The Catalytic Activity of TiO2 Toward a Multicomponent Reaction Depends on its Morphology, Mechanoactivation and Presence of Visible Light

2020 ◽  
Vol 1 (1) ◽  
pp. 37-42
Author(s):  
Subramanian Thirumeni ◽  
Choumini Balasanthiran ◽  
Grigoriy Sereda

Aims: Test the hypothesis that the catalytic activity of TiO2 nanoparticles towards a liquidphase or mechanoactivated multicomponent reaction can be tuned by visible light and the shape of nanoparticles. Background: Catalytic multicomponent reactions have been proven to be excellent synthetic approaches to a series of biologically relevant compounds including 2-amino-4H-benzo[b]pyrans. However, the potential photocatalytic activity and structural diversity of nanostructured catalysts remained underutilized in the design of new catalytic systems. Objective: Harness the photocatalytic potential and diverse morphology of TiO2 particles as catalysts for the liquid phase and mechanoactivated multicomponent organic reactions. Results: Catalytic activity of TiO2 nanoparticles towards multicomponent synthesis of 2-amino-4Hbenzo[ b]pyrans is increased by visible light. The nanorod-shaped TiO2 nanoparticles have shown substantially higher catalytic activity towards mechanoactivated multicomponent synthesis of 2- amino-4H-benzo[b]pyrans than their spherically-shaped counterparts. Conclusion: : An efficient methodology for the synthesis of 2-amino-4H-benzo[b]pyrans under ambient light condition has been developed using TiO2 nanorods (high aspect ratio anatase nanocrystals) as photocatalyst. This simple method furnished the corresponding terahydrobenzopyrans in high yields via three component reaction of aldehyde, malononitrile, and dimidone under solvent free reaction conditions at room temperature. The reaction takes 8-10 min at room temperature under ambient light condition and the catalyst can be reused multiple times. Utilization of light and the nanorod morphology of the catalyst through mechanoactivation has been applied for the -first time to the synthetic technique of multicomponent reactions. The synthetic procedures for 2-amino-4Hbenzo[ b]pyrans have been improved.

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54236-54240 ◽  
Author(s):  
Seyed Mohsen Sadeghzadeh

A green and efficient method for the synthesis of various triazolo[1,2-a]indazoletrione under mild conditions is reported, that making it a genuinely green protocol.


2021 ◽  
pp. 169-174
Author(s):  
Sandip R. Kale ◽  
Santosh Kumar Surve

One-pot synthesis of highly substituted pyridines has been demonstrated via multicomponent reaction of aldehydes, malononitrile and thiophenol using Mg-Al hydrotalcite as a solid base and reusable catalyst. The catalytic activity is intimately connected to the basicity of the catalyst. The best activities were observed with the Mg/Al: 5 catalyst. The catalyst could be reused for further run without a significant loss in activity. The protocol was also applicable for various aromatic aldehydes which affords desired product in good to excellent yield.


2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Biswa Mohan Sahoo ◽  
B. V. V. Ravi Kumar ◽  
Jnyanaranjan Panda ◽  
S. C. Dinda

A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1HNMR spectral data.


2019 ◽  
Author(s):  
Lina An ◽  
Fan Fan ◽  
Klaus Lunau ◽  
Mengyao Li ◽  
Xiaofan Yang ◽  
...  

SummaryThe chive gnat, Bradysia odoriphaga, is a notorious pest of Allium species in China. Colour trapping is an established method for monitoring and controlling of Bradysia species. In order to clarify the effect of colour preference of B. odoriphaga for the egg-laying substrate, multiple-choice tests were employed to assess the spontaneous response of the chive gnat to different colour hues and brightness levels under different intensities of white illumination and two spectrally different illuminations. Given the choice among four colours differing in hue under different intensities of white illumination and two spectrally different illuminations, chive gnat adults visited preferably the black substrate, a lesser extent to brown and green substrates, and the least extent to orange substrate irrespective of illumination. Given the choice among four levels of brightness under the same illumination conditions as those in the previous experiment (different intensities of white illumination and two spectrally different illuminations), chive gnats preferred black substrate over dark grey, and these over light grey and white substrates. Meanwhile, both virgin and copulated adults significantly preferred black over other colour hues and brightness. Based on our results, we conclude that the chive gnat adults significantly prefer black substrates irrespective of colour hues and brightness. This behaviour does not alter due to ambient light condition changes. No difference observed between choices of female and male adults. Our results provide new insight for understanding the colour choice behaviour in chive gnat and pave a way to improve monitoring and control of chive gnats and management.Summary statementChive gnat (Bradysia odoriphaga) innately prefer to move to black substrate irrespective of colour hues and brightness. This behaviour maintained the ambient lights change.


Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6839
Author(s):  
Yuliya E. Ryzhkova ◽  
Michail N. Elinson ◽  
Oleg I. Maslov ◽  
Artem N. Fakhrutdinov

Dimethyl sulfoxide is a widely used solvent in organic synthesis and in the pharmaceutical industry because of its low cost, stability, and low toxicity. Multicomponent reactions are an advanced approach that has become an efficient, economical, and eco-friendly substitute for the conventional sequential multi-step synthesis of various biologically active compounds. This approach was adopted for the synthesis of previously unknown 2-(2,4-diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonic acids via transformation of salicylaldehydes, malononitrile dimer, and malonic acid. It was shown that the use of DMSO at room temperature makes it possible to synthesize previously unavailable compounds. The investigation of the reaction mechanism using 1H-NMR monitoring made it possible to confirm the proposed mechanism of the transformation. The structure of synthesized 5H-chromeno[2,3-b]pyridines was confirmed by 2D-NMR spectroscopy.


Author(s):  
Seonghyeok Park ◽  
Kitae Hwang ◽  
Sohyun Yoon ◽  
Gyouhyung Kyung

E-mirrors comprised of cameras and visual displays are expected to replace current side mirrors. Although previous studies have extensively examined the effects of E-mirror size and location on drivers’ performance, safety, and preference, little is known about the required E-mirror luminance levels for diverse ambient light conditions that are typically involved in driving. This study examined the effects of ambient light conditions on the preferred E-mirror luminance levels. Sixteen individuals with a mean (SD) age of 25.7 (5.8) years participated in this study. All participants were recruited from a university student population and had more than two years of driving experience. All participants reported no color deficiency. A local institutional review board approved this study. This study considered four levels of ambient light conditions, two levels of eye adaptation (light and dark), and two levels of eye adaptation phase (initial and final). The four illuminance levels simulated daytime driving (600 lux), tunnel driving (daytime and nighttime; 100 lux), nighttime driving (3 lux), and sunlight condition. The daytime, tunnel, and nighttime driving involved looking at a corresponding driving scene projected on the front screen under a specific illuminance level, which was controlled by the indoor lighting system. The sunlight condition involved looking outside through the room window instead of looking at the front screen. A driving simulator was implemented using a car seat, a gaming steering wheel, and a beam projector. Two tablet PCs with an 8.0-inch screen of 9.8 (height) × 6.13 (width) cm (Galaxy Tab A 8.0 2017, Samsung Electronics, South Korea) were used as E-mirror displays. The E-mirror brightness could be manually adjusted using the steering wheel buttons, which were connected to the two tablet PCs. The SCANeRTM studio (v1.1, Oktal, France) driving scenes corresponding to each illumination condition were used in this study. Two distinct driving scenarios were considered. The first driving scenario was for daytime ambient light conditions, and consisted of the first daytime driving (DD1), first daytime tunnel driving (DTD1), DD2, DTD2, DD3, and daytime sunlight driving (DSD). In this scenario, DTD induced dark adaptation, and DD induced light adaptation. The second scenario was for nighttime driving, and consisted of the first nighttime driving (ND1), first nighttime tunnel driving (NTD1), ND2, NTD2, ND3, and nighttime sunlight driving NSD. ND involved dark adaptation, whereas NTD involved light adaptation. Both DD1 and ND1 were included to reduce the effect of the ambient light condition outside of the experimental room. The E-mirror brightness could increase or decrease by 10 within the range of 0-200 using the tablet PC brightness control function. The brightness of both tablet PCs was adjusted synchronously. For data analysis, the mean luminance (nit, cd/m2) of the image displayed on the left E-mirror was used. The luminance levels of the E-mirror images for the daytime, tunnel, and nighttime driving ranged from 1.5-184.4, 0-3.0, and 0-3.0 nit, respectively. The preferred luminance levels during eye adaptation were obtained every 15 s for the first 5 min and every 30 s for the remaining period of 5-30 min. The preferred luminance level after completion of each eye adaptation was measured using an ascending-descending series. During the eye adaptation period, the preferred luminance levels for ND1 were significantly different from those for ND3, which could be largely due to the carryover effects of pre-ambient light condition. The final difference in the preferred luminance levels between ND1 and ND3 was observed at 1,215s (20.25 min). In addition, significant differences in the preferred luminance were observed during the first min between DSD and NSD. The results of nighttime driving and sunlight driving indicated that the E-mirror luminance should be adjusted during the first 1,000 to 1,200 s for dark adaptation and the first 60 s for light adaptation. Eye adaptation inside the tunnel was completed during the first 15s for DTD1 and NTD1. However, there was no significant difference between DTD2 and NTD2 except for the time of 0s. Therefore, light and dark adaptation during tunnel driving appeared to be completed within 15 s. During the post-eye adaptation period, the effect of the pre-ambient light condition on the preferred luminance levels disappeared. The mean (SE) preferred luminance (nit) in the post-adaptation phase for the daytime, tunnel, nighttime, and sunlight driving was 126.1 (3.4), 1.5 (0.1), 0.8 (0.1), and 138.9 (3.7), respectively. The mean (SD) illuminance (lux) for DSD and NSD was 1404.7 (265.7) and 1339.9 (239.4), respectively. Some conditions showed significant differences between the initial and final preferred luminance levels. The preferred luminance levels decreased for ND1 and ND2, whereas the preferred luminance levels increased for NSD. Dark adaptation to the nighttime driving illuminance and light adaption to the extreme illuminance both affected the preferred luminance levels. These findings support the need for gradual luminance adjustment of E-mirrors during eye adaptation. Overall, this study showed that the preferred E-mirror luminance levels were affected by previous and current ambient light conditions. Several limitations of this study should be addressed in future studies. First, this study considered the preferred E-mirror luminance only and did not consider driving performance measures. Second, although the illuminance conditions considered in this study were carefully selected to represent distinct ambient light conditions encountered during driving, it is still necessary to examine additional illuminance conditions representing diverse driving contexts. Thus, in addition to the scenarios considered in this study, additional scenarios (e.g., different illuminance levels for daytime, tunnel, nighttime, and sunlight driving than those considered in this study as well as more rapid illuminance-changing cases) should be considered in future studies.


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