The assessment of triamcinolone acetonide cyclodextrin supramolecular inclusion complexa nasal spray

2021 ◽  
Vol 01 ◽  
Author(s):  
Jiaojiao Zhang ◽  
Xinghua Zhao ◽  
Cuiying Ren ◽  
Yujia Kang ◽  
Shi Ding ◽  
...  
Keyword(s):  
Particle Size ◽  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Inclusion Complex ◽  
Nasal Cavity ◽  
Triamcinolone Acetonide ◽  
Nasal Spray ◽  
Therapeutic Agent ◽  
Mean Particle Size ◽  
The Mean

Background: Allergic Rhinitis (AR) is a kind of systemic inflammatory response caused by a variety of allergic sources, which is mediated by immunoglobulin IgE. The major clinical manifestations including nasal congestion, itchy, runny nose, sneezing and so on. It affects the patient's normal life seriously. Using the nasal spray is the main way to treat and relieve symptoms allergic rhinitis. Triamcinolone acetonide was the first choice for treatment of allergic rhinitis medicine[1], because it has a very good treatment effect and less adverse reactions, but the solubility is poor[2], so we prepared it into supramolecular inclusion to increase the solubility[3], then promote the absorption of triamcinolone in the nasal cavity, and improving the bioavailability of the drug. Objective: The aim of the study was to improve triamcinolone acetonide solubility, So we prepared it into supramolecular inclusion to promote the absorption of triamcinolone in the nasal cavity, and improving the bioavailability of the drug. Methods: The supramolecular inclusion solids of triamcinolone cyclodextrin were prepared by freeze-drying method[4], and the preparation conditions of triamcinolone acetonide- hydroxypropyl -β -cyclodextrin supramolecular inclusion was as follows: the feed ratio of host to guest was 12:1, the inclusion time was 2h, and the temperature was 50℃. Results: The supramolecular inclusion complex was characterized by differential scanning calorimetry and scanning electron microscopy to verify that the supramolecular inclusion complex had been formed[5]. The results of infrared spectrum showed that triamcinolone acetonide molecules had entered the cavity of the cyclodextrin to form the supramolecular inclusion complex with the cyclodextrin[6], and phase solubility experiment showed that HP-β-CD had solubilization effect on triamcinolone acetonide. The mean particle size measured values of triamcinolone-HP-β-CD supramolecular inclusion compound is 13.61±1.03nm, much less than triamcinolone acetonide nasal spray, and the triamcinolone-HP-β-CD supramolecular inclusion nasal spray is 1.09±0.01, whith is smaller than triamcinolone acetonidewhich, too. This means triamcinolone-HP-β-CD supramolecular inclusion nasal spray has more uniform contact with the nasal cavity, which is better for absorption greatly improved its bioavailability and provided a new therapeutic agent for patients with allergic rhinitis. Discussion: In this study, triamcinolone acetonid-hydroxypropyl-β-cyclodextrin supramolecular inclusion complex was successfully synthesized, and then triamcinolone acetonide cyclodextrin nasal spray was successfully developed. Data shows that the mean particle size measured values and the ellipticity of triamcinolone-HP-β-CD supramolecular inclusion nasal spray are much less than triamcinolone acetonide nasal spray, this means triamcinolone-HP-β-CD supramolecular inclusion nasal spray has more uniform contact with the nasal cavity, so, triamcinolone-HP-β-CD supramolecular inclusion nasal spray is better for absorption, can greatly improved its bioavailability, also, provided a new therapeutic agent for patients with allergic rhinitis. In addition, the experimental results of nasal spray on guinea pig AR model showed that triamcinolone-HP-β-CD supramolecular inclusion nasal spray nasal spray had a significant inhibitory effect on guinea pig allergic rhinitis, and the effect was most obvious in the medium-dose and high-dose groups.

scholarly journals EFFICACY AND SAFETY OF NASAL SPRAY PREVALIN IN THE TREATMENT OF ALLERGIC RHINITIS PATIENTS

2012 ◽  
Vol 9 (5) ◽  
pp. 55-59
Author(s):  
A A Tsyvkina ◽  
L V Luss ◽  
S V Tsarev ◽  
N V Shartanova
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Nasal Spray ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Efficacy And Safety ◽  
Nasal Breathing ◽  
Results Of Treatment ◽  
Functional Methods ◽  
Positive Clinical Effect

Background. To study of efficacy, tolerability and safety of nasal spray Prevalin in the treatment of allergic rhinitis patients. Methods. 30 patients with allergic rhinitis in the age of18 till 45 years were observed. Prevalin was given as one insufflation into each nasal cavity 3 times a day for 21 days. Results of treatment were assessed by the dynamics of clinical symptoms and the results of functional methods . Results. The positive clinical effect was observed in 22 patients (73,3%), using Prevalin. Clinical effect was characterized by the restoration of nasal breathing, reduce swelling of the nasal mucosa. We did not establish a good result of treatment in 8 patients. Conclusion. The study demonstrated clinical efficacy and safety of spray Prevalin.

Effect of Ag addition in Sn on growth of SnTe compound during reaction between molten solder and tellurium

2010 ◽  
Vol 25 (2) ◽  
pp. 391-395 ◽  
Author(s):  
Chien-Neng Liao ◽  
Yen-Chun Huang
Keyword(s):  
Particle Size ◽  
Reaction Time ◽  
Electrical Properties ◽  
Bismuth Telluride ◽  
Molten Solder ◽  
Thermoelectric Modules ◽  
Ag Addition ◽  
Mean Particle Size ◽  
Mechanical And Electrical Properties ◽  
The Mean

SnTe is the most common compound formed at the bismuth telluride/metal soldered junction of thermoelectric modules. It affects the mechanical and electrical properties of the soldered junction. In the study we investigate the growth of SnTe compound during reaction between molten Sn–3.5Ag solder and tellurium at 250 °C. We found that the growth of SnTe is suppressed by Ag–Te bilayer compounds that block further reaction between liquid Sn and Te. With increasing reaction time, the SnTe morphology becomes rough as a result of coarsening of SnTe grains. The growth of SnTe grains follows the conservative ripening kinetics with the mean particle size proportional to one-third power of reaction time.

Microstructure and Thermodynamic Analysis of Graphene-Reinforced Coating Surface

2021 ◽  
Vol 1033 ◽  
pp. 56-60
Author(s):  
He Ping Liu ◽  
Heng Zhe Yang ◽  
Lang Lang Liu ◽  
Feng Er Sun ◽  
Xiao Min Yang ◽  
...  
Keyword(s):  
Particle Size ◽  
Thermodynamic Analysis ◽  
Induction Coil ◽  
Mean Particle Size ◽  
Substrate Distance ◽  
Cladding Layer ◽  
Coating Surface ◽  
The Mean ◽  
Graphene Content

The microstructure of coatings with different graphene content and the hardness of cladding layer under different distance between coil and samples were investigated. The results showed that with the increase of graphene, the mean particle size of the powder did not get significantly coarser. The defects and oxides were appeared in the cladding layer and graphene diffused into the substrate. Distance between induction coil and sample has great impact on the hardness of coating, the higher hardness was measured in the distance between 6-8cm. The thermodynamic analysis of coating nucleation was carried out.

Preparation of Nanocrystalline Fe2O3 Powder by Cryomilling with Liquid Nitrogen and its Magnetic Property

2020 ◽  
Vol 993 ◽  
pp. 806-810
Author(s):  
Zhi Wei Zhang ◽  
Bing Wei Luo ◽  
Hai Tao Zhou ◽  
Fen Wang
Keyword(s):  
Particle Size ◽  
Grain Size ◽  
Magnetic Property ◽  
Liquid Nitrogen ◽  
Room Temperature ◽  
Single Phase ◽  
Rapid Preparation ◽  
Mean Particle Size ◽  
Milling Temperature ◽  
The Mean

Rapid preparation of nanocrystalline γ-Fe2O3 powder with superparamagnetism was realized by cryomilling commercial Fe2O3 powder using liquid nitrogen. The effects of milling temperature and duration on the grain size, phase and microstructure of the nanocrystalline Fe2O3 powder were analyzed. Magnetic property of the nanocrystalline γ-Fe2O3 powder was also tested by magnetometer at room temperature. The results demonstrate that nanocrystalline γ-Fe2O3 powder with single phase can be prepared rapidly by cryomilling with liquid nitrogen. The mean particle size of γ-Fe2O3 powder can be reduced from 300 nm to 13 nm by cryomilling at −130 °C within 3 hours. The nanocrystalline γ-Fe2O3 powder shows superparamagnetism at room temperature.

Preparation and Research of Oil in Water Microemulsion

2020 ◽  
Vol 1001 ◽  
pp. 110-114
Author(s):  
Xiao Qi Chen ◽  
Meng Meng Zhou ◽  
Zheng Zheng Wang ◽  
Hai Jun Zhou ◽  
Shu Lan Yang ◽  
...  
Keyword(s):  
Particle Size ◽  
Constant Temperature ◽  
Polydispersity Index ◽  
Stable System ◽  
Mass Ratio ◽  
Drop Method ◽  
Mean Particle Size ◽  
Oil In Water ◽  
The Mean ◽  
The Stability

A series of oil in water (O/W) microemulsions were prepared through drop by drop method at constant temperature, taking Span80/Tween80 as a composite emulsifying system and Macol-52 as oil phase. Effects of the mass ratio of composite emulsifying system and oil/emulsifier ratio on the particle size were studied. Finally, the best technological conditions were selected and the stability of the microemulsion was also researched. Results showed that the most suitable Span80/Tween80 mass ratio was 1:1 and the oil/emulsifier ratio is 1:1. Under this condition, the mean particle size of the o/w microemulsion was 71.1 nm and the polydispersity index was 0.151. Moreover, the microemulsion maintain a bright and uniform stable system after 20minutes’ centrifugation at the speed of 4000r/min and the particle size increased slightly.

Daily versus self-adjusted dosing of topical mometasone furoate nasal spray in patients with allergic rhinitis: randomised, controlled trial

2009 ◽  
Vol 124 (4) ◽  
pp. 397-401 ◽  
Author(s):  
M A Khan ◽  
A S Abou-Halawa ◽  
A A Al-Robaee ◽  
A A Alzolibani ◽  
H A Al-Shobaili
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Nasal Spray ◽  
Controlled Trial ◽  
Symptom Control ◽  
Mometasone Furoate ◽  
The Self ◽  
Cavity Volume ◽  
Significant Difference ◽  
Randomised Controlled

AbstractBackground:Many patients with allergic rhinitis are reluctant to use daily intranasal steroids for prolonged periods. A self-adjusted regimen which delivers reasonable control of allergic rhinitis may be more acceptable to such patients.Objectives:To compare the efficacy of daily use of mometasone furoate nasal spray, versus a self-adjusted regimen, in patients with chronic allergic rhinitis, in terms of symptom control and nasal volume change.Setting:Ambulatory visits in an office setting.Patients and methods:Sixty patients with chronic allergic rhinitis were randomised: 30 were prescribed mometasone furoate nasal spray once daily for six weeks, while 30 were prescribed the same spray daily for one week, every alternate day for one week and then on a self-adjusted regimen for four weeks. Patients kept a symptom diary documenting sneezing, rhinorrhoea, nasal blockage and nasal itching. Acoustic rhinometry was used to measure the total nasal cavity volume at the first visit and at the end of the treatment period.Results:The total nasal score on treatment days showed an improvement in both groups, compared with baseline measurements. There was no significant difference in total nasal scores between the two groups, except on days 10 (p = 0.043), 20 (p = 0.008), 23 (p = 0.19), 30 (p = 0.008) and 37 (p = 0.000), when the daily group's total nasal score was significantly lower than the self-adjusted group's total nasal score, and on day 8 (p = 0.004), when the self-adjusted group's total nasal score was significantly lower than the daily group's total nasal score. Total nasal cavity volume significantly increased in both groups (p = 0.0001), with no statistically significant difference between the groups.Conclusions:Self-adjusted dosage of mometasone furoate nasal spray gives reasonable control of allergic rhinitis (albeit with some ‘breakthrough’ symptoms). Patients should learn how to control these symptoms with the least number of steroid doses.

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