Signal Detection in the UK: The Use of Quantitative Methods at the MHRA

Drug Safety ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 919-990 ◽  
Author(s):  
S Ekins-Daukes ◽  
S Kauser ◽  
L Wise
BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e024012
Author(s):  
Katherine Morton ◽  
Sarah Voss ◽  
Joy Adamson ◽  
Helen Baxter ◽  
Karen Bloor ◽  
...  

IntroductionPressure continues to grow on emergency departments in the UK and throughout the world, with declining performance and adverse effects on patient outcome, safety and experience. One proposed solution is to locate general practitioners to work in or alongside the emergency department (GPED). Several GPED models have been introduced, however, evidence of effectiveness is weak. This study aims to evaluate the impact of GPED on patient care, the primary care and acute hospital team and the wider urgent care system.Methods and analysisThe study will be divided into three work packages (WPs). WP-A; Mapping and Taxonomy: mapping, description and classification of current models of GPED in all emergency departments in England and interviews with key informants to examine the hypotheses that underpin GPED. WP-B; Quantitative Analysis of National Data: measurement of the effectiveness, costs and consequences of the GPED models identified in WP-A, compared with a no-GPED model, using retrospective analysis of Hospital Episode Statistics Data. WP-C; Case Studies: detailed case studies of different GPED models using a mixture of qualitative and quantitative methods including: non-participant observation of clinical care, semistructured interviews with staff, patients and carers; workforce surveys with emergency department staff and analysis of available local routinely collected hospital data. Prospective case study sites will be identified by completing telephone interviews with sites awarded capital funding by the UK government to implement GPED initiatives. The study has a strong patient and public involvement group that has contributed to study design and materials, and which will be closely involved in data interpretation and dissemination.Ethics and disseminationThe study has been approved by the National Health Service East Midlands—Leicester South Research Ethics Committee: 17/EM/0312. The results of the study will be disseminated through peer-reviewed journals, conferences and a planned programme of knowledge mobilisation.Trial registration numberISRCTN51780222.


2014 ◽  
Vol 4 (1) ◽  
pp. 44-65 ◽  
Author(s):  
Jon Talbot ◽  
Andy Lilley

Purpose – The purpose of this paper is to outline a small research project designed to explore the practices of the UK work-based learning (WBL) tutors in facilitating formal research projects in the workplace. Design/methodology/approach – Data were collected using a short questionnaire to practitioners administered electronically and a daylong workshop where issues were discussed in greater depth by participating tutors. Findings – The main findings are that there is a degree of agreement by WBL tutors about the distinctiveness of WBL research projects; that although there is increasing use of technology to support delivery only one institution is using e-learning as the principal means of delivery; emphasis is upon a relatively small number of techniques and there is a strong preference for qualitative over quantitative methods. Research limitations/implications – The main limitation of the study is the relatively small number of active participants. However, this is the only study of its kind and the results offer insights into an important element of pedagogic practice in WBL. Practical implications – The project enabled the identification of common approaches and facilitated discussion of problems shared by WBL tutors across the field. There appears to be a consensus that situated investigation exists within a different contextual framework to traditional academic dissertation projects and that the focus is therefore necessarily on generating data as the basis for active problem solving. Originality/value – This is the only empirical study of practice in respect of facilitating research projects on WBL programmes in higher education.


2019 ◽  
Vol 11 (5) ◽  
pp. 1229 ◽  
Author(s):  
Neil Cuthill ◽  
Mengqiu Cao ◽  
Yuqi Liu ◽  
Xing Gao ◽  
Yuerong Zhang

The pursuit of sustainability has been at the forefront of contemporary planning initiatives. However, most recent research has focused on the environmental and economic aspects of developing sustainable urban environment, whilst largely neglecting the social aspects. Contemporary political thinking in the UK often disregards the potential of the urban infrastructure to improve social equity. The aim of this study was to analyse the impact of transport infrastructure on a variety of social measures, in an empirical and ideologically unbiased fashion, using both quantitative and qualitative methods. We selected “Tramlink” as a case study: a light-rail system in the London Borough of Croydon which began operation in 2000. We used quantitative methods, including advanced spatial statistics, to produce a more detailed analysis of social equity than has been previously published. This acknowledges that determining localised issues can produce more informed and effective policy interventions. Our results demonstrate that the physical properties of transport infrastructure and the non-physical attributes of society, in combination, help to create opportunities for individuals to succeed. We also find that in order to reduce the negative effects of austerity, public money could be more effectively spent if diverted to areas that are most in need which can be highlighted through localised investigations.


2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
S Bandyopadhyay ◽  
J Moudgil-Joshi ◽  
E Norton ◽  
M Haq ◽  
K Saunders

Abstract Objective To explore how social media could be utilised to influence an individual’s motivation to pursue a neurosurgical career, an emerging topic area. The focus of this study was on women interested in neurosurgery. Background Women are significantly under-represented in neurosurgery. 18% of all neurosurgeons – including 8% of consultants – are women. Most previous studies have used quantitative methods that are not best suited to gaining an in-depth understanding of the barriers that women face in pursuing a career in neurosurgery, or what would enable more women to go into the speciality. Method In this qualitative study, individual semi-structured interviews were conducted until data saturation was achieved. Participants were women pre-neurosurgical trainees. The interview data was examined through a thematic analysis involving open and axial coding. Results Thirty women participated in the study. Four overarching themes were identified: (1) mentorship, (2) testimony from other women doing neurosurgery, (3) social media as a means of increasing interest in neurosurgery as a career choice, and (4) real-life exposure to the speciality. Conclusions There is scope to further improve uptake of women into neurosurgical training in the UK. Motivations and barriers to women pursuing neurosurgery should be addressed openly through early experience, role models and mentorship. Social media can help facilitate these opportunities, disseminate information and inspiration, and has the potential to undo societal biases.


2021 ◽  
Vol 9 (3) ◽  
pp. 144-153
Author(s):  
K. E. Zalolochina ◽  
E. A. Ushkalova ◽  
A. S. Kazakov ◽  
S. K. Zyryanov ◽  
V. A. Polivanov

2016 ◽  
Vol 34 (4) ◽  
pp. 332-344 ◽  
Author(s):  
Matthew Tucker ◽  
Mohd Rayme Anang Masuri

Purpose – The purpose of this paper is to justify the need to integrate facilities management (FM) into the development process (DP) and establish a framework that potentially serves as a guide to optimise the value of FM in the property development industry. Design/methodology/approach – This study looks at the relevant literature to identify the factors that are hindering FM to effectively integrate in the DP. Subsequently, the authors intend to carry out interviews with various professionals in the property development industry in the UK to identify the best practices. This research uses qualitative and quantitative methods in order to establish an FM-DP integration framework. Findings – The literature suggested that contribution of FM towards the property development industry is unquestionable. Surprisingly, in a real world FM has been given a low priority in the property development industry, resulting in Facilities Managers being inadequately integrated into the DP. There is currently no suitable generic mechanism that is practical in all stages of the DP to guide Facilities Managers and/or other professionals to integrate FM into the DP. Originality/value – This study is to provide evidence that the property development industry needs a framework that potentially serves as a guide to optimise the value of FM in the DP.


2015 ◽  
Vol 13 (2) ◽  
pp. 226-246 ◽  
Author(s):  
Imad Kutum ◽  
Ian Fraser ◽  
Khaled Hussainey

Purpose – This paper aims to explore the application of the business risk audit (BRA) approach within non-Big-4 audit firms in the USA, the UK and Canada. This paper focuses on the motivation for adopting this approach for non-Big-4 audit firms in the three countries, and the advantages, disadvantages and aftermath of applying this method. Design/methodology/approach – A combination of qualitative and quantitative methods to obtain the data necessary to address the research questions was used. Findings – It is found that non-Big-4 audit firms in the three countries have adopted BRA; their motivation was primarily to follow the standards in each country, and the general trend in the industry. The advantages identified are consistent with previous research; a direct benefit was noted for audit effectiveness and risk management for both clients and auditors. One major disadvantage of applying BRA is the cost burden to both the audit firm and their clients. Some of the interviewees claimed that this method is better suited to large firms and large audits. Originality/value – This is an innovative study that addresses a contemporary auditing issue. The majority of the audit research studies concentrate on the big audit firm practices; this study is the first to examine the application of audit practices within smaller audit firms.


Author(s):  
Charlotte Brookfield

Various initiatives have been launched to encourage sociology students studying in the UK to engage more with quantitative research methods (for example: Dale et al., 2008; Adney and Carey, 2009; Falkingham et al., 2009), however, their success has been limited. Embedding quantitative methods in substantive sociology curricula has been suggested as one way to reduce students’ anxieties about learning quantitative research methods (Williams et al., 2015). This approach has been employed at Cardiff University’s School of Social Sciences, where quantitative skills have been strategically incorporated into various aspects of a first year undergraduate substantive module. This paper will reflect on the experience of teaching on this module. The paper will conclude that while the introduction of quantitative content into substantive modules indicates support for change, embedding alone cannot be viewed as a single solution to encouraging to students’ to learn about or utilise quantitative research methods. Two possible reasons for this will be suggested. Firstly, it will be argued that the majority of students no longer pursue sociology at degree level in order to gain the skills to become a competent social researcher, but rather see sociology as a discipline that will equip them with transferable and desirable skills for many occupations. Consequently, engagement with quantitative research methods is not essential to students’ strategic approach to learning as it was for previous generations who wished to understand how to study their social world. Secondly, it will be suggested that the deficit of quantitative methods in mainstream British sociology journals and the methodological preferences of practicing sociologists leads to speculation over the available staff who are capable of delivering an integrated curriculum with quantitative methods embedded in substantive modules.


2015 ◽  
Vol 24 (1) ◽  
pp. 102-111
Author(s):  
Carmel Hannan

There is now a lack of quantitative capacity among practitioners and teachers in sociology in Ireland. Yet interest in the value of quantitative methods among governments, funding organisations and society in general are on the increase. Social science research councils and funders in other countries, notably the UK, have realised there is a problem and are now attempting to remedy this through increased funding for the recruitment of quantitatively trained academics for example, Q-Step. The paper examines a number of developments notably Big Data, increases in transdisciplinary research and developments in mixed methods research which, it is argued, underline the need for more and better quantitative methods teaching in sociology. The paper calls for sociology departments to re-think their curricula and actively promote the teaching of a range of methods at the undergraduate level.


2021 ◽  
Author(s):  
Paul Watkiss ◽  
Alistair Hunt

<p>Investing in weather and climate information services leads to improved information.  The use of this information by users leads to benefits from avoiding negative or realising positive outcomes (the value of information (VoI)).  This paper provides a systematic and applied approach that has developed methodological guidance for the valuation of climate services. The guidance has been commissioned by the UK Climate Resilience project to promote the application of economic benefit analysis for climate services in the UK.</p><p>Building on existing literature, the method has developed a series of steps that comprise: construction of a baseline scenario; scoping of potential benefits of the new W&CI service; choice of method(s) for benefit valuation; development of the value chain for the service; assessment of benefits in monetary terms; assessment of costs of the service; comparison of benefits against costs; sensitivity and bias analysis; and to consider how benefits could be enhanced.  It encourages a value chain approach, considering foundational activities including science research and observations, forecasting capacity and accuracy, effective communication to users, and the uptake and use of this information by end-users, taking account of efficiency fall-offs at each stage.</p><p>The method and guidance extends the typical focus of valuation studies (on short-term weather and seasonal forecasts) to cover four temporal elements.</p><ul><li>Observed and historic information;</li> <li>Forecasts over hours to weeks ahead (early warning, weather forecasts);</li> <li>Forecasts for months to years ahead (seasonal forecasting, inter-annual variability); and</li> <li>Projections for future decades (climate change) (adaptation services).</li> </ul><p>Each of these involves different issues and therefore requires slightly different methodological approaches (and for adaptation services, very different approaches). In order to model the benefits of specific new W&CI services – across these four areas - the approach provides guidance for quantitative methods, including:</p><ul><li>Ex ante modelling studies;</li> <li>Stated preference methods (contingent valuation and choice experiments);</li> <li>Experimental economic methods;</li> <li>Ex post surveys;</li> <li>Revealed preference (including econometric-based) methods;</li> <li>Value transfer procedures from existing studies.</li> </ul><p>The relative merits of these methods are identified and an initial mapping against the temporal elements is developed. Alongside these technical factors, the guidance also considers the methods in terms of required expertise; time, data availability and resources.</p><p>The guidance also recommends on how to improve the uptake of economic analysis as part of climate services proposals and design. It recommends inclusion in programme/project logical frameworks, such that economic benefits can be considered as an outcome or impact metric thereby providing an opportunity to demonstrate value for money.</p><p>Finally, the paper presents ongoing case study working that is applying the guidance to three operational climate service projects, covering different temporal aspects.</p>


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