A Review of Medicinal Uses, Phytochemistry and Biological Activities of Markhamia tomentosa

2020 ◽  
Vol 10 (4) ◽  
pp. 140-147
Author(s):  
Alfred Maroyi ◽  
Keyword(s):  
Biological Activities ◽  
Medicinal Uses

scholarly journals Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olumide Samuel Fadahunsi ◽  
Peter Ifeoluwa Adegbola ◽  
Olubukola Sinbad Olorunnisola ◽  
Temitayo Idris Subair ◽  
David Oluwasegun Adepoju ◽  
...  
Keyword(s):  
Tropical Rainforest ◽  
Biological Activities ◽  
Folk Medicine ◽  
Sub Saharan Africa ◽  
Phytochemical Analysis ◽  
Menstrual Pain ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Intestinal Worms ◽  
Sub Saharan

Abstract Background Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae) is a tropical rainforest tree commonly found in sub-Saharan region of Africa. It is a useful and very popular plant among the locals due to the outstanding anti-diabetic activity of the seeds. Methods A comprehensive literature search on articles published on phytochemical analysis and various pharmacological activities of Hunteria umbellate was carried out using search engines such as Google Scholar, PubMed and Science Direct. Results In this review, it was deduced that H. umbellate is employed in folk medicine as an elixir for obesity, fever, leprosy sores, menstrual pain, infertility, yaws, intestinal worms, abdominal discomfort and stomach ache. Due to their durability and immunity against termites, the stems are coveted and desired as timbers in the construction of houses, while the bark has been reportedly exported to Europe for medicinal uses. Pharmacological activities such as fertility enhancing, aphrodisiac, hypoglycemic, anti-inflammatory, has been ascribed to the different morphological organs of H. umbellate. Moreover, compounds belonging to important classes of secondary metabolites with biological activities such as triterpenoids, flavonoids, tannins, alkaloids, quinic acids have been identified and characterized from the plant. Conclusion From this review, it can be inferred that, numerous and bioactive principles with known biological usefulness are present in the extracts of H. umbellate and might be responsible for the observed biological and pharmacological activities.

scholarly journals GC-MS Assisted Phytoactive Chemical Compounds Identification and Profiling with Mineral Constituents from Biologically Active Extracts of Aerva javanica (Burm. f) Juss. ex Schult.

2018 ◽  
Vol 46 (2) ◽  
pp. 517-524
Author(s):  
Kandhan KARTHISHWARAN ◽  
Subban KAMALRAJ ◽  
Chelliah JAYABASKARAN ◽  
Shyam S. KURUP ◽  
Sabitha SAKKIR ◽  
...  
Keyword(s):  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Biologically Active ◽  
Scavenging Activity ◽  
Medicinal Uses ◽  
Chemical Structures ◽  
Aerial Parts ◽  
Mineral Constituents

Aerva javanica (Burm. f) Juss. ex Schult. (Family: Amaranthaceae) family is one of the traditional medicinal plant growing in the United Arab Emirates. Apart from studies related to some medicinal properties, phytochemical, GC MS compound characterization and biological activities still to be investigated. An experiment was conducted to determine the possible bioactive components with their chemical structures and elucidation of phytochemicals from the aerial parts of the plant. The macro and micro-mineral constituents and antioxidant activities were also evaluated. Aerial parts of A. javanica were extracted sequentially with hexane, chloroform, ethyl acetate, acetone, methanol by cold percolation method. Free radical scavenging and antioxidant properties of methanolic extract were evaluated by using in vitro antioxidant assays such as hydroxyl radical scavenging activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, superoxide radical scavenging activity and ABTS radical scavenging activity. Primary phytochemical and micro-macro element was tested using standard protocol. The chemical characterization was done with the help of Gas Chromatography-Mass Spectrometry (GC–MS), and the mass spectra of the total compounds in the extract were matched with the National Institute of Standard and Technology (NIST) library. Mineral constituents were identified and estimated by ICP-OES. Ninety-nine metabolites were obtained by GC-MS anslysis; indole was found to be major components followed by 2-Chlorallyl diethyldithiocarbamate (CDEC), Carbaril, Bis(2-ethylhexyl) phthalate, Quinoline, 4H-Cyclopenta[def]phenanthrene,2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide, Phenobarbital, 1H-Indole, 2-methyl-, 2,3,7,8-Tetrachlorodibenzo-p-dioxin Disulfide, diphenyl. The presence of various bioactive compounds in the extract validates the traditional medicinal uses of this plant.

Ethnopharmacology, pharmacological activities, and chemistry of the Hypericum genus

2021 ◽  
Vol 10 (2) ◽  
pp. 105-113
Author(s):  
Omambia Mokoro Vincent ◽  
◽  
Joseph Mwanzia Nguta ◽  
Eric Simon Mitema ◽  
Fredrick Mutie Musila ◽  
...  
Keyword(s):  
Plant Species ◽  
Biological Activities ◽  
Mild Depression ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Phytochemical Composition ◽  
Depth Analysis ◽  
Microbial Infections ◽  
Safety Studies ◽  
Hypericum Species

There are over 500 species in the Hypericum genus worldwide. Crude extracts from Hypericum species have been reported in folkloric medicine as analgesics, anthelmintics, astringents, antidepressants, diuretics, and anti-inflammatories. The current review aims to provide an in-depth analysis of local uses, pharmacological activities, and phytochemical composition of different extracts generated from Hypericum species. The review data was collected via literature search from Google, Google Scholar, Medline, Pubmed, Mendeley, Science Direct, Chemical Abstracts, Web of Science, and Scopus. The most studied of the entire Hypericum genus is H. perforatum, approved to manage mild depression. Other species that have been reported to have ethnomedicinal value are H. erectum, H. monogynum, H. attenuatum, H. japonicum, H. beanii, H. monantheum, H. wightianum, H. scabrum, H. monogynum, H. monogynum, H. geminiflorum, H. ascyron, H. seniawinii, H. elodeoides, H. petiolulatum, H. wightianum, H. hengshanense, H. japonicum, and H. revolutum. Over 900 phytochemicals have been isolated from the Hypericum genus plant species, mostly phenolics, and terpenoids. Studies have been carried out to validate the ethnopharmacological use of extracts from Hypericum species against depression, cancer, inflammation, and microbial infections. There are limited safety studies involving medicinal plants from the Hypericum genus; however,further investigations on toxic effects, phytochemical composition, and biological activities are necessary to validate the medicinal uses of plant species of the Hypericum genus empirically. The present article reviews ethnopharmacology, phytochemistry, and toxicology of the Hypericum genus, which several communities have used to treat various conditions.

scholarly journals HELICHRYSUM LONGIFOLIUM AND HELICHRYSUM PEDUNCULATUM: A COMPARATIVE ANALYSIS OF THEIR MEDICINAL USES, CHEMISTRY AND BIOLOGICAL ACTIVITIES

2019 ◽  
pp. 41-46
Author(s):  
ALFRED MAROYI
Keyword(s):  
Biological Activities ◽  
Herbal Medicines ◽  
Pharmaceutical Products ◽  
Medicinal Uses ◽  
Additional Information ◽  
Medicinal Use ◽  
Need To Evaluate ◽  
History Of ◽  
Cytotoxicity Activities ◽  
The University

Helichrysum longifolium and Helichrysum pedunculatum have a long history of medicinal use, particularly managing wounds acquired during male circumcision rites in South Africa. There is a need to evaluate the existence of any correlation between the ethnomedicinal applications, the phytochemistry and pharmacological properties of the species. Therefore, in this review, analyses of the botanical, medicinal, and chemical and biological activities of H. longifolium and H. pedunculatum are presented as well as exploring the potential of the two species as important sources of health and pharmaceutical products. Information on the botany, medicinal uses, and phytochemistry and biological activities of H. longifolium and H. pedunculatum was assembled from several internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, PubMed, SciFinder, and BMC. Additional information was sourced from journal articles, scientific reports, theses, books, and book chapters obtained from the University library. This study showed that alkaloids, flavonoids, linoleic acid, oleic acid, phenol, proanthocyanidin, saponins, and tannins have been identified from the leaves of H. longifolium and H. pedunculatum. The pharmacological research showed that H. longifolium and H. pedunculatum extracts and compounds isolated from the species have antibacterial, antifungal, anti-inflammatory, antioxidant, antiplasmodial, antiprotozoal, and cytotoxicity activities. For local communities to use H. longifolium and H. pedunculatum extracts with confidence as herbal medicines, there is a need for extensive phytochemical and pharmacological studies. Further research is required to establish the safety profiles of different H. longifolium and H. pedunculatum preparations.

scholarly journals LANNEA DISCOLOR: ITS BOTANY, ETHNOMEDICINAL USES, PHYTOCHEMISTRY, AND PHARMACOLOGICAL PROPERTIES

2018 ◽  
Vol 11 (10) ◽  
pp. 49 ◽  
Author(s):  
Alfred Maroyi
Keyword(s):  
Health Care ◽  
Biological Activities ◽  
Health Care Systems ◽  
Pharmacological Properties ◽  
Medicinal Uses ◽  
Gastrointestinal Problems ◽  
Organic Extracts ◽  
Care Systems ◽  
The University ◽  
Ethnomedicinal Uses

Lannea discolor is an important component of the traditional, complementary, and alternative medicine health-care systems in several countries. This study is aimed at reviewing the botany, ethnomedicinal uses, phytochemical and biological activities of L. discolor. Information on its botany, medicinal uses, chemistry and pharmacological properties was undertaken using electronic databases such as Pubmed, SCOPUS, Medline, SciFinder, ScienceDirect, Google Scholar, EThOS, ProQuest, OATD and Open-thesis. Pre-electronic literature was sourced from the University Library. The species is used as herbal medicine for 24 human diseases. The major diseases and ailments treated using concoctions prepared from L. discolor include gastrointestinal problems, gonorrhea, infertility in women, convulsions, dizziness, injury, and wounds. Different aqueous and organic extracts of L. discolor exhibited anthelmintic, antibacterial, antimycobacterial, antifungal, antioxidant, antiplasmodial, and nematicidal activities. Detailed studies on the phytochemistry, pharmacological, and toxicological properties of L. discolor are required to correlate the medicinal uses of the species with its phytochemistry and pharmacological properties.

scholarly journals A Deep Learning-Based Approach for Identifying the Medicinal Uses of Plant-Derived Natural Compounds

2020 ◽  
Vol 11 ◽  
Author(s):  
Sunyong Yoo ◽  
Hyung Chae Yang ◽  
Seongyeong Lee ◽  
Jaewook Shin ◽  
Seyoung Min ◽  
...  
Keyword(s):  
Deep Learning ◽  
Large Scale ◽  
Natural Compound ◽  
Biological Activities ◽  
Natural Compounds ◽  
Model Potential ◽  
Medicinal Uses ◽  
Large Scale Analysis ◽  
Investigational Drugs

Medicinal plants and their extracts have been used as important sources for drug discovery. In particular, plant-derived natural compounds, including phytochemicals, antioxidants, vitamins, and minerals, are gaining attention as they promote health and prevent disease. Although several in vitro methods have been developed to confirm the biological activities of natural compounds, there is still considerable room to reduce time and cost. To overcome these limitations, several in silico methods have been proposed for conducting large-scale analysis, but they are still limited in terms of dealing with incomplete and heterogeneous natural compound data. Here, we propose a deep learning-based approach to identify the medicinal uses of natural compounds by exploiting massive and heterogeneous drug and natural compound data. The rationale behind this approach is that deep learning can effectively utilize heterogeneous features to alleviate incomplete information. Based on latent knowledge, molecular interactions, and chemical property features, we generated 686 dimensional features for 4,507 natural compounds and 2,882 approved and investigational drugs. The deep learning model was trained using the generated features and verified drug indication information. When the features of natural compounds were applied as input to the trained model, potential efficacies were successfully predicted with high accuracy, sensitivity, and specificity.

scholarly journals A REVIEW OF BOTANY, THERAPEUTIC VALUE, PHYTOCHEMISTRY, AND PHARMACOLOGY OF CUSSONIA PANICULATA

2019 ◽  
pp. 1-6
Author(s):  
ALFRED MAROYI
Keyword(s):  
Herbal Medicine ◽  
Skin Diseases ◽  
Intestinal Parasites ◽  
Biological Activities ◽  
Triterpene Glycosides ◽  
Future Research ◽  
Steroidal Saponin ◽  
Scientific Publications ◽  
Triterpenoid Saponins ◽  
Medicinal Uses

Cussonia paniculata is a small tree widely used as herbal medicine throughout its distributional range in southern Africa. This study is aimed at providing a critical review of the botany, biological activities, phytochemistry, and medicinal uses of C. paniculata. Documented information on the botany, biological activities, medicinal uses, and phytochemistry of C. paniculata was collected from several online sources which included BMC, Scopus, SciFinder, Google Scholar, Science Direct, Elsevier, PubMed, and Web of Science. Additional information on the botany, biological activities, phytochemistry, and medicinal uses of C. paniculata was gathered from pre-electronic sources such as book chapters, books, journal articles, and scientific publications sourced from the University library. This study showed that the bark, fruits, leaves, roots, and stems of C. paniculata are used as emetic, immune booster, and herbal medicine for dysmenorrhea, intestinal parasites and worms, mental problems, boils, shingles and skin diseases, indigestion and stomach complaints, sores, and wounds. Phytochemical compounds identified from the leaves of C. paniculata include acetylated triterpene glycosides, unacetylated triterpene glycosides, flavonoid, steroidal saponin, and triterpenoid saponins. Pharmacological research revealed that C. paniculata extracts have analgesic, antibacterial, anticancer, anti-inflammatory, antiplasmodial, antiprotozoan, Aβ42 protein reduction, and cytotoxicity activities. Future research should focus on evaluating the phytochemical, pharmacological, and toxicological properties of C. paniculata crude extracts as well as compounds isolated from the species.

scholarly journals PHARMACOLOGICAL IMPORTANCE OF MORINGA CONCANENSIS NIMMO LEAF: AN OVERVIEW

2019 ◽  
pp. 27-31
Author(s):  
AMERENDRA SINGH ◽  
JAI NARAYAN MISHRA ◽  
SANTOSH KUMAR SINGH
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
Medicinal Uses ◽  
Plant Life ◽  
Crude Extracts ◽  
The Future ◽  
Anti Inflammatory ◽  
Scientific Facts

In the current years, the use of traditional medicine is increasing and gaining popularity. The extracts of Moringa concanensis Nimmo leaves have reported many medicinal uses. In the previous few decades, a massive quantity of scientific facts concerning plants, crude extracts, and quite a number supplies from plant life as medicinal dealers has come to light. M. concanensis is a plant whose components are oftentimes used in the medicinal treatments. There are good sized anecdotal facts about the organic undertaking of M. concanensis which includes anticancerous, antibacterial, antifungal, analgesic, and anti-inflammatory type of activities. The leaves of M. concanensis had been located to contain a higher quantity of triterpenoids and flavonoids. The existing assessment includes the phytochemical, ethnopharmacological, and pharmacological reviews of M. concanensis. The future scope of the plant has been emphasized with a view to isolate bioactive moieties which should be used for multifarious biological activities.

A Review on Annona squamosa L.: Phytochemicals and Biological Activities

2017 ◽  
Vol 45 (05) ◽  
pp. 933-964 ◽  
Author(s):  
Chengyao Ma ◽  
Yayun Chen ◽  
Jianwei Chen ◽  
Xiang Li ◽  
Yong Chen
Keyword(s):  
Biological Activities ◽  
Fruit Tree ◽  
Research Projects ◽  
Annona Squamosa ◽  
Annonaceous Acetogenins ◽  
Medicinal Uses ◽  
Wide Range ◽  
History Of ◽  
Anti Oxidant ◽  
Available Information

Annona squamosa L. (Annonaceae) is a fruit tree with a long history of traditional uses. A. squamosa is an evergreen plant mainly located in tropical and subtropical regions. Srikayas, the fruits of A. squamosa, are extensively used to prepare candies, ice creams and beverages. A wide range of ethno-medicinal uses has been related to different portions of A. squamosa, such as tonic, apophlegmatisant, cool medicine, abortient and heart sedative. Numerous research projects on A. squamosa have found that it has anticancer, anti-oxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidel and molluscicidal activities. Phytochemistry investigations on A. squamosa have considered annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs) and cyclopeptides (CPs) as the main constituents. Until 2016, 33 DITs, 19 ALKs, 88 ACGs and 13 CPs from this species were reported. On the basis of the multiple researches on A. squamosa, this review strives to integrate available information on its phytochemicals, folklore uses and bioactivities, hoping to promote a better understanding of its medicinal values.

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