Comparative Study of LC/MS and EMIT in Therapeutic Monitoring of Carbamazepine and its Clinical Applications

2017 ◽  
Vol 13 (5) ◽  
Author(s):  
Abdul Sami Shaikh ◽  
Fanlong Bu ◽  
Huanjun Liu ◽  
Chunmei Geng ◽  
Pingli Li ◽  
...  
Keyword(s):  
Comparative Study ◽  
Clinical Applications ◽  
Therapeutic Monitoring

scholarly journals A Comparative Study on Root Canal Repair Materials: A Cytocompatibility Assessment in L929 and MG63 Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yuqing Jiang ◽  
Qinghua Zheng ◽  
Xuedong Zhou ◽  
Yuan Gao ◽  
Dingming Huang
Keyword(s):  
Cell Adhesion ◽  
Comparative Study ◽  
Root Canal ◽  
Clinical Applications ◽  
Rapid Setting ◽  
Repair Materials ◽  
Mg63 Cells ◽  
Future Work

Cytocompatibility of repair materials plays a significant role in the success of root canal repair. We conducted a comparative study on the cytocompatibility among iRoot BP Plus, iRoot FS, ProRoot MTA, and Super-EBA in L929 cells and MG63 cells. The results revealed that iRoot FS was able to completely solidify within 1 hour. iRoot BP Plus required 7-day incubation, which was much longer than expected (2 hours), to completely set. ProRoot MTA and Super-EBA exhibited a similar setting duration of 12 hours. All the materials except Super-EBA possessed negligiblein vitrocytotoxicity. iRoot FS had the best cell adhesion capacity in both L929 and MG63 cells. With rapid setting, negligible cytotoxicity, and enhanced cell adhesion capacity, iRoot FS demonstrated great potential in clinical applications. Future work should focus on longer-termin vitrocytocompatibility and anin vivoassessment.

scholarly journals Comparative Study of Modified Mueller Matrix Transformation and Polar Decomposition Parameters for Transmission and Backscattering Tissue Polarimetries

2021 ◽  
Vol 11 (21) ◽  
pp. 10416
Author(s):  
Binguo Chen ◽  
Yuxiang Lan ◽  
Haoyu Zhai ◽  
Liangyu Deng ◽  
Honghui He ◽  
...  
Keyword(s):  
Optical Properties ◽  
Comparative Analysis ◽  
Comparative Study ◽  
Polar Decomposition ◽  
Mueller Matrix ◽  
Clinical Applications ◽  
Matrix Transformation ◽  
Tissue Samples ◽  
Axis Orientation ◽  
Transmission Imaging

Mueller matrix polarimetry is widely used in biomedical studies and applications, for it can provide abundant microstructural information about tissues. Recently, several methods have been proposed to decompose the Mueller matrix into groups of parameters related to specific optical properties which can be used to reveal the microstructural information of tissue samples more clearly and quantitatively. In this study, we thoroughly compare the differences among the parameters derived from the Mueller matrix polar decomposition (MMPD) and Mueller matrix transformation (MMT), which are two popular methods in tissue polarimetry studies and applications, while applying them on different tissue samples for both backscattering and transmission imaging. Based on the Mueller matrix data obtained using the setups, we carry out a comparative analysis of the parameters derived from both methods representing the same polarization properties, namely depolarization, linear retardance, fast axis orientation and diattenuation. IN particular, we propose several modified MMT parameters, whose abilities are also analyzed for revealing the information about the specific type of tissue samples. The results presented in this study evaluate the applicability of the original and modified MMT parameters, then give the suggestions for appropriate parameter selection in tissue polarimetry, which can be helpful for future biomedical and clinical applications.

Therapeutic Monitoring of Carbamazepine in Epilepsy Patients by Highly Sensitive LC/MS Method and its Clinical Applications

2018 ◽  
Vol 14 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Abdul Sami Shaikh ◽  
Fanlong Bu ◽  
Huanjun Liu ◽  
Chunmei Geng ◽  
Pingli Li ◽  
...  
Keyword(s):  
Clinical Applications ◽  
Therapeutic Monitoring ◽  
Highly Sensitive

scholarly journals In Vivo Comparative Study of Two Injectable/Moldable Calcium Phosphate Bioceramics

2012 ◽  
Vol 529-530 ◽  
pp. 291-295 ◽  
Author(s):  
Thomas Miramond ◽  
E. Aguado ◽  
E. Goyenvalle ◽  
Pascal Borget ◽  
Serge Baroth ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Comparative Study ◽  
Bone Regeneration ◽  
Bone Ingrowth ◽  
Close Contact ◽  
Bone Defects ◽  
Clinical Applications ◽  
Time Period ◽  
Rabbit Bone

Calcium phosphate bioceramic granules associated with hydrosoluble polymers formed putties currently more used in clinical applications as they are easy to handle (injectability, moldability). In this study, 2 kinds of materials were tested in rabbit bone defects. The first one is InOss (Biomatlante), a microporous biphasic CaP granules (BCP, HA/TCP mixture) with polysaccharidic hydrogel; and the second one is Actifuse ABX (Baxter/Apatech), pure hydroxyapatite granules containing silicate (HA-Si) with blocks copolymer hydrogel (poloxamer), . The aim of this study was to compare osteogenic properties of two kinds of CaP putties containing HA-Si versus BCP and the kinetic of resorption of their hydrogel. Data have demonstrated that both hydrogels increase the handling properties. Bone regeneration was observed in the two types of sample, however at 3 weeks, Actifuse ABX hydrogel was not totally absorbed, while InOss hydrogel was no longer observed. The second difference observed was osteoconduction. Newly formed bone over the time period studied was moreover in close contact with BCP granules than with HA-Si granules. Larger granules resorption on time was observed for BCP compared to HA-Si. Resorption of Actifuse ABX remains limited and explains the faster kinetic of absorption for InOss. This study demonstrates biocompatibility, absorbability and bone ingrowth at the expense of the two types of putty injectable/moldable bioceramic used for bone regeneration.

Author response for "Laminar distribution of cortical projection neurons to the pulvinar: A comparative study in cats and mice"

2020 ◽  
Author(s):  
Bruno Oliveira Ferreira de Souza ◽  
Éve‐Marie Frigon ◽  
Robert Tremblay‐Laliberté ◽  
Christian Casanova ◽  
Denis Boire
Keyword(s):  
Comparative Study ◽  
Author Response ◽  
Projection Neurons ◽  
Cortical Projection ◽  
Laminar Distribution

Specimen Preparation for Clinical Applications of X-Ray Microanalysis

1990 ◽  
Vol 48 (2) ◽  
pp. 328-329
Author(s):  
J.D. Shelburne ◽  
G.M. Roomans
Keyword(s):  
Carbon Coating ◽  
Clinical Applications ◽  
Point Of View ◽  
Practical Significance ◽  
Sweat Test ◽  
Specimen Preparation ◽  
Tissue Preparation ◽  
X Ray ◽  
Gallbladder Stones ◽  
Clinical Problems

Proper preparative procedures are a prerequisite for the validity of the results of x-ray microanalysis of biological tissue. Clinical applications of x-ray microanalysis are often concerned with diagnostic problems and the results may have profound practical significance for the patient. From this point of view it is especially important that specimen preparation for clinical applications is carried out correctly.Some clinical problems require very little tissue preparation. Hair, nails, and kidney and gallbladder stones may be examined and analyzed after carbon coating. High levels of zinc or copper in hair may be indicative of dermatological or systemic diseases. Nail clippings may be analyzed (as an alternative to the more conventional sweat test) to confirm a diagnosis of cystic fibrosis. X-ray microanalysis in combination with scanning electron microscopy has been shown to be the most reliable method for the identification of the components of kidney or gallbladder stones.A quantitatively very important clinical application of x-ray microanalysis is the identification and quantification of asbestos and other exogenous particles in lung.

Reduction of Potassium in Kidney Proximal Tubules to Aid in Electron Probe X-Ray Microanalysis of Calcium

1985 ◽  
Vol 43 ◽  
pp. 474-475
Author(s):  
A. LeFurgey ◽  
P. Ingram ◽  
L.J. Mandel
Keyword(s):  
Smooth Muscle ◽  
Proximal Tubule ◽  
Electron Probe ◽  
Clinical Applications ◽  
Proximal Tubules ◽  
Rabbit Kidney ◽  
Target Cells ◽  
X Ray ◽  
Freeze Dried

For quantitative determination of subcellular Ca distribution by electron probe x-ray microanalysis, decreasing (and/or eliminating) the K content of the cell maximizes the ability to accurately separate the overlapping K Kß and Ca Kα peaks in the x-ray spectra. For example, rubidium has been effectively substituted for potassium in smooth muscle cells, thus giving an improvement in calcium measurements. Ouabain, a cardiac glycoside widely used in experimental and clinical applications, inhibits Na-K ATPase at the cell membrane and thus alters the cytoplasmic ion (Na,K) content of target cells. In epithelial cells primarily involved in active transport, such as the proximal tubule of the rabbit kidney, ouabain rapidly (t1/2= 2 mins) causes a decrease2 in intracellular K, but does not change intracellular total or free Ca for up to 30 mins. In the present study we have taken advantage of this effect of ouabain to determine the mitochondrial and cytoplasmic Ca content in freeze-dried cryosections of kidney proximal tubule by electron probe x-ray microanalysis.

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