Peptide-Modified Nanoparticles for Tumor Targeting and Molecular Imaging

: Nanoparticles hold great promise in tumor targeting and molecular imaging because they can co-deliver therapeutic drugs and imaging agents to the tumor site with a single entity. Nanoparticles modified with ligands against moieties overexpressed on tumor tissues have gained increasing attention due to their active targeting mechanisms. Peptides are well suited for nanoparticle targeting modifications because they are small, easy to synthesize and typically non-immunogenic. Herein, we review the peptide-modified nanoparticles used for tumor targeting therapy and molecular imaging based on the classification of peptide-targeting ligands. The development of targeting peptides and nanoparticles will also be discussed.

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Dual-Functionalized Janus Mesoporous Silica Nanoparticles with Active Targeting and Charge Reversal for Synergistic Tumor-Targeting Therapy

ACS Applied Materials & Interfaces ◽

10.1021/acsami.9b15434 ◽

2019 ◽

Vol 11 (47) ◽

pp. 44582-44592 ◽

Cited By ~ 8

Author(s):

Yajun Liu ◽

Rui Dai ◽

Qiuyu Wei ◽

Wenzhe Li ◽

Guang Zhu ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Tumor Targeting ◽

Mesoporous Silica Nanoparticles ◽

Active Targeting ◽

Charge Reversal ◽

Targeting Therapy

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Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

Current Pharmaceutical Design ◽

10.2174/1381612825666190903154847 ◽

2019 ◽

Vol 25 (37) ◽

pp. 3917-3926

Author(s):

Sajjad Molavipordanjani ◽

Seyed Jalal Hosseinimehr

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Medical Imaging ◽

Cancer Diagnosis ◽

Carbon Nanoparticles ◽

Tumor Targeting ◽

Polymeric Nanoparticles ◽

Inorganic Nanoparticles ◽

Active Targeting ◽

Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

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CNN architecture comparison for radio galaxy classification

Monthly Notices of the Royal Astronomical Society ◽

10.1093/mnras/stab325 ◽

2021 ◽

Vol 503 (2) ◽

pp. 1828-1846

Author(s):

Burger Becker ◽

Mattia Vaccari ◽

Matthew Prescott ◽

Trienko Grobler

Keyword(s):

Comparative Study ◽

Galaxy Evolution ◽

Radio Galaxy ◽

Recognition Performance ◽

Model Complexity ◽

Great Promise ◽

Radio Sources ◽

Morphological Classification ◽

Computational Performance

ABSTRACT The morphological classification of radio sources is important to gain a full understanding of galaxy evolution processes and their relation with local environmental properties. Furthermore, the complex nature of the problem, its appeal for citizen scientists, and the large data rates generated by existing and upcoming radio telescopes combine to make the morphological classification of radio sources an ideal test case for the application of machine learning techniques. One approach that has shown great promise recently is convolutional neural networks (CNNs). Literature, however, lacks two major things when it comes to CNNs and radio galaxy morphological classification. First, a proper analysis of whether overfitting occurs when training CNNs to perform radio galaxy morphological classification using a small curated training set is needed. Secondly, a good comparative study regarding the practical applicability of the CNN architectures in literature is required. Both of these shortcomings are addressed in this paper. Multiple performance metrics are used for the latter comparative study, such as inference time, model complexity, computational complexity, and mean per class accuracy. As part of this study, we also investigate the effect that receptive field, stride length, and coverage have on recognition performance. For the sake of completeness, we also investigate the recognition performance gains that we can obtain by employing classification ensembles. A ranking system based upon recognition and computational performance is proposed. MCRGNet, Radio Galaxy Zoo, and ConvXpress (novel classifier) are the architectures that best balance computational requirements with recognition performance.

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The Origin of Tumor DNA in Urine of Urogenital Cancer Patients: Local Shedding and Transrenal Excretion

Cancers ◽

10.3390/cancers13030535 ◽

2021 ◽

Vol 13 (3) ◽

pp. 535

Author(s):

Anouk E. Hentschel ◽

Rianne van den Helder ◽

Nienke E. van Trommel ◽

Annina P. van Splunter ◽

Robert A. A. van Boerdonk ◽

...

Keyword(s):

Cervical Cancer ◽

Bladder Cancer ◽

Cancer Patients ◽

Liquid Biopsy ◽

Bladder Tumor ◽

Great Promise ◽

Tumor Tissues ◽

Catheter Urine ◽

Tumor Dna ◽

Urogenital Cancers

In urogenital cancers, urine as a liquid biopsy for non-invasive cancer detection holds great promise for future clinical application. Their anatomical position allows for the local shedding of tumor DNA, but recent data indicate that tumor DNA in urine might also result from transrenal excretion. This study aims to assess the origin of tumor-associated DNA in the urine of 5 bladder and 25 cervical cancer patients. Besides natural voided urine, paired urine samples were collected in which contact with the local tumor was circumvented to bypass local shedding. The latter concerned nephrostomy urine in bladder cancer patients, and catheter urine in cervical cancer patients. Methylation levels of GHSR, SST, and ZIC1 were determined using paired bladder tumor tissues and cervical scrapes as a reference. Urinary methylation levels were compared to natural voided urine of matched controls. To support methylation results, mutation analysis was performed in urine and tissue samples of bladder cancer patients. Increased methylation levels were not only found in natural voided urine from bladder and cervical cancer patients, but also in the corresponding nephrostomy and catheter urine. DNA mutations detected in bladder tumor tissues were also detectable in all paired natural voided urine as well as in a subset of nephrostomy urine. These results provide the first evidence that the suitability of urine as a liquid biopsy for urogenital cancers relies both on the local shedding of tumor cells and cell fragments, as well as the transrenal excretion of tumor DNA into the urine.

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A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy

Scientific Reports ◽

10.1038/srep44210 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 18

Author(s):

Guoqin Chen ◽

Jinliang Li ◽

Yanbin Cai ◽

Jie Zhan ◽

Jie Gao ◽

...

Keyword(s):

Liver Tumor ◽

Tumor Targeting ◽

Glycyrrhetinic Acid ◽

Supramolecular Hydrogel ◽

Targeting Therapy

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Tumor targeting therapy using peplomycin-conjugated ST433 monoclonal antibody in nude mice

International Journal of Immunopharmacology ◽

10.1016/0192-0561(88)90232-9 ◽

1988 ◽

Vol 10 ◽

pp. 30

Author(s):

K. Shibuya ◽

T. Someno ◽

F. Abe ◽

T. Setoh ◽

S. Fukushima ◽

...

Keyword(s):

Monoclonal Antibody ◽

Nude Mice ◽

Tumor Targeting ◽

Targeting Therapy

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Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

BioMed Research International ◽

10.1155/2014/963891 ◽

2014 ◽

Vol 2014 ◽

pp. 1-13 ◽

Cited By ~ 30

Author(s):

Qiu-Lan Zhou ◽

Zhi-Yi Chen ◽

Yi-Xiang Wang ◽

Feng Yang ◽

Yan Lin ◽

...

Keyword(s):

Gene Delivery ◽

Research Progress ◽

Great Promise ◽

Blood Capillary ◽

Tumor Tissues ◽

Ultrasound Molecular Imaging ◽

Pass Through ◽

Capillary Walls

With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. Nanocarriers, with the properties of smaller particle size, and long circulation time, would be advantageous in diagnostic and therapeutic applications. Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. The mechanisms of interaction between ultrasound and nanocarriers are not clearly understood, which may be related to cavitation, mechanical effects, thermal effects, and so forth. These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers.

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