Pharmacological Effects of Curcuma longa, Focused on Anti-inflammatory, Antioxidant and Immunomodulatory Effects

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

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Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways

Pharmaceutics ◽

10.3390/pharmaceutics13081184 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1184

Author(s):

Armin Mooranian ◽

Thomas Foster ◽

Corina M Ionescu ◽

Daniel Walker ◽

Melissa Jones ◽

...

Keyword(s):

Bile Acids ◽

Biological Effects ◽

Cellular Respiration ◽

Full Potential ◽

Protective Effects ◽

Pharmacological Effects ◽

Β Cells ◽

Positive Effects ◽

Wide Range ◽

Anti Inflammatory

Introduction: Recent studies in our laboratory have shown that some bile acids, such as chenodeoxycholic acid (CDCA), can exert cellular protective effects when encapsulated with viable β-cells via anti-inflammatory and anti-oxidative stress mechanisms. However, to explore their full potential, formulating such bile acids (that are intrinsically lipophilic) can be challenging, particularly if larger doses are required for optimal pharmacological effects. One promising approach is the development of nano gels. Accordingly, this study aimed to examine biological effects of various concentrations of CDCA using various solubilising nano gel systems on encapsulated β-cells. Methods: Using our established cellular encapsulation system, the Ionic Gelation Vibrational Jet Flow technology, a wide range of CDCA β-cell capsules were produced and examined for morphological, biological, and inflammatory profiles. Results and Conclusion: Capsules’ morphology and topographic characteristics remained similar, regardless of CDCA or nano gel concentrations. The best pharmacological, anti-inflammatory, and cellular respiration, metabolism, and energy production effects were observed at high CDCA and nano gel concentrations, suggesting dose-dependent cellular protective and positive effects of CDCA when incorporated with high loading nano gel.

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Potential Antioxidative, Anti‐inflammatory and Immunomodulatory Effects of Ghrelin, an Endogenous Peptide from the Stomach in SARS-CoV2 Infection

International Journal of Peptide Research and Therapeutics ◽

10.1007/s10989-021-10217-9 ◽

2021 ◽

Author(s):

Abbas Jafari ◽

Sonia Sadeghpour ◽

Hojat Ghasemnejad-Berenji ◽

Sarvin Pashapour ◽

Morteza Ghasemnejad-Berenji

Keyword(s):

Immunomodulatory Effects ◽

Endogenous Peptide ◽

Anti Inflammatory

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Pharmacological effects of Lavandula officinalis Chaix and its polyphenols: Focus on their in vivo estrogenic and anti-inflammatory properties

South African Journal of Botany ◽

10.1016/j.sajb.2021.11.014 ◽

2022 ◽

Vol 146 ◽

pp. 354-364

Author(s):

Meryem Slighoua ◽

Ismail Mahdi ◽

Fatima ez-zahra Amrati ◽

Nabil Boucetta ◽

Francesca Di Cristo ◽

...

Keyword(s):

Pharmacological Effects ◽

Anti Inflammatory ◽

Lavandula Officinalis

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Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor

Fitoterapia ◽

10.1016/j.fitote.2018.10.016 ◽

2018 ◽

Vol 131 ◽

pp. 189-199 ◽

Cited By ~ 2

Author(s):

Rajaram Azad ◽

Neela Kishore Babu ◽

Aparna Dutta Gupta ◽

Pallu Reddanna

Keyword(s):

Immunomodulatory Effects ◽

Dual Inhibitor ◽

Cox 2 ◽

Anti Inflammatory

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Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Frontiers in Immunology ◽

10.3389/fimmu.2021.751772 ◽

2021 ◽

Vol 12 ◽

Author(s):

Feifei Qiu ◽

Junfeng Liu ◽

Xiumei Mo ◽

Huazhen Liu ◽

Yuchao Chen ◽

...

Keyword(s):

Autoimmune Diseases ◽

Molecular Mechanisms ◽

Transplant Rejection ◽

Antimalarial Drugs ◽

Therapeutic Effects ◽

Immunomodulatory Effects ◽

Clinical Safety ◽

The Past ◽

Tremendous Progress ◽

Anti Inflammatory

Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic effects on malaria. Apart from antimalarial effects, mounting evidence has demonstrated that ARTs exert therapeutic effects on inflammation and autoimmune disorders because of their anti-inflammatory and immunoregulatory properties. In this aspect, tremendous progress has been made during the past five to seven years. Therefore, the present review summarizes recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection. In this review, we also discuss the cellular and molecular mechanisms underlying the immunomodulatory effects of ARTs. Recent preclinical studies will help lay the groundwork for clinical trials using ARTs to treat various immune-based disorders, especially autoimmune diseases.

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Lavandulae aetheroleum Oil: A Review on Phytochemical Screening, Medicinal Applications, and Pharmacological Effects

Biointerface Research in Applied Chemistry ◽

10.33263/briac113.98369847 ◽

2020 ◽

Vol 11 (3) ◽

pp. 9836-9847

Keyword(s):

Central Nervous System ◽

Clinical Pharmacology ◽

Nervous System ◽

Chemical Constituents ◽

Cardiovascular Effects ◽

Pharmacological Effects ◽

Lavandula Angustifolia ◽

Experimental Pharmacology ◽

Central Nervous System Depressant ◽

Anti Inflammatory

Lavandulae aetheroleum, the oil, was obtained by vapor condensation from the flower of Lavandula angustifolia Mill. or Lavandula intermedia Loisel (Lamiaceae) plant. Other names of Lavandulae aetheroleum oil are Al birri, common or English lavender. The Lavandula angustifolia Mill. or Lavandula intermedia Loisel plant is spreading in the Mediterranean, southern Europe, Bulgaria, Russia, and USA. The Lavandula angustifolia Mill. or Lavandula intermedia Loisel plant, is an odor shrub with 1-2 m in height. The oil is a clear, colorless, or pale yellow. The gas chromatography studies reported the following percentage of the major chemical constituents in the oil: linalyl acetate (25-46%), linalool (20-45%), terpinen-4-ol (1.2-6.0%), lavendulyl acetate (> 1.0%), 1,8-cineole (1,8-cineol, cineol, cineole, eucalyptol) (< 2.5%), 3-octanone (< 2.5%), camphor (< 1.2%), limonene (< 1.0%), and α-terpineol (< 2.0%). Medicinal applications of the oil include the treatment of restlessness, anxiety, cardiovascular disorders, insomnia, and gastrointestinal disorders, burns, diarrhea, headache, sore throats, and wounds. Pharmacological effects include experimental and clinical pharmacology. Experimental pharmacology includes anesthetic, anticonvulsant, sedative, anti-inflammatory, antimicrobial, antispasmodic, antispasmodic, central nervous system depressant effects. Clinical pharmacology includes anxiolytic, analgesic, and cardiovascular effects. The oil dose by inhalation = 0.06-0.2 ml/ 3 times/day while oil dose internally = 1-4 drops approximately 20-80 mg on a sugar cube per day. In conclusion, Lavandulae aetheroleum oil had an anesthetic, anticonvulsant, sedative, anti-inflammatory, antimicrobial, antispasmodic, antispasmodic, central nervous system depressant, anxiolytic, analgesic, and cardiovascular effects.

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