Review of the Phytochemistry and Biological Activity of Cissus incisa Leaves

2021 ◽  
Vol 21 ◽  
Author(s):  
Deyani Nocedo-Mena ◽  
Adrián Alejandro Galván-Rodrigo ◽  
Colin W. Wright ◽  
Pierluigi Caboni
Keyword(s):  
Biological Activities ◽  
Resistant Bacteria ◽  
Fusion Model ◽  
Medicinal Uses ◽  
Drug Resistant Bacteria ◽  
Biological Studies ◽  
Review Reports ◽  
The One ◽  
Fatty Acyls ◽  
Synthetic Derivatives

Background: Cissus incisa is a Vitaceae with pantropical distribution. In northern Mexico its leaves have traditionally been used to treat skin infections, abscesses and tumors. Despite its medicinal uses, few studies are reported. Objective: To summarize the phytochemical and biological studies carried out so far on the leaves of C. incisa, since this part of the plant is the one frequently used, and awaken scientific interest towards the plant. Method: Since C. incisa was an undocumented species, most of the information comes from reports of our research group. Databases, books, and websites were also consulted. The information collected was organized and presented in a synthesized way. Plant name was checked with the database “The Plant List”. Results: 171, 260, and 114 metabolites were identified by UHPLC-QFTOF-MS in the hexane, chloroform/methanol, and aqueous extracts, respectively. Fatty acyls, sphingolipids, sterols, glycerolipids, prenol lipids, and terpenes are common metabolites found in these extracts. 2-(2´-hydroxydecanoyl amino)-1,3,4-hexadecanotriol-8-ene, 2,3-dihydroxypropyl tetracosanoate, β-sitosterol, β-sitosterol-D-glucopyranoside, α-amyrin-3-O-β-D-glucopyranoside were also isolated and characterized. Extracts, phytocompounds and semi-synthetic derivatives showed antimicrobial activity against multi-drug resistant bacteria, and various cancer cell lines. Results from Perturbation-Theory-Machine Learning-Information-Fusion model (PTMLIF), molecular docking, and vesicular contents assay identified potential targets on cell membrane, suggesting an antibacterial mechanism of action for ceramides from C. incisa leaves. Conclusion: This review reports the efforts of the scientific community in authenticating species used in traditional medicine. Moreover, it gives a compendium of phytochemistry and the biological activities of the components from C. incisa leaves.

scholarly journals AN OVERVIEW OF MEDICINAL VALUE OF CURCUMA SPECIES

2018 ◽  
Vol 11 (12) ◽  
pp. 40 ◽  
Author(s):  
Vanita Kanase ◽  
Farha Khan
Keyword(s):  
Southern China ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Traditional Use ◽  
Medicinal Uses ◽  
Medicinal Value ◽  
The Pacific ◽  
The Family ◽  
The One ◽  
Diabetic Wounds

Curcuma is a genus of about 100 accepted species in the family Zingiberaceae that contains such species as turmeric and Siam tulip. They are native to Southeast Asia, southern China, ISSN (Online): 2319-7064 ISSN (Online): 2319-7064 naturalized in other warm parts of the world such as Tropical Africa, Central America, Florida, and various islands of the Pacific, Indian, and Atlantic Oceans. Few known species of Curcuma with reported pharmacological activity are Curcuma longa, Curcuma aeruginosa, Curcuma pseudomontana, Curcuma aromatica, Curcuma xanthorrhiza, Curcuma zedoaria, Curcuma angustifolia. Among them, C. longa is the one species extensively studied and has ancient traditional medicinal uses. These Curcuma species have been used in traditional medicine as a household remedy for various diseases, including biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. For the past few decades, extensive work has been done to establish the biological activities and pharmacological actions of Curcuma species and its extracts. This review article is created with an intention to give an overview on the reported research carried out on the Curcuma species such as anticancer activity, antitumor, antitubercular, antibacterial, antimicrobial, toxicity activity, and wound healing. And also, these Curcuma species can be considered as herbal medicinal plant having a plethora of research opportunities based on its traditional use and biological activity.

scholarly journals Comparison between Biological Activities of Commercial and Synthesized Carbon Nanotubes by Flame Fragments Deposition Technique

2019 ◽  
Vol 16 (4) ◽  
pp. 0878 ◽  
Author(s):  
Alwindawi Et al.
Keyword(s):  
Carbon Nanotubes ◽  
Standard Sample ◽  
Biological Activities ◽  
Resistant Bacteria ◽  
Liquefied Petroleum Gas ◽  
Standard Samples ◽  
Pharmaceutical Application ◽  
Drug Resistant Bacteria ◽  
Different Types

Carbon nanotubes (CNTs) were synthesized via liquefied petroleum gas (LPG) as precursor using flame fragments deposition (FFD) technique. In vitro, biological activates of carbon nanotubes (CNTs) synthesized by FFD technique were investigated. The physiochemical characterizations of synthesized CNTs are similar to other synthesized CNTs and to the standard sample. Pharmaceutical application of synthesized CNTs was studied via conjugation and adsorption with different types of medicines as promote groups. The conjugation of CNTs was performed by adsorption the drugs such as sulfamethoxazole (SMX) and trimethoprim (TMP) on CNTs depending on physical properties of both bonded parts. The synthesized CNTs almost have the same performance in antibiotic activity compared with standard sample of CNTs (commercial CNTs).The products were effective antibiotic in the treatment as resistant bacteria, may higher concentration of CNTs would have antibacterial activity on multi-drug resistant bacteria such as Acinetobacter and also on resistant E.coli. The bioactivity synthesized and standard samples of CNTs were almost the same against different types of bacteria.

scholarly journals Green Synthesis of Metal Nanoparticles for Antimicrobial Activity

2020 ◽  
Author(s):  
Jerushka S. Moodley ◽  
Suresh Babu Naidu Krishna ◽  
Karen Pillay ◽  
Patrick Govender
Keyword(s):  
Targeted Delivery ◽  
Biological Activities ◽  
Underlying Mechanism ◽  
Antimicrobial Activities ◽  
Therapeutic Agents ◽  
Health Concern ◽  
Resistant Bacteria ◽  
Human Pathogens ◽  
Drug Resistant Bacteria ◽  
Recent Developments

The development and extensive spread of multi-drug resistant bacteria are considered as a major public health concern. Failures to control severe infections due to antibiotic resistance have augmented healthcare costs as well as patient morbidity and mortality. Presently, natural product-based therapeutics are gaining significant attention both for their antimicrobial effectiveness and for not persuading drug resistance. Furthermore, recent developments in nanoscience on new drug delivery systems built on nanostructured materials from plants and microbes have emerged which focus on targeted delivery and controlled release of therapeutic agents. This review examines the recent investigations on the biological activities of plant and bacterial biological material for silver nanoparticle (AgNP) synthesis. Also, the underlying mechanism of antimicrobial activities of silver nanoparticles against human pathogens will be discussed. A fact of the biological activities and/or chemical responses of plants is required, not only for the discovery of new therapeutic agents, but because such evidence may be of value in disclosing new sources of already known biologically active compounds.

scholarly journals Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

2019 ◽  
Vol 68 (3) ◽  
pp. 309-316 ◽  
Author(s):  
AFAF SAKHRI ◽  
NOREDDINE KACEM CHAOUCHE ◽  
MARIA ROSARIA CATANIA ◽  
ALBERTO RITIENI ◽  
ANTONELLO SANTINI
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Inhibition Zone ◽  
Resistant Bacteria ◽  
Antioxidant Compounds ◽  
Scavenging Effect ◽  
Drug Resistant Bacteria ◽  
High Level ◽  
Promising Source

Among the species belonging to the Aspergillus section Versicolores, Aspergillus creber has been poorly studied and still unexplored for its biological activities. The present study was undertaken to analyze A. creber extract and to evaluate its in vitro antimicrobial and antioxidant activities. UHPLC-MS/MS analysis of A. creber extract allowed the characterization of five known fungal metabolites including: asperlactone, emodin, sterigmatocystin, deoxybrevianamide E, and norsolorinic acid. The highest antimicrobial activity was displayed against Candida albicans, with a mean strongest inhibition zone of 20.6 ± 0.8 mm, followed by Gram-positive drug-resistant bacteria. The MIC values of A. creber extract varied from 0.325 mg/ml to 5 mg/ml. A. creber extract was shown a potent antioxidant activity and a high level of phenolic compounds by recording 89.28% scavenging effect for DPPH free radical, 92.93% in ABTS assay, and 85.76 mg gallic acid equivalents/g extract in Folin-Ciocalteu assay. To our knowledge, this is the first study concerning biological and chemical activities of A.creber species. Based on the obtained results, A.creber could be a promising source of natural antimicrobial and antioxidant compounds.

scholarly journals Prenylated Flavonoids with Potential Antimicrobial Activity: Synthesis, Biological Activity, and In Silico Study

2021 ◽  
Vol 22 (11) ◽  
pp. 5472
Author(s):  
Mauricio Osorio ◽  
Marcela Carvajal ◽  
Alejandra Vergara ◽  
Estefania Butassi ◽  
Susana Zacchino ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Biological Activities ◽  
Pathogenic Fungi ◽  
Resistant Bacteria ◽  
Prenylated Flavonoids ◽  
Atp Binding Cassette Transporter ◽  
Drug Resistant Bacteria ◽  
In Silico Study

Prenylated flavonoids are an important class of naturally occurring flavonoids with important biological activity, but their low abundance in nature limits their application in medicines. Here, we showed the hemisynthesis and the determination of various biological activities of seven prenylated flavonoids, named 7–13, with an emphasis on antimicrobial ones. Compounds 9, 11, and 12 showed inhibitory activity against human pathogenic fungi. Compounds 11, 12 (flavanones) and 13 (isoflavone) were the most active against clinical isolated Staphylococcus aureus MRSA, showing that structural requirements as prenylation at position C-6 or C-8 and OH at positions C-5, 7, and 4′ are key to the antibacterial activity. The combination of 11 or 12 with commercial antibiotics synergistically enhanced the antibacterial activity of vancomycin, ciprofloxacin, and methicillin in a factor of 10 to 100 times against drug-resistant bacteria. Compound 11 combined with ciprofloxacin was able to decrease the levels of ROS generated by ciprofloxacin. According to docking results of S enantiomer of 11 with ATP-binding cassette transporter showed the most favorable binding energy; however, more studies are needed to support this result.

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