The Scalability of Wet Ball Milling for The Production of Nanosuspensions

2019 ◽  
Vol 7 (2) ◽  
pp. 147-161 ◽  
Author(s):  
Maria L.A.D. Lestari ◽  
Rainer H. Müller ◽  
Jan P. Möschwitzer
Keyword(s):  
Ball Milling ◽  
Large Scale ◽  
Milling Time ◽  
High Energy ◽  
Small Scale ◽  
Particle Sizes ◽  
Scale Production ◽  
Batch Mode ◽  
Pharmaceutical Ingredients ◽  
Large Scale Production

Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be performed on a large scale. Ideally, the information generated at small scale is predictive for large scale production. Objective: This study was aimed to investigate the scalability when producing nanosuspensions starting from a 10 g scale of nanosuspension using low energy wet ball milling up to production scales of 120 g nanosuspension and 2 kg nanosuspension by using a standard high energy wet ball milling operated in batch mode or recirculation mode, respectively. Methods: Two different active pharmaceutical ingredients, i.e. curcumin and hesperetin, have been used in this study. The investigated factors include the milling time, milling speed, and the type of mill. Results: Comparable particle sizes of about 151 nm to 190 nm were obtained for both active pharmaceutical ingredients at the same milling time and milling speed when the drugs were processed at 10 g using low energy wet ball milling or 120 g using high energy wet ball milling in batch mode, respectively. However, an adjustment of the milling speed was needed for the 2 kg scale produced using high energy wet ball milling in recirculation mode to obtain particle sizes comparable to the small scale process. Conclusion: These results confirm in general, the scalability of wet ball milling as well as the suitability of small scale processing in order to correctly identify the most suitable formulations for large scale production using high energy milling.

scholarly journals The Synthesis of Peculiar Structure of Springlike Multiwall Carbon Nanofibers/Nanotubes via Mechanothermal Method

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sahebali Manafi ◽  
Mohammad Reza Rahimipour ◽  
Iman Mobasherpour ◽  
Atefeh Soltanmoradi
Keyword(s):  
Carbon Nanofibers ◽  
Large Scale ◽  
Annealing Temperature ◽  
Milling Time ◽  
Nanocomposite Materials ◽  
Scale Production ◽  
Multiwalled Carbon ◽  
Large Scale Production ◽  
First Time ◽  
Multiwall Carbon

Mechanothermal (MT) method is one of the methods used for large-scale production of carbon nanotubes/nanofibers. The different peculiar morphologies of carbon allotropes are introduced with an extraordinary structure for the first time by MT method. In this paper, the influence of milling time and annealing temperature on the crystallinity and morphology of the synthesized nanopowders was investigated. Surprisingly, in this investigation, we report the synthesis of springlike multiwalled carbon nanofibers (S-MWCNFs) by a two-step annealing of milled graphite in an Ar atmosphere. On the other hand, the MT method could be used for the preparation of suitable structures with applications in nanocomposite materials, which is an important task in the era of nanotechnology.

scholarly journals Low-cost Large Scale Vermicompost Unit

2021 ◽  
Vol 2115 (1) ◽  
pp. 012026
Author(s):  
Sonam Solanki ◽  
Gunendra Mahore
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Small Scale ◽  
Scale Production ◽  
Key Innovation ◽  
Main Challenge ◽  
Long Run ◽  
Large Scale Production ◽  
Term Maintenance

Abstract In the current process of producing vermicompost on a large-scale, the main challenge is to keep the worms alive. This is achieved by maintaining temperature and moisture in their living medium. It is a difficult task to maintain these parameters throughout the process. Currently, this is achieved by building infrastructure but this method requires a large initial investment and long-run maintenance. Also, these methods are limited to small-scale production. For large-scale production, a unit is developed which utilises natural airflow with water and automation. The main aim of this unit is to provide favourable conditions to worms in large-scale production with very low investment and minimum maintenance in long term. The key innovation of this research is that the technology used in the unit should be practical and easy to adopt by small farmers. For long-term maintenance of the technology lesser number of parts are used.

scholarly journals Solutions for changing production scale in the agricultural sector in Vietnam

2020 ◽  
Vol 175 ◽  
pp. 10008
Author(s):  
Thi Hoai Nguyen ◽  
Duc Luan Nguyen
Keyword(s):  
Labor Productivity ◽  
Agricultural Production ◽  
Large Scale ◽  
Agricultural Sector ◽  
Current Situation ◽  
Small Scale ◽  
Scale Production ◽  
Number Of Solutions ◽  
Production Scale ◽  
Large Scale Production

In this paper, the authors analyze the current situation of agricultural production in Vietnam and affirm that fragmentation is one of the basic causes leading to ineffective potentials and low labor productivity. Based on this, the authors propose a number of solutions to convert small-scale production to large-scale production in order to improve labor productivity and optimally exploit resources in the agricultural sector in Vietnam today.

Sucrose-mediated mechanical exfoliation of graphite: a green method for the large scale production of graphene and its application in catalytic reduction of 4-nitrophenol

2017 ◽  
Vol 41 (20) ◽  
pp. 11969-11978 ◽  
Author(s):  
Sowmya Balasubramanyan ◽  
Sreenikesh Sasidharan ◽  
Raveendran Poovathinthodiyil ◽  
Resmi M. Ramakrishnan ◽  
Binitha N. Narayanan
Keyword(s):  
Ball Milling ◽  
Large Scale ◽  
Catalytic Reduction ◽  
Scale Production ◽  
Green Method ◽  
Mechanical Exfoliation ◽  
Large Scale Production

A simple and green method for the large scale production of graphene by ball-milling of graphite with sucrose is exploited here.

scholarly journals Melanin Produced by the Fast-Growing Marine Bacterium Vibrio natriegens through Heterologous Biosynthesis: Characterization and Application

2019 ◽  
Vol 86 (5) ◽  
Author(s):  
Zheng Wang ◽  
Tanya Tschirhart ◽  
Zachary Schultzhaus ◽  
Erin E. Kelly ◽  
Amy Chen ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Large Scale ◽  
Marine Bacterium ◽  
Redox Activity ◽  
Small Scale ◽  
Scale Production ◽  
Content Type ◽  
Fast Growing ◽  
Tyrosinase Gene ◽  
Large Scale Production

ABSTRACT Melanin is a pigment produced by organisms throughout all domains of life. Due to its unique physicochemical properties, biocompatibility, and biostability, there has been an increasing interest in the use of melanin for broad applications. In the vast majority of studies, melanin has been either chemically synthesized or isolated from animals, which has restricted its use to small-scale applications. Using bacteria as biocatalysts is a promising and economical alternative for the large-scale production of biomaterials. In this study, we engineered the marine bacterium Vibrio natriegens, one of the fastest-growing organisms, to synthesize melanin by expressing a heterologous tyrosinase gene and demonstrated that melanin production was much faster than in previously reported heterologous systems. The melanin of V. natriegens was characterized as a polymer derived from dihydroxyindole-2-carboxylic acid (DHICA) and, similarly to synthetic melanin, exhibited several characteristic and useful features. Electron microscopy analysis demonstrated that melanin produced from V. natriegens formed nanoparticles that were assembled as “melanin ghost” structures, and the photoprotective properties of these particles were validated by their protection of cells from UV irradiation. Using a novel electrochemical reverse engineering method, we observed that melanization conferred redox activity to V. natriegens. Moreover, melanized bacteria were able to quickly adsorb the organic compound trinitrotoluene (TNT). Overall, the genetic tractability, rapid division time, and ease of culture provide a set of attractive properties that compare favorably to current E. coli production strains and warrant the further development of this chassis as a microbial factory for natural product biosynthesis. IMPORTANCE Melanins are macromolecules that are ubiquitous in nature and impart a large variety of biological functions, including structure, coloration, radiation resistance, free radical scavenging, and thermoregulation. Currently, in the majority of investigations, melanins are either chemically synthesized or extracted from animals, which presents significant challenges for large-scale production. Bacteria have been used as biocatalysts to synthesize a variety of biomaterials due to their fast growth and amenability to genetic engineering using synthetic biology tools. In this study, we engineered the extremely fast-growing bacterium V. natriegens to synthesize melanin nanoparticles by expressing a heterologous tyrosinase gene with inducible promoters. Characterization of the melanin produced from V. natriegens-produced tyrosinase revealed that it exhibited physical and chemical properties similar to those of natural and chemically synthesized melanins, including nanoparticle structure, protection against UV damage, and adsorption of toxic compounds. We anticipate that producing and controlling melanin structures at the nanoscale in this bacterial system with synthetic biology tools will enable the design and rapid production of novel biomaterials for multiple applications.

Development of a large scale production of 67Cu from 68Zn at the high energy proton accelerator: Closing the 68Zn cycle

2012 ◽  
Vol 70 (3) ◽  
pp. 423-429 ◽  
Author(s):  
Dmitri G. Medvedev ◽  
Leonard F. Mausner ◽  
George E. Meinken ◽  
Slawko O. Kurczak ◽  
Henry Schnakenberg ◽  
...  
Keyword(s):  
Large Scale ◽  
High Energy ◽  
Proton Accelerator ◽  
Scale Production ◽  
High Energy Proton ◽  
Energy Proton ◽  
Large Scale Production

The Stansfields of Halifax: A Case Study of the Making of the Middle Class

1992 ◽  
Vol 24 (1) ◽  
pp. 27-47 ◽  
Author(s):  
John Smail
Keyword(s):  
Textile Industry ◽  
Large Scale ◽  
Industrial Revolution ◽  
Small Scale ◽  
Scale Production ◽  
Economic Activities ◽  
Textile Production ◽  
Large Scale Production ◽  
History Of

Between the Civil War and the Industrial Revolution, four generations of the Stansfield family lived in Halifax—an upland parish in the West Riding of Yorkshire. Although its politics were calm, the century and a half between England's two great “revolutions” was not devoid of change in other respects. Significant social, economic, and cultural developments during this period laid the foundations for the ferment of the Industrial Revolution. The history of the Stansfield family is an excellent illustration of these changes, for there was a world of difference between the great-grandfather, Josias Stansfield, who was in his prime at the Restoration, and his great-grandsons, George and David Stansfield, who were in their primes a century later.For his part, Josias was recognizably a man of the middling sort. A yeoman engaged in farming and small-scale textile production, his economic activities and his social standing place him in the ranks of families who fell between the few gentlemen who lived in the area and the mass of simple artisans and laborers who had to struggle just to survive. Josias's great-grandsons, George and David Stansfield lived in a different world. By the mid-eighteenth century, Halifax's textile industry was increasingly dominated by large-scale production of which George's large putting-out concern and David's substantial export business were typical. George and David's social position was also quite different. No longer merely comfortable, these two second cousins were among the wealthiest residents of their respective townships, and they had assumed an appropriately significant share of the political and social leadership in the parish.

scholarly journals Development of New Isolation and Quantification Method of Piperine from White Pepper Seeds (Piper Nigrum L) Using A Validated HPLC

2021 ◽  
pp. 158-165
Author(s):  
Nindya Kusumorini ◽  
Akhmad Kharis Nugroho ◽  
Suwijiyo Pramono ◽  
Ronny Martien
Keyword(s):  
Melting Point ◽  
Large Scale ◽  
Antioxidant Activities ◽  
Piper Nigrum ◽  
Scale Production ◽  
Active Pharmaceutical Ingredients ◽  
White Pepper ◽  
Pharmaceutical Ingredients ◽  
Quantification Method ◽  
Large Scale Production

Most of the active pharmaceutical ingredients in the pharmaceutical world are obtained from natural ingredients, one of which is white pepper. White pepper seeds (Piper nigrum L.) contain the main alkaloid compound piperine, which has a broad spectrum pharmacological effect. This research aimed to isolate the piperine compound from white pepper seeds to make piperine more economical, simple, and effective so that it can be applied to large scale production in the pharmaceutical industry. The method of extracting and purifying piperine compounds was carried out using n-hexane and cyclohexane. The results of the isolated piperine were tested for their purity with a set of melting point apparatus, bidimensional TLC, and HPLC. The structure compound was then analyzed using FTIR and NMR. Furthermore, the isolated piperine was tested for its antioxidant activities using DPPH, ABTS, and FRAP. Cyclohexane was successfully used to remove the resinous matter from the n-hexane extract of white pepper to produce isolated piperine with 97.24% of purity. The results of the melting point, FTIR, 1H-NMR, and 12C-NMR of the isolated piperine were similar to that of the piperine reference substance and the literature review. The isolated piperine has weak antioxidant activities in the ABTS and FRAP test with the results of 15.25 ± 0.004 mM and 10.53 mol TE/g of the sample, respectively. 

scholarly journals An Exploratory Examination on Small Scale Sugarcane Harvesting Machine

2020 ◽  
Vol 8 (6) ◽  
pp. 5265-5268
Keyword(s):  
Sugar Cane ◽  
Large Scale ◽  
Low Cost ◽  
Small Scale ◽  
Scale Production ◽  
High Demand ◽  
Large Scale Production ◽  
By Products

The work in this paper is focused , about the sugarcane harvesting machine, as India is considered as one of the higher consumers and producers of sugarcane and its by products and to due to huge population, there is a high demand of sugarcane and to meet the demand of population, large scale production has to be adopted, hence for farming and harvesting the sugarcane an automated, low cost harvester is necessary for the farmers to reduce the efforts of sugarcane harvesting and to increase the rate of sugar cane cutting. This machine will be helpful for the farmers having both small and big farms, the work on this paper was carried to identify the major options along with the opportunities and major chances for future enhancement in the field of agriculture industries.

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