scholarly journals Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

Lubricants ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 15
Author(s):  
Valentin L. Popov ◽  
Aleksandr M. Poliakov ◽  
Vladimir I. Pakhaliuk
Keyword(s):  
Treatment Effectiveness ◽  
Developed Countries ◽  
Operating Conditions ◽  
World Health ◽  
Pharmacological Agents ◽  
Synovial Joints ◽  
Wide Range ◽  
Fundamental Research ◽  
Serious Disease ◽  
Health Organization

Synovial joints are unique biological tribosystems that allow a person to perform a wide range of movements with minimal energy consumption. In recent years, they have been increasingly called “smart friction units” due to their ability to self-repair and adapt to changing operating conditions. However, in reality, the elements of the internal structure of the joints under the influence of many factors can degrade rather quickly, leading to serious disease such as osteoarthritis. According to the World Health Organization, osteoarthritis is already one of the 10 most disabling diseases in developed countries. In this regard, at present, fundamental research on synovial joints remains highly relevant. Despite the fact that the synovial joints have already been studied fully, many issues related to their operating, prevention, development of pathology, diagnosis and treatment require more detailed consideration. In this article, we discuss the urgent problems that need to be solved for the development of new pharmacological agents, biomaterials, scaffolds, implants and rehabilitation devices for the prevention, rehabilitation and improvement of the treatment effectiveness of synovial joints at various stages of osteoarthritis.

The impact of SARS-Cov-2 on the Nervous system and Mental Health

2021 ◽  
Vol 19 ◽  
Author(s):  
Mohamed Said Boulkrane ◽  
Victoria Ilina ◽  
Roman Melchakov ◽  
Mikhail Arisov ◽  
Julia Fedotova ◽  
...  
Keyword(s):  
Mental Health ◽  
Respiratory Illness ◽  
World Health ◽  
Current Review ◽  
Wide Range ◽  
Serious Disease ◽  
Health Organization ◽  
The Impact ◽  
The Brain ◽  
Severe Acute Respiratory Illness

: The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness. The possible damages on the brain should be considered, too.

Effects of grain size on the performance of brake linings with Al2O3 additives

2021 ◽  
Vol 63 (9) ◽  
pp. 822-828
Author(s):  
Faruk Karaca ◽  
İlhan Can
Keyword(s):  
Developed Countries ◽  
Operating Conditions ◽  
World Health ◽  
International Labor Organization ◽  
Negative Effects ◽  
Material Content ◽  
Mechanical And Tribological Properties ◽  
Surface Areas ◽  
Lining Material ◽  
Health Organization

Abstract International organizations such as the World Health Organization (WHO) and the International Labor Organization (ILO) have called for an end to the use of asbestos and its derivatives in all sectors, primarily due to the negative effects on human and environmental health. For this reason, manufacturing and use of asbestos linings are also prohibited in most developed countries. For this purpose, there are many studies in the literature on the development and research of nonasbestos linings. In the literature, topics such as material content, production, cost, braking performances and mechanical properties of composite linings are commonly encountered. With the technology in the developing world, the working conditions of vehicle elements are getting more difficult. For this reason, during braking, the amount of energy required to be damped against the unit area in the pad surfaces increases, and since the lining surface areas get smaller, the operating temperatures exceed the limits of the material components. Under these conditions, the design of the lining material content is extremely important, taking into account parameters such as load and operating conditions, in order to slow down or stop the vehicle safely. In this study, the braking performance, mechanical and tribological properties of the samples obtained from a number of production processes such as mixing, pre-shaping and pressing of the materials by altering the particle sizes (50 μm, 75 μm and 125 μm) of the filler and friction materials used together with powdered alumina (Al2O3) were investigated. The most suitable parameters were determined as lining material for the samples obtained.

EVALUATION OF TREATMENT EFFECTIVENESS OF PATIENTS WITH TUBERCULOSIS IN MODERN CONDITIONS ON THE EXAMPLE OF KYZYLORDA REGIONAL TUBERCULOSIS DISPENSARY (LITERATURE REVIEW)

2021 ◽  
pp. 56-60
Author(s):  
А.Ж. Алкожа ◽  
К.К. Куракбаев
Keyword(s):  
Developing Countries ◽  
Literature Review ◽  
World Health Organization ◽  
National Health ◽  
Health Problem ◽  
Scientific Literature ◽  
Treatment Effectiveness ◽  
Developed Countries ◽  
World Health ◽  
Health Organization

В данной статье дана оценка эффективности лечения больных туберкулезом и научно литературный обзор факторов, влияющих на эффективность его лечения. Проблема туберкулеза с каждым годом приобретает все большее внимание. Показано, что это связано с ростом заболеваемости, возникновением тяжелых заболеваний с летальным исходом.Всемирной организации здравоохранения (ВОЗ) была вынуждена констатировать, что туберкулез попрежнему является международной и национальной проблемой здравоохранения не только в развивающихся странах, но и в экономически высокоразвитых странах. The article provides an assessment of treatment effectiveness of patients with tuberculosis and scientific literature review of the factors afecting the treatment effectiveness. The problem of tuberculosis is gaining more and more attention every year. It is shown that this is associated with an increase in morbidity, the occurrence of severe diseases with a fatal outcome.The World Health Organization (WHO) was forced to state that tuberculosis is still an international and national health problem not only in developing countries, but also in economically highly developed countries

April 20 to 26, 2020 – World Immunization Week

2020 ◽  
pp. 76-79
Author(s):  
Oksana Rybachok
Keyword(s):  
Western Europe ◽  
Whooping Cough ◽  
Developed Countries ◽  
World Health ◽  
Modern World ◽  
Pneumococcal Infections ◽  
Preventive Vaccination ◽  
The Russian Federation ◽  
Health Organization ◽  
The Third World

Infectious diseases in the modern world continue to claim millions of human lives despite the achievements of medicine. While in developed countries the main cause of death is cancer and diseases of the cardiovascular system, it is the infectious processes that occupy leading positions in the structure of mortality in the third world countries. About 1.7 million children die from infections that could have been avoided by vaccination according to the World Health Organization. In contrast to the countries of Western Europe, where preventive vaccinations for the population are carried out for a fee, preventive vaccination in the Russian Federation is funded by the state. Immunoprophylaxis includes not only prevention of 12 major infections included in the calendar of preventive vaccinations (diphtheria, polio, tetanus, whooping cough, tuberculosis, measles, rubella, mumps, hepatitis B, pneumococcal infections and haemophilus influenzae, influenza), but also vaccination against 17 additional infections in case of epidemiological indications.

As(III) Removal by Dynamic Adsorption onto Amberlite XAD7 Functionalized with Crown Ether and Doped with Fe(III) Ions

2019 ◽  
Vol 70 (7) ◽  
pp. 2330-2334
Author(s):  
Mihaela Ciopec ◽  
Adina Negrea ◽  
Narcis Duteanu ◽  
Corneliu Mircea Davidescu ◽  
Iosif Hulka ◽  
...  
Keyword(s):  
Adsorption Process ◽  
Arsenic Removal ◽  
Arsenic Concentration ◽  
Fixed Bed ◽  
World Health ◽  
Arsenic Content ◽  
Arsenic Adsorption ◽  
Stage Of Development ◽  
Wide Range ◽  
Health Organization

Arsenic content in groundwater�s present a wide range of concentration, ranging from hundreds of micrograms to thousands of micrograms of arsenic per litter, while the maximum permitted arsenic concentration established by World Health Organization (WHO) is 10 mg L-1. According to the WHO all people, regardless of their stage of development and their social economic condition, have the right to have access to adequate drinking water. The most efficient and economic technique used for arsenic removal is represented by adsorption. In order to make this remediation technique more affordable and environmentally friendly is important to new materials with advance adsorbent properties. Novelty of present paper is represented by the usage of a new adsorbent material obtained by physical - chemical modification of Amberlite XAD polymers using crown ethers followed by iron doping, due to well-known affinity of arsenic for iron ions. Present paper aims to test the obtained modified Amberlite polymer for arsenic removal from real groundwater by using adsorption in a fixed bed column, establishing in this way a mechanism for the adsorption process. During experimental work was studied the influence of competing ions from real water into the arsenic adsorption process.

scholarly journals The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 451
Author(s):  
José María Gutiérrez ◽  
Laura-Oana Albulescu ◽  
Rachel H. Clare ◽  
Nicholas R. Casewell ◽  
Tarek Mohamed Abd Abd El-Aziz ◽  
...  
Keyword(s):  
Snake Venom ◽  
Serine Proteinase ◽  
Global Strategy ◽  
World Health ◽  
Wide Range ◽  
Variable Chemical ◽  
Snake Venom Metalloproteinase ◽  
Health Organization ◽  
The Impact ◽  
Natural And Synthetic

A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments. The mainstay in the therapy of snakebite envenoming is the administration of animal-derived antivenoms. In addition, new therapeutic options are being explored, including recombinant antibodies and natural and synthetic toxin inhibitors. In this review, snake venom toxins are classified in terms of their abundance and toxicity, and priority actions are being proposed in the search for snake venom metalloproteinase (SVMP), phospholipase A2 (PLA2), three-finger toxin (3FTx), and serine proteinase (SVSP) inhibitors. Natural inhibitors include compounds isolated from plants, animal sera, and mast cells, whereas synthetic inhibitors comprise a wide range of molecules of a variable chemical nature. Some of the most promising inhibitors, especially SVMP and PLA2 inhibitors, have been developed for other diseases and are being repurposed for snakebite envenoming. In addition, the search for drugs aimed at controlling endogenous processes generated in the course of envenoming is being pursued. The present review summarizes some of the most promising developments in this field and discusses issues that need to be considered for the effective translation of this knowledge to improve therapies for tackling snakebite envenoming.

scholarly journals Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia

Blood ◽  
2012 ◽  
Vol 120 (4) ◽  
pp. 748-760 ◽  
Author(s):  
Cassandra D. Josephson ◽  
Suzanne Granger ◽  
Susan F. Assmann ◽  
Marta-Inés Castillejo ◽  
Ronald G. Strauss ◽  
...  
Keyword(s):  
Bleeding Risk ◽  
World Health ◽  
Age Group ◽  
Transplant Recipients ◽  
Disease Treatment ◽  
Platelet Counts ◽  
Wide Range ◽  
Treatment Category ◽  
Dose Trial ◽  
Health Organization

Age-group analyses were conducted of patients in the prophylactic platelet dose trial (PLADO), which evaluated the relation between platelet dose per transfusion and bleeding. Hospitalized patients with treatment-induced hypoproliferative thrombocytopenia were randomly assigned to 1 of 3 platelet doses: 1.1 × 1011, 2.2 × 1011, or 4.4 × 1011 platelets/m2 per transfusion, given for morning counts of ≤ 10 000 platelets/μL. Daily hemostatic assessments were performed. The primary end point (percentage of patients who developed grade 2 or higher World Health Organization bleeding) was evaluated in 198 children (0-18 years) and 1044 adults. Although platelet dose did not predict bleeding for any age group, children overall had a significantly higher risk of grade 2 or higher bleeding than adults (86%, 88%, 77% vs 67% of patients aged 0-5 years, 6-12 years, 13-18 years, vs adults, respectively) and more days with grade 2 or higher bleeding (median, 3 days in each pediatric group vs 1 day in adults; P < .001). The effect of age on bleeding differed by disease treatment category and was most pronounced among autologous transplant recipients. Pediatric subjects were at higher risk of bleeding over a wide range of platelet counts, indicating that their excess bleeding risk may be because of factors other than platelet counts. This trial was registered at www.clinicaltrials.gov as #NCT00128713.

scholarly journals Cross-cultural differences in the epidemiology of unexplained fatigue syndromes in primary care

2003 ◽  
Vol 182 (3) ◽  
pp. 205-209 ◽  
Author(s):  
Petros Skapinakis ◽  
Glyn Lewis ◽  
Venetsanos Mavreas
Keyword(s):  
Primary Care ◽  
Secondary Analysis ◽  
Composite International Diagnostic Interview ◽  
Developed Countries ◽  
Diagnostic Interview ◽  
World Health ◽  
Less Developed Countries ◽  
Cross Cultural Differences ◽  
International Data ◽  
Health Organization

BackgroundUnexplained fatigue has been extensively studied but most of the samples used were from Western countries.AimsTo present international data on the prevalence of unexplained fatigue and fatigue as a presenting complaint in primary care.MethodSecondary analysis of the World Health Organization study of psychological problems in general health care. A total of 5438 primary care attenders from 14 countries were assessed with the Composite International Diagnostic Interview.ResultsThe prevalence of unexplained fatigue of 1-month duration differed across centres, with a range between 2.26 (95% CI 1.17–4.33) and 15.05 (95% CI 10.85–20.49). Subjects from more-developed countries were more likely to report unexplained fatigue but less likely to present with fatigue to physicians compared with subjects from less developed countries.ConclusionsIn less-developed countries fatigue might be an indicator of unmet psychiatric need, but in more-developed countries it is probably a symbol of psychosocial distress.

scholarly journals World Health Organization Sub-Types, Initial Treatment Outcome and Prognostic Study of Unselected Adult Patients with Acute Myeloid Leukaemia in Shanghai: An Analysis of 623 Cases

2009 ◽  
Vol 37 (4) ◽  
pp. 1191-1201 ◽  
Author(s):  
Y Ma ◽  
X Wang ◽  
X Xu ◽  
G Lin
Keyword(s):  
Prognostic Factor ◽  
Acute Myeloid Leukaemia ◽  
World Health Organization ◽  
Myeloid Leukaemia ◽  
Treatment Effect ◽  
Developed Countries ◽  
World Health ◽  
Health Organization ◽  
Acute Myeloid

This study investigated the complete remission (CR) rate and survival of 623 newly diagnosed patients with acute myeloid leukaemia (AML) in Shanghai, China, classified according to World Health Organization and French–American–British criteria, and compared the differences in treatment effect with those reported in developed countries and those reported in Shanghai from 1984 to 1994. Total CR rate was 66.5%, median survival was 18 months and estimated survival at 3 years was 30.8%. The 3-year relapse rate was 55.1%. These data showed that the CR rate was similar to that achieved in studies from developed countries, but long-term survival was worse. The CR rate and survival were increased markedly compared with data previously collected in Shanghai (1984-1994). Induction chemotherapeutic regimens based on idarubicin, daunorubicin or homoharringtonine all had similar CR rates and survivals. Karyotype was the most important prognostic factor. Multilineage dysplasia in de novo AML was not an independent prognostic factor. Improvement in the long-term treatment effect in China is an important challenge for the future.

scholarly journals Osteopathic correction in the treatment of pain in the lower back

2020 ◽  
pp. 140-146
Author(s):  
V. O. Belash ◽  
Yu. O. Novikov
Keyword(s):  
Back Pain ◽  
Developed Countries ◽  
Economic Problem ◽  
World Health ◽  
Randomized Controlled ◽  
Lower Back ◽  
The World ◽  
Working Age ◽  
Acute Back Pain ◽  
Health Organization

According to experts of the World Health Organization the lower back pain (LBP) prevalence in developed countries reaches the pandemic size, and it is a serious medical and socio-economic problem. Acute back pain is transformed into chronic in 10–20 % of working age patients′ cases; this causes serious psychological disorders appearing, forms painful behavior and persists even when the initial pain trigger is eliminated. Data from metaanalyses of randomized controlled trials indicate the effectiveness of the osteopathic approach in the treatment of LBP patients. At the same time the osteopathic correction is effective not only for acute pain, but also for chronic pain. A case from clinical practice is described demonstrating the possibility of osteopathic correction of a LBP patient.

Sign in / Sign up

Export Citation Format

Share Document