scholarly journals The role of Staphylococcus aureus in the course of polyposis sinusitis

2021 ◽  
pp. 44-48
Author(s):  
A. B. Turovski ◽  
G. P. Bondareva ◽  
K. M. Musaev
Keyword(s):  
Specific Ige ◽  
Staphylococcal Infection ◽  
Skin Tests ◽  
Topical Steroids ◽  
Nasal Colonization ◽  
Bacteriological Examination ◽  
Initial Visit ◽  
Eosinophilic Inflammation ◽  
Cytological Examination

Introduction. Today, there are lot of theories of pathogenesis of polypoid sinusitis. The contribution of Starchylocossus aureus (S. aureus) to the occurrence of this pathogenetic reaction is being actively discussed.Objective: to improve the effectiveness of treatment of polypoid sinusitis using the results of the study of the effect of persistent staphylococcal infection on the onset and course of the disease.Materials and methods. The authors examined 105 patients with recurrent polyposis sinusitis aged 20 to 65 years. All patients underwent FESS surgery for recurrent polypous sinusitis at the initial visit. In the postoperative period, all patients received treatment according to one of two schemes. The first scheme included antihistamines and topical steroids, the second additionally included clarithromycin. The patients underwent bacteriological examination of smears for flora and fungi from the cavity; cytological examination of smears-prints from the mucous membrane of the nasal cavity (we counted neutrophils, eosinophils and lymphocytes in the preparation); immunological and allergic examination (skin tests, serum specific IgE levels).Results and discussion. It has been established that the presence of a carriage and sensitization to S. aureus in a patient, especially in combination with atopy, results in a more severe course of polyposis sinusitis severe nasal obstruction (91% versus 69.5%, respectively) and is characterized by more pronounced eosinophilic inflammation than Polypoid Sinusitis associated with infection with other microorganisms (the number of eosinophils in the blood: 7.5% and 4.3%, respectively; the level of eosinophils in smears from the nasal mucosa is 13 and 4.8%, respectively; the average ECP level is 17.6 and 8.1 ug / ml, respectively).Conclusions. The use of topical GCS remains one of the leading methods for preventing recurrence of PS. However, in addition to the backbone therapy with topical GCS and antihistamines, it is advisable to complete a course of antibiotics during nasal colonization with S. aureus.

scholarly journals Peculiarities of non-allergic rhinitis with eosinophilia syndrome

2015 ◽  
Vol 12 (4) ◽  
pp. 3-7
Author(s):  
V A Utesheva ◽  
G P Bondareva ◽  
A I Kryukov ◽  
T G Barkhina
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Specific Ige ◽  
Skin Tests ◽  
Eosinophilic Infiltration ◽  
Eosinophilic Inflammation ◽  
Nonallergic Rhinitis ◽  
Provocation Tests ◽  
Nasal Provocation ◽  
Non Allergic Rhinitis

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a syndrome containing the symptoms similar to allergic rhinitis, with absence of atopy and the presence of eosinophila more than 20% in smears from nasal mucosa. Pathophysiology of NARES has not been studied completely, but permanent eosinophilic inflammation is the keystone of NARES pathogenesis. This disease is marked by local eosinophilic infiltration without atopy, confirmed by negative skin tests, normal levels of total and specific IgE in serum, negative nasal provocation tests with allergens. Nowadays this nosology is considered to be poorly understood.

scholarly journals Invited review: The role of allergen‐specific IgE, IgG and IgA in allergic disease

Allergy ◽  
2021 ◽  
Author(s):  
Mohamed H. Shamji ◽  
Rudolf Valenta ◽  
Theodore Jardetzky ◽  
Valerie Verhasselt ◽  
Stephen R. Durham ◽  
...  
Keyword(s):  
Allergic Disease ◽  
Specific Ige

Anaphylaxis to the 23-valent pneumococcal vaccine in child: a case-control study based on immediate responses in skin tests and specific IgE determination

Vaccine ◽  
2001 ◽  
Vol 19 (32) ◽  
pp. 4588-4591 ◽  
Author(s):  
Claude Ponvert ◽  
Delia Ardelean-Jaby ◽  
Anne-Marie Colin-Gorski ◽  
Bruno Soufflet ◽  
Christine Hamberger ◽  
...  
Keyword(s):  
Pneumococcal Vaccine ◽  
Case Control Study ◽  
Specific Ige ◽  
Case Control ◽  
Skin Tests ◽  
Ige Determination ◽  
Control Study

The role of TNF-α in eosinophilic inflammation associated with RSV bronchiolitis

2010 ◽  
Vol 21 (3) ◽  
pp. 474-479 ◽  
Author(s):  
Jungi Choi ◽  
Zak Callaway ◽  
Hyo-Bin Kim ◽  
Takao Fujisawa ◽  
Chang-Keun Kim
Keyword(s):  
Eosinophilic Inflammation ◽  
Tnf Α

scholarly journals Component resolved diagnosis of egg yolk is an indispensable part of egg allergy

2021 ◽  
Vol 49 (2) ◽  
pp. 6-14
Author(s):  
Huang Lunhui ◽  
Shao Yanhong ◽  
Li Shaoshen ◽  
Bao Huijing ◽  
Liu Yunde ◽  
...  
Keyword(s):  
Operating Characteristic ◽  
Egg Yolk ◽  
Specific Ige ◽  
Diagnostic Value ◽  
Egg White ◽  
Enzyme Linked Immunosorbent Assay ◽  
Egg Allergy ◽  
Component Resolved Diagnosis ◽  
Allergen Components

Introduction and objectives: It was urgent to explain the role of egg yolk allergen sensitization to the egg allergic population and we would evaluate the diagnostic value of allergen components in whole eggs, including egg white and egg yolk.Materials and methods: Firstly, we collected 99 positive and 21 negative sera against egg allergy. Then we used modified enzyme linked immunosorbent assay (ELISA) to survey specific IgE (sIgE) to all-proven and single component in eggs, Ovomucoid (Gal d 1), Ovalbumin (Gal d 2), Ovotransferrin (Gal d 3), Lysozyme C (Gal d 4), Serum Albumin (Gal d 5), and YGP42(Gal d 6) in allergic and non-allergic populations. Last but not least, we studied the sIgE reactivities to egg allergen components by receiver operating characteristic (ROC) analysis.Results: Among egg-allergic individuals, nearly 10% were sensitized to five of six egg allergen components, and the cross-reaction frequency between two egg yolk allergens with Gal d 1 was about 30% in the groups diagnosed with egg allergy or non-allergy. The best component-combination diagnosis in egg allergy of Gal d 1+ Gal d 6 demonstrated the largest area under curve (AUC) of 0.994.Conclusions: Our results suggested that there were individual differences in allergenicity of different egg allergen components, especially in the samples negative to egg allergy diagnosed but sensitive to egg yolk components. It was indicated that component resolved diagnosis of egg yolk improved the value for egg allergy management indispensably.

scholarly journals Study of episootic sıtuation at poultry farms for colibacteriosis and salmonellosis in Azerbaijan

2021 ◽  
Vol 23 (103) ◽  
pp. 56-59
Author(s):  
S. B. Abbasov
Keyword(s):  
Research Work ◽  
Winter Season ◽  
Winter Period ◽  
Bacteriological Examination ◽  
Spring Season ◽  
Autumn Period ◽  
E Coli ◽  
Poultry Farms ◽  
The Republic

The article refers to the research work carried out in recent years at the poultry farms of the Khachmaz region of the Republic of Azerbaijan, the influence of opportunistic microbes on the activities of the farm. The role of opportunistic microbes in the occurrence of certain diseases with deficiencies in the process of feeding and raising of birds, and the microclimate in poultry farms is shown. During the bacteriological examination of breeding eggs by seasons there were revealed the presence of infection in the winter season with E. coli, Salmonella, Staphylococcus and Streptococcus – with each infection separately 13.0 %, in the spring season with E. coli, Salmonella, Staphylococcus – with each infection separately 20.0 %, in the autumn period with E. coli 27.0%, Salmonella 40.0 %, Staphylococcus 13.0 % and Streptococcus 13.0 %. In the course of bacteriological examination of dead embryos, the presence of infection in the winter period with E. coli 20.0 %, salmonella 30.0 %, staphylococcus 25.0 % and streptococcus 25.0 %, in the spring  season with E. coli 30.0 %, salmonella 40.0 %, staphylococcus 15.0 % and streptococcus 15.0 %, in the autumn season with E. coli 45.0 %, salmonella 55.0 % was revealed. In the autumn period, infection with staphylococci and streptococci was not detected. When studying as a whole, pseudomoniasis and mold fungi were not found.

scholarly journals Mast cells are associated with exacerbations and eosinophilia in children with severe asthma

2016 ◽  
Vol 48 (5) ◽  
pp. 1320-1328 ◽  
Author(s):  
Guillaume Lezmi ◽  
Louise Galmiche-Rolland ◽  
Sabine Rioux ◽  
Francis Jaubert ◽  
Isabelle Tillie-Leblond ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Mast Cells ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Eosinophilic Inflammation ◽  
Symptomatic Group ◽  
Mucosal Mast Cells ◽  
Bronchial Biopsies ◽  
Positive Correlations

The role of mast cells in the pathogenesis of childhood asthma is poorly understood. We aimed to estimate the implication of airway mucosal mast cells in severe asthma and their relationship with clinical, functional, inflammatory and remodelling parameters.Bronchial biopsies were performed in 36 children (5–18 years) with severe asthma: 24 had frequent severe exacerbations and/or daily symptoms in the previous year (symptomatic group), and 12 had few symptoms and a persistent obstructive pattern (paucisymptomatic group). Nine children without asthma were included as control subjects. We assessed mast cells in the submucosa and airway smooth muscle using c-kit antibodies and in the entire biopsy area using Giemsa.The number of submucosal mast cells was higher in the symptomatic group than in the paucisymptomatic group (p=0.02). The number of submucosal mast cells correlated with the number of severe exacerbations (p=0.02, r=0.37). There were positive correlations between the number of submucosal mast cells (p<0.01, r=0.44), airway smooth muscle mast cells (p=0.02, r= 0.40), mast cells stained by Giemsa (p<0.01, r=0.44) and submucosal eosinophils.Mast cells are associated with severe exacerbations and submucosal eosinophilic inflammation in children with severe asthma.

scholarly journals Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice

2018 ◽  
Vol 10 (2) ◽  
pp. 106-118 ◽  
Author(s):  
Yoko Ito ◽  
Niccolette Schaefer ◽  
Amelia Sanchez ◽  
David Francisco ◽  
Rafeul Alam ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Negative Regulator ◽  
Airflow Limitation ◽  
Eosinophilic Inflammation ◽  
Interacting Protein ◽  
Proinflammatory Responses ◽  
Cytokine Milieu ◽  
Underlying Mechanisms

Toll-interacting protein (Tollip) is a key negative regulator of innate immunity by preventing excessive proinflammatory responses. Tollip genetic variation has been associated with airflow limitation in asthma subjects and Tollip expression. Whether Tollip regulates lung inflammation in a type 2 cytokine milieu (e.g., IL-13) is unclear. Our goal was to determine the in vivo role of Tollip in IL-13-mediated lung eosinophilic inflammation and the underlying mechanisms. Tollip-knockout (KO) and wild-type (WT) mice were inoculated intranasally with recombinant mouse IL-13 protein to examine lung inflammation. To determine how Tollip regulates inflammation, alveolar macrophages and bone marrow-derived macrophages from Tollip KO and WT mice were cultured with or without IL-13 and/or IL-33. IL-13-treated Tollip KO mice significantly increased lung eosinophilic inflammation and eotaxin-2 (CCL24) levels compared with the WT mice. IL-13- treated Tollip KO (vs. WT) macrophages, in the absence and particularly in the presence of IL-33, increased expression of the IL-33 receptor ST2L and CCL24, which was in part dependent on enhanced activation of interleukin (IL)-1 receptor-associated kinase 1 (IRAK1) and signal transducer and activator of transcription 6 (STAT6). Our results suggest that Tollip downregulates IL-13-mediated pulmonary eosinophilia in part through inhibiting the activity of the ST2L/IL-33/IRAK1 axis and STAT6.

The role of molecular biology in the diff erential diagnosis of pancreatic cystic neoplasias

2021 ◽  
Vol 75 (5) ◽  
pp. 417-423
Author(s):  
Ivo Horný ◽  
Tomáš Hucl
Keyword(s):  
Precancerous Lesions ◽  
Clinical Status ◽  
Pancreatic Disease ◽  
Pancreatic Cysts ◽  
Cytological Examination ◽  
Asymptomatic Patients ◽  
Wide Range ◽  
Risk Of Malignancy ◽  
History Of

Summary: Pancreatic cysts have been detected ever more frequently in recent years due to the advanced and wider use of imaging methods. We find them on CT or MR also in asymptomatic patients who do not have a history of any pancreatic disease. Pancreatic cystic lesions represent a wide range of pathological changes from simple cysts through precancerous lesions to malignant cysts. Accurate dia­gnosis remains difficult despite the combination of clinical status evaluation, imaging findings, and bio­chemical and cytological examination. Molecular bio­logical examination of cyst aspirate obtained by endosonographic examination increases the detection rate of mucinous cysts (KRAS/GNAS/VHL) and cysts with a high risk of malignancy (KRAS/GNAS/p53/PIK3CA/PTEN/CDKN2A/SMAD4) and optimizes therapeutic approach. Larger prospective validation studies are necessary to make this costly and limited method a routine part of clinical practice. Key words: molecular bio­logy – neoplasia – pancreatic cysts

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