Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams

2016 ◽  
Vol 16 (15) ◽  
pp. 1727-1739 ◽  
Author(s):  
Guangtao Zhang ◽  
Wenjun Zhang ◽  
Subhasish Saha ◽  
Changsheng Zhang
Keyword(s):  
Genome Mining ◽  
Recent Advances

scholarly journals Epsilon-poly-L-lysine: Recent Advances in Biomanufacturing and Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Liang Wang ◽  
Chongyang Zhang ◽  
Jianhua Zhang ◽  
Zhiming Rao ◽  
Xueming Xu ◽  
...  
Keyword(s):  
Industrial Waste ◽  
Genome Mining ◽  
Process Engineering ◽  
Polymerization Degree ◽  
Future Perspectives ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Wild Strains ◽  
Purification Methods ◽  
Pharmaceutical Industries

ε-poly-L-lysine (ε-PL) is a naturally occurring poly(amino acid) of varying polymerization degree, which possesses excellent antimicrobial activity and has been widely used in food and pharmaceutical industries. To provide new perspectives from recent advances, this review compares several conventional and advanced strategies for the discovery of wild strains and development of high-producing strains, including isolation and culture-based traditional methods as well as genome mining and directed evolution. We also summarize process engineering approaches for improving production, including optimization of environmental conditions and utilization of industrial waste. Then, efficient downstream purification methods are described, including their drawbacks, followed by the brief introductions of proposed antimicrobial mechanisms of ε-PL and its recent applications. Finally, we discuss persistent challenges and future perspectives for the commercialization of ε-PL.

scholarly journals Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1541 ◽  
Author(s):  
Luo ◽  
Dong
Keyword(s):  
Natural Products ◽  
Molecular Basis ◽  
Enzyme Catalysis ◽  
Cyclic Peptides ◽  
Genome Mining ◽  
Review Article ◽  
Biosynthetic Pathways ◽  
Biosynthetic Enzyme ◽  
Recent Advances ◽  
Modified Peptides

Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. This review article presents recent advances in the discovery of eukaryotic RiPP natural products, the elucidation of their biosynthetic pathways, and the molecular basis for their biosynthetic enzyme catalysis.

scholarly journals Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Meng Zhang ◽  
Liyuan Kong ◽  
Rong Gong ◽  
Marianna Iorio ◽  
Stefano Donadio ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Synthetic Biology ◽  
Plant Protection ◽  
Biological Activities ◽  
Genome Mining ◽  
Nucleoside Antibiotics ◽  
Future Developments ◽  
Recent Advances ◽  
Microbial Natural Products ◽  
Epidemic Diseases

AbstractEpidemic diseases and antibiotic resistance are urgent threats to global health, and human is confronted with an unprecedented dilemma to conquer them by expediting development of new natural product related drugs. C-nucleoside antibiotics, a remarkable group of microbial natural products with diverse biological activities, feature a heterocycle base linked with a ribosyl moiety via an unusual C-glycosidic bond, and have played significant roles in healthcare and for plant protection. Elucidating how nature biosynthesizes such a group of antibiotics has provided the basis for engineered biosynthesis as well as targeted genome mining of more C-nucleoside antibiotics towards improved properties. In this review, we mainly summarize the recent advances on the biosynthesis of C-nucleoside antibiotics, and we also tentatively discuss the future developments on rationally accessing C-nucleoside diversities in a more efficient and economical way via synthetic biology strategies.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

Recent Advances in the Treatment of Pulmonary Tuberculosis

1950 ◽  
Vol 34 (5) ◽  
pp. 1363-1380
Author(s):  
Theodore L. Badger ◽  
William E. Patton
Keyword(s):  
Pulmonary Tuberculosis ◽  
Recent Advances
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