scholarly journals Features of the phenotypic and genotypic lipid status of the indigenous ethnic group of the Arctic in the conditions of island living

2020 ◽  
pp. 44-55
Author(s):  
N. A. Vorobyeva ◽  
N. I. Belova ◽  
A. I. Vorobyeva
Keyword(s):  
Ethnic Group ◽  
Metabolic Diseases ◽  
Arctic Region ◽  
The Arctic ◽  
Genetic Profile ◽  
Cross Sectional ◽  
Genetic Characteristics ◽  
Lipid Status ◽  
Indigenous Ethnic Group ◽  
Reported Study

Introduction. Dyslipidemia and obesity are interdisciplinary and “multi-metabolic” diseases, pathogenetically associated with the development of atherothrombosis, which creates practical health problems. The development of both dyslipidemia and obesity is influenced by socio-demographic, environmental, genetic and many physiological and behavioral factors, while the contribution of genetic factors is 40-70%. The goal is to identify the genetic characteristics oflipid status and fat metabolism in the indigenous ethnic group of the Arctic region of the Russian Federation under conditions of permanent islandliving.Methods. A cross-sectional population study of an indigenous ethnic group (n = 44) living on Vaygach Island (70 ° 01 ' Nlat 59 ° 33 ' E). The reported study was funded by RFBR according to the research project №18-00-00814-(18-00-00478). Serum cholesterol and triglycerides were determined as markers oflipid metabolism in blood serum. To analyze the genetic profile, the polymorphism of the FTO A23525T gene and the LPL Ser447Ter gene was determined by polymerase chain reaction.Results. In the sample of the indigenous ethnic group, BMI was 26.0 [21.5; 29.75] kg/m2. BMI for men is 23.0 [18.0; 28.0] kg/m2, for women - 25.0 [18.0; 29.25] kg / m2. Carriers of the unfavorable allele A had a higher BMI than carriers of the T allele. Analysis of the effect of rs9939609 genetic polymorphism on thelevel of total cholesterol did not show statistically significant differences between the FTO gene genotypes. A minimal triglyceride concentration was observed in carriers of the protective genotype Ter/Ter.Conclusion. Understanding the similarities and differences in genetic susceptibility among different ethnic groups can ultimately contribute to a more focused primary prevention and patient-oriented approach of cardiovascular pathology. 

STORM ICE OIL WIND WAVE WATCH SYSTEM (SIOWS): WEB GIS APPLICATION FOR MONITORING THE ARCTIC

2017 ◽  
Author(s):  
Alexander Myasoedov ◽  
Alexander Myasoedov ◽  
Sergey Azarov ◽  
Sergey Azarov ◽  
Ekaterina Balashova ◽  
...  
Keyword(s):  
Satellite Data ◽  
Wind Wave ◽  
Arctic Region ◽  
Web Gis ◽  
The Arctic ◽  
Flexible Tool ◽  
In Situ Data ◽  
Current State ◽  
Watch System

Working with satellite data, has long been an issue for users which has often prevented from a wider use of these data because of Volume, Access, Format and Data Combination. The purpose of the Storm Ice Oil Wind Wave Watch System (SIOWS) developed at Satellite Oceanography Laboratory (SOLab) is to solve the main issues encountered with satellite data and to provide users with a fast and flexible tool to select and extract data within massive archives that match exactly its needs or interest improving the efficiency of the monitoring system of geophysical conditions in the Arctic. SIOWS - is a Web GIS, designed to display various satellite, model and in situ data, it uses developed at SOLab storing, processing and visualization technologies for operational and archived data. It allows synergistic analysis of both historical data and monitoring of the current state and dynamics of the "ocean-atmosphere-cryosphere" system in the Arctic region, as well as Arctic system forecasting based on thermodynamic models with satellite data assimilation.

Prévoir les variations saisonnières de la glace de mer arctique et leurs impacts sur le climat

2020 ◽  
pp. 024
Author(s):  
Rym Msadek ◽  
Gilles Garric ◽  
Sara Fleury ◽  
Florent Garnier ◽  
Lauriane Batté ◽  
...  
Keyword(s):  
Sea Ice ◽  
Arctic Region ◽  
Arctic Sea Ice ◽  
Climate Impacts ◽  
The Arctic ◽  
Recent Effort ◽  
Sea Ice Thickness ◽  
Arctic Sea ◽  
Ice Conditions ◽  
Upper Level

L'Arctique est la région du globe qui s'est réchauffée le plus vite au cours des trente dernières années, avec une augmentation de la température de surface environ deux fois plus rapide que pour la moyenne globale. Le déclin de la banquise arctique observé depuis le début de l'ère satellitaire et attribué principalement à l'augmentation de la concentration des gaz à effet de serre aurait joué un rôle important dans cette amplification des températures au pôle. Cette fonte importante des glaces arctiques, qui devrait s'accélérer dans les décennies à venir, pourrait modifier les vents en haute altitude et potentiellement avoir un impact sur le climat des moyennes latitudes. L'étendue de la banquise arctique varie considérablement d'une saison à l'autre, d'une année à l'autre, d'une décennie à l'autre. Améliorer notre capacité à prévoir ces variations nécessite de comprendre, observer et modéliser les interactions entre la banquise et les autres composantes du système Terre, telles que l'océan, l'atmosphère ou la biosphère, à différentes échelles de temps. La réalisation de prévisions saisonnières de la banquise arctique est très récente comparée aux prévisions du temps ou aux prévisions saisonnières de paramètres météorologiques (température, précipitation). Les résultats ayant émergé au cours des dix dernières années mettent en évidence l'importance des observations de l'épaisseur de la glace de mer pour prévoir l'évolution de la banquise estivale plusieurs mois à l'avance. Surface temperatures over the Arctic region have been increasing twice as fast as global mean temperatures, a phenomenon known as arctic amplification. One main contributor to this polar warming is the large decline of Arctic sea ice observed since the beginning of satellite observations, which has been attributed to the increase of greenhouse gases. The acceleration of Arctic sea ice loss that is projected for the coming decades could modify the upper level atmospheric circulation yielding climate impacts up to the mid-latitudes. There is considerable variability in the spatial extent of ice cover on seasonal, interannual and decadal time scales. Better understanding, observing and modelling the interactions between sea ice and the other components of the climate system is key for improved predictions of Arctic sea ice in the future. Running operational-like seasonal predictions of Arctic sea ice is a quite recent effort compared to weather predictions or seasonal predictions of atmospheric fields like temperature or precipitation. Recent results stress the importance of sea ice thickness observations to improve seasonal predictions of Arctic sea ice conditions during summer.

Nuclear icebreaker fleet and power supply on the basis of floating power units

2018 ◽  
Vol 35 (4) ◽  
pp. 110-113
Author(s):  
V. A. Tupchienko ◽  
H. G. Imanova
Keyword(s):  
Foreign Policy ◽  
Power Supply ◽  
Nuclear Power ◽  
Arctic Region ◽  
Nuclear Industry ◽  
The Arctic ◽  
Far North ◽  
The Arctic Region

The article deals with the problem of the development of the domestic nuclear icebreaker fleet in the context of the implementation of nuclear logistics in the Arctic. The paper analyzes the key achievements of the Russian nuclear industry, highlights the key areas of development of the nuclear sector in the Far North, and identifies aspects of the development of mechanisms to ensure access to energy on the basis of floating nuclear power units. It is found that Russia is currently a leader in the implementation of the nuclear aspect of foreign policy and in providing energy to the Arctic region.

Chemical Composition of Atmospheric Aerosol in the Arctic Region and Adjoining Seas along the Routes of Marine Expeditions in 2018–2019

2020 ◽  
Vol 33 (5) ◽  
pp. 480-489
Author(s):  
L. P. Golobokova ◽  
T. V. Khodzher ◽  
O. N. Izosimova ◽  
P. N. Zenkova ◽  
A. O. Pochyufarov ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Atmospheric Aerosol ◽  
Arctic Region ◽  
The Arctic ◽  
The Arctic Region

Estimating Friction Reduction ForCasing Operations in High-Angle Wells in The Arctic Region - A Russia Case History

2011 ◽  
Author(s):  
Chimerebere Onyekwere Nkwocha ◽  
Evgeny Glebov ◽  
Alexey Zhludov ◽  
Sergey Galantsev ◽  
David Kay
Keyword(s):  
Case History ◽  
Arctic Region ◽  
Friction Reduction ◽  
The Arctic ◽  
High Angle ◽  
The Arctic Region

scholarly journals Cross-Sectional Association between Hypercholesterolemia and Knee Pain in the Elderly with Radiographic Knee Osteoarthritis: Data from the Korean National Health and Nutritional Examination Survey

2021 ◽  
Vol 10 (5) ◽  
pp. 933
Author(s):  
Byung Woo Cho ◽  
Du Seong Kim ◽  
Hyuck Min Kwon ◽  
Ick Hwan Yang ◽  
Woo-Suk Lee ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Knee Pain ◽  
Logistic Regression Analysis ◽  
National Health ◽  
Large Scale ◽  
Metabolic Diseases ◽  
The Elderly ◽  
Cross Sectional ◽  
Ordinal Logistic Regression Analysis

Few studies have reported the relationship between knee pain and hypercholesterolemia in the elderly population with osteoarthritis (OA), independent of other variables. The aim of this study was to reveal the association between knee pain and metabolic diseases including hypercholesterolemia using a large-scale cohort. A cross-sectional study was conducted using data from the Korea National Health and the Nutrition Examination Survey (KNHANES-V, VI-1; 2010–2013). Among the subjects aged ≥60 years, 7438 subjects (weighted number estimate = 35,524,307) who replied knee pain item and performed the simple radiographs of knee were enrolled. Using multivariable ordinal logistic regression analysis, variables affecting knee pain were identified, and the odds ratio (OR) was calculated. Of the 35,524,307 subjects, 10,630,836 (29.9%) subjects experienced knee pain. Overall, 20,290,421 subjects (56.3%) had radiographic OA, and 8,119,372 (40.0%) of them complained of knee pain. Multivariable ordinal logistic regression analysis showed that among the metabolic diseases, only hypercholesterolemia was positively correlated with knee pain in the OA group (OR 1.24; 95% Confidence Interval 1.02–1.52, p = 0.033). There were no metabolic diseases correlated with knee pain in the non-OA group. This large-scale study revealed that in the elderly, hypercholesterolemia was positively associated with knee pain independent of body mass index and other metabolic diseases in the OA group, but not in the non-OA group. These results will help in understanding the nature of arthritic pain, and may support the need for exploring the longitudinal associations.

scholarly journals Multimorbidity patterns in old adults and their associated multi-layered factors: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiao Lu ◽  
Yuan Wang ◽  
Lihong Hou ◽  
Zhenxing Zuo ◽  
Na Zhang ◽  
...  
Keyword(s):  
Latent Class ◽  
Metabolic Diseases ◽  
Ecological Model ◽  
Explanatory Power ◽  
Cross Sectional Study ◽  
Shanxi Province ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Old Patients ◽  
Old Adults

Abstract Background Influenced by various factors such as socio-demographic characteristics, behavioral lifestyles and socio-cultural environment, the multimorbidity patterns in old adults remain complex. This study aims to identify their characteristics and associated multi-layered factors based on health ecological model. Methods In 2019, we surveyed a total of 7480 participants aged 60+ by using a multi-stage random cluster sampling method in Shanxi province, China. Latent class analysis was used to discriminate the multimorbidity patterns in old adults, and hierarchical regression was performed to determine the multi-layered factors associated with their various multimorbidity patterns. Results The prevalence of multimorbidity was 34.70% among the old patients with chronic disease. Over half (60.59%) of the patients with multimorbidity had two co-existing chronic diseases. “Degenerative/digestive diseases”, “metabolic diseases” and “cardiovascular diseases” were three specific multimorbidity patterns. Behavioral lifestyles-layered factors had the most explanatory power for the three patterns, whose proportions of explanatory power were 54.00, 43.90 and 48.15% individually. But the contributions of other multi-layered factors were different in different patterns; balanced diet, medication adherence, the size of family and friendship network, and different types of basic medical insurance might have the opposite effect on the three multimorbidity patterns (p < 0.05). Conclusions In management of old patients with multimorbidity, we should prioritize both the “lifestyle change”-centered systematic management strategy and group-customized intervention programs.

Association between the FINDRISC score and the risk of metabolic syndrome and hepatic steatosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Godoi Bernardes Da Silva ◽  
R Dias Santos ◽  
M Sommer Bittencourt ◽  
J.A.M Carvalho ◽  
M Franken ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Hepatic Steatosis ◽  
Longitudinal Analysis ◽  
Metabolic Diseases ◽  
Low Cost ◽  
Cross Sectional ◽  
Predictive Values ◽  
Cross Sectional Analysis ◽  
The Cross ◽  
Sectional Analysis

Abstract Introduction The Finnish Diabetes Risk Score (FINDRISC) was developed in Europe to predict type 2 diabetes mellitus (T2DM) risk without need of laboratory tests. Small cross-sectional studies analyzed the association between RF with metabolic syndrome (MS) or hepatic steatosis (HS). Our objective was to test the association of FINDRISC with MS or HS, in a transversal and longitudinal way. Methods In 41,668 individuals (age 41.9±9.7 years; 30.8% women) who underwent health evaluation between 2008 and 2016 in a single centre in Brazil, we tested the transversal association between FINDRISC and MS or HS, in multivariate models. The same analyzes were performed longitudinally in non-diabetic subgroups, followed for 5±3 years, to test the predictive value of FINDRISC and the incidental risk of MS (n=10,075 individuals) or HS (n=7,097 individuals), using logistic regression. Models were adjusted for confounders such as sex, use of medications for dyslipidemia, smoking, and baseline plasma levels of glucose, creatinine and lipids. A receiver operating characteristic (ROC) curve was used to evaluate the discriminative and predictive values of FINDRISC for MS and HS. Results In the cross-sectional analysis, 2,252 (5%) individuals had MS and 14,176 (34%) HS. In the longitudinal analysis, there were 302 cases of incidental MS (2%) and 1,096 cases of HS (15%). FINDRISC was independently associated with MS and HS in the cross-sectional analysis (respectively, OR 1.27, 95% CI: 1.25–1.28, P&lt;0.001; and OR 1.21, 95% CI: 1.20–1.22, P&lt;0.001, per FINDRISC unit) and in longitudinal analysis (respectively, OR of 1.18, 95% CI: 1.15–1.21, P&lt;0.001; and OR of 1.10, 95% CI: 1.08–1.11, P&lt;0.001, per FINDRISC unit). In comparison with individuals with low FINDRISC, those with moderate, high and very high values showed significant and proportional increases of the 12 to 77 fold in the chance of current SM (P&lt;0.001) and 3 to 10 fold in the chance of HS (P&lt;0.001). During follow-up, these increases were 3 to 10 fold in the chance of incidental MS (P&lt;0.001) and 1 to 3 fold in the chance of HS (P&lt;0.001). The AUC from cross-sectional analysis for MS and HS were respectively 0.82 (95% CI 0.81–0.83) and 0.76 (95% CI 0.75–0.76), and in longitudinal analysis 0.73 (95% CI 0.70–0.76) and 0.63 (95% CI 0.61–0.65), respectively. Conclusion FINDRISC was associated with the presence and onset of MS and HS, but it predicted better metabolic syndrome risk than hepatic steatosis. Therefore, this simple, practical and low-cost score can be useful for population screening and identification of subgroups of individuals at higher risk future metabolic diseases. Funding Acknowledgement Type of funding source: None

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