scholarly journals Effects of Maternal Obesity On Placental Phenotype

2020 ◽  
Vol 19 (2) ◽  
pp. 113-131 ◽  
Author(s):  
A.L. Fowden ◽  
E.J. Camm ◽  
A.N. Sferruzzi-Perri
Keyword(s):  
Potential Role ◽  
Maternal Obesity ◽  
Endocrine Function ◽  
Obstetric Outcomes ◽  
Contributory Factor ◽  
Intrauterine Development ◽  
Maternal Undernutrition ◽  
Clinical Complications ◽  
Adverse Impacts

: The incidence of obesity is rising rapidly worldwide with the consequence that more women are entering pregnancy overweight or obese. This leads to an increased incidence of clinical complications during pregnancy and of poor obstetric outcomes. The offspring of obese pregnancies are often macrosomic at birth although there is also a subset of the progeny that are growth-restricted at term. Maternal obesity during pregnancy is also associated with cardiovascular, metabolic and endocrine dysfunction in the offspring later in life. As the interface between the mother and fetus, the placenta has a central role in programming intrauterine development and is known to adapt its phenotype in response to environmental conditions such as maternal undernutrition and hypoxia. However, less is known about placental function in the abnormal metabolic and endocrine environment associated with maternal obesity during pregnancy. This review discusses the placental consequences of maternal obesity induced either naturally or experimentally by increasing maternal nutritional intake and/or changing the dietary composition. It takes a comparative, multi-species approach and focusses on placental size, morphology, nutrient transport, metabolism and endocrine function during the later stages of obese pregnancy. It also examines the interventions that have been made during pregnancy in an attempt to alleviate the more adverse impacts of maternal obesity on placental phenotype. The review highlights the potential role of adaptations in placental phenotype as a contributory factor to the pregnancy complications and changes in fetal growth and development that are associated with maternal obesity.

scholarly journals The Potential Role of Wedololactone in Treating Particle-induced Osteolysis _A Mouse Calvarial Model

2021 ◽  
Author(s):  
Yung-Chang Lu ◽  
Ting-Kuo Chang ◽  
Tzu-Chiao Lin ◽  
Shu-Ting Yeh ◽  
Hsu-Wei Fang ◽  
...  
Keyword(s):  
Potential Role ◽  
Histological Analysis ◽  
Total Joint Replacement ◽  
Disease Model ◽  
Potential Treatment ◽  
Micro Ct ◽  
Mineral Density ◽  
Clinical Complications ◽  
Significant Difference

Abstract Background: Osteolysis is one of the most prevalent clinical complications of total joint replacement (TJR). Wedelolactone (WDL) is a coumestan compound derived from the Wedelia chinensis plant and has been demonstrated to exhibit anti-inflammatory properties. This study aimed to investigate the use of WDL as a potential treatment for reducing the risk of particle-induced osteolysis using a well-established particle-induced mice calvarial disease model. Methods: Thirty-two C57BL/6J mice were randomized into four groups: sham, polystyrene particles (PS), PS particles with WDL treatment for 4 weeks (WDL 4w) and PS particles with WDL treatment for 8 weeks (WDL 8w). Micro-CT was used to quantitatively analyze the bone mass. Osteoclast numbers were also measured from histological analysis. Results: The results showed that bone mineral density was significantly higher in the WDL 8w group than in the PS group (p < 0.05), and both the WDL 4 and WDL 8w groups had lower osteoclast numbers (p < 0.05). No significant difference in osteoclast number was found between the WDL 4w and WDL 8w groups. Conclusions: These results support the use of WDL as a herbal medicine for reducing the severity of particle-induced osteolysis after TJR.

scholarly journals Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos

Reproduction ◽  
2001 ◽  
pp. 455-461 ◽  
Author(s):  
E Patsoula ◽  
D Loutradis ◽  
P Drakakis ◽  
K Kallianidis ◽  
R Bletsa ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Potential Role ◽  
Endocrine Function ◽  
Preimplantation Embryos ◽  
Rt Pcr ◽  
Mouse Development ◽  
Lh Receptor ◽  
Mouse Oocytes ◽  
Early Mouse

The gonadotrophins LH and FSH are known to regulate gonadal growth, and differentiation, endocrine function and gametogenesis. The LH receptor is expressed in ovarian theca, granulosa and luteal cells, and in testicular Leydig cells. The FSH receptor is expressed only in ovarian granulosa cells and in testicular Sertoli cells. The expression of the FSH and LH receptors was analysed by RT-PCR to study the role of these receptors in early mouse development. After reverse transcription, strategically designed nested primers were used for amplification from cDNA. Transcripts for the receptors were present in mouse oocytes and preimplantation embryos. The presence of mRNA for FSH and LH receptors in oocytes, zygotes and preimplantation embryos indicates a potential role for the gonadotrophins in the modulation of meiotic resumption and completion of oocyte maturation, as well as a beneficial effect on early embryonic development in mice.

scholarly journals Maternal obesity and stillbirth at term; placental pathology—A case control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250983
Author(s):  
Hanna Åmark ◽  
Magnus Westgren ◽  
Meeli Sirotkina ◽  
Ingela Hulthén Varli ◽  
Martina Persson ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Potential Role ◽  
Maternal Obesity ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Obese Women ◽  
Control Study ◽  
Velamentous Cord Insertion

Objective The aim was to explore the potential role of the placenta for the risk of stillbirth at term in pregnancies of obese women. Methods This was a case-control study comparing placental findings from term stillbirths with placental findings from live born infants. Cases were singleton term stillbirths to normal weight or obese women, identified in the Stockholm stillbirth database, n = 264 and n = 87, respectively. Controls were term singletons born alive to normal weight or obese women, delivered between 2002–2005 and between 2018–2019. Placentas were compared between women with stillborn and live-born infants, using logistic regression analyses. Results A long and hyper coiled cord, cord thrombosis and velamentous cord insertion were stronger risk factors for stillbirth in obese women compared to normal weight women. When these variables were adjusted for in the logistic regression analysis, also adjusted for potential confounders, the odds ratio for stillbirth in obese women decreased from 1.89 (CI 1.24–2.89) to 1.63 (CI 1.04–2.56). Conclusion Approximately one fourth of the effect of obesity on the risk of stillbirth in term pregnancies is explained by umbilical cord associated pathology.

Maternal obesity alters circRNA expression and the potential role of mmu_circRNA_0000660 via sponging miR_693 in offspring liver at weaning age

Gene ◽  
2020 ◽  
Vol 731 ◽  
pp. 144354 ◽  
Author(s):  
Qiutong Chen ◽  
Mingwei Liu ◽  
Yongwen Luo ◽  
Hongjie Yu ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Potential Role ◽  
Maternal Obesity ◽  
Weaning Age

Nutrient availability, the microbiome, and intestinal transport during pregnancy

2015 ◽  
Vol 40 (11) ◽  
pp. 1100-1106 ◽  
Author(s):  
Stuart Astbury ◽  
Alison Mostyn ◽  
Michael E. Symonds ◽  
Rhonda C. Bell
Keyword(s):  
Gastrointestinal Tract ◽  
Potential Role ◽  
Maternal Obesity ◽  
Intestinal Transport ◽  
Significant Degree ◽  
Historical Evidence ◽  
Nutrient Demand ◽  
The Metabolic Syndrome ◽  
Pregnancy Hormones

Adequate adaptation of the gastrointestinal tract is important during pregnancy to ensure that the increased metabolic demands by the developing fetus are met. These include changes in surface area mediated by villus hypertrophy and enhanced functional capacity of individual nutrient receptors, including those transporting glucose, fructose, leucine, and calcium. These processes are regulated either by the enhanced nutrient demand or are facilitated by changes in the secretion of pregnancy hormones. Our review also covers recent research into the microbiome, and how pregnancy could lead to microbial adaptations, which are beneficial to the mother, yet are also similar to those seen in the metabolic syndrome. The potential role of diet in modulating the microbiome during pregnancy, as well as the potential for the intestinal microbiota to induce pregnancy complications, are examined. Gaps in the current literature are highlighted, including those where only historical evidence is available, and we suggest areas that should be a priority for further research. In summary, although a significant degree of adaptation has been described, there are both well-established processes and more recent discoveries, such as changes within the maternal microbiome, that pose new questions as to how the gastrointestinal tract effectively adapts to pregnancy, especially in conjunction with maternal obesity.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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