scholarly journals Cytomegalovirus, Macrophages and Breast Cancer

2017 ◽  
Vol 11 (1) ◽  
pp. 15-27 ◽  
Author(s):  
S. Pasquereau ◽  
F. Al Moussawi ◽  
W. Karam ◽  
M. Diab Assaf ◽  
A. Kumar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Human Cytomegalovirus ◽  
Breast Tumor ◽  
Poor Prognosis ◽  
Tumor Tissue ◽  
Tumor Associated Macrophages ◽  
Potential Implication ◽  
Breast Tumor Tissue

The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.

scholarly journals An unsupervised MVA method to compare specific regions in human breast tumor tissue samples using ToF-SIMS

The Analyst ◽  
2016 ◽  
Vol 141 (6) ◽  
pp. 1947-1957 ◽  
Author(s):  
Blake M. Bluestein ◽  
Fionnuala Morrish ◽  
Daniel J. Graham ◽  
Jamie Guenthoer ◽  
David Hockenbery ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Tumor ◽  
Tumor Tissue ◽  
Regions Of Interest ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Tissue Samples ◽  
Breast Tumor Tissue ◽  
Tof Sims ◽  
Selection Of

PCA-generated regions of interest (ROI) selection of imaging ToF-SIMS data allows chemical comparison of multiple breast cancer specimens.

scholarly journals Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth

2021 ◽  
Vol 22 (12) ◽  
pp. 6526
Author(s):  
Maliha Tabassum Munir ◽  
Matthew K. Kay ◽  
Min H. Kang ◽  
Md Mizanur Rahman ◽  
Ahmed Al-Harrasi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune Cells ◽  
Breast Tumor ◽  
Poor Prognosis ◽  
Current Knowledge ◽  
Tumor Associated Macrophages ◽  
Potential Therapeutic Target ◽  
The Poor ◽  
Treat Breast Cancer ◽  
Related Mortality

Breast cancer is the most commonly occurring cancer in women of Western countries and is the leading cause of cancer-related mortality. The breast tumor microenvironment contains immune cells, fibroblasts, adipocytes, mesenchymal stem cells, and extracellular matrix. Among these cells, macrophages or tumor-associated macrophages (TAMs) are the major components of the breast cancer microenvironment. TAMs facilitate metastasis of the breast tumor and are responsible for poor clinical outcomes. High TAM density was also found liable for the poor prognosis of breast cancer. These observations make altering TAM function a potential therapeutic target to treat breast cancer. The present review summarizes the origin of TAMs, mechanisms of macrophage recruitment and polarization in the tumor, and the contributions of TAMs in tumor progression. We have also discussed our current knowledge about TAM-targeted therapies and the roles of miRNAs and exosomes in re-educating TAM function.

Infrared Spectra of Human Breast Tumor Tissue and Experimental Animal Tumors

2015 ◽  
Vol 81 (6) ◽  
pp. 1012-1018
Author(s):  
G. B. Tolstorozhev ◽  
M. V. Belkov ◽  
I. V. Skornyakov ◽  
V. I. Pekhnyo ◽  
A. N. Kozachkova ◽  
...  
Keyword(s):  
Experimental Animal ◽  
Infrared Spectra ◽  
Breast Tumor ◽  
Tumor Tissue ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Breast Tumor Tissue

scholarly journals Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry-Possibilities and limitations

2010 ◽  
Vol 77A (4) ◽  
pp. 387-398 ◽  
Author(s):  
Arabel Vollmann-Zwerenz ◽  
Simone Diermeier-Daucher ◽  
Anja Kathrin Wege ◽  
Andrea Sassen ◽  
Elisabeth Schmidt-Brücken ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Breast Tumor ◽  
Tumor Tissue ◽  
Tissue Samples ◽  
Breast Tumor Tissue

scholarly journals Sex Steroid Hormones in Serum and Tissue of Benign and Malignant Breast Tumor Patients

2000 ◽  
Vol 16 (3-4) ◽  
pp. 151-157 ◽  
Author(s):  
Essam A. Mady ◽  
Ezz El-Din H. Ramadan ◽  
Alaa A. Ossman
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Steroid Hormones ◽  
Breast Tumor ◽  
Tumor Tissue ◽  
Breast Tumors ◽  
Sex Steroid ◽  
Malignant Breast Tumor ◽  
Malignant Breast ◽  
Benign Breast Tumors

The ability of breast tumors to synthesize sex steroid hormones is well recognized and their local production is thought to play a role in breast cancer development and growth. The aim of this study was to estimate local intra-tumoral and circulating levels of Estrone (E1), Estrone Sulfate (E1S), Estradiol (E2), Estriol (E3), and Testosterone (T) in 33 pre- and postmenopausal women with primary breast cancer in comparison to 12 pre- and postmenopausal women with benign breast tumors. The mean levels of the studied sex hormones were higher in serum and tumor tissue of breast cancer women than those with benign breast tumors apart from Testosterone which showed a significant decrease in pre- and postmenopausal women with breast cancer (P< 0.001 for follicular phase,P< 0.001 for luteal phase, andP< 0.001 for postmenopausal). The levels of the five hormones were significantly higher intra-tumoral than in serum of both benign and malignant breast tumor women with E1S as the predominant estrogen. There was only a positive significant correlation between serum and tumor tissue levels of E1(rs= 0.52,P< 0.05 for follicular;rs= 0.63,P< 0.05 for luteal andrs= 0.58,P< 0.05 for postmenopausal) and a significant correlation between serum and tumor tissue of T (rs= 0.64,P< 0.05 for follicular;rs= -0.51,P< 0.05 for luteal andrs= -0.81,P< 0.04 for postmenopausal).

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