Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome

2020 ◽  
Vol 20 (2) ◽  
pp. 116-121
Author(s):  
Leila Shirmohammadi ◽  
Majid Ghayour-Mobarhan ◽  
Maryam Saberi-Karimian ◽  
Mehrdad Iranshahi ◽  
Shima Tavallaie ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cathepsin D ◽  
International Diabetes Federation ◽  
Control Groups ◽  
Anthropometric Indices ◽  
Elisa Kit ◽  
Significant Difference ◽  
Before And After ◽  
Post Trial ◽  
And Control

Background: Inflammation has been shown to accompany Metabolic Syndrome (MetS) and its features. Cathepsin D is one of a proinflammatory mediator. In the current study, we aimed to investigate the effect of curcumin supplementation on serum cathepsin D levels in patients with MetS. Methods: The current study was conducted on 18-65 years old individuals with MetS diagnosed according to the International Diabetes Federation guidelines. A total of 80 participants were randomly divided into treatment and control groups. The first group (n=40) was given 2 capsules containing 500 mg of phosphatidylcholine complex of curcumin, and the other group (n=40) was given two 500 mg placebo capsules for 6 weeks. Before (week 0) and after (week 6) the intervention, anthropometric indices and blood pressure were measured and blood samples were taken. Serum cathepsin D was measured using an ELISA kit. Results: There was no significant difference between treatment and control groups in terms of weight, body mass index, waist circumference and serum cathepsin D levels before and after the intervention. In addition, there was no significant difference between pre- and post-trial values of serum cathepsin D. Conclusion: The present results do not suggest any effect of curcumin on cathepsin D levels in patients with MetS.

scholarly journals Effect of Cold Dialysis Solution on the Sexual Dysfunction of Patients with Chronic Renal Failure Undergoing Hemodialysis: A Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Rahele Hassanpour Moghaddam ◽  
Fatemeh Nazemian ◽  
Sedigheh Rastaghi ◽  
Mostafa Rad
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Female Sexual Function ◽  
Control Groups ◽  
Male And Female ◽  
Dialysis Solution ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
Experimental Group

Background: The present study aimed to evaluate the effect of cold dialysis solution on the sexual dysfunction of patients with chronic renal failure undergoing hemodialysis. Methods: This randomized clinical trial was conducted with a before and after parallel design among 60 hemodialysis patients diagnosed with sexual dysfunction. The selected subjects were randomly allocated to the two groups of experimental and control (30 per each). Patients in the experimental and control groups underwent hemodialysis for one month using 35.5°C and 37°C dialysis solutions, respectively. Following the procedure, male and female sexual function was assessed in the study groups. Data were collected using the International Index of Erectile Functions, the female sexual function index (FSFI), and a demographic questionnaire. Data analysis was performed using Chi-square, Fisher's exact test, Mann-Whitney U test, t-test, paired t-test, and Wilcoxon test at 95% confidence interval. Results: No significant difference was observed between the experimental and control groups regarding male sexual function before and after the intervention (P > 0.05). However, the Mann-Whitney U test indicated a significant difference in the female subjects’ arousal in the experimental group before (3.68 ± 0.38) and after the intervention (3.98 ± 0.46; z = 2.216; P = 0.027). Conclusions: Cold dialysis solution could only increase the sexual arousal of the women in the experimental group, and no changes were observed in other sexual function domains of the male and female patients. Given the short duration of our intervention, it is recommended that further longitudinal studies be performed on larger cohorts of patients in different geographical regions.

Attitude of the Canine in Secondary Bone-Grafted and Nongrafted Patients with Cleft Lip and Palate

2005 ◽  
Vol 42 (6) ◽  
pp. 679-686 ◽  
Author(s):  
Enkhtuvshin Gereltzul ◽  
Yoshiyuki Baba ◽  
Kimie Ohyama
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Panoramic Radiography ◽  
Control Groups ◽  
Significant Difference ◽  
Before And After ◽  
Group 2 ◽  
Two Stages ◽  
And Control ◽  
Group 1

Objective To investigate the eruption pattern of the cleft-side canine regarding its pre-eruption position relative to the cleft in bone-grafted (BG) and nongrafted (NonBG) patients with cleft lip and palate. Methods Fifty-three patients with cleft lip and palate (21 BG, 32 NonBG) were examined by panoramic radiography and posteroanterior cephalography taken before and after canine eruption. Subjects were categorized into BG, NonBG, and control groups. Canines at the pre-eruption stage were categorized as close to (group 1) or distant from (group 2) the cleft area. The canine angle and its change between the two stages were evaluated. Results No significant differences were noted between the initial canine angle of the BG and NonBG groups. Although canines in the BG group erupted without a significant change in angle, the canine angle increased significantly (p < .0001) in the NonBG and control groups. In group 1, a greater change in canine angle was noted in the NonBG (p < .05) and control (p < .01) groups than in the BG group. In group 2, no significant difference was noted among the three groups. Conclusions In BG patients, a canine located near the cleft appears to erupt at the same angle as it had before grafting. However, in NonBG patients, it erupts more vertically, guided by cortical bone. For canines distant from the cleft area, there is no significant difference in the change in angulation between NonBG and BG patients.

scholarly journals EFFECT OF 12.5% VIRGIN COCONUT OIL (COCOS NUCIFERA) MOUTHWASH ON PLAQUE INDEX OF FIXED PROSTHETIC DENTURE USERS

2018 ◽  
Vol 9 ◽  
pp. 41
Author(s):  
Leo Saputra ◽  
Farisza Gita ◽  
Ratna Sari Dewi
Keyword(s):  
Cocos Nucifera ◽  
Coconut Oil ◽  
Plaque Index ◽  
Control Groups ◽  
Index Measurement ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
And Gender ◽  
And Control

Objective: To find out the difference in the plaque index scores of FPD users before and after using a 12.5% VCO mouthwash.Methods: The plaque index measurement of an abutment tooth was taken on 40 subjects with FPD in both test and control groups. Subjects used a 12.5% VCO mouthwash or aquades twice a day for 4 days after brushing their teeth. Statistical analysis of the measurement result of the plaque index scores before and after using the coconut oil mouthwash was done using the Wilcoxon test.Results: There is a statistically significant difference in the plaque index scores of FPD users before and after using the 12.5% VCO mouthwash with a statistically significant decrease in plaque index scores among restoration margin locations and tooth brushing habits, but not among age and gender groups.Conclusion: Using a 12.5% VCO mouthwash may decrease the plaque index of fixed prosthetic denture users.

scholarly journals The Effect of Goal Setting Difficulty on Serving Success in Table Tennis and the Mediating Mechanism of Self-regulation

2012 ◽  
Vol 33 (1) ◽  
pp. 173-185 ◽  
Author(s):  
Weina Liu ◽  
Chenglin Zhou ◽  
Liu Ji ◽  
Jack Watson
Keyword(s):  
Goal Setting ◽  
Athletic Performance ◽  
Self Regulation ◽  
Measurement Tool ◽  
Table Tennis ◽  
Control Groups ◽  
Small Triangle ◽  
Significant Difference ◽  
Before And After ◽  
And Control

The Effect of Goal Setting Difficulty on Serving Success in Table Tennis and the Mediating Mechanism of Self-regulationGoal setting difficulty has been shown to contribute to athletic performance (Burton et al., 2000). However, the potential mediating mechanism of goal difficulty on performance is unclear. Therefore, the purpose of this study was to verify the effect of goal setting difficulty on serving success in table tennis, and determine if self-regulation is the mediating variable. The current study used serving success within a one minute period as the task, and the "Athlete's Self-regulation in Motor Learning" as the measurement tool. The experiment was designed as a 3 (serving frequency: 20/min, 23/min, and 26/min) x 2 (serving placement: left "small triangle", and right "small triangle") model. Participants (N = 60) in the current study were students from a physical education school. These participants were randomly assigned into the experimental and control groups. After the intervention, differences in self-regulation (p < 0.001) and serving success (p < 0.05) between the experimental and control groups were significant. For the experimental groups, there was a significant difference in self-regulation (p < 0.001) and serving success (p < 0.05) before and after the experiment. Serving frequency had a main effect on self-regulation (F (5, 24) = 12.398, p < 0.01) and serving success (F (5, 24) = 37.601, p < 0.001). Moderately difficult goal setting contributed to athletic performance. Regression analysis using bootstrapping methods revealed that self-regulation partially mediated the relationship between the two.

scholarly journals Recycling Waste of Rice Husk to Improve Entrepreneurship Motivation

2016 ◽  
Vol 5 (1) ◽  
pp. 75
Author(s):  
Fatwa Tentama ◽  
Surahma Asti Mulasari ◽  
Muchsin Maulana ◽  
Rini Anggraeni
Keyword(s):  
Rice Husk ◽  
T Test ◽  
Control Group ◽  
Control Groups ◽  
Control Group Design ◽  
Paired Sample ◽  
Growing Medium ◽  
Significant Difference ◽  
Before And After ◽  
And Control

The farmers in Indonesia have not maximally taken advantage of the existence of rice husk; therefore the huge number of the husk becomes disturbing waste, which spoils environment. The waste of rice husk is potentially capable of improving the farmers’ economy amidst the people’s lack of knowledge about its potential to commercially produce charcoal briquettes from it, make it a plant growing medium, and change it into manure. This research aims at knowing if the training of recycling waste of rice husk can improve the farmers’ entrepreneurship motivation. The subjects of the research were farmers in groups at Bimomartani village, Ngemplak district, Sleman regency. They were 60 participants divided into experintal and control groups. The planned experiment used <em>untreated control group design with dependent pretest and posttest samples.</em> The <em>paired sample t-test</em> and <em>independent sample t-test</em> were used as the techniques of analysis in this research. The result of t-test on <em>paired sample t-test</em> for the experimental group resulted in the value of t = -6.659 with p = 0.000 (p&lt;0.01), which means there was a significant difference of entrepreneurship motivation before and after the training of recycling rice husk. The analysis for <em>Independent sample t-test</em> resulted in the value of t = 7.411 with p = 0.000 (p&lt;0.01), which means there was a significant difference of entrepreneurship motivation between experimental and control groups. It can be concluded that the training of recycling waste of rice husk was effective in improving the farmers’ entrepreneurship motivation.

scholarly journals Outcomes of a retrospective study on sustained release betamethasone for transient radicular symptoms in patients after Transforaminal Lumbar Interbody Fusion operation

2019 ◽  
Author(s):  
Haojie Li ◽  
Yang Wang ◽  
Weihu Ma ◽  
Dingli Xv
Keyword(s):  
Sustained Release ◽  
Transforaminal Lumbar Interbody Fusion ◽  
Gelatin Sponge ◽  
Observation Group ◽  
Control Groups ◽  
Significant Difference ◽  
Before And After ◽  
Fusion Operation ◽  
Radicular Symptoms ◽  
And Control

Abstract Objective To observe the efficacy and Complications of gelatin sponge sustained release betamethasone for transient radicular symptoms in patients after TLIF operation.Method A total of 218 patients with single-level LDH were retrospectively analyzed from March 2017 to July 2019. Patients were divided into observation group and control groups according to different approach.Clinical data such as lasegue sign, VAS score, ODI index were compared, the data analyzed by SPSS 24.0 statistical software.Results 186 patients were finally included. The observation group has significantly different between the control groups(P<0.05)at five days after surgery. And there was no significant difference in VAS and ODI between the four groups (P > 0.05)at 2-3 months after surgery, . There was no significant difference in blood glucose before and after operation in the observation group(P > 0.05), and numeration of leukocyte in the four groups was significantly higher than before operation (P<0.05), but there was no statistically significant difference between the four groups before and after operation (P > 0.05). The patients in the four groups had basically the same satisfaction with the final efficacy (> 90%) . In addition, there was the same Complications in four groups(eg.postoperative nausea, vomiting and other complications.)Conclusion the use of gelatin sponge sustained-release steroids and other mixed solutions can significantly relieve transient radicular symptoms after TLIF operation,and does not influence the occurrence of postoperative complications.

scholarly journals Effect of an aged wearing suit on nursing student’s knowledge and attitude

BMC Nursing ◽  
2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zahra Mandegari Bamakan ◽  
Khadijeh Nasiriani ◽  
Farzan Madadizadeh ◽  
Fatemeh Keshmiri
Keyword(s):  
Nursing Students ◽  
The Elderly ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Knowledge And Attitude ◽  
And Control ◽  
Experimental Group

Abstract Background The knowledge and attitude of health care providers are important and influential factors in providing care services to the elderly and need to be considered during the training course. Simulation in geriatric nursing education can be an opportunity for learners to experience the restrictions of the elderly. The present study was conducted to determine the effect of training through simulation on the attitude and knowledge of nursing students in elderly care. Methods This study was quasi-experimental with two experimental and control groups of pre and post-test, which was conducted on 70 nursing students of the 5th semester (two groups of 35 people). For the experimental group, the elderly simulation suit was worn for two hours, which was designed by the researcher and created sensory, physical, and motor restrictions similar to the elderly for students. Before and after the study, Kogan’s attitudes toward older people scale and Palmore’s “facts on aging quiz” were completed by students. The data were analyzed using an independent t-test and paired t-test using SPSS version 16 software. Results The mean scores of students’ knowledge in the experimental and control groups had no significant difference at the beginning of the study (p < 0.05). But the mean scores of knowledge in the experimental group before and after the intervention was (9.2 ± 2.6) and (15.3 ± 3.5), respectively, and in the control group before and after the intervention was (10.4 ± 2.9) and (11.3 ± 2.6), respectively, which had a statistically significant difference (p = 0.0001). The mean scores of students’ attitudes in the experimental and control groups had no significant difference at the beginning of the study (p < 0.05). The mean scores of attitude in the experimental group before and after the intervention was (114.69 ± 8.4) and (157.31 ± 10.7), respectively and in the control group before and after the intervention was (113.34 ± 13.6) and (108.5 ± 16.6), respectively, which was significantly different (p = 0.0001). Conclusions Based on the findings, the experience of aging restrictions through simulation has improved the knowledge and attitude of nursing students towards the elderly. Nursing education requires the growth of attitudinal skills, individuals’ beliefs, and creating empathy among them, so creating simulation opportunities can assist nursing students in the educational processes.

Effect of Liquid Polishing System on Color Stability of Bleached Enamel

2013 ◽  
Vol 804 ◽  
pp. 141-145
Author(s):  
Xiu Lan Chen ◽  
Huang Qin Chen
Keyword(s):  
Red Wine ◽  
Color Change ◽  
Color Stability ◽  
Control Groups ◽  
Significant Difference ◽  
Before And After ◽  
Total Color Change ◽  
Post Hoc ◽  
And Control ◽  
One Way Anova

The purpose of this study was to investigate the effect of liquid polishing system (BisCover) on color stability of the bleached enamel upon exposure to a staining agent-red wine. Forty specimens were prepared. They were divided into 2 groups and different procedures, including only bleaching with Opalescence PF (PF) or Opalescence regular (R) gels, and application of BisCover after blaeching (PF-B, R-B) were used. Unbleached specimens were served as control groups (control-1 and control-2). The specimens were stored for 48 h in red wine. The color of all specimens was measured before and after exposure with a spectrophotometer, and total color change (ΔE*) were calculated. The data were analyzed with a one-way ANOVA and the means were compared by Tukeys post hoc analysis (α=0.05). PF-B and R-B groups demonstrated significantly less color change than PF and R groups. the control-1 and control-2 groups had the least color change. No significant difference were observed between PF and R group. BisCover improved the color stability of bleached enamel in red wine.

scholarly journals The effect of problem-based learning on nursing students' decision making skills and styles

2017 ◽  
Vol 7 (6) ◽  
pp. 108 ◽  
Author(s):  
Mona Thabet ◽  
Eman EL-Sayed Taha ◽  
Sahar Ahmed Abood ◽  
Shadia Ramdan Morsy
Keyword(s):  
Decision Making ◽  
Nursing Students ◽  
Problem Based Learning ◽  
Control Groups ◽  
Decision Style ◽  
Innovative Teaching ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental ◽  
And Control

Decision making skill is deemed to be a key feature of the nurse’s role in today’s health care organizations. Thus, educators should use innovative teaching strategies that grow students’ competence in problem-solving and decision making skills like problem-based learning (PBL). The aim of this study is to determine the effect of problem-based learning on nursing students' decision making skills and styles. A quasi-experimental research design was utilized. The sample consisted of 84 students from the fourth year in the Faculty of Nursing, Minia University. Two tools were used: Nursing Students’ Decision Making Skills Scale and Nursing Students’ Decision Making Style. This study revealed that the mean scores of decision making skills in the study group students increased before and after applying PBL (before: 71 + 8.5, after: 116.3 + 10.4) with a statistical significant difference (p = .001). There was no statistical significant differences between the study and control groups (p = 1.000) before intervention. The most dominant decision-making style among the study and control groups in relation to before and after applying PBL was a behavioral decision style with no statistical significant differences. This study concluded that using PBL has a curial role in developing and improving nursing students' decision making skills; however, it has no effect on decision-making style.

scholarly journals Evaluation of Sex Hormone Levels in Benign Prostatic Hyperplasia Patients Treated with 5 Alpha-Reductase Inhibitor (Finasteride) in Amara city/Iraq

2020 ◽  
Vol 17 (1) ◽  
pp. 0001
Author(s):  
Hashim Et al.
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Reductase Inhibitor ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Control Group ◽  
Control Groups ◽  
Hormone Levels ◽  
Significant Difference ◽  
Before And After ◽  
And Control

The present study aimed to determine the serum sex hormone levels among Benign Prostatic Hyperplasia (BPH) patients before and after 3 months of oral administration of 5-α reductase inhibitor(finasteride). Forty BPH patients and 40 healthy men from Amara city were involved in this study, their ages were between 40-59 year. They were all subjected  to direct estimation of hormones by MinVidas method including Testosterone (T), Estradiol (E2), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (PRL), and Dihydrotestosterone (DHT) before and after 3 months of treatment with 5α-reductase inhibitor (finasteride) (the healthy individuals didn’t take finasteride).The results showed that T level was significantly lower (P<0.05) in pre-treated compared to the post-treated patients and control group, whereas no significant difference was observed between the two latter groups. Levels of E2 - and DHT were significantly lower (P<0.01) in post-treated compared to the pre-treated patients with no significant difference with control group, while they were significantly higher (P<0.01) in pre-treated patients compared to control group. FSH and LH levels showed no significant differences in the pre-treated in comparison with post-treated and control groups. PRL levels insignificantly higher in pre-treated in comparison with post-treated patients, while significantly higher (P<0.05) in comparison with control group, with the later showing a significant lower (P<0.05) in comparison with post-treated patients. It is concluded that 5α-reductase inhibitor (finasteride) plays a role in decreasing levels of DHT and E2 which have vital roles in enlargement of prostate.

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