Patent Review of Nanoparticles in Drug Delivery and Cancer Therapy in The Last Decade

Background: The application of nanotechnology has been considered a powerful platform in improving the current situation in drug delivery and cancer therapy, especially in targeting the desired site of action. Objective: The main objective of the patent review is to survey and review patents from the past ten years that are related to the two particular areas of nanomedicines. Methods: The patents related to the nanoparticle-based inventions utilized in drug delivery and cancer treatment from 2010 onwards were browsed in databases like USPTO, WIPO, Google Patents, and Free Patents Online. After conducting numerous screening processes, a total of 40 patents were included in the patent analysis. Results: Amongst the selected patents, an overview of various types of nanoparticles are presented in this paper, including polymeric, metallic, silica, lipid-based nanoparticles, quantum dots, carbon nanotubes, and albumin-based nanomedicines. Conclusion: Nanomedicines advantages include improvements in terms of drug delivery, bioavailability, solubility, penetration, and stability of drugs. It is concluded that the utilization of nanoparticles in medicines is essential in the pursuit of better clinical practice.

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Role of Nanostructured Materials in Health and Medicine

Applications of Nanomaterials in Agriculture, Food Science, and Medicine - Advances in Chemical and Materials Engineering ◽

10.4018/978-1-7998-5563-7.ch017 ◽

2021 ◽

pp. 310-329

Author(s):

Rafia Bashir ◽

Hamida Tun-Nisa Chisti ◽

Tauseef Ahmad Rangreez ◽

Rizwana Mobin

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Quantum Dots ◽

Cancer Therapy ◽

Nanostructured Materials ◽

Tuberculosis Treatment ◽

Human Diseases ◽

Site Specific

In the recent times, nanotechnology has been the most explored and extensively studied area. With the application of nanotechnology, many devices were devised at a lightning speed, which were earlier impossible to imagine. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific and target-oriented delivery of precise medicines. This chapter describes the importance of nanoparticle-based devices like nanotubes, quantum dots, carbon nanotubes, dendrimers, etc. and their applications for the treatment of several diseases. Applications of nanoparticles in drug delivery, tuberculosis treatment, and cancer therapy are also explained in this chapter. Nanomedicines can also be used to detect diseases at much earlier stages.

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Neurotoxicity of Nanomaterials: An Up-to-Date Overview

Nanomaterials ◽

10.3390/nano9010096 ◽

2019 ◽

Vol 9 (1) ◽

pp. 96 ◽

Cited By ~ 26

Author(s):

Daniel Teleanu ◽

Cristina Chircov ◽

Alexandru Grumezescu ◽

Raluca Teleanu

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Quantum Dots ◽

Cancer Therapy ◽

Biomedical Applications ◽

Environmental Science ◽

Bulk Materials ◽

Food And Agriculture ◽

Neurotoxic Effects

The field of nanotechnology, through which nanomaterials are designed, characterized, produced, and applied, is rapidly emerging in various fields, including energy, electronics, food and agriculture, environmental science, cosmetics, and medicine. The most common biomedical applications of nanomaterials involve drug delivery, bioimaging, and gene and cancer therapy. Since they possess unique properties which are different than bulk materials, toxic effects and long-term impacts on organisms are not completely known. Therefore, the purpose of this review is to emphasize the main neurotoxic effects induced by nanoparticles, liposomes, dendrimers, carbon nanotubes, and quantum dots, as well as the key neurotoxicology assays to evaluate them.

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Carbon Nanotubes, Quantum Dots and Dendrimers as Potential Nanodevices for Nanotechnology Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2013.6.3.2 ◽

2013 ◽

Vol 6 (3) ◽

pp. 2113-2124

Author(s):

Prashant Malik ◽

Neha Gulati ◽

Raj Kaur Malik ◽

Upendra Nagaich

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Quantum Dots ◽

Self Assembly ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Atomic Scale ◽

Sustained Drug Delivery ◽

Pharmaceutical Nanotechnology ◽

Conventional Device

Nanotechnology deal with the particle size in nanometers. Nanotechnology is ranging from extensions of conventional device physics to completely new approaches based upon molecular self assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale. In nanotechnology mainly three types of nanodevices are described: carbon nanotubes, quantum dots and dendrimers. It is a recent technique used as small size particles to treat many diseases like cancer, gene therapy and used as diagnostics. Nanotechnology used to formulate targeted, controlled and sustained drug delivery systems. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials and as devices like drug delivery, diagnostic, imaging and biosensor materials. Pharmaceutical nanotechnology has provided more fine tuned diagnosis and focused treatment of disease at a molecular level.

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Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment

Cancer Research ◽

10.1158/0008-5472.can-08-1468 ◽

2008 ◽

Vol 68 (16) ◽

pp. 6652-6660 ◽

Cited By ~ 915

Author(s):

Zhuang Liu ◽

Kai Chen ◽

Corrine Davis ◽

Sarah Sherlock ◽

Qizhen Cao ◽

...

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Cancer Treatment

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Quantum Dots Conjugated with Fe3O4-Filled Carbon Nanotubes for Cancer-Targeted Imaging and Magnetically Guided Drug Delivery

Langmuir ◽

10.1021/la303957y ◽

2012 ◽

Vol 28 (47) ◽

pp. 16469-16476 ◽

Cited By ~ 99

Author(s):

Mei-Ling Chen ◽

Ye-Ju He ◽

Xu-Wei Chen ◽

Jian-Hua Wang

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Quantum Dots ◽

Targeted Imaging

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Versatile Nanoplatform Loaded with Doxorubicin and Graphene Quantum Dots/Methylene Blue for Drug Delivery and Chemophotothermal/Photodynamic Synergetic Cancer Therapy

ACS Applied Bio Materials ◽

10.1021/acsabm.0c00942 ◽

2020 ◽

Vol 3 (10) ◽

pp. 7122-7132

Author(s):

Junlong Liang ◽

Jianjun Liu ◽

Xiaokang Jin ◽

Shuting Yao ◽

Biling Chen ◽

...

Keyword(s):

Drug Delivery ◽

Methylene Blue ◽

Quantum Dots ◽

Cancer Therapy ◽

Graphene Quantum Dots

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Liposomes as Anticancer Therapeutic Drug Carrier’s Systems: More than a Tour de Force

Current Nanomedicine ◽

10.2174/2468187309666190618171332 ◽

2020 ◽

Vol 10 (2) ◽

pp. 178-185 ◽

Cited By ~ 5

Author(s):

Mahfoozur Rahman ◽

Sarwar Beg ◽

Amita Verma ◽

Imran Kazmi ◽

Farhan Jalees Ahmed ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Real Time ◽

Clinical Application ◽

Review Article ◽

Therapeutic Drug ◽

Triggered Release ◽

Extensive Discussion ◽

Stealth Liposomes ◽

The Past

A liposome is a spherical vesicle composed of a bilayer of lipid with central aqueous cavity. Liposomes are the first nano vesicular drug delivery carriers, which are successfully translated into real-time clinical application and gained great potential in the past 30 years. The characteristics of liposomes to encapsulate both hydrophilic and hydrophobic drugs, their biocompatibility and biodegradability make it attractive nanocarriers in drug delivery area. Apart from this, great technical advancement has been made to develops second-generation liposomes named as stealth liposomes, cationic liposomes, triggered release liposomes and ligand targeted liposomes. This led to widespread use of liposomes in various areas including anticancer therapeutics, diagnostics and imaging agents. Therefore, the presents review article made an extensive discussion of various liposomes and its applications in cancer treatment.

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Application of Carbon Nanotubes in Drug Delivery of Non-Cancerous Diseases: A Review

Current Pharmaceutical Design ◽

10.2174/1381612826666201015153637 ◽

2020 ◽

Vol 26 ◽

Author(s):

Shahebaaz Khan ◽

Puja Jawlikar ◽

Swaroop Lahoti ◽

Omprakash Bhusnure ◽

Sohan Chitlange ◽

...

Keyword(s):

Infectious Disease ◽

Alzheimer’S Disease ◽

Carbon Nanotubes ◽

Drug Delivery ◽

Alzheimer's Disease ◽

Pulmonary Diseases ◽

Cancer Disease ◽

The Past ◽

The Future ◽

Asthma Patients

: Carbon nanotubes (CNT) are the allotropes of carbon in nanosize rendering them popular in the field of medicines. These nano-based technologies are gaining interest in the treatment of disease which was previously seemed to be impossible for treating. CNT gained significance in the treatment of the majority of disorders such as Malaria, Alzheimer’s disease, Infectious disease, Asthma. Patients responsiveness has increased in cardiovascular, pulmonary diseases. To date, the number of reviews available in the literature covering applications of CNT in the cancer disease. However, the purpose of this review is to focus on the use of carbon nanotubes in drug delivery of non-cancerous disease. The novelty of this review is it is focused on the applicability of CNT in the various non-cancerous diseases. Detailed information gathered from the past literature can guide and encourage researchers to explore the applicability of CNT in various non-cancerous diseases in the future.

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Pharmaceutical Applications of Carbon Nanotube-Mediated Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2012.5.2.4 ◽

2012 ◽

Vol 5 (2) ◽

pp. 1685-1696 ◽

Cited By ~ 2

Author(s):

Pradeep Kumar S ◽

Prathibha D ◽

Gowri Shankar N L ◽

Parthibarajan R ◽

Mastyagiri L ◽

...

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Cancer Treatment ◽

Drug Delivery System ◽

Delivery System ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Width Ratio ◽

Wide Range

Carbon nanotubes, which are elongated fullerenes, resemble graphite sheets wrapped into cylinders with a high length-to-width ratio (few nm in diameter and up to 1 mm in length). Carbon nanotubes are molecular-scale tubes of graphitic carbon with outstanding properties. Carbon nanotubes have drawn great interest and attraction in the field of novel drug delivery system. Nanomedicines can target, diagnose, monitor and treat cancerous cell also. The small nanoscale dimension and astonishing properties make them a distinctive carrier with a wide range of promising applications. These cylindrical carbon molecules have novel properties that make them potentially useful in many applications in nanotechnology. The various nano-size carrier systems are available for biotechnological applications including the drug delivery. Carbon nanotubes are typically used for bioactive delivery due to their some unique outstanding properties. Carbon nanotubes drug delivery system opens up new potential and possibilities over nanoparticles, dendrimers, liposomes etc. for biomedical applications and new drug delivery. In last few years, Carbon nanotubes (CNTs) have shown unexpected advantages in the field of cancer treatment and drug delivery systems. Present review article discuss in brief about the methods of synthesis, with purification as well as sorting techniques for giving different grades to different types of CNTs and biomedical applications. These show very good adsorption properties which helps in the detection of various chemicals, toxic agents etc. Research done using CNTs for cancer treatment is also discussed in brief.

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