Metallic Nanoparticles for Drug Delivery and Biomedical Applications: Patent Perspectives

2019 ◽  
Vol 8 (3) ◽  
pp. 176-176 ◽  
Author(s):  
Mahfoozur Rahman ◽  
Amit K. Nayak ◽  
Sarwar Beg ◽  
M. Saquib Hasnain
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Biomedical Applications

scholarly journals Gold Nanoparticles synthesis, properties, and forthcoming applications : A review

2015 ◽  
Vol 3 (02) ◽  
pp. 13-27 ◽  
Author(s):  
Naveen Sharma ◽  
Ganesh Bhatt ◽  
Preeti Kothiyal
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Anticancer Agent ◽  
Delivery Vehicle ◽  
Pharmaceutical Drug ◽  
Therapeutic Drugs ◽  
Cancerous Cell ◽  
Synthesis Properties

Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characteristics. AuNPs can be conjugated with ligands, imaging labels, therapeutic drugs and other functional moieties for site specific drug delivery application. In this present review we are discussing the synthesis, properties, and forthcoming applications of gold nanoparticle (AuNPs) which is the most studied among all other metallic-nanoparticles. Here our main focus is to explain the AuNPs application in cancer treatment. AuNPs provides non-toxic carrier system for pharmaceutical drug and gene delivery applications. Currently various anticancer drugs are available but these are cause the necrosis of cancerous cell as well as normal cells. AuNPs cause the necrosis of only cancer cells therefore we can utilize it as a delivery vehicle as well as anticancer agent

scholarly journals A REVIEW ON PROPERTIES, APPLICATIONS AND TOXICITIES OF METAL NANOPARTICLES

2020 ◽  
pp. 58-63
Author(s):  
SANGEETHA G. ◽  
USHA N. ◽  
NANDHINI R. ◽  
KAVIYA P. ◽  
VIDHYA G. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Noble Metals ◽  
Novel Technology ◽  
Current Review ◽  
The World ◽  
History Of

Nanotechnology is a broad and novel technology related to all branches of science. However, in the Pharmaceutical industry, it plays an immense role in the drug delivery system. Nanotechnology applied on metal-based drug delivery systems varies; the size ranges from 100 nm or less. Metallic nanoparticles are existing the world from the 4th century. The noble metals, like gold and silver have attracted many researchers in the class of anticancer and anti-microbial. Metallic nanoparticles are not only used in the biomedical applications also have major functions in the domain of textiles, agriculture, photography, etc. Various metals are found in various applications in the biomedical industries. At the same time, the metallic nanoparticles have been evidences of remarkable toxicity in various studies. The rationale behind this topic was that the properties, applications and toxicity of individual metal nanoparticles. As this study have not been compiled and reported. So, in the current review, the gap was filled. The main sources for the preparation of the manuscript are Pubmed, Elsevier and google scholars. Keywords used includes metallic nanoparticles, reported toxicity of metals in drug delivery, applications of metals in drug delivery, history of novel metals in drug delivery, etc. Approximately 400 reviews and academic papers were reviewed to compose the manuscript and sorted by reference to the need for a manuscript.

Surface-bioengineered Gold Nanoparticles for Biomedical Applications

2018 ◽  
Vol 25 (16) ◽  
pp. 1920-1944 ◽  
Author(s):  
Zhicong Miao ◽  
Zilin Gao ◽  
Ruoxia Chen ◽  
Xiaoqing Yu ◽  
Zhiqiang Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gold Nanoparticles ◽  
Surface Functionalization ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Structure Functions ◽  
Functionalized Nanoparticles ◽  
Recent Advances

The conjugation of gold nanoparticles (AuNPs) with biomolecules could create many outstanding biofunctions for the surface-functionalized nanoparticles and extend their biomedical applications. In this review, we summarize the recent advances in the surface bioengineering of AuNPs with biomolecules, such as DNA, proteins, peptides, and biopolymers, in which the details on the structure, functions, and properties of surface- bioengineered AuNPs are discussed. In addition, the surface-biofunctionalization of AuNPs for biomedical applications like biosensing, bioimaging, drug delivery, and tissue engineering are introduced. It is expected that this work will be very helpful for readers to understand the surface functionalization and engineering techniques for various metallic nanoparticles and design novel biomaterials for biomedical applications.

scholarly journals Recent Advances in Hollow Gold Nanostructures for Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Jeong-Min Park ◽  
Hye Eun Choi ◽  
Dauletkerey Kudaibergen ◽  
Jae-Hyuk Kim ◽  
Ki Su Kim
Keyword(s):  
Drug Delivery ◽  
Surface Plasmon ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Synthetic Methods ◽  
Gold Nanostructures ◽  
Infrared Light ◽  
Localized Surface Plasmon ◽  
Recent Advances

The localized surface plasmon resonance of metallic nanoparticles has attracted much attention owing to its unique characteristics, including the enhancement of signals in sensors and photothermal effects. In particular, hollow gold nanostructures are highly promising for practical applications, with significant advantages being found in their material properties and structures: 1) the interaction between the outer surface plasmon mode and inner cavity mode leads to a greater resonance, allowing it to absorb near-infrared light, which can readily penetrate tissue; 2) it has anti-corrosiveness and good biocompatibility, which makes it suitable for biomedical applications; 3) it shows a reduced net density and large surface area, allowing the possibility of nanocarriers for drug delivery. In this review, we present information on the classification, characteristics, and synthetic methods of hollow gold nanostructures; discuss the recent advances in hollow gold nanostructures in biomedical applications, including biosensing, bioimaging, photothermal therapy, and drug delivery; and report on the existing challenges and prospects for hollow gold nanostructures.

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers

Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

2020 ◽  
Vol 21 ◽  
Author(s):  
Dickson Pius Wande ◽  
Qin Cui ◽  
Shijie Chen ◽  
Cheng Xu ◽  
Hui Xiong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Dissolution ◽  
Glycol Succinate ◽  
Permeation Enhancer ◽  
P Glycoprotein ◽  
Us Fda ◽  
Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

Biomedical Applications and Patents on Metallic Nanoparticles

2020 ◽  
Vol 10 ◽  
Author(s):  
Geetanjali Singh ◽  
Pramod Kumar Sharma ◽  
Rishabha Malviya
Keyword(s):  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Size Range ◽  
Biomedical Application ◽  
Chemical Reduction ◽  
Chemical Methods ◽  
Future Challenges ◽  
Biological Methods ◽  
Cancer Diagnosis And Therapy ◽  
Physical And Chemical

Aim/Objective: The author writes the manuscript by reviewing the literatures related to the biomedical application of metallic nanoparticles. The term metal nanoparticles are used to describe the nanosized metals with the dimension within the size range of 1-100 nm. Methods: The preparation of metallic nanoparticles and their application is an influential area for research. Among various physical and chemical methods (viz. chemical reduction, thermal decomposition, etc.) for synthesizing silver nanoparticles, biological methods have been suggested as possible eco-friendly alternatives. The synthesis of metallic nanoparticles is having many problems inclusive of solvent toxicity, the formation of hazardous byproducts and consumption of energy. So it is important to design eco-friendly benign procedures for the synthesis of metallic nanoparticles. Results: From the literature survey, we concluded that metallic nanoparticles have applications in the treatment of different diseases. Metallic nanoparticles are having a great advantage in the detection of cancer, diagnosis, and therapy. And it can also have properties such as antifungal, antibacterial, anti-inflammatory, antiviral and anti-angiogenic. Conclusion: In this review, recent upcoming advancement of biomedical application of nanotechnology and their future challenges has been discussed.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

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