scholarly journals Role of Omega-3 Polyunsaturated fatty acids in Inflammation and rheumatoid arthritis disorders

2014 ◽  
Vol 2 (1) ◽  
pp. 3-17
Author(s):  
Mohammad Asif
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Assessment ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Lower Risk ◽  
Risk Category ◽  
Omega 3 ◽  
High Concentration ◽  
Related Risk

Reviewing the relationships between polyunsaturated FAs (PUFAs) with inflammation and rheumatoid arthritis disorders, the PUFAs containing ω-3, ω-6 and ω-9, these ω-3FAs levels were correlated with ω-6: ω-3 ratios including arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Based on previously-reports, the levels of ω-3 FAs considered being as a 'lower risk' category for inflammation and rheumatoid arthritis. Certain PUFAs ratios may aid in inflammation and rheumatoid arthritis-related risk assessment. PUFA are the most effective for the production of oil with high concentration of DHA and EPA content significantly.DOI: http://dx.doi.org/10.3126/ijasbt.v2i1.9783Int J Appl Sci Biotechnol, Vol. 2(1): 3-17

scholarly journals Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis

2009 ◽  
Vol 35 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Ashoke Bijoy Das Gupta ◽  
A.K.M. Mosharrof Hossain ◽  
Md. Hilalul Islam ◽  
Sudhangshu Ranjan Dey ◽  
Md. Abdul Latif Khan
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Disease Activity ◽  
Morning Stiffness ◽  
Treated Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Omega 3 Fatty Acid

 A study was conducted to see the diseases activity suppression role of omega-3 fatty acids with indomethacin in patients with rheumatoid arthritis. One group received indomethacin (75 mg) only daily while another group received indomethacin (75 mg) along with omega-3 fatty acids (3 g) daily for 12 weeks. The main outcome measures were DAS 2-28 joints score, number of swollen joints, number of tender joints, duration of morning stiffness, grip strength, pain VAS, patients global VAS, erythrocyte sedimentation rate and C-reactive protein. In terms of outcome both the groups experienced a modest improvement in disease activity after 12 weeks of treatment. However, compared to indomethacin–treated group, omega-3 plus indomethacin–treated group achieved a better improvement in terms of reducing disease activity. Physical functioning, physical role, bodily pain, general health, vitality, social functioning, grip strength, duration of morning stiffness improved significantly better in the combination group compared to indomethacin only group. The safety measures included liver and kidney function tests done didn’t differ between the study groups. This study suggests that omega-3 fatty acid supplementation with indomethacin might ameliorate disease activity and be non-steroidal anti-inflammatory drugs (NSAIDs) sparing in rheumatoid arthritis.Keywords: Rheumatoid arthritis; Indomethacin; Omega-3 fatty acidOnline: 25 August 2009DOI: 10.3329/bmrcb.v35i2.3020Bangladesh Med Res Counc Bull 2009; 35: 63-68  

Jumping on the Omega-3 Bandwagon: Distinguishing the Role of Long-Chain and Short-Chain Omega-3 Fatty Acids

2012 ◽  
Vol 52 (9) ◽  
pp. 795-803 ◽  
Author(s):  
Giovanni M. Turchini ◽  
Peter D. Nichols ◽  
Colin Barrow ◽  
Andrew J. Sinclair
Keyword(s):  
Fatty Acids ◽  
Short Chain ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain

Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation

2013 ◽  
Vol 29 (6) ◽  
pp. 431-445 ◽  
Author(s):  
Michael R. Flock ◽  
Connie J. Rogers ◽  
K. Sandeep Prabhu ◽  
Penny M. Kris-Etherton
Keyword(s):  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain

scholarly journals Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia

2015 ◽  
Vol 87 (2 suppl) ◽  
pp. 1475-1486 ◽  
Author(s):  
ALEXANDRA I. ZUGNO ◽  
LARA CANEVER ◽  
GUSTAVO MASTELLA ◽  
ALEXANDRA S. HEYLMANN ◽  
MARIANA B. OLIVEIRA ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Animal Model ◽  
Prefrontal Cortex ◽  
Immune System ◽  
Mechanism Of Action ◽  
Neurotrophic Factor ◽  
Concomitant Treatment ◽  
Omega 3 ◽  
Preventive Effect

ABSTRACTNew studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive effect of omega-3 on interleukines (IL) and neurotrophin brain-derived neurotrophic factor (BDNF) levels in the brains of young rats subjected to a model of schizophrenia. Treatment was performed over 21 days, starting on the 30th day of rat's life. After 14 days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25 mg/kg) was started and maintained until the last day of the experiment. BDNF levels in the rat's prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3 showed a decrease in BDNF levels only after 24 h. In contrast, both interventions induced similar responses in levels of IL-1β and IL6. These findings suggest that the similarity of IL-1β and IL6 levels in our experimental groups is due to the mechanism of action of ketamine on the immune system. More studies have to be carried out to explain this pathology. In conclusion, according to previous studies and considering the current study, we could suggest a prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia.

scholarly journals Fish consumption, contaminants and sudden unexpected death in epilepsy: many more benefits than risks

2010 ◽  
Vol 70 (3) ◽  
pp. 665-670 ◽  
Author(s):  
FA. Scorza ◽  
RM. Cysneiros ◽  
RM. Arida ◽  
VC. Terra ◽  
HR. Machado ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fish Consumption ◽  
Sudden Unexpected Death ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Unexpected Death ◽  
Positive Effects ◽  
Increased Risk ◽  
Fish And Shellfish

People with epilepsy have an increased risk of dying prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). SUDEP is mainly a problem for patients with chronic uncontrolled epilepsy. The ultimate goal of research in SUDEP is to develop new methods to prevent it and actions other than medical and surgical therapies that could be very useful. Nutritional aspects, i.e., omega-3 fatty acids deficiency, could have an interesting role in this scenario. Some animal and clinical studies have suggested that omega-3 fatty acids could be useful in the prevention and treatment of epilepsy and hence SUDEP. It has been ascertained that the only foods that provide large amounts of omega-3 are seafood (fish and shellfish); however, some fish are contaminated with methylmercury, which may counteract the positive effects of omega-3 fatty acids. Our update review summarises the knowledge of the role of fish consumption on epilepsy research.

Sign in / Sign up

Export Citation Format

Share Document