Participation of Maternal and Fetal CRH in Early Phases of Human Implantation: The Role of Antalarmin

2004 ◽  
Vol 4 (1) ◽  
pp. 75-78 ◽  
Author(s):  
A. Makrigiannakis ◽  
E. Zoumakis ◽  
S. Kalantaridou ◽  
G. Chrousos ◽  
A. Gravanis
Keyword(s):  
Early Phases ◽  
Human Implantation

scholarly journals The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2036 ◽  
Author(s):  
Beatriz Martínez-Poveda ◽  
José Antonio Torres-Vargas ◽  
María del Carmen Ocaña ◽  
Melissa García-Caballero ◽  
Miguel Ángel Medina ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Essential Role ◽  
Chemopreventive Agents ◽  
Angiogenic Potential ◽  
Slowing Down ◽  
Interesting Approach ◽  
The Mediterranean ◽  
Tumor Growth And Metastasis ◽  
Early Phases

Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention strategy. In this review, we focus on natural bioactive compounds derived from the main foods included in the Mediterranean diet that display anti-angiogenic activity, as well as their possible use as angiopreventive agents.

The role of the cytoskeleton in the movement and positioning of nuclei in Coprinus cinereus

1995 ◽  
Vol 73 (S1) ◽  
pp. 364-368 ◽  
Author(s):  
Takashi Kamada ◽  
Shigeru Tanabe
Keyword(s):  
Life Cycle ◽  
Immunofluorescence Microscopy ◽  
Coprinus Cinereus ◽  
Nuclear Movement ◽  
Nuclear Positioning ◽  
Mitotic Apparatus ◽  
Tubulin Mutations ◽  
Early Phases ◽  
Hyphal Apex

Coprinus cinereus exhibits conspicuous nuclear movement and precise nuclear positioning during its life cycle. Examples include transhyphal migration of nuclei in compatible mating giving rise to a dikaryon, nuclear positioning relative to the hyphal apex in the dikaryon, the close spacing in interphase and conjugate division of the two nuclei in the dikaryon, and the migration of nuclei from the basidium into developing spores. We have investigated the roles of the cytoskeleton in these processes using cytoskeleton mutants as well as fluorescence microscopy. Some of the α1- and β1-tubulin mutations examined blocked nuclear migration in dikaryosis and disturbed nuclear pairing in the dikaryon, demonstrating that microtubules are involved in these processes. The same mutations, however, did not affect the positioning of nuclei in interphase nor in conjugate division in the dikaryon, nor the migration of nuclei into the developing spores. Immunofluorescence microscopy revealed that these mutations inhibit the formation of asters of the mitotic apparatus in conjugate division, providing evidence against direct involvement of astral microtubules in nuclear movement during conjugate division. Actin was concentrated in hyphal regions where the nuclei sit in early phases of conjugate division, suggesting the involvement of actin in conjugate division. Key words: Coprinus cinereus, dikaryon, nuclear movement, microtubules, aster, actin.

See What I Mean? Analogical Objects for Knowledge Mediation in Early Phases of Cross-Industry Innovation

2021 ◽  
Author(s):  
Hilda Bø Lyng ◽  
Eric Christian Brun
Keyword(s):  
Nonverbal Communication ◽  
Visual Representations ◽  
Research Literature ◽  
Knowledge Domains ◽  
Collaborative Engagement ◽  
Epistemic Objects ◽  
Industry Sectors ◽  
Early Phases

The objective of this research is to explore the nature and role of analogies as objects for knowledge transfer in cross-industry collaborations. A case study of an organization seeking cross-industry innovation (CII) across two industry sectors was conducted, and the empirical data were analyzed qualitatively. We found that analogies used as knowledge mediation objects could be classified as explanatory or inventive, each expressed as linguistic or visual representations. Explanatory analogical objects help build prior knowledge of a foreign industry domain, thus easing later use of inventive analogical objects to identify how knowledge from one industry can be applied in another industry for innovation purposes. In these roles, the analogies serve as boundary objects. Both explanatory and inventive analogies can also serve as epistemic objects, motivating for further collaborative engagement. Visual representations of analogies help bridge the abstract with the concrete, thereby easing the process of creating analogies. They also enable nonverbal communication, thus helping bypass language barriers between knowledge domains. The reported research expands current research literature on knowledge mediation objects to the context of CII and provides added detailed understanding of the use of analogies in CII.

scholarly journals Primary care and the early phases of schizophrenia in the Czech Republic

2010 ◽  
Vol 19 (3) ◽  
pp. 243-250
Author(s):  
David Holub ◽  
Barbora Wenigová ◽  
Daniel Umbricht ◽  
Andor E. Simon
Keyword(s):  
Primary Care ◽  
Czech Republic ◽  
Warning Signs ◽  
Outpatient Services ◽  
The Czech Republic ◽  
Mental Health Reforms ◽  
Low Threshold ◽  
The City ◽  
Early Phases

SUMMARYAim– To explore knowledge, treatment setting, attitudes and needs associated with patients in early phases of psychosis among general practitioners (GPs) in Prague, andto compare results with GPs from 6 countries participating in theInternational GP Study(IGPS)on Early Psychosis(Canada, Australia, New Zealand, England, Norway,Austria).Methods– Survey questionnaires were mailed to 648 GPs in the city of Prague.Results– The response rate was 19.9%. Prague GPs showed significantly lower diagnostic knowledge of early phases of psychosis compared to their international colleagues. They frequently indicated depression/anxiety and somatic complaints as early warnings of psychosis. They more often considered their behaviour to be problematic and more commonly handed them over to specialists. The majority of Prague GPs wished specialized outpatient services for low-threshold referrals of such patients.Conclusions– Along the mental health reforms in the Czech Republic which emphasis the role of primary care, GPs' knowledge of the early warning signs of psychosis needs to be improved.Declaration of Interest:The study was supported by an unrestricted grant from Sanofi-Synthélabo SA, Switzerland, to the principal investigators of the IGPS (AES, DU). The authors have stated that there are none; all authors are independent from the funding body and the views expressed in this paper have not been influenced by the funding source.

The Development of Social Capital in Different life Cycles of Tunisian Agritourism Entrepreneur

2021 ◽  
Author(s):  
Nesrine Khazami ◽  
Zoltan Lakner
Keyword(s):  
Social Capital ◽  
Risk Analysis ◽  
Family Business ◽  
Concept Formation ◽  
Life Cycles ◽  
Remote Areas ◽  
Phases Of Development ◽  
Early Phases

Abstract The role of social capital in the early phases of development of a family business is well documented, but the dynamism of the entrepreneur's social capital in the agritourism business remains is relatively lesser studied area. The current research on an inductive, exploratory, and qualitative base aims to uncover the place and role of social capital in the establishment of agritourism enterprise, from concept formation to stabilisation. Results of the study highlight the importance of governmental help in financial and networking help for launching the enterprise especially in remote areas, where these additional activities are relatively lesser known. The role of the network is relatively weak in the risk analysis of the business. This fact enhances the vulnerability of enterprises.

scholarly journals The Role of Sketching Activities and Outcomes in Conceptual Design Phase

2019 ◽  
Vol 1 (1) ◽  
pp. 399-408
Author(s):  
Marija Nikolić ◽  
Stanko Škec ◽  
Tomislav Martinec ◽  
Nikola Horvat
Keyword(s):  
Conceptual Design ◽  
Design Process ◽  
Design Phase ◽  
Verbal Explanation ◽  
Conceptual Design Phase ◽  
Essential Form ◽  
Protocol Study ◽  
Early Phases

AbstractSketching-related activities are considered as an essential form of communication in the early phases of a design process. In the presented study, it is argued that both the sketching and the sketch-related verbalisations are reflected in the level of elaboration of the sketching outputs. Hence, a protocol study was conducted to analyse the frequencies of different sketching-related activities during team conceptual design sessions and the associated levels of elaboration for each of the sketching outputs in the form of concept drawings. The results show that although teams generate sketches of various number, complexity and clarity, there exist commonalities across the studied experiment sessions. For example, teams share a pattern of developing solutions without transformations or using lateral transformations within the first part of the sessions and using vertical transformations to produce final concepts towards the end of the sessions. Moreover, teams used associated sketch elements to start drawing new sketches and then alternated to other activities, most of all verbal explanation, for the sake of elaboration and better understanding.

The Plausibility of the Independent Origins of Canadian Pentecostalism: Winds from the North

Pneuma ◽  
2011 ◽  
Vol 33 (3) ◽  
pp. 417-425
Author(s):  
Steven M. Studebaker
Keyword(s):  
Women Leaders ◽  
The North ◽  
Global Movement ◽  
History Of ◽  
Role Of Women ◽  
Azusa Street ◽  
Early Phases

Abstract Winds from the North showcases the role of early Canadian Pentecostals in the development of the global movement. It adds to the recent polygenetic thesis that challenges the popular notion that Pentecostalism originated largely in American revival centers, principally Azusa Street, and makes the case for diverse global points of origin. Canadian Pentecostalism exhibits unique characteristics, and its leaders made seminal and independent contributions to worldwide Pentecostalism. In addition to presenting a case for the independent origins and unique features, it highlights the role of women leaders in the early phases and spotlights the history of the Oneness and the Latter Rain movements of Canadian Pentecostalism. Though a vital addition to the field of Pentecostal research, the plausibility and necessity of independent origins and autonomous characteristics of the Canadian contribution to global Pentecostalism needs examination.

Modulation of Prothrombinse Assembly and Activity by Phosphotidylethanolamine.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4207-4207
Author(s):  
Rinku Majumder ◽  
Xiaoe Liang ◽  
Mary Ann Quinn-Allen ◽  
Barry R. Lentz ◽  
William H. Kane
Keyword(s):  
Binding Sites ◽  
Conflicts Of Interest ◽  
Membrane Surface ◽  
Factor Xa ◽  
Catalytic Efficiency ◽  
Prothrombinase Complex ◽  
Factor Va ◽  
Naturally Occurring ◽  
Early Phases

Abstract Abstract 4207 Constituents of naturally occurring phospholipid membranes regulate the activity of the prothrombinase complex. In the present study we demonstrate that membranes containing phosphatidylcholine and phosphatidylethanolamine (PC:PE) bind factor Va with high affinity (Kd ∼10 nM) in the absence of phosphatidylserine (PS). These membranes support formation of a functional prothrombinase complex though thrombin generation at saturating factor Va concentrations is reduced approximately 60-70% compared to membranes containing 5% or more PS. The presence of PE markedly enhances the catalytic efficiency of the prothrombinase complex on membranes containing 1% PS with only modest effects on membranes containing 5% or more PS. The effect of PE on factor Va membrane binding appears to be due to direct interactions between PE and factor Va rather than to changes in membrane surface packing. Finally, we find that soluble C6PE is able to bind to factor Va (Kd ∼6.5 uM) and factor Xa (Kd ∼ 91 uM). We also show that soluble C6PE is able to stimulate formation of a partially active factor Va-factor Xa complex capable of catalyzing conversion of prothrombin to thrombin in the absence of a membrane surface. We further demonstrate that C6PE and C6PS binding sites in factor Xa are linked, as binding of one lipid enhances the binding and activity of the other. These findings provide important new insights into the role of PE in assembly of the prothrombinase complex that are relevant to understanding the activity of factor Xa on the surface of platelets particularly in the early phases of hemostasis when the concentration of PS may be limiting. Disclosures: No relevant conflicts of interest to declare.

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