The Monitoring of Serum Electrolytes and Creatinine in Patients Treated with Antihypertensive Drugs: A Retrospective Analysis in UK General Practice

Drug Safety ◽  
2008 ◽  
Vol 31 (10) ◽  
pp. 885-960
Keyword(s):  
General Practice ◽  
Retrospective Analysis ◽  
Antihypertensive Drugs ◽  
Serum Electrolytes

scholarly journals Doctors recognized by the British honours systems: A retrospective analysis of the last decade

2011 ◽  
Vol 104 (12) ◽  
pp. 521-524 ◽  
Author(s):  
Shofiq Islam ◽  
Jennifer L Cole ◽  
Christopher J Taylor
Keyword(s):  
Public Health ◽  
General Practice ◽  
Clinical Practice ◽  
Retrospective Analysis ◽  
Medical Profession ◽  
Statistical Tests ◽  
Medical Community ◽  
Public Health Medicine ◽  
Significant Difference ◽  
The World

Objectives The British honours system is one of the oldest in the world rewarding individuals, including those of the medical profession. The authors were interested to see if any particular specialty was honoured to a greater extent. We aimed to establish the number of those honoured, the duration of clinical practice involved, as well as additional factors. Design A retrospective analysis of doctors receiving honours (Knight/Dame, CBE, OBE, MBE) in the last decade was performed. Setting UK-registered doctors. Participants Doctors were identified from publicly available listings. Main outcome measures Demographics of all honoured doctors, including number of years of service, specialty affiliation and the number of recipients holding professorial status were collected. Clinicians were stratified into four subgroups: General Practitioners, Physicians, Surgeons and Others. Data were analysed using parametric statistical tests. Results Four hundred and seventeen doctors were identified. Four hundred and two clinicians had a documented subspecialty affiliation. Of the 402: GPs ( n = 142), Physicians ( n = 100), Surgeons ( n = 34) and Others ( n = 126). The number of years in clinical practice from registration to conference of honours was significantly shorter for GPs when compared to hospital-based specialties ( P < 0.05). The top 10 specialties of individuals honoured are tabulated. Professors constituted 30% ( n = 131) of those honoured. These individuals were sub-divided according to specialty affiliation with a significant difference observed ( P < 0.05). Conclusions The most honoured specialty was General Practice. However, when corrected for total subspecialty population, the number one ranking specialty was Public Health Medicine. Academic clinicians are well represented. The findings may be of interest to the medical community.

Persistence and adherence with mirabegron vs antimuscarinics in overactive bladder: Retrospective analysis of a UK General Practice prescription database

2017 ◽  
Vol 71 (10) ◽  
pp. e12996 ◽  
Author(s):  
Adrian S. Wagg ◽  
Steve Foley ◽  
John Peters ◽  
Jameel Nazir ◽  
Leanne Kool-Houweling ◽  
...  
Keyword(s):  
General Practice ◽  
Overactive Bladder ◽  
Retrospective Analysis ◽  
Prescription Database

scholarly journals P-120 Retrospective analysis of the timeliness of completion of paperwork and communication to general practice (GP) following death

2017 ◽  
Vol 7 (Suppl 1) ◽  
pp. A44.3-A45
Author(s):  
Juliet Carmichael ◽  
Natasha Wiggins ◽  
Joanne Droney ◽  
Jayne Wood ◽  
Edith Obogagu
Keyword(s):  
General Practice ◽  
Retrospective Analysis

scholarly journals The safety of antihypertensive drugs. Retrospective analysis of adverse reactions based on a regional database

2021 ◽  
Vol 27 (2) ◽  
pp. 216-228
Author(s):  
A. V. Matveev ◽  
A. E. Krasheninnikov ◽  
A. V. Ushakov ◽  
E. A. Egorova ◽  
A. G. Dormidor
Keyword(s):  
Calcium Channel ◽  
Retrospective Analysis ◽  
Calcium Channel Blockers ◽  
Adverse Reactions ◽  
Antihypertensive Drugs ◽  
Channel Blockers ◽  
Drug Reactions ◽  
Life Threatening ◽  
Β Blockers ◽  
Design And Methods

Objective. To analyze adverse drug reactions (ADR) occuring in patients taking antihypertensive drugs (AHD).Design and methods. We have analyzed 459 cases of ADR caused by AHD and recorded in the regional database (register) called ARCADe (Adverse Reactions in Crimea, Autonomic Database) during 2011–2018 years.Results. Out of all ADR, 304 cases (3,9 4,4 4,9 % of the total number of cases) were associated with AHD affecting renin-angiotensin-aldosterone system,101 (1,2 1,5 1,8 %) — with calcium channel blockers, and 54 cases (0,6 0,8 1,0 %) — with β-blockers. In the majority of cases, the ADRs were attributed to Enalapril (85 cases) and Amlodipine (76 cases). The analysis of the outcomes showed that serious reactions (life-threatening conditions, hospitalization, and disability) occurred in 72 cases. The remaining 387 ADRs were not considered serious. The majority of reported ADRs were unavoidable reactions of mild severity.

scholarly journals A Retrospective Analysis of Owner-reported Reasons for Canine Illness and Injury Visits in Veterinary General Practice: A List of the Top 50% of Complaints

2020 ◽  
Author(s):  
Gilbert Patterson ◽  
Michele O. Trofatter ◽  
Kathryn E. Daily-Trude ◽  
Rebecca L. Pierce ◽  
Stanley R. Robertson ◽  
...  
Keyword(s):  
General Practice ◽  
Retrospective Analysis ◽  
Care Delivery ◽  
Evidence Based ◽  
Delivery Methods ◽  
Veterinary Students ◽  
List Ranking ◽  
Veterinary Practice ◽  
One Year ◽  
Case Presentations

Abstract Background Veterinarians are required to use critical thinking and communication skills to proficiently guide a client through available options for disease treatment or management. While multiple viable approaches exist for treating common problems, data describing the actual types of owner-reported complaints most often encountered in general veterinary practices is lacking. An understanding of the nature and distribution of common conditions, as reported by the owner, is a key step in providing the evidence-based foundation directing further efforts toward solutions to overcome barriers in general practice, veterinary-care delivery. Methods A retrospective analysis of common canine owner-reported complaints presented in general veterinary practice over a one-year period was performed. Data was collected from participating practices, cleaned, and analyzed to reflect the top 50% new presenting complaints of owners at all participating practices for canine patients with an illness or injury during their visit. Results The outcome is a comprehensive list ranking the top canine owner-reported presenting illnesses/injuries complaints seen by general veterinary practices included in the study. Conclusions These results provide evidence-based knowledge of the distribution of owner complaints potentially encountered in general practice, providing justification for the need to emphasize certain clinical case presentations in veterinary educational curriculums. Being prepared with such knowledge, veterinary students can be empowered with the necessary skills and tools required to provide informed, ethical, and affordable choices for canine care in the general veterinary practice setting. This information also provides the scientific foundation for canine conditions which may benefit from additional evidence-based trials to better identify the outcomes of spectrum of care interventions for benefits to the owner, the canine, and the veterinarian.

scholarly journals Expert Approaches to the Assessment of Losartan Drugs Bioequivalence

2020 ◽  
Vol 10 (1) ◽  
pp. 51-62
Author(s):  
D. P. Romodanovsky ◽  
D. V. Goryachev
Keyword(s):  
Retrospective Analysis ◽  
Antihypertensive Drugs ◽  
Weighted Average ◽  
Individual Variability ◽  
Pharmacokinetic Parameters ◽  
Angiotensin Ii Receptor ◽  
Russian Market ◽  
Men And Women ◽  
Starting Compound

Angiotensin II receptor antagonists (ARAs) are one of the most promising classes of antihypertensive drugs. They are most widely represented on the Russian market by losartan drugs which total 24 items. Therefore, it is crucial to analyse the factors that may affect the results of comparison of generic and reference losartan drugs.The aim of the study was to perform a retrospective analysis of bioequivalence studies of generic losartan drugs in order to develop approaches to expert evaluation of research protocols and reports.Materials and methods: the retrospective analysis covered the results of 27 bioequivalence studies of losartan and included the calculation of the pharmacokinetic parameters Cmax and AUC0-t, their intra-individual variability, and the weighted average of intra-individual variability. The calculations were made for the pooled population of men and women, as well as separately for each gender.Results: the data obtained indicate borderline high variability of losartan in bioequivalence studies (for Cmax in 50 % of the studies). It was demonstrated that losartan drugs may have different pharmacokinetics in men and women in terms of Cmax and AUC0-t. The retrospective analysis of the data made it possible to formulate relevant expert approaches to evaluation of protocols and reports of bioequivalence studies of losartan drugs.Conclusions: Bioequivalence of losartan should be evaluated in three- or four-period, double crossover, two-sequence replicate design studies. The study has to determine the pharmacokinetic parameters of the starting compound and its active metabolite; the period of determination of analytes should be at least 36 hours; the washout period of 7 days is sufficient; blood sampling should be more frequent during the first hour after administration for losartan and during the first 3–4 hours for the metabolite. When determining the sample size, the weighted average of the coefficient of intra-individual variability of Cmax of losartan (33 %) should be taken into account. The bioequivalence margins for Cmax can be scaled up.

An analysis of general practice referral behaviour to psychiatric out-patient clinics

1994 ◽  
Vol 11 (4) ◽  
pp. 177-179 ◽  
Author(s):  
Teresa Carey ◽  
John Owens ◽  
Pauline Mulligan ◽  
Damien Moran
Keyword(s):  
General Practice ◽  
Retrospective Analysis ◽  
Vocational Training ◽  
Psychiatric Training ◽  
Group Practice ◽  
Referral Rates ◽  
Group Practices ◽  
Patient Variables ◽  
Referral Behaviour

AbstractObjective: The objective of this study was to analyse general practice referrals to psychiatric out-patient clinics and their relation to practice and patient variables.Method: Retrospective analysis of new episode attendances at out-patient services over a three year period was undertaken. Referring practices were examined for referral rates, single or group practice and the presence of Vocational/Psychiatric training within the practice.Results: Referral rates were similar to national rates, but were lower than other jurisdictions. There was a tendency for group practices to have lower referral rates.Conclusions: There was considerable difference between practices in referral rates. These differences were significantly related to GP vocational training.

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