Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling - Part 3

2021 ◽  
Vol 22 (6) ◽  
pp. 412-414
Author(s):  
Rajeev K. Singla
Keyword(s):  
Secondary Metabolites ◽  
Infectious Diseases ◽  
Metabolic Profiling ◽  
Metabolic Disorders

Metabolic Profiling of Lignans and Other Secondary Metabolites from Rapeseed (Brassica napus L.)

2012 ◽  
Vol 60 (42) ◽  
pp. 10523-10529 ◽  
Author(s):  
Jingjing Fang ◽  
Michael Reichelt ◽  
Marco Kai ◽  
Bernd Schneider
Keyword(s):  
Brassica Napus ◽  
Secondary Metabolites ◽  
Metabolic Profiling ◽  
Brassica Napus L

Role of cannabinoids in various diseases: A review

2021 ◽  
Vol 23 ◽  
Author(s):  
Simran Kaur ◽  
Nikita Sharma ◽  
Arpita Roy
Keyword(s):  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Viral Infections ◽  
Cannabis Sativa ◽  
Endocannabinoid System ◽  
Psychological Disorders ◽  
Bioactive Compound ◽  
The Body ◽  
Therapeutic Aspect

Background: The plant, Cannabis sativa is heavily explored and researched with many industrial and pharmaceutical applications. The medicinal and therapeutic role of cannabis Sativa has been summarized in the paper, citing its mechanism of action and influence on the human body. Diseases like metabolic disorders, infectious diseases, and psychological disorders pose negative and long-term drastic effects on the body like neurodegeneration and other chronic system failures. Several existing literature has proved its effectiveness against such diseases. Objectives: This review aims to provide an overview of the role of cannabinoids in various diseases like metabolic disorders, infectious diseases, and psychological disorders. Method: Various e-resources like Pubmed, Science Direct, and Google Scholar were thoroughly searched and read to form a well-informed and information-heavy manuscript. Here we tried to summaries the therapeutic aspect of Cannabis sativa and its bioactive compound cannabinoids in various diseases. Result: This review highlights the various constituents which are present in Cannabis sativa, the Endocannabinoid system, and the role of cannabinoids in various diseases Conclusion: Recent research on Cannabis has suggested its role in neurodegenerative diseases, inflammation, sleep disorders, pediatric diseases, and their analgesic nature. Therefore, the authors majorly focus on the therapeutic aspect of Cannabis sativa in various diseases. The focus is also on the endocannabinoid system (ECS) and its role in fighting or preventing bacterial, parasitic, fungal, and viral infections.

Burden of chronic conditions among persons with HIV/AIDS and psychiatric comorbidity

2021 ◽  
Vol 19 ◽  
Author(s):  
Sumedha Chhatre ◽  
George Woody ◽  
David S Metzger ◽  
Ravishankar Jayadevappa
Keyword(s):  
Cardiovascular Disease ◽  
Substance Use ◽  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Psychiatric Comorbidity ◽  
Medical Expenditure ◽  
Medical Comorbidity ◽  
Medical Comorbidities ◽  
Persons Living With Hiv ◽  
Intermediate Outcomes

Background: Improved survivorship among persons living with HIV translates into higher risk of medical comorbidities. Objective : We assessed the association between intersection of physical (HIV) and mental health (psychiatric) conditions and intermediate outcomes. Methods: Cross-sectional study of Medical Expenditure Panel Survey (MEPS)-Household Component between 1996 and 2016. We created four groups for persons aged ≥18: (1) HIV + psychiatric comorbidity, (2) HIV, (3) psychiatric comorbidity, and (4) no-HIV/no-psychiatric comorbidity. We compared the burden of medical comorbidities (metabolic disorders, cardiovascular disease, cancers, infectious diseases, pain, and substance use) across groups using chi square tests. We used logistic regression to determine the association between group status and medical comorbidity. Results: Of 218,133,630 (weighted) persons aged ≥18, 0.18% were HIV-positive. Forty-three percent of HIV group and 19% of no-HIV group had psychiatric comorbidities. Half of the HIV+ psychiatric disorder group had at least one medical comorbidity. Compared to the no-HIV/no-psychiatric comorbidity group, the HIV + psychiatric comorbidity group had highest odds of medical comorbidity (OR= 3.69, 95% CI = 2.99, 4.52). Conclusion: Persons presenting with HIV + psychiatric comorbidity had higher odds of medical comorbidities of pain, cancer, cardiovascular disease, substance use, metabolic disorders and infectious diseases, beyond that experienced by persons with HIV infection or psychiatric disorders, independently. Future research will focus on the mediating effects of social determinants and biological factors on outcomes as quality of life, cost and mortality. This will facilitate a shift away from the single-disease framework and compress morbidity of the aging cohort of HIV-infected persons.

scholarly journals Gallstone disease in children and comorbiditi

2021 ◽  
Vol 66 (3) ◽  
pp. 34-39
Author(s):  
S. Yu. Matalayeva
Keyword(s):  
Metabolic Syndrome ◽  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Gallstone Disease ◽  
Comorbid Conditions ◽  
Causal Factors ◽  
Current Information ◽  
Mechanisms Of Formation ◽  
Adults And Children

The article provides current information on comorbid diseases in both adults and children with cholelithiasis. It describes their pathogenetic relationship with the formation of gallstones. The authors highlight the causal factors in the development of both gallstone disease and accompanying comorbid conditions. They demonstrate the generality of metabolic disorders in cholelithiasis and metabolic syndrome. The article describes the mechanisms of formation of both cholesterol and pigmented gallstones, which can be formed against the background of both somatic and infectious diseases. The article shows the role of drugs in the formation of gallstones. The authors substantiate the necessity of an individual approach and the development of personalized methods of prevention and treatment of cholelithiasis in children.

scholarly journals Metabolic Profiling Provides Unique Insights to Accumulation and Biosynthesis of Key Secondary Metabolites in Annual Pasture Legumes of Mediterranean Origin

Metabolites ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 267
Author(s):  
Sajid Latif ◽  
Paul A. Weston ◽  
Russell A. Barrow ◽  
Saliya Gurusinghe ◽  
John W. Piltz ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Metabolic Profiling ◽  
Mediterranean Region ◽  
Biosynthetic Pathway ◽  
Positive Association ◽  
Total Polyphenol ◽  
Pasture Legumes ◽  
Flavonoid Biosynthetic Pathway ◽  
Mediterranean Origin ◽  
Pasture Legume

Annual legumes from the Mediterranean region are receiving attention in Australia as alternatives to traditional pasture species. The current study employed novel metabolic profiling approaches to quantify key secondary metabolites including phytoestrogens to better understand their biosynthetic regulation in a range of field-grown annual pasture legumes. In addition, total polyphenol and proanthocyanidins were quantified using Folin–Ciocalteu and vanillin assays, respectively. Metabolic profiling coupled with biochemical assay results demonstrated marked differences in the abundance of coumestans, flavonoids, polyphenols, and proanthocyanidins in annual pasture legume species. Genetically related pasture legumes segregated similarly from a chemotaxonomic perspective. A strong and positive association was observed between the concentration of phytoestrogens and upregulation of the flavonoid biosynthetic pathway in annual pasture legumes. Our findings suggest that evolutionary differences in metabolic dynamics and biosynthetic regulation of secondary metabolites have logically occurred over time in various species of annual pasture legumes resulting in enhanced plant defense.

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