scholarly journals Molecular mechanisms of cardiovascular benefits of exercise: Running for cover from heart disease

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Mohamed Hassan ◽  
Yasmine Aguib ◽  
Magdi Yacoub

The benefits of exercise have been recognized since ancient times. Physically active men and women have an approximately 30% lower risk of death compared with inactive people. Several trials have recently shown the favorable impact of exercise on survival and quality of life. In the PARIS study, four months of endurance exercise training in elderly patients with heart failure and preserved ejection fraction caused a significant improvement in peak exercise capacity. Moreover in the Copenhagen City Heart Study, jogging up to 2.5 h per week at a slow or average pace and a frequency of 3 times per week was associated with a significant increase in survival (6.2 years in men and 5.6 years in women). These findings imply that exercise improves peripheral vascular, microvascular, and/or skeletal muscle functions and causes an increase in oxygen transport and utilization by the active skeletal muscle.1 However, the exact molecular mechanisms of the cardiovascular benefits of exercise remained largely unknown until very recently. Two recent reports serve to shed some light on the potential role for irisin and miRNA-222 in this subject. 

2019 ◽  
Vol 21 (Supplement_L) ◽  
pp. L20-L23 ◽  
Author(s):  
Guilherme Wesley Peixoto da Fonseca ◽  
Stephan von Haehling

Abstract Sarcopaenia is defined as reduced skeletal muscle mass associated with either a decline in muscle strength or low physical performance. It has been shown to affect 17.5% of people worldwide, with a prevalence of 20% or higher in patients with heart failure (HF). Sarcopaenia has severe impact on mortality, physical capacity, and quality of life. Even though several mechanisms, such as autonomic imbalance, reduced muscle blood flow, increased inflammation, hormonal alterations, increased apoptosis, and autophagy have been proposed to fuel the pathogenesis of sarcopaenia, additional studies assessing the interaction of these conditions need to be conducted to elucidate how the presence of sarcopaenia can exacerbate the progression of HF and vice-versa. Resistance training combined with nutritional protein intake seems to be effective in the treatment of sarcopaenia, although current pharmacotherapies have not been extensively studied with this endpoint in mind. In conclusion, sarcopaenia is interwoven with HF and leads to worse exercise capacity in these patients. The mechanisms associated with this bilateral relationship between sarcopaenia and HF are still to be elucidated, leading to effective treatment, not only for the heart, but also for the skeletal muscle.


Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2540 ◽  
Author(s):  
Elia Pancheri ◽  
Valeria Guglielmi ◽  
Grzegorz M. Wilczynski ◽  
Manuela Malatesta ◽  
Paola Tonin ◽  
...  

The overall approach to the treatment of multiple myeloma (MM) has undergone several changes during the past decade. and proteasome inhibitors (PIs) including bortezomib, carfilzomib, and ixazomib have considerably improved the outcomes in affected patients. The first-in-class selective PI bortezomib has been initially approved for the refractory forms of the disease but has now become, in combination with other drugs, the backbone of the frontline therapy for newly diagnosed MM patients, as well as in the maintenance therapy and relapsed/refractory setting. Despite being among the most widely used and highly effective agents for MM, bortezomib can induce adverse events that potentially lead to early discontinuation of the therapy with negative effects on the quality of life and outcome of the patients. Although peripheral neuropathy and myelosuppression have been recognized as the most relevant bortezomib-related adverse effects, cardiac and skeletal muscle toxicities are relatively common in MM treated patients, but they have received much less attention. Here we review the neuromuscular and cardiovascular side effects of bortezomib. focusing on the molecular mechanisms underlying its toxicity. We also discuss our preliminary data on the effects of bortezomib on skeletal muscle tissue in mice receiving the drug.


1997 ◽  
Vol 83 (6) ◽  
pp. 1933-1940 ◽  
Author(s):  
Chim C. Lang ◽  
Don B. Chomsky ◽  
Javed Butler ◽  
Shiv Kapoor ◽  
John R. Wilson

Lang, Chim C., Don B. Chomsky, Javed Butler, Shiv Kapoor, and John R. Wilson. Prostaglandin production contributes to exercise-induced vasodilation in heart failure. J. Appl. Physiol. 83(6): 1933–1940, 1997.—Endothelial release of prostaglandins may contribute to exercise-induced skeletal muscle arteriolar vasodilation in patients with heart failure. To test this hypothesis, we examined the effect of indomethacin on leg circulation and metabolism in eight chronic heart failure patients, aged 55 ± 4 yr. Central hemodynamics and leg blood flow, determined by thermodilution, and leg metabolic parameters were measured during maximum treadmill exercise before and 2 h after oral administration of indomethacin (75 mg). Leg release of 6-ketoprostaglandin F1α was also measured. During control exercise, leg blood flow increased from 0.34 ± 0.03 to 1.99 ± 0.19 l/min ( P < 0.001), leg O2 consumption from 13.6 ± 1.8 to 164.5 ± 16.2 ml/min ( P < 0.001), and leg prostanoid release from 54.1 ± 8.5 to 267.4 ± 35.8 pg/min ( P < 0.001). Indomethacin suppressed release of prostaglandin F1α( P < 0.001) throughout exercise and decreased leg blood flow during exercise ( P < 0.05). This was associated with a corresponding decrease in leg O2 consumption ( P < 0.05) and a higher level of femoral venous lactate at peak exercise ( P < 0.01). These data suggest that release of vasodilatory prostaglandins contributes to skeletal muscle arteriolar vasodilation in patients with heart failure.


2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jill K. Onesti ◽  
Denis C. Guttridge

Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting.


2017 ◽  
Vol 34 (02) ◽  
pp. 107-113
Author(s):  
L. Gonçalves ◽  
D. Madureira ◽  
J. Santana ◽  
E. França ◽  
M. Miranda ◽  
...  

AbstractSkeletal muscle mass gain is beneficial in several situations. It improves athlete's performance and quality of life in pathological situations. The existence of different methods that are able to increase muscle mass brings up discussions about nutritional supplements use on physically active individuals. β-hydroxy-β-methylbutyrate is a Leucine metabolite and it's believed to have an anticatabolic effect with different results depending on the type of exercise done. Objective: The objective of this research was to identify and categorize the methodological features and results of β-hydroxy-β-methylbutyrate (HMβ) studies, physical exercise and its effects on skeletal muscle in the last 20 years. Materials and Methods: We carried out a review in the literature using PUBMED and Medline data bases. We analyzed 19 articles from the 4587 initially found, according to the inclusion and exclusion criteria. After the selection we analyzed the date of publishing and country of origin, sample size and type, dosage used, exercise protocol and results on skeletal muscle. Results: Most of the studies came from the USA, were published between the years of 2000 and 2005. Most of the papers used only males and the main dosage used was 3.0g/day with resistance exercise, although endurance exercise and untrained individuals showed some interesting results. Data from these studies varied from increase in muscle mass and muscle strength, recovery of isokinetic and isometric muscle function, decrease in lactate dehydrogenase and proteolysis and decrease in creatine kinase. Conclusion We can conclude that although HMβ has some positive effects on untrained individuals, its effects on trained individuals still need further conirmation.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Klompstra ◽  
T Jaarsma ◽  
A Stromberg ◽  
M.H.L Van Der Wal

Abstract Background Being physically active is important for patients with heart failure (HF) to improve clinical outcome, however, adherence to exercise is low (&lt;50%). To tailor intervention that increase physical activity, it is important to know what motivates HF patients to exercise. Therefore, the aim of the study is to describe motivations of HF patients to exercise and describe variables that are related to their exercise motivation. Methods This is a cross-sectional analysis of baseline data of 605 patients with HF (mean age 67±12, 71% male, 60%NYHA I/II) who were included in the HF-Wii study. Stepwise regression modelling was used with exercise motivation as dependent variable. Exercise motivation was measured with the Exercise Motivation Index, including 15 statements with answers ranging from 0 (not important) to 4 (extremely important), with 3 subscales (physical, psychological and social motivation). Based on previous research the following predictors were included in the model: quality of life (MLwHFQ), self-efficacy (Exercise self-efficacy scale), cognition (MoCA), depression (HADs), sleeping difficulties (MISS), HF symptoms (fatigue, shortness of breath), age, gender, NYHA-class, comorbidity and educational level. Results Mean total motivation to exercise was 2.3±0.9 and physical and psychological motivation were rated as the more important (2.7±0.9 and 2.5±0.9) than social motivation (1.8±1.1). Motivation statements that were considered extremely important were being healthier (55% rated 4), slow down the ageing process (38% rated 4) and increasing well-being (31% rated 4). From the multiple linear regression model lower quality of life (β=−0.31, P&lt;0.0001), lower self-efficacy (β=0.16, P&lt;0.0001), experiencing shortness of breath (β=−0.28, P&lt;0.0001), having COPD (β=−0.14, P=0.001) and low educational level (β=−0.09, P&lt;0.028) were predictors related to lower motivation. This model explained 17% of the exercise motivation variability (p&lt;0.0001). Cognition, sleeping difficulties, age, gender, NYHA-class and experiencing fatigue were not significantly related to motivation. Conclusion Lower quality of life, lower self-efficacy, experiencing shortness of breath, having COPD and lower educational level, decreases the motivation to exercise and may therefore be considered as barriers for exercise. These barriers should be assessed and considered when motivating patients to become more physically active. Funding Acknowledgement Type of funding source: None


2011 ◽  
Vol 7 (1) ◽  
pp. 66 ◽  
Author(s):  
Ewa Piotrowicz ◽  
Ryszard Piotrowicz ◽  
◽  

Exercise training (ET) is now recommended as an important component of a comprehensive approach to patients with heart failure (HF). Despite the existence of proven benefits of ET, many HF patients remain physically inactive. Introducing telerehabilitation (TR) may eliminate most of the factors that result in the currently low number of patients undergoing outpatient-based rehabilitation programmes and thus increase the percentage of those who will undergo cardiac rehabilitation. Despite the fact that TR is highly applicable and effective, there are few papers dedicated to the study of TR in HF patients. Until recently, only a couple of home rehabilitation-monitoring models have been presented, from the simplest, i.e. heart rate monitoring and transtelephonic electrocardiographic monitoring, through to the more advanced tele-electocardiogram (tele-ECG) monitoring (via a remote device) and realtime electrocardiographic and voice transtelephonic monitoring. It seems the last two are the most useful and reliable. Based on published studies, TR in HF patients could be equally effective as and provide similar improvements in health-related quality of life to standard outpatient cardiac rehabilitation. In addition, adherence to cardiac rehabilitation seems to be better during TR. Due to disease-related limitations, TR seems to be a viable alternative for comprehensive cardiac rehabilitation in HF patients. Further studies are needed to confirm the utility of this type of rehabilitation in routine clinical practice, including its cost-effectiveness. Because of the diversity of technological systems, it is necessary to create a platform to ensure compatibility between the devices used in telemedicine.


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