scholarly journals Evaluation of the possible therapeutic role of omega-3 on ankle joint and lung in a model of rheumatoid arthritis in rats: A histological and immunohistochemical study

2018 ◽  
Vol 41 (3) ◽  
pp. 1-14
Author(s):  
Mona Raafat ◽  
Ghada Hamam ◽  
Maha Farhan ◽  
Laura Sabbagh ◽  
Nour Abeduldaem ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankle Joint ◽  
Immunohistochemical Study ◽  
Omega 3 ◽  
Therapeutic Role

scholarly journals Role of Omega-3 Polyunsaturated fatty acids in Inflammation and rheumatoid arthritis disorders

2014 ◽  
Vol 2 (1) ◽  
pp. 3-17
Author(s):  
Mohammad Asif
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Assessment ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Lower Risk ◽  
Risk Category ◽  
Omega 3 ◽  
High Concentration ◽  
Related Risk

Reviewing the relationships between polyunsaturated FAs (PUFAs) with inflammation and rheumatoid arthritis disorders, the PUFAs containing ω-3, ω-6 and ω-9, these ω-3FAs levels were correlated with ω-6: ω-3 ratios including arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Based on previously-reports, the levels of ω-3 FAs considered being as a 'lower risk' category for inflammation and rheumatoid arthritis. Certain PUFAs ratios may aid in inflammation and rheumatoid arthritis-related risk assessment. PUFA are the most effective for the production of oil with high concentration of DHA and EPA content significantly.DOI: http://dx.doi.org/10.3126/ijasbt.v2i1.9783Int J Appl Sci Biotechnol, Vol. 2(1): 3-17

Potential role of bioactive lipids in rheumatoid arthritis

2021 ◽  
Vol 27 ◽  
Author(s):  
Wheeler Torres ◽  
Mervin Chávez-Castillo ◽  
José L. Peréz-Vicuña ◽  
Rubén Carrasquero ◽  
María P. Díaz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Potential Role ◽  
The Body ◽  
Omega 3 ◽  
Bioactive Lipids ◽  
Dietary Interventions ◽  
Complex Disorder ◽  
Inflammatory Autoimmune Disease

: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, which involves a pathological inflammatory response against articular cartilage in multiple joints throughout the body. It is a complex disorder associated with comorbidities such as depression, lymphoma, osteoporosis and cardiovascular disease (CVD), which significantly deteriorate patients’ quality of life and prognosis. This has ignited a large initiative to elucidate the physiopathology of RA, aiming to identify new therapeutic targets and approaches in its multidisciplinary management. Recently, various lipid bioactive products have been proposed to have an essential role in this process; including eicosanoids, specialized pro-resolving mediators, phospholipids/sphingolipids, and endocannabinoids. Dietary interventions using omega-3 polyunsaturated fatty acids or treatment with synthetic endocannabinoids agonists have been shown to significantly ameliorate RA symptoms. Indeed, the modulation of lipid metabolism may be crucial in the pathophysiology and treatment of autoimmune diseases.

scholarly journals Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis

2009 ◽  
Vol 35 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Ashoke Bijoy Das Gupta ◽  
A.K.M. Mosharrof Hossain ◽  
Md. Hilalul Islam ◽  
Sudhangshu Ranjan Dey ◽  
Md. Abdul Latif Khan
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Disease Activity ◽  
Morning Stiffness ◽  
Treated Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Omega 3 Fatty Acid

 A study was conducted to see the diseases activity suppression role of omega-3 fatty acids with indomethacin in patients with rheumatoid arthritis. One group received indomethacin (75 mg) only daily while another group received indomethacin (75 mg) along with omega-3 fatty acids (3 g) daily for 12 weeks. The main outcome measures were DAS 2-28 joints score, number of swollen joints, number of tender joints, duration of morning stiffness, grip strength, pain VAS, patients global VAS, erythrocyte sedimentation rate and C-reactive protein. In terms of outcome both the groups experienced a modest improvement in disease activity after 12 weeks of treatment. However, compared to indomethacin–treated group, omega-3 plus indomethacin–treated group achieved a better improvement in terms of reducing disease activity. Physical functioning, physical role, bodily pain, general health, vitality, social functioning, grip strength, duration of morning stiffness improved significantly better in the combination group compared to indomethacin only group. The safety measures included liver and kidney function tests done didn’t differ between the study groups. This study suggests that omega-3 fatty acid supplementation with indomethacin might ameliorate disease activity and be non-steroidal anti-inflammatory drugs (NSAIDs) sparing in rheumatoid arthritis.Keywords: Rheumatoid arthritis; Indomethacin; Omega-3 fatty acidOnline: 25 August 2009DOI: 10.3329/bmrcb.v35i2.3020Bangladesh Med Res Counc Bull 2009; 35: 63-68  

Sign in / Sign up

Export Citation Format

Share Document