Feasibility of the preparation of solvent-free vs solvent liposomes with trans-fatty acids for animal studies

The present review comes from the authors of the recent Scientific Advisory Committee on Nutrition (SACN) review Update on Trans Fatty Acids and Health, and focuses on assessing the strength of the evidence for a link between trans-fatty acid (trans-FA) intake and cancer. It evaluates a range of human ecological, case–control and prospective studies with trans-FA exposure assessed using either dietary assessment methods or trans-FA levels in tissues. Relevant animal studies are also presented in order to elucidate potential mechanisms. It concludes that there is weak and inconsistent evidence for a relationship between trans-FA and breast or colorectal cancer. Evidence for an association between trans-FA and prostate cancer is limited, but a recent large case–control study has shown a strong interaction between risk and trans-FA intake for the RNASEL QQ/RQ genotype that is present in about 35 % of the population. This potential association requires further investigation. The single study on non-Hodgkin's lymphoma reported a strong positive association, but only used a single assessment of dietary trans-FA made at the start of the study in 1980, and the significant changes in trans-FA intakes between then and the end of follow-up in 1994 limit the reliability of this observation. There is insufficient evidence to allow any differentiation between the effects of trans-FA from animal or vegetable origin on cancer risk.

Download Full-text

Trans fatty acids

AccessScience ◽

10.1036/1097-8542.yb081250 ◽

2015 ◽

Keyword(s):

Fatty Acids ◽

Trans Fatty Acids

Download Full-text

The effect of paternal trans fatty acids diet on sperm quality and expression profile of PPAR genes in the testis of rat offspring

10.26226/morressier.5af300ad738ab10027aa9259 ◽

2018 ◽

Author(s):

Narges Khamehiee

Keyword(s):

Fatty Acids ◽

Expression Profile ◽

Trans Fatty Acids ◽

Sperm Quality ◽

Rat Offspring

Download Full-text

Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the EPIC cohort

International Journal of Cancer ◽

10.1002/ijc.33615 ◽

2021 ◽

Author(s):

Elom K. Aglago ◽

Neil Murphy ◽

Inge Huybrechts ◽

Geneviève Nicolas ◽

Corinne Casagrande ◽

...

Keyword(s):

Colorectal Cancer ◽

Fatty Acids ◽

Cancer Risk ◽

Dietary Intake ◽

Trans Fatty Acids ◽

Plasma Phospholipid ◽

Colorectal Cancer Risk

Download Full-text

Short-Term Variations of C18:1 Trans Fatty Acids in Plasma Lipoproteins and Ruminal Fermentation Parameters of Non-Lactating Cows Subjected to Ruminal Pulses of Oils

Animals ◽

10.3390/ani11030788 ◽

2021 ◽

Vol 11 (3) ◽

pp. 788

Author(s):

Einar Vargas-Bello-Pérez ◽

Juan J. Loor ◽

Philip C. Garnsworthy

Keyword(s):

Fatty Acids ◽

Trans Fatty Acids ◽

Latin Square ◽

Density Lipoprotein ◽

Plasma Lipoproteins ◽

Ruminal Fermentation ◽

Short Term ◽

Lactating Cows ◽

Fermentation Parameters ◽

Partially Hydrogenated Vegetable Oil

The objective of this study was to evaluate short-term variations of trans fatty acids (TFA) in plasma lipoproteins and ruminal fermentation parameters of non-lactating cows subjected to ruminal pulses of vegetable oils. Three non-lactating, non-pregnant Holstein cows, each with a ruminal cannula, were arranged in a 3 × 3 Latin square design with three-day pulsing periods and four-day washout intervals between treatments. Cows were treated with single ruminal pulses of: (1) control (skimmed milk (SM); 500 mL); (2) soybean oil (SO; 250 g/d in 500 mL of SM) and (3) partially-hydrogenated vegetable oil (PHVO; 250 g/d in 500 mL of SM). Time changes after infusion in TFA contents were only observed for plasma C18:1 trans-4, trans-5 and trans-12, and high-density lipoprotein fraction C18:1 trans-9. After ruminal pulses, concentration of acetate decreased linearly; molar concentrations of propionate and valerate increased linearly; molar concentrations of butyrate and isovalerate changed quadratically and were greater at 1 h than at other times. There was an accumulation of several C18:1 TFA in plasma and lipoproteins, especially on the third day of pulsing. Overall, naturally occurring C18:1 TFA isomers (produced during ruminal biohydrogenation of SO) and preformed TFA (supplied by PHVO) elicited differential TFA partitioning and transport in plasma and lipoproteins.

Download Full-text

Engineering Fatty Acid Photodecarboxylase To Enable the Highly selective Decarboxylation of trans Fatty Acids

Angewandte Chemie ◽

10.1002/ange.202107694 ◽

2021 ◽

Author(s):

Qi Wu ◽

Danyang Li ◽

Tao Han ◽

Jiadan Xue ◽

Weihua Xu ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Trans Fatty Acids

Download Full-text

Fatty Acid Composition of Cosmetic Argan Oil: Provenience and Authenticity Criteria

Molecules ◽

10.3390/molecules25184080 ◽

2020 ◽

Vol 25 (18) ◽

pp. 4080

Author(s):

Milena Bučar Miklavčič ◽

Fouad Taous ◽

Vasilij Valenčič ◽

Tibari Elghali ◽

Maja Podgornik ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Discriminant Analysis ◽

Trans Fatty Acids ◽

Correct Classification ◽

Fatty Acid Profiles ◽

Correct Classification Rate ◽

Classification Rate ◽

Argan Oil ◽

Geographical Regions

In this work, fatty-acid profiles, including trans fatty acids, in combination with chemometric tools, were applied as a determinant of purity (i.e., adulteration) and provenance (i.e., geographical origin) of cosmetic grade argan oil collected from different regions of Morocco in 2017. The fatty acid profiles obtained by gas chromatography (GC) showed that oleic acid (C18:1) is the most abundant fatty acid, followed by linoleic acid (C18:2) and palmitic acid (C16:0). The content of trans-oleic and trans-linoleic isomers was between 0.02% and 0.03%, while trans-linolenic isomers were between 0.06% and 0.09%. Discriminant analysis (DA) and orthogonal projection to latent structure—discriminant analysis (OPLS-DA) were performed to discriminate between argan oils from Essaouira, Taroudant, Tiznit, Chtouka-Aït Baha and Sidi Ifni. The correct classification rate was highest for argan oil from the Chtouka-Aït Baha province (90.0%) and the lowest for oils from the Sidi Ifni province (14.3%), with an overall correct classification rate of 51.6%. Pairwise comparison using OPLS-DA could predictably differentiate (≥0.92) between the geographical regions with the levels of stearic (C18:0) and arachidic (C20:0) fatty acids accounting for most of the variance. This study shows the feasibility of implementing authenticity criteria for argan oils by including limit values for trans-fatty acids and the ability to discern provenance using fatty acid profiling.

Download Full-text