Baseline Levels of Interleukine-6, Tumor-Necrosis Factor-Alpha and C-Reactive Protein in Treatment Naive Human Immunodeficiency Virus Infected Patients-A Study from a Tertiary-Care Hospital in Eastern India

2017 ◽  
Vol 6 (2) ◽  
Author(s):  
Anindita Debnath ◽  
Madhuchhanda Mandal ◽  
Sayantani Choudhuri ◽  
Malay K. Saha ◽  
Subhasish Kamal Guha
Keyword(s):  
Tertiary Care ◽  
Care Hospital ◽  
Eastern India ◽  
C Reactive Protein ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Immunodeficiency Virus ◽  
Treatment Naïve ◽  
Factor Alpha ◽  
Necrosis Factor

Effects of concurrent training on interleukin-6, tumour necrosis factor-alpha and C-reactive protein in middle-aged men

2011 ◽  
Vol 29 (14) ◽  
pp. 1573-1581 ◽  
Author(s):  
Cleiton Augusto Libardi ◽  
Giovana Verginia Souza ◽  
Arthur Fernandes GÁspari ◽  
Claudinei Ferreira Dos Santos ◽  
Sabrina Toffoli Leite ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Concurrent Training ◽  
C Reactive Protein ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Jirayu Lainampetch ◽  
Pornpimol Panprathip ◽  
Chanchira Phosat ◽  
Noppanath Chumpathat ◽  
Pattaneeya Prangthip ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Inflammatory Marker ◽  
C Reactive Protein ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Factor Alpha ◽  
Necrosis Factor

The linkage of obesity, inflammation, and type 2 diabetes mellitus (T2DM) has been extensively investigated for over a decade. However, the association between inflammatory biomarkers, including C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α), and T2DM is still inconsistent and limited. Thus, this study is aimed at elucidating the association between inflammatory marker levels and the risk of developing T2DM in many aspects. Among 296 subjects enrolled in 2013, 248 non-T2DM subjects who were completely reinvestigated in 2014 and 2015 were included in a 2-year retrospective analysis. Multivariate logistic regression was performed to evaluate the association of baseline inflammatory marker levels and variation with incidence of T2DM. After the 2-year follow-up, 18.6% of total subjects had developed T2DM. The risk of developing T2DM was significantly increased in subjects with a high level of baseline CRP (OR=4.02, 95% CI: 1.77-9.12, P=0.001), and a stronger impact was found with the combination of high CRP and IL-6 levels (OR=5.11, 95% CI: 1.27-20.49, P=0.021). One-year inflammatory marker variation analysis also revealed the significant association of elevated TNF-α and risk of developing T2DM (OR=4.88, 95% CI: 1.01-23.49, P=0.048). In conclusion, besides consideration of CRP levels alone, our findings suggested that IL-6 outstandingly plays a contributing role in T2DM progression and elevated TNF-α levels over time could be a potential predictor of T2DM.

scholarly journals Peran Hipertensi terhadap Mediator Peradangan dalam Perkembangan Penyakit Periodontal dan Jantung Koroner

2010 ◽  
Vol 17 (1) ◽  
pp. 68
Author(s):  
Rendy Sumali ◽  
Sri Lelyati C Masulili ◽  
Robert Lessang ◽  
Irene Sukardi
Keyword(s):  
Adhesion Molecule ◽  
Intercellular Adhesion Molecule ◽  
C Reactive Protein ◽  
Angiotensin I ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Factor Alpha ◽  
Vascular Adhesion ◽  
Necrosis Factor ◽  
Diabetes Melitus

Badan kesehatan dunia (WHO) pada tahun 2002 melaporkan bahwa lebih dari 7 juta orang meninggal dunia akibat penyakit kardiovaskular. Prevalensi penyakit periodontal pun dapat mencapai sekitar 70% pada usia produktif. Mengingat besarnya prevalensi keduanya, ada baiknya kita mentelaah lebih dalam hubungan diantara keduanya. Penyakit periodontal merupakan penyakit peradangan yang berhubungan dengan sejumlah kecil bakteri anaeob negatif Gram yang terdapat pada plak supragingiva. Bakteri negatif Gram anaerob tersebut juga mempunyai peluang menjadi penyebab tiga penyakit sistemik, seperti diabetes melitus, penyakit kardiovaskular, dan masalah penggumpalan darah. Penyakit kardiovaskular yang paling banyak dijumpai adalah penyakit jantung koroner dan hipertensi. Penyebab utama penyakit jantung koroner adalah aterosklerosis koroner, jika ditelaah lebih dalam, periodontitis dan aterosklerosis keduanya mempunyai faktor risiko yang sama, seperti: merokok, umur, etnis, jenis kelamin laki-Iaki, hipertensi, hiperkolesterol dan stress. Hubungan antara hipertensi dan penyakit periodontal bahwa keduanya merupakan proses peradangan. Baik pada penderita hipertensi dan penyakit periodontal dijumpai adanya peningkatan kadar C-reactive protein (CRP), sitokin-sitokin peradangan seperti IL-6, IL-1~, dan Tumour Necrosis Factor Alpha (TNF-a). C-Reactive Protein (CRP) juga menstimulasi pelepasan monosit yang menghasilkan Intercellular Adhesion Molecule (ICAM) -1 dan Vascular Adhesion Molecule (VCAM) -1 yang berperan dalam proses aterosklerosis. Disfungsi endotel pembuluh darah akibat proses aterosklerosis ini dapat memicu pengeluaran hormon Angiotensin /I (Ang II) yang berperan dalam mengatur tekanan darah. Hipertensi dapat menyebabkan disfungsi mikrosirkulasi pada jaringan periodontal, sehingga dapat mengakibatkan terjadi kelainan periodontal dan secara tidak langsung juga sebagai faktor risiko terjadinya penyakit jantung koroner.

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