Biomedical Applications and Patents on Metallic Nanoparticles

Author(s):  
Geetanjali Singh ◽  
Pramod Kumar Sharma ◽  
Rishabha Malviya

Aim/Objective: The author writes the manuscript by reviewing the literatures related to the biomedical application of metallic nanoparticles. The term metal nanoparticles are used to describe the nanosized metals with the dimension within the size range of 1-100 nm. Methods: The preparation of metallic nanoparticles and their application is an influential area for research. Among various physical and chemical methods (viz. chemical reduction, thermal decomposition, etc.) for synthesizing silver nanoparticles, biological methods have been suggested as possible eco-friendly alternatives. The synthesis of metallic nanoparticles is having many problems inclusive of solvent toxicity, the formation of hazardous byproducts and consumption of energy. So it is important to design eco-friendly benign procedures for the synthesis of metallic nanoparticles. Results: From the literature survey, we concluded that metallic nanoparticles have applications in the treatment of different diseases. Metallic nanoparticles are having a great advantage in the detection of cancer, diagnosis, and therapy. And it can also have properties such as antifungal, antibacterial, anti-inflammatory, antiviral and anti-angiogenic. Conclusion: In this review, recent upcoming advancement of biomedical application of nanotechnology and their future challenges has been discussed.

2016 ◽  
Vol 20 (17) ◽  
pp. 1797-1812 ◽  
Author(s):  
Xiaoyue Yu ◽  
Cuie Tang ◽  
Shanbai Xiong ◽  
Qijuan Yuan ◽  
Zhipeng Gu ◽  
...  

Author(s):  
LATIF MS ◽  
ABBAS S ◽  
KORMIN F ◽  
MUSTAFA MK

The use of metal nanoparticles (MNPs) in various fields is increasing day-by-day leading to a genuine concern about the issues related to their environmental and biological safety. The major approaches for the synthesis of NPs include physical and chemical methods which are expensive and hazardous to health in addition to being toxic to the environment. This review highlights the potential of plant extracts to carry out the synthesis of MNPs with a special emphasis on the role of flavonoids in nanosynthesis. This green and clean approach have been actively utilized in recent years as an alternative to conventional hazardous approaches. It has proved as cost-effective, non-toxic, less time and labor consuming, efficient, and eco-friendly method for the synthesis of MNPs with specific biological actions. This review also focuses on the role of polyphenols, including the flavonoids as bioreductants of metal salts for the synthesis of NPs along with their biomedical applications. Various examples of the MNPs, along with their biological actions, have also been summarized.


2019 ◽  
Vol 25 (24) ◽  
pp. 2650-2660 ◽  
Author(s):  
Rajasree Shanmuganathan ◽  
Indira Karuppusamy ◽  
Muthupandian Saravanan ◽  
Harshiny Muthukumar ◽  
Kumar Ponnuchamy ◽  
...  

Generally, silver is considered as a noble metal used for treating burn wound infections, open wounds and cuts. However, the emerging nanotechnology has made a remarkable impact by converting metallic silver into silver nanoparticles (AgNPs) for better applications. The advancement in technology has improved the synthesis of NPs using biological method instead of physical and chemical methods. Nonetheless, synthesizing AgNPs using biological sources is ecofriendly and cost effective. Till date, AgNPs are widely used as antibacterial agents; therefore, a novel idea is needed for the successful use of AgNPs as therapeutic agents to uncertain diseases and infections. In biomedicine, AgNPs possess significant advantages due to their physical and chemical versatility. Indeed, the toxicity concerns regarding AgNPs have created the need for non-toxic and ecofriendly approaches to produce AgNPs. The applications of AgNPs in nanogels, nanosolutions, silver based dressings and coating over medical devices are under progress. Still, an improvised version of AgNPs for extended applications in an ecofriendly manner is the need of the hour. Therefore, the present review emphasizes the synthesis methods, modes of action under dissipative conditions and the various biomedical applications of AgNPs in detail.


2021 ◽  
Vol 2 (10) ◽  
pp. 977-984
Author(s):  
Divya Chauhan ◽  
Mohammad Ashfaq ◽  
Neetu Talreja ◽  
Ramalinga Viswanathan Managalraja

Recently 2D materials are booming in the field of energy, environment, and biomedical application. Incorporation of metal/non-metal within 2D materials significantly influences the physical and chemical properties, making them intriguing materials for various applications. The advancement of 2D material requires strategic modification by manipulating the electronic structure, which remains a challenge. Herein, we describe 2D materials for the environment, energy, and biomedical application. A predominant aim of this short communication is to summarize the literature on the advanced environment, energy, and biomedical application (especially COVID-19).


2020 ◽  
pp. 465-470
Author(s):  
Hutoryanina ◽  
Dumbadze ◽  
Dimidova

The problem of environmental pollution has now acquired global significance. Helminth eggs in liquid manure laid in open-type sedimentation tanks in October-November, remain viable for 12 months or more, and in spring-summer manure for 4–5 months. Therefore, uninfected liquid manure in both winter and summer poses a serious threat of contamination of reservoirs, soil, groundwater, feed and pastures with dangerous pathogens for humans and animals. This circumstance makes it necessary to carry out disinfestation of manure of all categories. Based on the above, the purpose of the work was to analyze existing methods of manure disinfection and manure effluents. All methods of deworming (disinvasion) of manure and its fractions can be divided into three groups: biological, physical and chemical. It is generally recognized that biological methods for decomposing organic waste are considered environmentally acceptable and cost-effective. Some of the analyzed physical and chemical methods also have a certain effectiveness of disinfection. When using these groups of disinfectants, constant monitoring and compliance with technological parameters is necessary, as well as the norms for the consumption of disinfectants and the exposure time must be observed.


The usage of various plant extracts for green synthesis of magnetite nanoparticles, these plant extracts gaining importance day today when compared to the physical and chemical methods of synthesis due to its various advantages such as low cost, biocompatible, biodegradable, non-toxic. They also act as both reducing and capping agents during the synthesis of nanoparticles and this association achieved various pharmaceutical, and other biomedical applications. this study investigates the Plant mediated green synthesized Magnetite Nanoparticles (Fe3O4 NPs) for Antioxidant, antibacterial, Anticancer activities


Author(s):  
Mariana Marinescu ◽  
M. Dumitru ◽  
Anca Lacatusu

The exploitation of petroleum has generated various sources of pollution in soil. In order to resolve this problem, several techniques have been developed. Physical and chemical methods are the most widely methods used for land treatment of oil polluted soils. These methods are expensive, ineffective and could cause a lot of damages on soil. The biological methods are not expensive and do not cause changes in the soil physical and chemical characteristics. Bioremediation is based on the capacity of microorganisms to degrade organic pollutant compounds, such as hydrocarbons. This study presents the preliminary results of a bioremediation alternative for soils polluted with crude oil (petroleum hydrocarbons). The bioremediation was achieved by increasing the microbial population by adding the fibers provided from celluloid wastes and bacteria inoculum. The paper presents the effect of a bioremediation treatment applied to a cambic chernozem polluted with 50000 mg kg-1 (5% crude oil) and 100000 mg kg-1 (10% crude oil) of a complex mixture of total petroleum hydrocarbons (TPH).


Plants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1929
Author(s):  
Jumoke A. Aboyewa ◽  
Nicole R. S. Sibuyi ◽  
Mervin Meyer ◽  
Oluwafemi O. Oguntibeju

The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their functions, which are attributed to their physicochemical properties, have gained prominence in various technological fields. Although MNPs can be produced via rigorous physical and chemical techniques, in recent years, a biological approach utilizing natural materials has been developed. With the increasing enthusiasm for safe and efficient nanomaterials, the biological method incorporating microorganisms and plants is preferred over physical and chemical methods of nanoparticle synthesis. Of these bio-entities, plants have received great attention owing to their capability to reduce and stabilize MNPs in a single one-pot protocol. South Africa is home to ~10% of the world’s plant species, making it a major contributor to the world’s ecological scenery. Despite the documented contribution of South African plants, particularly in herbal medicine, very few of these plants have been explored for the synthesis of the noble MNPs. This paper provides a review of some important South African medicinal plants that have been utilized for the synthesis of MNPs. The enhanced biological properties of the biogenic MNPs attest to their relevance in medicine. In this endeavour, more of the African plant biodiversity must be explored for the synthesis of MNPs and be validated for their potential to be translated into future nanomedicine.


2016 ◽  
Vol 5 (6) ◽  
Author(s):  
Agbaje Lateef ◽  
Sunday A. Ojo ◽  
Joseph A. Elegbede

AbstractNanotechnology has remained relevant as a multifacet discipline, which cuts across different areas of science and technology. Several successful attempts had been documented regarding the involvement of biological materials in the green synthesis of various metal nanoparticles (MeNPs) because of their eco-friendliness, cost-effectiveness, safe handling, and ultimately less toxicity as opposed to the physical and chemical methods with their concomitant problems. Biological agents, including bacteria, fungi, algae, enzymes, plants, and their extracts, have been implicated in most cases by several authors. Moreover, nanotechnology in recent times has also made an inroad for animal species, specifically arthropods and metabolites thereof to be used as excellent candidates for the green synthesis of MeNPs. The increasing literature on the use of metabolites of arthropods for the green synthesis of nanoparticles has necessitated the need to document a review on their relevance in nanobiotechnology. The review, which represents the first of its kind, seeks to underscore the importance of arthropods in the multidisciplinary subject of nanoscience and nanotechnology.


2020 ◽  
Vol 8 (10) ◽  
pp. 1542 ◽  
Author(s):  
Francesca Cappitelli ◽  
Cristina Cattò ◽  
Federica Villa

The microbial deterioration of cultural heritage includes physical and chemical damage as well as aesthetic alteration. With the technological advancement, a plethora of techniques for removing unwanted microorganisms have opened up new opportunities for microbiologists and conservators. This article reviews the most applied, up-to-date, and sustainable techniques developed for the control of cultural heritage microbial deterioration presenting noteworthy case studies. These techniques include chemical methods, i.e., traditional biocides and nanoparticles; physical methods, such as mechanical removal, UV irradiation, gamma radiation, laser cleaning, heat shocking, microwaves, and dry ice treatment; and biological methods, such as natural molecules with biocidal activity, enzymes, and microorganisms. The application of control systems requires the comprehension of their behavior toward the unwanted microorganisms and possible interactions with the heritage materials. This overview shows also the control methods drawbacks for the purpose of creating awareness in selecting the most suitable technique or combination of techniques.


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