were determined the index ADO and of comorbidity of Charlson. Results: The index ADO increased with stage of COPD, minimum of level ADO was observed in patients with COPD 2 stage 2,23 ± 0,88, in patients with 3 stage COPD ADO was 5,05 ± 1,19, 4 stages of COPD 7,0 ± 1,0. The correlation coefficient between ADO index and and index of comorbidity Charlson was -0,71, p <0,005. The correlation coefficient between ADO and VC was -0,57, p <0,05, between ADO and ERV was -0,63, p <0,05. 

scholarly journals Investigation Regarding the Correlation between Particulate Matter 2.5 Air Pollution and Mortality Rates due to Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 6 (1) ◽  
pp. 53-59
Author(s):  
Ekta Dhanoa
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Air Pollution ◽  
Particulate Matter ◽  
Pulmonary Disease ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Chronic Obstructive ◽  
Pearson Correlation Coefficient ◽  
Obstructive Pulmonary Disease ◽  
The Relationship

In 2015, 3.2 million people died due to Chronic Obstructive Pulmonary Disease (COPD), worldwide. In fact, survival rates for those living with severe COPD are lower than for those with cancer. The one known contributor to this disease is air pollution, and with its rising levels every year, it is necessary to determine the exact correlation between air pollution and COPD. Data was gathered for a selection of 20 countries from the World Bank Database and Health Data Database. This data was graphed and analyzed using the Pearson correlation coefficient, which is a statistical test that measures the relationship between 2 variables. When calculated, the Pearson correlation coefficient was 0.756, determining that there is a significant relationship between air pollution and COPD. Through the investigation, it is concluded that there is a positive correlation between PM2.5 air pollution and mortality rate due to COPD. PM2.5 is a component of air pollution defined as the amount of atmospheric particulate matter with a diameter less than 2.5 micrometers. Due to its small physical nature, PM2.5 can easily infiltrate the lungs, causing infections in the respiratory organs. They can reach the bronchi and even the alveoli, causing inflammation which ultimately results in COPD and premature deaths. Therefore, this research will aim to investigate the relationship between PM2.5 air pollution and COPD, allowing for a better understanding of these variables.

scholarly journals Age and Multimorbidity Predict Death Among COVID-19 Patients

Hypertension ◽  
2020 ◽  
Vol 76 (2) ◽  
pp. 366-372 ◽  
Author(s):  
Guido Iaccarino ◽  
Guido Grassi ◽  
Claudio Borghi ◽  
Claudio Ferri ◽  
Massimo Salvetti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Charlson Comorbidity Index ◽  
Renin Angiotensin System ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Angiotensin System ◽  
Comorbidity Index

Several factors have been proposed to explain the high death rate of the coronavirus disease 2019 (COVID-19) outbreak, including hypertension and hypertension-related treatment with Renin Angiotensin System inhibitors. Also, age and multimorbidity might be confounders. No sufficient data are available to demonstrate their independent role. We designed a cross-sectional, observational, multicenter, nationwide survey in Italy to verify whether renin-angiotensin system inhibitors are related to COVID-19 severe outcomes. We analyzed information from Italian patients diagnosed with COVID-19, admitted in 26 hospitals. One thousand five hundred ninety-one charts (male, 64.1%; 66±0.4 years) were recorded. At least 1 preexisting condition was observed in 73.4% of patients, with hypertension being the most represented (54.9%). One hundred eighty-eight deaths were recorded (11.8%; mean age, 79.6±0.9 years). In nonsurvivors, older age, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, chronic kidney disease, coronary artery diseases, and heart failure were more represented than in survivors. The Charlson Comorbidity Index was significantly higher in nonsurvivors compared with survivors (4.3±0.15 versus 2.6±0.05; P <0.001). ACE (angiotensin-converting enzyme) inhibitors, diuretics, and β-blockers were more frequently used in nonsurvivors than in survivors. After correction by multivariate analysis, only age ( P =0.0001), diabetes mellitus ( P =0.004), chronic obstructive pulmonary disease ( P =0.011), and chronic kidney disease ( P =0.004) but not hypertension predicted mortality. Charlson Comorbidity Index, which cumulates age and comorbidities, predicts mortality with an exponential increase in the odds ratio by each point of score. In the COVID-19 outbreak, mortality is predicted by age and the presence of comorbidities. Our data do not support a significant interference of hypertension and antihypertensive therapy on COVID-19 lethality. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04331574.

scholarly journals Comorbidity and thirty-day hospital readmission odds in chronic obstructive pulmonary disease: a comparison of the Charlson and Elixhauser comorbidity indices

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Russell G. Buhr ◽  
Nicholas J. Jackson ◽  
Gerald F. Kominski ◽  
Steven M. Dubinett ◽  
Michael K. Ong ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Standard Deviation ◽  
Pulmonary Disease ◽  
Model Fit ◽  
Sensitivity Analyses ◽  
Chronic Obstructive ◽  
Model Parameters ◽  
Standard Deviation Increase ◽  
Obstructive Pulmonary Disease ◽  
Comorbidity Index

Abstract Background Readmissions following exacerbations of chronic obstructive pulmonary disease (COPD) are prevalent and costly. Multimorbidity is common in COPD and understanding how comorbidity influences readmission risk will enable health systems to manage these complex patients. Objectives We compared two commonly used comorbidity indices published by Charlson and Elixhauser regarding their ability to estimate readmission odds in COPD and determine which one provided a superior model. Methods We analyzed discharge records for COPD from the Nationwide Readmissions Database spanning 2010 to 2016. Inclusion and readmission criteria from the Hospital Readmissions Reduction Program were utilized. Elixhauser and Charlson Comorbidity Index scores were calculated from published methodology. A mixed-effects logistic regression model with random intercepts for hospital clusters was fit for each comorbidity index, including year, patient-level, and hospital-level covariates to estimate odds of thirty-day readmissions. Sensitivity analyses included testing age inclusion thresholds and model stability across time. Results In analysis of 1.6 million COPD discharges, readmission odds increased by 9% for each half standard deviation increase of Charlson Index scores and 13% per half standard deviation increase of Elixhauser Index scores. Model fit was slightly better for the Elixhauser Index using information criteria. Model parameters were stable in our sensitivity analyses. Conclusions Both comorbidity indices provide meaningful information in prediction readmission odds in COPD with slightly better model fit in the Elixhauser model. Incorporation of comorbidity information into risk prediction models and hospital discharge planning may be informative to mitigate readmissions.

scholarly journals Cardiovascular comorbid conditions and risk of stroke and systemic thromboembolism in chronic obstructive pulmonary disease.

2018 ◽  
Vol 96 (5) ◽  
pp. 443-446
Author(s):  
E. V. Kochetova
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Comorbid Conditions ◽  
Obstructive Pulmonary Disease ◽  
Cardiovascular Comorbidity ◽  
Copd Patients ◽  
History Of ◽  
Comorbidity Index

The aim of this study was to study the cardiovascular comorbidity in patients with chronic obstructive pulmonary disease (COPD), as well as the assessment of the risk of stroke and systemic thromboembolism on the scale CHA2DS2-VASc in patients with COPD with atrial fibrillation. Material and methods. 224 patients with COPD were examined, who had a long history of smoking (smoker's index 240 and smoking experience 40 packs/years). Research of function of external breath was studied with multimodular installation of type «Master-Lab/Jaeger». The Charlson index was used in the evaluation of comorbidity. An analysis of the risk of thromboembolic complications in patients with COPD with atrial fibrillation was performed on a scale of CHA2DS2-VASc. Results: Atrial fibrillation was noted in 10.7% ofpatients with COPD. The risk of stroke and system thromboembolism on the scale CHA2DS2-Е4Рс in COPD patients with atrial fibrillation was 3.27 ± 1.55 points in patients with COPD 2 st, and 3.0 ± 1.04 in patients with COPD 3 st. The correlation coefficient between the risk of stroke and system thromboembolism on the scale CHA2DS2-Е4Рс and the Charlson comorbidity index was 0.89, p <0,005.

scholarly journals A study of C reactive proteins in patients with stable chronic obstructive pulmonary disease

2019 ◽  
Vol 6 (2) ◽  
pp. 227
Author(s):  
Ashok Kumar Gudagunti ◽  
Sudhir Chaudhri
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Correlation Coefficient ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Baseline Serum ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serum Crp

Background: Whenever there is damage to the tissue or inflammatory process, the hepatocytes synthesize a protein which is an acute phase reactant, and this is the C reactive protein. Studies have shown that serum C reactive protein levels are usually elevated during acute exacerbations of COPD. The objective of this study was studying the baseline serum C reactive protein levels in patients with stable chronic obstructive pulmonary disease.Methods: During the study period, 90 subjects were studied. Out of them, 47 had stable COPD and 43 were without COPD. The subjects were either admitted in indoor wards or were attending OPD of department of tuberculosis and respiratory diseases, Dr. Murari Lal Chest Hospital, G.S.V.M Medical College, Kanpur, Uttar Pradesh, and were recruited if they fulfilled the criteria for inclusion. Informed consent was taken from all study subjects and the study protocol was approved by the board of faculty of medicine.Results: Of the 47 patients in the stable COPD group, 23 were found to be active smokers. Pearson’s correlation coefficient showed that lower limit of serum CRP levels were significantly negatively correlating with 6 MWD (r= -0.707; p=0.0001), FEV1% (r=-0.635; p=0.0001), PaO2 (r=-0.592; p=0.0001), and BMI (r= -0.534; p=0.0001). Pearson’s correlation coefficient showed that upper limit of serum CRP levels were significantly negatively correlating with 6 MWD (r= -0.707; p=0.0001), FEV1% (r= -0.633; p=0.0001), PaO2 (r= -0.61; p=0.001) and BMI (r= -0.520; p=0.0001).Conclusions: The circulating levels of inflammatory marker, baseline serum CRP are significantly elevated in patients with stable chronic obstructive pulmonary disease.

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