scholarly journals Gold Nanoparticles synthesis, properties, and forthcoming applications : A review

2015 ◽  
Vol 3 (02) ◽  
pp. 13-27 ◽  
Author(s):  
Naveen Sharma ◽  
Ganesh Bhatt ◽  
Preeti Kothiyal
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Anticancer Agent ◽  
Delivery Vehicle ◽  
Pharmaceutical Drug ◽  
Therapeutic Drugs ◽  
Cancerous Cell ◽  
Synthesis Properties

Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characteristics. AuNPs can be conjugated with ligands, imaging labels, therapeutic drugs and other functional moieties for site specific drug delivery application. In this present review we are discussing the synthesis, properties, and forthcoming applications of gold nanoparticle (AuNPs) which is the most studied among all other metallic-nanoparticles. Here our main focus is to explain the AuNPs application in cancer treatment. AuNPs provides non-toxic carrier system for pharmaceutical drug and gene delivery applications. Currently various anticancer drugs are available but these are cause the necrosis of cancerous cell as well as normal cells. AuNPs cause the necrosis of only cancer cells therefore we can utilize it as a delivery vehicle as well as anticancer agent

Surface-bioengineered Gold Nanoparticles for Biomedical Applications

2018 ◽  
Vol 25 (16) ◽  
pp. 1920-1944 ◽  
Author(s):  
Zhicong Miao ◽  
Zilin Gao ◽  
Ruoxia Chen ◽  
Xiaoqing Yu ◽  
Zhiqiang Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gold Nanoparticles ◽  
Surface Functionalization ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Structure Functions ◽  
Functionalized Nanoparticles ◽  
Recent Advances

The conjugation of gold nanoparticles (AuNPs) with biomolecules could create many outstanding biofunctions for the surface-functionalized nanoparticles and extend their biomedical applications. In this review, we summarize the recent advances in the surface bioengineering of AuNPs with biomolecules, such as DNA, proteins, peptides, and biopolymers, in which the details on the structure, functions, and properties of surface- bioengineered AuNPs are discussed. In addition, the surface-biofunctionalization of AuNPs for biomedical applications like biosensing, bioimaging, drug delivery, and tissue engineering are introduced. It is expected that this work will be very helpful for readers to understand the surface functionalization and engineering techniques for various metallic nanoparticles and design novel biomaterials for biomedical applications.

Metallic Nanoparticles for Drug Delivery and Biomedical Applications: Patent Perspectives

2019 ◽  
Vol 8 (3) ◽  
pp. 176-176 ◽  
Author(s):  
Mahfoozur Rahman ◽  
Amit K. Nayak ◽  
Sarwar Beg ◽  
M. Saquib Hasnain
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Biomedical Applications

scholarly journals Gold–Protein Composite Nanoparticles for Enhanced X-ray Interactions: A Potential Formulation for Triggered Release

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1407
Author(s):  
Courtney van Ballegooie ◽  
Alice Man ◽  
Alessia Pallaoro ◽  
Marcel Bally ◽  
Byron D. Gates ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
External Beam Radiation ◽  
Therapeutic Effects ◽  
Delivery Vehicle ◽  
Triggered Release ◽  
Gold Particles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Zein Protein

Drug-delivery vehicles have been used extensively to modulate the biodistribution of drugs for the purpose of maximizing their therapeutic effects while minimizing systemic toxicity. The release characteristics of the vehicle must be balanced with its encapsulation properties to achieve optimal delivery of the drug. An alternative approach is to design a delivery vehicle that preferentially releases its contents under specific endogenous (e.g., tissue pH) or exogenous (e.g., applied temperature) stimuli. In the present manuscript, we report on a novel delivery system with potential for triggered release using external beam radiation. Our group evaluated Zein protein as the basis for the delivery vehicle and used radiation as the exogenous stimulus. Proteins are known to react with free radicals, produced during irradiation in aqueous suspensions, leading to aggregation, fragmentation, amino acid modification, and proteolytic susceptibility. Additionally, we incorporated gold particles into the Zein protein matrix to create hybrid Zein–gold nanoparticles (ZAuNPs). Zein-only nanoparticles (ZNPs) and ZAuNPs were subsequently exposed to kVp radiation (single dose ranging from 2 to 80 Gy; fractionated doses of 2 Gy delivered 10 times) and characterized before and after irradiation. Our data indicated that the presence of gold particles within Zein particles was correlated with significantly higher levels of alterations to the protein, and was associated with higher rates of release of the encapsulated drug compound, Irinotecan. The aggregate results demonstrated a proof-of-principle that radiation can be used with gold nanoparticles to modulate the release rates of protein-based drug-delivery vehicles, such as ZNPs.

Biogenic Synthesis of Gold Nanoparticles and Their Antimicrobial Activities

2020 ◽  
pp. 216-233
Author(s):  
Snežana Radisavljević ◽  
Biljana Petrović
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Food Packaging ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Bactericidal Effect ◽  
Antimicrobial Activities ◽  
Physiochemical Properties

Gold nanoparticles (AuNPs) are widely used in biomedical applications, especially diagnostic and drug delivery. The antibacterial activity of nanoparticles depends on the dimensions of the particles. AuNPs may associate with the surface of the cell membrane and cause disorder such as respiration and permeability. The method of binding of particles for bacteria depends on their surface available for interaction. Smaller particles which have the larger surface area available for interaction will show better bactericidal effect than the larger particles. Useful antibacterial agents should also be toxic to various pathogenic bacteria with the ability to coat different surfaces like biomaterials, devices, textiles, food packaging, and so on. The biological and physiochemical properties of synthesized AuNPs have impact on the use of gold nanoparticles like antimicrobial agents, especially for water purification, as well as other biomedical applications.

The biocompatible validity of amino acid ionic liquid mediated gold nanoparticles for enhanced activity and structural stability of papain

2021 ◽  
Author(s):  
Sumit Kumar ◽  
Pannuru Venkatesu
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Ionic Liquid ◽  
Amino Acid ◽  
Structural Stability ◽  
Biomedical Applications ◽  
Biomolecular Interactions ◽  
The Past ◽  
Enhanced Activity ◽  
Amino Acid Ionic Liquid

During the past few decades, gold nanoparticles (AuNPs) have attracted a numerous of attention owing to their biomedical applications like therapeutic and drug delivery, however, the detailed biomolecular interactions and...

scholarly journals ROLE OF DENDRIMERS IN ADVANCED DRUG DELIVERY AND BIOMEDICAL APPLICATIONS: A REVIEW

2018 ◽  
Vol 40 (3) ◽  
pp. 178-183 ◽  
Author(s):  
A Akbarzadeh ◽  
R Khalilov ◽  
E Mostafavi ◽  
N Annabi ◽  
T Kafshdooz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Retention Time ◽  
Structural Design ◽  
Open Study ◽  
Biomedical Applications ◽  
Delivery Vehicle ◽  
Chemical Substances ◽  
Biologically Relevant ◽  
Polymer Size

Aim: Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of specific properties of chemical substances. Dendrimers are an ideal delivery vehicle candidate for open study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, bio-distribution, internalization, blood plasma retention time, and filtration. This article reviews role of dendrimers in advanced drug delivery and biomedical applications.

Biomedical Applications of Gold Nanoparticles

2018 ◽  
pp. 837-858 ◽  
Author(s):  
Irshad Ahmad Wani
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Optical Properties ◽  
Diagnostic Imaging ◽  
Biomedical Applications ◽  
Recent Advances ◽  
The Subject

Gold nanoparticles are the subject of intense studies due to the exceptional photo-optical properties combined with the biocompatibility and has proved to be a powerful tool in various nanomedicinal applications. This book chapter discusses the recent advances and current challenges facing the biomedical applications of gold nanoparticles of various sizes and shapes. This chapter summarizes the applications of gold nanoparticles in biomedical area including diagnostic imaging, biosensing, drug delivery, and photothermal and photodynamic strategies etc. The key advantages of the gold nanoparticles including their ease of synthesis and functionalization together with biodistribution and toxicity has also been discussed.

scholarly journals Assessing the Role of Modern Excipients for Delivery of Gold Nanoparticles

2020 ◽  
Vol 10 (6-s) ◽  
pp. 151-158
Author(s):  
Abdul Waheed ◽  
Nayela Ghazal
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Binding Sites ◽  
Biomedical Applications ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Polymer Compatibility ◽  
Nanoparticles Stability ◽  
Delivery Approach

Using the drug delivery approach, we explain the role lipids and polymers perform in the delivery of gold nanoparticles. They were tested alongside drug and polymer compatibility using pharmacodynamics and pharmacokinetics. The collected data demonstrate the production of gold nanoparticles' stability and strong therapeutic effects. We illustrate some of the intriguing categories of targeting systems for the delivery of Au G Nanoparticles that are under development. Polymers containing reactive functional groups to combine targeting binding sites, cell receptors, or drugs are also coated with nanoparticles engineered for biomedical applications. The present review focuses on utilization of modern excipients, lipids, polymers in formulation of delivery systems that can efficiently delivery the gold nanoparticles. Gold nanoparticles have outranged in their use for treating wide health diseases with limited side effects. The next generation medical deliverables are majorly focused on gold nanoparticles. Keywords: Gold nanoparticles, Lipids, Polymers, Delivery systems, Excipients, Diseases.

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