The present trial was investigated the dietary effect of Azomite with low energy on growth, carcass and biochemical indexes in broiler chickens. A total of 180 AA broiler chicks were randomly allotted in to three treatment groups with six replicates and 10 birds/replicate: Control fed a basal diet, (2) Low ME fed (basal diet -100kcal kg1 (3) AZO-0.25 fed (Low ME +AZO-0.25). The results showed that, birds fed diet with AZO-0.25 had higher average daily gain (ADG) than that in Low ME group (P>0.05), while feed conversion ratio (FCR) was lower (P>0.05) compared to Low ME. Percentage of eviscerated carcass, breast muscle and leg muscle were higher significantly (P<0.05) in the AZO-0.25 than Low ME. Serum TP, IgG and CT levels significantly (P<0.05) higher in AZO-0.25 than Low ME. Overall, 0.25% Azomite showed positive effect on growth and carcass performance and it could compensate the negative effect of low-energy diet for broiler chickens by improving the digestion and utilization of nutrients.