scholarly journals Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women

2021 ◽  
Vol 5 (1) ◽  
pp. 13
Author(s):  
Innawati Jusup ◽  
Lusiana Batubara ◽  
Dwi Ngestiningsih ◽  
Faizah Fulyani ◽  
Devina Afraditya Paveta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Secondary Data ◽  
Reduced Form ◽  
Enzyme Linked Immunosorbent Assay ◽  
Moderate Correlation ◽  
Mineral Density ◽  
Cross Sectional

Background: Osteoporosis is one of chronic degenerative diseases especially in postmenopausal women, characterized by a decreased bone mass due to imbalance activity between osteoblasts and osteoclasts. Recently, oxidative stress is believed to play an important role in osteoporosis pathogenesis. Oxidative stress is commonly considered as the consequence of an imbalance between pro and antioxidants species, which results in damage in the affected tissue. Malondialdehyde (MDA) is frequently used as a biomarker of oxidative stress in many health problems since MDA is produced at high levels during lipid peroxidation. Meanwhile, glutathione is well known as one of antioxidant which against oxidative stress by preserving its homeostasis in the reduced form of glutathione sulfhydryl (GSH) and the oxidized form of glutathione disulphide (GSSG). This study was aimed to determine the association between MDA, GSH/GSSG ratio and bone mineral density (BMD) in postmenopausal women.Materials and method: We conducted a cross-sectional study in 40 postmenopausal women. MDA and GSH/GSSG ratio were assessed by enzyme-linked immunosorbent assay (ELISA). Bone mineral density (BMD) was obtained from secondary data. The statistical analysis was conducted using Spearman rho’s correlation test.Results: Based on the test, we didn’t found significant correlation between MDA and BMD (r=-0.054, p=0.741), but we found significant moderate correlation between GSH/GSSG ratio (r=0.436, p=0.005) and BMD in postmenopausal women. Conclusion: There was no correlation between MDA and BMD in postmenopausal women. However, there was significant moderate correlation between GSH/GSSG ratio and BMD in postmenopausal women.Keywords: MDA, GSH/GSSG ratio, BMD, osteoporosis 

scholarly journals Resistance training versus weight-bearing aquatic exercise: a cross-sectional analysis of bone mineral density in postmenopausal women

2013 ◽  
Vol 53 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Sandor Balsamo ◽  
Licia Maria Henrique da Mota ◽  
Frederico Santos de Santana ◽  
Dahan da Cunha Nascimento ◽  
Lídia Mara Aguiar Bezerra ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Resistance Training ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Aquatic Exercise ◽  
Mineral Density ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Correlation between bone mineral density and oxidative stress in postmenopausal women

2015 ◽  
Vol 19 (4) ◽  
pp. 491 ◽  
Author(s):  
Jamal Ahmad ◽  
Nishat Akhtar ◽  
Mujahid Beg ◽  
Tripti Sharma ◽  
Najmul Islam
Keyword(s):  
Oxidative Stress ◽  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
And Oxidative Stress

scholarly journals Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

2019 ◽  
Vol 12 (2) ◽  
pp. 44-49
Author(s):  
AKM Shaheen Ahmed ◽  
Wasim Md Mohosin Ul Haque ◽  
Khwaja Nazim Uddin ◽  
Fadlul Azim Abrar ◽  
Farhana Afroz ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Age Groups ◽  
Urban Hospital ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Ipth ◽  
Vitamin D Levels

Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD. Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined. Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively). Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status. IMC J Med Sci 2018; 12(2): 44-49

CROSS-SECTIONAL ASSOCIATIONS AMONG NUTRIENT INTAKES AND BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN

2001 ◽  
Vol 33 (5) ◽  
pp. S194
Author(s):  
M M. Harris ◽  
L B. Houtkooper ◽  
C Berndt ◽  
V Stanford ◽  
J Weber ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Nutrient Intakes ◽  
Cross Sectional

The Association between Bone Mineral Density and Complete Blood Count in Postmenopausal Women: A Cross-Sectional Study

2021 ◽  
Vol 104 (3) ◽  
pp. 432-437
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Study Results ◽  
The Relationship

Objective: To demonstrate the relationship between anemia and complete blood count (CBC) parameters with bone mineral density (BMD) in postmenopausal women. Materials and Methods: A cross-sectional chart-review study was conducted between November 2017 and June 2019. Three hundred twenty-four postmenopausal women aged 50 years or older who had BMD and CBC results were included in the present study. Results: The prevalence of osteopenia and osteoporosis diagnosed by T-score were 53.1% and 32.7%, respectively. Simple and multiple linear regression analyses showed that no association between CBC parameter with BMD except basophil count, which was negatively associated with BMD (p=0.011). There was no correlation between anemia and BMD status (p=0.168). Conclusion: CBC parameters such as hemoglobin or white blood cell count were not statistically correlated with BMD. This is the first study demonstrating that basophil count may be an associated factor for deceased BMD. Keywords: Postmenopausal women, Bone mineral density, Complete blood count, Basophil

scholarly journals Evaluation of postural balance in postmenopausal women and its relationship with bone mineral density- a cross sectional study

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Luciana Mendes Cangussu ◽  
Jorge Nahas-Neto ◽  
Eliana Aguiar Petri Nahas ◽  
Ana Beatriz Cesar Rodrigues Barral ◽  
Davi de Araujo Buttros ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Postural Balance ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional

scholarly journals Associations of Polyunsaturated Fatty Acid Intake with Bone Mineral Density in Postmenopausal Women

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Margaret Harris ◽  
Vanessa Farrell ◽  
Linda Houtkooper ◽  
Scott Going ◽  
Timothy Lohman
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Secondary Analysis ◽  
Mineral Density ◽  
Dietary Pufa ◽  
Cross Sectional ◽  
Pufa Intake ◽  
Total Body

A secondary analysis of cross-sectional data was analyzed from 6 cohorts (Fall 1995–Fall 1997) of postmenopausal women (n=266;56.6±4.7years) participating in the Bone Estrogen Strength Training (BEST) study (a 12-month, block-randomized, clinical trial). Bone mineral density (BMD) was measured at femur neck and trochanter, lumbar spine (L2–L4), and total body BMD using dual-energy X-ray absorptiometry (DXA). Mean dietary polyunsaturated fatty acids (PUFAs) intakes were assessed using 8 days of diet records. Multiple linear regression was used to examine associations between dietary PUFAs and BMD. Covariates included in the models were total energy intake, body weight at year 1, years after menopause, exercise, use of hormone therapy (HT), total calcium, and total iron intakes. In the total sample, lumbar spine and total body BMD had significant negative associations with dietary PUFA intake atP<0.05. In the non-HT group, no significant associations between dietary PUFA intake and BMD were seen. In the HT group, significant inverse associations with dietary PUFA intake were seen in the spine, total body, and Ward’s triangle BMD, suggesting that HT may influence PUFA associations with BMD. This study is registered with clinicaltrials.gov, identifier:NCT00000399.

scholarly journals Protective role of serum uric acid for bone loss in postmenopausal women

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 157-160
Author(s):  
Hephzibah Kirubamani N
Keyword(s):  
Bone Mineral Density ◽  
Uric Acid ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Antioxidant Properties ◽  
Density Lipoprotein ◽  
Protective Role ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score

Researchers had found that there is an association between oxidative stress and osteoporosis. Postmenopausal osteoporosis causes major public health problems. Since Uric acid has strong antioxidant properties, it will improve bone quality. This cross-sectional observational study was done to determine the association of Uric Acid and Bone Mineral Density of 75 healthy postmenopausal women who came for a master health checkup. The mean age was 60.5 years.  After ethical clearance and informed consent, women were recruited for the study at Saveetha Medical Hospital Chennai. Women with medical conditions or who were using drugs affecting bone metabolism or uric acid were excluded. Basic investigations were Hb, serum UA, blood urea, serum creatinine, serum calcium and alkaline phosphatase, blood glucose and glycosylated Hb.  Total Cholesterol, HDL, LDL, VLDL, 25 hydroxy Vitamin D were also done. Serum UA levels were graded as <3.9, 3.9–4.9, 5–6.1, and ≥6.2  mg/dl. Bone Mineral Density (BMD) was calculated with Dual Energy X-ray Absorptiometer (DXA). Osteoporosis was defined as BMD   T-score −2.5 and below. BMD with a T-score of -1  −2.5 was classified as osteopenia (WHO).  In women with high UA, there were significantly higher levels of low-density lipoprotein, and calcium, as compared to women with low UA group (p<0.05). High UA group, as compared to the low UA group, also had lower levels of high-density lipoprotein (p<0.001). Women with higher   Uric acid levels had lower BMI, lesser years of duration of Menopause and increased BMD. Serum   UA level had a positive correlation with the Lumbar BMD T score and    Right Femoral Neck BMD T Score. In UA >5.4mg/dl group Osteoporosis was nil.

scholarly journals Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density

2019 ◽  
Vol 14 ◽  
pp. 117727191984382 ◽  
Author(s):  
Fawaz Y Azizieh ◽  
Diaa Shehab ◽  
Khaled Al Jarallah ◽  
Renu Gupta ◽  
Raj Raghupathy
Keyword(s):  
Oxidative Stress ◽  
Bone Mineral Density ◽  
Superoxide Dismutase ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Serum Levels ◽  
Oxidative Stress Markers ◽  
Mineral Density ◽  
Stress Markers ◽  
And Oxidative Stress

Introduction: Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial. The aim of this study was to measure circulatory levels of these parameters in postmenopausal women with normal or low BMD. Methods: The study population included 71 postmenopausal women, of whom 25 had normal BMD, 31 had osteopenia, and 15 had osteoporosis. Serum levels of RANKL, OPG, and 5 oxidative stress markers (catalase, peroxiredoxin 2 [PRX2], superoxide dismutase 1 [SOD1], superoxide dismutase 2 [SOD2], and thioredoxin [TRx1]) were measured using the Multiplex system. Results: As compared with subjects having normal BMD, subjects with low BMD had significantly lower median serum levels of OPG, catalase, SOD2, and PRX2 ( P = .004, .031, .044, and .041 respectively). Although levels of RANKL were not different between the 2 groups, the RANKL/OPG ratio was higher in women with low BMD ( P = .027). Conclusions: These data provide insights into the possible roles of OPG, RANKL, and oxidative stress in the pathogenesis of postmenopausal osteoporosis. However, the lack of association between these markers and BMD indicates that osteoporosis is complex and multivariate.

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